Genetic basis of depressive disorders by Yu. D. Davydova, R. F. Enikeeva, A. V. Kazantseva, R. N. Mustafin, A. R. Romanova, S. B. Malykh, E. K. Khusnutdinov

“…In addition, there is evidence of the involvement of HPA-axis genes (OXTR, AVPR1A, and AVPR1B), sex hormone receptors genes (ESR1, ESR2, and AR), neurotrophin (BDNF) and methylenetetrahydrofolate reductase (MTHFR) genes, neuronal apoptosis (CASP3, BCL-XL, BAX, NPY, APP, and GRIN1) and inflammatory system (TNF, CRP, IL6, IL1B, PSMB4, PSMD9, and STAT3) genes in DD development. …”
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Spinorphin Molecules as Opportunities for Incorporation into Spinorphin@AuNPs Conjugate Systems for Potential Sustained Targeted Delivery to the Brain by Stela Georgieva, Petar Todorov, Jana Tchekalarova

“…This suggests that these formulations may effectively target the underlying neuronal hyperexcitability. In addition, the prepared Rh-S@AuNP formulations also showed anticonvulsant activity in the maximal electroshock test performed in mice, which was evident after systemic (intraperitoneal) administration. …”
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Two-year follow-up of gait and postural control following initiation of recombinant human tripeptidyl intracerebroventricular enzyme replacement therapy in two atypical CLN2 patien... by Rahul Soangra, Marybeth Grant-Beuttler, Harriet Chang, Raymond Y. Wang

“…Abstract Neuronal ceroid lipofuscinosis type 2 (CLN2) is a rapidly progressive neurodegenerative disorder leading to premature mortality. …”
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A reactive oxygen species-responsive hydrogel loaded with Apelin-13 promotes the repair of spinal cord injury by regulating macrophage M1/M2 polarization and neuroinflammation by Zhiyue Li, Qun Zhao, Jiahui Zhou, Yuyan Li, Yifan Zheng, Linxi Chen

“…During acute trauma, dominant M1 macrophages produce high levels of reactive oxygen species (ROS), leading to increased apoptosis in neurons, glial cells, and oligodendrocytes. This study investigated the specific effects of a ROS-responsive hydrogel loaded with Apelin-13 (Apelin-13@ROS-hydrogel) on macrophage polarization and neuroinflammation, thereby exploring its role in boosting SCI repair. …”
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Deep learning models reveal the link between dynamic brain connectivity patterns and states of consciousness by Chloé Gomez, Lynn Uhrig, Vincent Frouin, Edouard Duchesnay, Béchir Jarraya, Antoine Grigis

“…We demonstrated the model’s efficiency in summarizing consciousness-specific information encoded in key inter-areal connections, as described in the global neuronal workspace theory of consciousness. The proposed framework advocates the possibility of developing an interpretable computational brain model of interest for disorders of consciousness, paving the way for a dynamic diagnostic support tool.…”
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Dimensionality cutback and deep learning algorithms efficacy as to the breast cancer diagnostic dataset by Gennady Chuiko, Denys Honcharov

“…Two clustering algorithms that use neurons (Self Organized Map, SOM, and Learning Vector Quantization, LVQ) have also shown similar results. …”
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Age-related aspects of glioma: current understanding. Literature review by Serhii P. Luhovskyi, Tetiana Y. Kvitnytska-Ryzhova

“…This classification groups gliomas within the category "Gliomas, glioneuronal tumors, and neuronal tumors," distinguishing between adult-type and pediatric-type diffuse gliomas, corresponding to low-grade and high-grade malignancies (LGG and HGG), highlighting the fundamental role of age in gliomagenesis. …”
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Prediction analysis of human brucellosis cases in Ili Kazakh Autonomous Prefecture Xinjiang China based on time series by Lian Lu, Tongxia Yang, Zhisheng Chen, Qidi Ge, Jing Yang, Gan Sen

“…We constructed a SARIMA(4,1,1)(3,1,2)12 model, an XGBoost model with a time lag of 22, and an LSTM model featuring 3 LSTM layers and 100 neurons in the fully connected layer to predict monthly reported cases from January 2021 to September 2023. …”
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Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study by Karel Pavelka, Marta Olejárova, Veronika Balajková, Aneta Prokopcová, Martin Elisak, Hana Mojžišová

“…Background The neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum as a marker of neuronal damage may be a potential biomarker of neuropsychiatric involvement in SLE (NPSLE).Methods 80 patients with SLE were included.We obtained paired serum and CSF samples from 48 patients (NPSLE n=32, non-NPSLE n=16) and 31 controls. …”
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Pathogenesis of Disorders of the Motor Function of the Large Intestine in Functional Constipation by M. M. Galagudza, Yu. P. Uspensky, Yu. A. Fominykh, D. Yu. Butko

“…FC-associated changes in the enteric nervous system include a relative excess of the contribution of inhibitory influences and a decrease in the activity of cholinergic and serotonergic neurons that stimulate intestinal motility. A certain role in the occurrence of reduced motor function of the colon may have an imbalance in the production of intestinal hormones synthesized by enteroendocrine cells, namely, a deficiency of motility stimulants, which include motilin, gastrin, ghrelin and cholecystokinin, as well as a relative excess of hormones that suppress motility (somatostatin and vasoactive intestinal polypeptide). …”
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Silver Nanoparticles Conjugate Attenuates Highly Active Antiretroviral Therapy-Induced Hippocampal Nissl Substance and Cognitive Deficits in Diabetic Rats by Sodiq Kolawole Lawal, Samuel Oluwaseun Olojede, Ayobami Dare, Oluwaseun Samuel Faborode, Edwin Coleridge S. Naidu, Carmen Olivia Rennie, Onyemaechi Okpara Azu

