Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route by Anne-Claire Groo, Thomas Curel, Aurélie Malzert-Fréon, Line Séguy, Ophélie Bento, Sophie Corvaisier, Thomas Culerier, Romain Legrand, Noëlle Callizot, Alexandre Henriques, Georgia Culley, Sylvie Claeysen, Christophe Rochais, Patrick Dallemagne

“…Finally, intranasal administration of low doses of bambuterol gel in mice intoxicated with Aβ peptides, prevented long-term spatial memory impairment and showed beneficial effects on the survival of neurons and on synapse preservation.…”
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Dendritic Spines in Depression: What We Learned from Animal Models by Hui Qiao, Ming-Xing Li, Chang Xu, Hui-Bin Chen, Shu-Cheng An, Xin-Ming Ma

“…Meanwhile, neurons of the amygdala and nucleus accumbens exhibit an increase in spine density. …”
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Evolution of Cerebral Atrophy in a Patient with Super Refractory Status Epilepticus Treated with Barbiturate Coma by Christopher R. Newey, Pravin George, Premkumar Nattanmai, Christine Ahrens, Stephen Hantus, Aarti Sarwal

“…Status epilepticus is associated with neuronal breakdown. Radiological sequelae of status epilepticus include diffusion weighted abnormalities and T2/FLAIR cortical hyperintensities corresponding to the epileptogenic cortex. …”
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Changes in Retinal Function and Cellular Remodeling Following Experimental Retinal Detachment in a Rabbit Model by Tilda Barliya, Ron Ofri, Shai Sandalon, Dov Weinberger, Tami Livnat

“…Eyes were harvested on day 21 and evaluated immunohistochemically (IHC) for remodeling of second- and third-order neurons. Results. Retinal reattachment occurred within two weeks following surgery. …”
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Targeting Oxidative Stress Injury after Ischemic Stroke in Conscious Rats: Limited Benefits with Apocynin Highlight the Need to Incorporate Long Term Recovery by Robert M. Weston, Bin Lin, Gregory J. Dusting, Carli L. Roulston

“…This study evaluated the effects of apocynin, a known antioxidant and inhibitor of Nox2 NADPH, on neuronal injury and cell-specific responses to stroke induced in the conscious rat. …”
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Distribution of Adiponectin Receptors 1 and 2 in the Rat Olfactory Bulb and the Effect of Adiponectin Injection on Insulin Receptor Expression by Alfredo Miranda-Martínez, Octavio Fabián Mercado-Gómez, Virginia Arriaga-Ávila, Rosalinda Guevara-Guzmán

“…Although its receptors AdipoR1 and AdipoR2 are expressed in the brain, their function in neurons is poorly understood. The aims of this work were to describe the distribution of APN receptors in the olfactory bulb (OB) as well as the possible effects of APN injection on the insulin receptor (InsR) content and Akt kinase. …”
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Stable coding of aversive associations in medial prefrontal populations by Herry, Cyril, Jercog, Daniel

“…What mPFC neuronal populations represent when we face threats? …”
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Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences by Gloria Ortiz-Guerrero, Diana Amador-Muñoz, Carlos Alberto Calderón-Ospina, Daniel López-Fuentes, Mauricio Orlando Nava Mesa

“…Further, AD is characterized by selective synaptic and neuronal degeneration, vascular dysfunction, and two histopathological features: extracellular amyloid plaques composed of amyloid beta peptide (Aβ) and neurofibrillary tangles formed by hyperphosphorylated tau protein. …”
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Exploring the Potential Imaging Biomarkers for Parkinson’s Disease Using Machine Learning Approach by Illia Mushta, Sulev Koks, Anton Popov, Oleksandr Lysenko

“…Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and neuropsychiatric symptoms resulting from the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). …”
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The Role of the Gastrointestinal Microbiota in Parkinson’s Disease by Maurizio Gabrielli, Lorenzo Zileri Dal Verme, Maria Assunta Zocco, Enrico Celestino Nista, Veronica Ojetti, Antonio Gasbarrini

