Visual Outcome Ambliopia Refraktif Yang Mendapat Cam Vision Stimulator Di RS. M. Djamil Padang Januari-Desember 2017 by Suci Fitri, Julita Julita

“…The Cambridge Amblyopic (CAM) Vision stimulator merupakan salah satu teknik pengobatan ambliopia yang bekerja sesuai teori neurofisiologi oleh Hubel dan Wiesel, dimana seluruh neuron dari kortek visual dapat diaktivasi dan pulih dengan stimulasi grating sensitivitas kontras tinggi yang berputar dengan besar spatial frequency yang berbeda. …”
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Biomaterial-based strategies: a new era in spinal cord injury treatment by Shihong Zhu, Sijun Diao, Xiaoyin Liu, Zhujun Zhang, Fujun Liu, Wei Chen, Xiyue Lu, Huiyang Luo, Xu Cheng, Qiang Liao, Zhongyu Li, Jing Chen

“…Ideal biomaterial scaffolds should not only provide structural support for neuron migration, adhesion, proliferation, and differentiation but also mimic the mechanical properties of natural spinal cord tissue. …”
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Learning-induced sensory plasticity of mouse olfactory epithelium by A. V. Romashchenko, Р. Е. Kireeva, M. В. Sharapova, Т. A. Zapara, A. S. Ratushnyak

“…The observed increase in OE response to orange oil may be the result of neurogenesis, i. e. the maturation of new olfactory neurons responsive to this stimulus, or the consequence of an increase in individual sensitivity of each OE neuron. …”
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Analysis of Upper Facial Weakness in Central Facial Palsy Following Acute Ischemic Stroke by Monton Wongwandee, Kantham Hongdusit

“…Background: Central facial palsy (CFP), resulting from upper motor neuron lesions in the corticofacial pathway, is traditionally characterized by the sparing of the upper facial muscles. …”
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Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma by Ting Li, Zhanyi Zhao, Meichang Peng, Lu Zhang, Cheng Wang, Feiyang Luo, Meiqin Zeng, Kaijian Sun, Zhencheng Fang, Yunhao Luo, Yugu Xie, Cui Lv, Jiaxuan Wang, Jian-Dong Huang, Hongwei Zhou, Haitao Sun

“…Further mediation analysis suggested that the intratumoral microbiome may affect the expression of neuron-related genes through bacteria-associated metabolites. …”
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Wheat disease recognition method based on the SC-ConvNeXt network model by Tianliang Dong, Xiao Ma, Bin Huang, Wenyu Zhong, Qingan Han, Qinghai Wu, You Tang

“…Subsequently, the CBAM attention module is integrated into ConvNeXt-T to enhance the model’s feature extraction and generalization capabilities in complex backgrounds, and each attention module’s loss function is improved with a LeakyReLU activation function to prevent neuron deactivation when inputs are negative. Furthermore, by introducing the Focal Loss function, the model addresses the imbalance in the quantity of easy and difficult-to-classify samples. …”
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Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats by Nian Yu, Qing Di, Hao Liu, Yong Hu, Ying Jiang, Yu-kui Yan, Yan-fang Zhang, Ying-dong Zhang

“…Both PDTC and DEX pre-treatment significantly increased the latency to grade III or V seizure onset compared to EP group but failed to show neuron-protective effect as the number of survival neurons didn't significantly differ from that in EP group. …”
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The Long-Term Outcome Comparison of Different Time-Delayed Kallikrein Treatments in a Mouse Cerebral Ischemic Model by Yaohui Ni, Kefu Cai, Yujie Hu, Chuan-hui Wang, Yuanyuan Zhang, Hua Huang, Xing Su, Jin-hua Gu