“…Interestingly, diabetic HAART-AgNP-treated rats showed a significantly improved memory, increased GSH, SOD, and number of positive Nissl-stained neurons compared to diabetic-treated HAART only. Conclusion. …”
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Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Epileptic Cognitive Impairment by Wen Li, Huimin Zhou, Xiaona Li, Gengyao Hu, Dong Wei

“…Reactive astrogliosis and acidosis, common features of epileptogenic lesions, express a high level of astrocytic acid-sensing ion channel-1a (ASIC1a), a proton-gated cation channel and key mediator of responses to neuronal injury. This study investigates the role of astrocytic ASIC1a in cognitive impairment following epilepsy. …”
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Pain in pancreatitis: issue and ways out by A. V. Okhlobystin

“…Sensitization affect not only nerve terminals, but neurones of spinal cord and brain as well. Patients develop plastic changes in central nervous system as well, i.e. …”
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INTERRELATION OF PRIONS WITH NON-CODING RNAS by R. N. Mustafin, E. K. Khusnutdinova

“…In the brain of animals and humans, transposon activity has been observed, which has a regulatory effect on the differentiation of neuronal stem cells. Transposons form the basis of domain structures of long non-coding RNAs. …”
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Effects of <italic>Cistanche Deserticola</italic> on Behavior and Expression of GSK-3β in Hippocampus of Rat Model of Parkinson's Disease by Shasha YANG, Wei QIN, Shiya CHEN, Jing CAI

“…In the Western Blotting, the protein expression of GSK-3β, β-catenin and p-β-catenin in model group were significantly increased compared with normal group (<italic>P</italic>&lt;0.01); compared with model group, the protein expression of GSK-3β was respectively decreased in middle and high dose group (<italic>P</italic>&lt;0.01), the protein expression of β-catenin was respectively increased in low, middle and high dose group (<italic>P</italic>&lt;0.01), and the protein expression of p-β-catenin in low, middle and high dose group was respectively decreased (<italic>P</italic>&lt;0.01, <italic>P</italic>&lt;0.05).Conclusion:<italic>Cistanche deserticola</italic> can improve the behavior disorder in Parkinson's disease, and its mechanism is probably related with inhibiting the activity of GSK-3β and expression of p-β-catenin, increasing the expression of β-catenin to start the Wnt signaling pathway and protect the PD neurons.…”
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Biomechanics Parameters of Gait Analysis to Characterize Parkinson’s Disease: A Scoping Review by Michela Russo, Marianna Amboni, Noemi Pisani, Antonio Volzone, Danilo Calderone, Paolo Barone, Francesco Amato, Carlo Ricciardi, Maria Romano

“…Parkinson’s disease (PD) is characterized by a slow, short-stepping, shuffling gait pattern caused by a combination of motor control limitations due to a reduction in dopaminergic neurons. Gait disorders are indicators of global health, cognitive status, and risk of falls and increase with disease progression. …”
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Diagnostics and Treatment of Esophageal Achalasia (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russ... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, A. I. Martynov, O. A. Storonova, E. A. Godgello, M. P. Korolev, T. L. Lapina, P. V. Pavlov, A. V. Paraskevova, I. A. Tarasova, E. D. Fedorov, A. T. Tskhovrebov, M. P. Shapka, A. L. Shestakov, A. V. Yurasov

“…However, it is believed that the key role belongs to the changes in the myenteric (Auerbach’s) intermuscular plexus of the enteric nervous system of the esophagus, leading to loss of neuronal function. The following hypotheses have been proposed as the main mechanisms for the development of achalasia: genetic predisposition, exposure to viral infections, and idiopathic autoimmune triggers. …”
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Electroacupuncture and Tongbian decoction ameliorate CUMS-induced depression and constipation in mice via TPH2/5-HT pathway of the gut-brain axis by Yi Chen, Peihua Shen, Qi Li, Shun Seng Ong, Yunzhi Qian, Hai Lu, Ming Li, Tianshu Xu

“…Furthermore, EA + TB reduced intestinal inflammation, restored neuronal morphology, increased the expression of tryptophan hydroxylase 2 (TPH2) in both the prefrontal cortex (PFC) and colon, elevated the serum levels of 5-hydroxytryptophan (5-HTP)—a molecule that acts as a gut-brain connector—and promoted the synthesis and production of serotonin (5-HT) in both the gastrointestinal tract and the brain. …”
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Deregulated methylation and expression of PCDHGB7 in patients with non-small cell lung cancer: a novel prognostic and immunological biomarker by Yue Yuan, Yue Yuan, Xin Nie, Jiayi Gao, Jiayi Gao, Yumeng Tian, Yumeng Tian, Liuer He, Liuer He, Xue Wang, Ping Zhang, Junling Ma, Lin Li, Lin Li

“…BackgroundsProtocadherin gamma subfamily B, 7 (PCDHGB7), a member of the protocadherin family, plays critical roles in neuronal connections and has been implicated in female reproductive system cancers. …”
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The development of the Cough Hypersensitivity Questionnaire for chronic cough by Barnaby Hirons, Peter S.P. Cho, Chris Krägeloh, Richard J. Siegert, Richard Turner, Katherine Rhatigan, Harini Kesavan, Ewan Mackay, Ha-Kyeong Won, Ju-Young Kim, Woo-Jung Song, Surinder S. Birring

“…Introduction Chronic cough is considered a disorder of neuronal hypersensitivity in which patients frequently report abnormal laryngeal and chest sensations, and excessive triggers. …”
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