“…Background/Objectives: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons leading to debilitating motor and non-motor symptoms. …”
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Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function by Gustavo Della-Flora Nunes, Lindsay A. Osso, Johana A. Haynes, Lauren Conant, Michael A. Thornton, Michael E. Stockton, Katherine A. Brassell, Amanda Morris, Yessenia I. Mancha Corchado, John A. Gaynes, Anthony R. Chavez, Michaelanne B. Woerner, Deidre A. MacKenna, Aryan Alavi, Anne Danks, Alon Poleg-Polsky, Rohan Gandhi, Jeffrey A. Vivian, Daniel J. Denman, Ethan G. Hughes

“…However, we find regeneration of oligodendrocytes and myelin to healthy levels is not necessary for recovery of visual neuronal function. These findings advance our understanding of remyelination and its impact on functional recovery to inform future therapeutic strategies.…”
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Effect of Body Weight Supported Treadmill Training on Motor Function of Rats with Spinal Cord Injury Based on AMPK-Autophagy Signaling Pathway by CAI Jili, ZHAI Chenyuan, WANG Zun, WU Qi, FANG Lu, WANG Yu, WANG Tong

“…Nissl staining was used to observe the morphology and count of spinal cord neurons. Western blot method was used to detect the protein expression levels of p-AMPK, t-AMPK, LC3 and p62 in spinal cord tissue.Results(1) BBB score: compared with the sham operation group, the BBB score of the model group and the exercise group were significantly lower at the 1st, 7th, 14th, 21st and 28th days after modeling (<italic>P</italic>&lt;0.05). …”
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Classification of Myopathy and Amyotrophic Lateral Sclerosis Electromyograms Using Bat Algorithm and Deep Neural Networks by A. Bakiya, A. Anitha, T. Sridevi, K. Kamalanand

“…Correspondingly, the developed conventional single layer artificial neural network (neurons=7) with time domain features has shown an accuracy of 83.3%, sensitivity of 100%, and specificity of 71.42%. …”
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Lane-Changing Trajectory Prediction Modeling Using Neural Networks by Hamidreza Hamedi, Rouzbeh Shad

“…The present study adopts a dual-layer feed-forward backpropagation neural network involving sigmoid hidden neurons and linear output neurons for evaluating intrinsic LC complexity. …”
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Construction of a Multicellular Communication Network Model for Cell Co-Culture Technology and Evaluation of Its Simulation Capability by Yuan-Yuan Geng, Chao Wei, Guo-Fei Chen, Bai-Xia Zhang

“…Through the correspondence and location information of signal molecules and receptors, type-specific networks of single cells were connected and a multicellular network of smooth muscle cells, neurons, and vascular endothelial cells was constructed. …”
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Bone Mineral Density Prediction from CT Image: A Novel Approach using ANN by S. L. Resmi, V. Hashim, Jesna Mohammed, P. N. Dileep

“…The network used in this study is a standard backpropagation neural network having five input neurons with one hidden layer having 40 neurons with a tan-sigmoidal activation function. …”
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Pilocarpine-Induced Status Epilepticus Is Associated with Changes in the Actin-Modulating Protein Synaptopodin and Alterations in Long-Term Potentiation in the Mouse Hippocampus by Maximilian Lenz, Marina Ben Shimon, Thomas Deller, Andreas Vlachos, Nicola Maggio

“…Epilepsy is a complex neurological disorder which can severely affect neuronal function. Some patients may experience status epilepticus, a life-threatening state of ongoing seizure activity associated with postictal cognitive dysfunction. …”
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A comprehensive transcriptional reference for severity and progression in spinal cord injury reveals novel translational biomarker genes by Rubén Grillo-Risco, Marta R. Hidalgo, Beatriz Martínez-Rojas, Victoria Moreno-Manzano, Francisco García-García

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Cerebral organoids: a promising model in cellular technologies by T. A. Shnaider

“…Generation of hybrid three-dimensional cerebral organoids with different brain region identity allows remodeling some of them, including long-distance neuronal migration or formation of major axonal tracts. …”
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Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies by Wouter Claeys, Anja Geerts, Lien Van Hoecke, Christophe Van Steenkiste, Roosmarijn E. Vandenbroucke

“…Furthermore, state of the art research increasingly implicates neuronal dysfunction and possibly even irreversible neuronal cell death. …”
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