“…Additionally, kallikrein treatment at 8 h after MCAO significantly enhanced cell proliferation including neural stem cell and induced differentiation of neural stem cell into mature neuron. Kallikrein treatment starting at 8 h also promoted more angiogenesis than other two treatment regimens, which was associated with AKT-GSK3β-VEGF signaling pathway. …”
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Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy by Baoyi Feng, Chenxi Jin, Zhenzhe Cheng, Xingle Zhao, Zhuoer Sun, Xiaofei Zheng, Xiang Li, Tingting Dong, Yong Tao, Hao Wu

“…Auditory neuropathies (AN) were proved to play a substantial role in SNHL recently, and spiral ganglion neuron (SGN) dysfunction is a dominant pathogenesis of AN. …”
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Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice by Mengjie He, Mengying Hu, Tingqiao Wang, Zeping Zuo, Hongkai Li, Zhiwei Zhao, Yunwen Hao, Xueling Dai, Jianfang Wang, Yaxuan Sun

“…The aim of this study was to investigate the potential effects of Morinda officinalis oligosaccharides (MOO) on depression and its concomitant symptom, sexual dysfunction.MethodsChronic unpredictable mild stress (CUMS)-induced depression model was constructed, and the effects of MOO on depression and sexual abilities were evaluated.ResultsThe results revealed that MOO was able to alleviate CUMS-induced depression-like behavior in mice, to inhibit hippocampal neuron apoptosis, to reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus, to modulate the composition and distribution of gut microbiota, and to increase the abundance of probiotics after continuous gavage of MOO for 28 days. …”
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Individual and joint effects of exposure to multiple organophosphate esters and the risk of depression in adults: Differences in sex, age, and physical activity by Qingmiao Wei, Jiyun Wei, Jun Liang

“…Organophosphate esters (OPEs) are neuron-disrupting chemicals that potentially cause depression. …”
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Cannabis use amongst tinnitus patients: consumption patterns and attitudes by Dorsa Mavedatnia, Marc Levin, Jong Wook Lee, Amr F. Hamour, Kaye Dizon, Trung Le

“…Cannabis is known to modulate neuron hyperexcitability, provide protection against auditory damage, and has been used for treatment for many diseases which have physiological similarities with tinnitus. …”
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Neurofilament Light Chain Assessment in Type 2 Diabetic Patients with Distal Symmetrical Polyneuropathy by Israa Abdelmalik Salem, Sura Ahmed Abdulsattar, Haider Fadhil Alrubaye

“… Background: A neuron-specific cytoskeletal protein called Neurofilament light chain is present in the cytoplasm of myelinated axons especially those with a large diameter which is essential for maintaining the size as well as for structural support.   …”
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An emerging view of neural geometry in motor cortex supports high-performance decoding by Sean M Perkins, Elom A Amematsro, John Cunningham, Qi Wang, Mark M Churchland

“…MINT’s computations are simple, scale favorably with increasing neuron counts, and yield interpretable quantities such as data likelihoods. …”
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Rare Manifestation of a c.290 C>T, p.Gly97Glu VCP Mutation by Nivedita U. Jerath, Cameron D. Crockett, Steven A. Moore, Michael E. Shy, Conrad C. Weihl, Tsui-Fen Chou, Tiffany Grider, Michael A. Gonzalez, Stephan Zuchner, Andrea Swenson

“…Our patient reflects the clinical heterogeneity of VCP mutations, as his neurological localization is a spectrum between a lower motor neuron disorder and a hereditary axonal peripheral neuropathy such as CMT2. …”
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Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO by Sue J. Hong, Bradley J. De Souza, Kristen K. Penberthy, Lisa Hwang, David E. Procaccini, John N. Kheir, Melania M. Bembea

“…Central nervous system (CNS) neuronal and astroglial cellular-derived neuron-specific enolase (NSE), tau, glial fibrillary acidic protein (GFAP) and S100β elevations have been detected in ABI and are associated with poorer outcomes. …”
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Multi-step Prediction of Monthly Sediment Concentration Based on WPT-ARO-DBN/WPT-EPO-DBN Model by GAO Xuemei, CUI Dongwen

“…Accurate multi-step sediment concentration prediction is of significance for regional soil erosion control,flood control and disaster reduction.To improve the multi-step prediction accuracy of sediment concentration and the prediction performance of the deep belief network (DBN),this paper proposes a multi-step prediction model of monthly sediment concentration by combining the artificial rabbit optimization (ARO) algorithm,eagle habitat optimization (EPO) algorithm,and DBN based on wavelet packet transform (WPT).The model is validated using time series data of monthly sediment concentration from Longtan Station in Yunnan Province.Firstly,WPT is employed to decompose the time series data of the monthly sediment concentration of the case in three layers,and eight more regular subsequence components are obtained.Secondly,the principles of ARO and EPO algorithms are introduced,and hyperparameters such as the neuron number in the hidden layer of DBN are optimized by ARO and EPO.Meanwhile,WPT-ARO-DBN and WPT-EPO-DBN prediction models are built,and WPT-PSO (particle swarm optimization)-DBN and WPT-DBN are constructed for comparative analysis.Finally,four models are adopted to predict each subsequence component,and the predicted values are superimposed to obtain the multi-step prediction results of the final monthly sediment concentration.The results are as follows.① WPT-ARO-DBN and WPT-EPO-DBN models have satisfactory prediction effects on the monthly sediment concentration of the case from one step ahead to four steps ahead.This yields sound prediction results for five steps ahead.The prediction effect for six steps ahead and seven steps ahead is average,and the prediction accuracy for eight steps ahead is poor and cannot meet the prediction accuracy requirements.② The multi-step prediction performance of WPT-ARO-DBN and WPT-EPO-DBN models is superior to WPT-PSO-DBN models and far superior to WPT-DBN models,with higher prediction accuracy,better generalization ability,and larger prediction step size.③ ARO and EPO can effectively optimize DBN hyperparameters,improve DBN prediction performance,and have better optimization effects than PSO.Additionally,WPT-ARO-DBN and WPT-EPO-DBN models can give full play to the advantages of WPT,new swarm intelligence algorithms and the DBN network and improve the multi-step prediction accuracy of monthly sediment concentration,and the prediction accuracy decreases with the increasing prediction steps.…”
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Electroacupuncture Therapy Effectively Protects the Rat Brain after Intracerebral Hemorrhage by Li Huang, Xuehui Fan, Yao Chen, Heng Lin, Xiaoqian Jiang, Chaoxian Yang

“…The serum myelin basic protein (MBP), neuron-specific enolase (NSE), calcium-binding protein B (S100B), and tumor necrosis factor-α (TNF-α) concentrations were examined with ELISA. …”
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Safety and Efficacy of Nusinersen Focusing on Renal and Hematological Parameters in Spinal Muscular Atrophy by Hüseyin Bahadır Şenol, Gizem Yıldız, Ayşe İpek Polat, Adem Aydın, Ayşe Semra Hız, Alper Soylu, Uluç Yiş

“…ABSTRACT Background Spinal muscular atrophy (SMA) is a motor neuron disease caused by mutations in the SMN1 gene. …”
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Clinical Efficacy of Subhypothermia in the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy Combined with Myocardial Damage by XiaoPing Dang, XiaoJian Hu, Xun Jiang, WeiGuo Chen, YuanCui Meng, Qi Pan, Fen Yang

“…The serum levels of S-100β protein, Tau protein, neuron-specific enolase (NSE), creatine kinase (CK), creatine kinase isoenzyme MB (CK-MB), lactate dehydrogenase (LDH), alpha-hydroxybutyrate dehydrogenase (ɑ-HBDH), myoglobin (Myo), cardiac trophic factor-1 (CT-1), cardiac troponin I (cTnI), superoxide dismutase (SOD), reactive oxygen species (ROS), glutathione peroxidase (GSH-Px), interleukin-1β (IL-1β), interleukin-8 (IL-8), and tumor necrosis factor-ɑ (TNF-ɑ) were measured in both groups before and after treatment, respectively. …”
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