A Self-Emulsifying Nanococktail of Pomegranate and Cannabidiol Reduces Cognitive Decline in Mice by Shoseyov O, Palatnik A, Dadon-Freiberg M, Dagan O, Shaltiel Karyo R

“…This work assessed the impact of Nano-PSO:CBD on memory and learning.Methods: A battery of hemp extracts was screened for their effects on acetylcholine esterase inhibition and neuronal protection activities. The best-performing extract in the in-vitro assays was nano-formulated via self-emulsifying system with PSO and administered to aged mice and mice with MK-801-induced cognitive decline, which were then subjected to a Morris water maze test and Y-maze test, respectively.Results: Aged mice chronically fed Nano-PSO:CBD performed with a 22– 31% shorter escape latency (p ≤ 0.05), 23% shorter distance swam and increased average speed as compared to aged control mice. …”
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A Differential Evolution-Oriented Pruning Neural Network Model for Bankruptcy Prediction by Yajiao Tang, Junkai Ji, Yulin Zhu, Shangce Gao, Zheng Tang, Yuki Todo

“…Inspired by the mechanism of biological neurons, we propose an evolutionary pruning neural network (EPNN) model to conduct financial bankruptcy analysis. …”
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Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review by Siddharth Shah, Hadeel M. Mansour, Brandon Lucke-Wold

“…A key feature of HD is the loss of striatal neurons and cortical atrophy. Although there is no cure at present, the discovery of the gene causing HD has brought us into a new DNA era and therapeutic advances for several neurological disorders. …”
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Uncertainty-aware deep learning in healthcare: A scoping review. by Tyler J Loftus, Benjamin Shickel, Matthew M Ruppert, Jeremy A Balch, Tezcan Ozrazgat-Baslanti, Patrick J Tighe, Philip A Efron, William R Hogan, Parisa Rashidi, Gilbert R Upchurch, Azra Bihorac

“…The predominant method for quantifying uncertainty was Monte Carlo dropout, producing predictions from multiple networks for which different neurons have dropped out and measuring variance across the distribution of resulting predictions. …”
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IONPs-induced neurotoxicity via cascade of neuro-oxidative stress, parthanatos-mediated cell death, neuro-inflammation and neurodegenerative changes: Ameliorating effect of rosemar... by Arwa A. Elsheikh, Noha Ali Abd-Almotaleb, Mona Mostafa Ahmed, Eman El-Sayed Khayal

“…IONPs induced neurotoxicity via triggering a cascade of neuro-oxidative stress, neuro-inflammation, and parthanatos-mediated neuronal cell death by increasing MDA, NO, TNF-α levels, PARP-1, AIF, and NF-κB mRNA expression alongside reducing GSH levels. …”
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Spatiotemporal Expression and Molecular Characterization of miR-344b and miR-344c in the Developing Mouse Brain by Jia-Wen Leong, Syahril Abdullah, King-Hwa Ling, Pike-See Cheah

“…Further investigation on the locality of miR-344b and miR-344c showed that both miRNAs were localized in nuclei of immature neurons. In conclusion, miR-344b and miR-344c were expressed spatiotemporally during mouse brain developmental stages.…”
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Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy by Elena Garcia-Martin, Marta Cipres, Isabel Melchor, Laura Gil-Arribas, Elisa Vilades, Vicente Polo, Maria Jesus Rodrigo, Maria Satue

“…Patients with type 2 DM without diabetic retinopathy and good metabolic control present neurodegeneration affecting neurons in the macular area and axons in different sectors of the optic disc. …”
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Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson’s Disease by Kawinthra Khwanraj, Suriyat Madlah, Khwanthana Grataitong, Permphan Dharmasaroja

“…Recently, gene profiling on dopaminergic neurons from postmortem PD patients showed both upregulation and downregulation of some PI3K and mTOR genes. …”
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Neuroprotective Effect of Wharton’s Jelly-Derived Mesenchymal Stem Cell-Conditioned Medium (WJMSC-CM) on Diabetes-Associated Cognitive Impairment by Improving Oxidative Stress, Neu... by Zohre Aghaei, Narges Karbalaei, Mohammad Reza Namavar, Masoud Haghani, Mahboobeh Razmkhah, Mahdi Khorsand Ghaffari, Marzieh Nemati

“…Reduced TNF-α and enhanced Bcl-2 gene expression levels and elevated neuronal and nonneuronal (astrocytes and oligodendrocytes) cells were detected in the hippocampus of WJMSC-CM-treated diabetic rats. …”
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Gestational stress disrupts dopamine and oxytocin signaling in the postpartum reward system of rats: implications for mood, motivation and mothering by Achikam Haim, Christopher Albin-Brooks, Holly Brothers, Michaela Breach, Benedetta Leuner

“…Lastly, we assessed mRNA expression of OT and OT receptors (OTR) and found that gestational stress increased OT expression in the hypothalamus but reduced OTR expression in the postpartum ventral tegmental area (VTA), a target of hypothalamic OT neurons. In the VTA, a reduction in OT-immunoreactive fibers following gestational stress was also seen. …”
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Chromosomal Regions in Prostatic Carcinomas Studied by Comparative Genomic Hybridization, Hierarchical Cluster Analysis and Self-Organizing Feature Maps by Torsten Mattfeldt, Hubertus Wolter, Danilo Trijic, Hans‐Werner Gottfried, Hans A. Kestler

“…In this paper we applied hierarchical cluster analysis as well as two implementations of self‐organizing feature maps as classical and neuronal tools for cluster analysis of CGH data from prostatic carcinomas to such transposed data sets. …”
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DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce α-Synuclein Levels in the 6-OHDA Parkinson’s Disease Rat Model by Lingyu Zhang, Chun Li, Zijuan Zhang, Zhenqiang Zhang, Qian-Qian Jin, Lin Li, Christian Hölscher

“…In addition, both drugs protected dopaminergic neurons and increased TH expression in the substantia nigra. …”
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Sevoflurane versus propofol on immediate postoperative cognitive dysfunction in patients undergoing cardiac surgery under cardiopulmonary bypass: a comparative analysis by Na Zhao, Rui Qin, Bin Liu, Dongmei Zhang

“…It provides superior anesthetic effects and offers better protection against neuronal damage and serum inflammation compared to SEV. …”
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Modeling of CO2 solubility and partial pressure in blended diisopropanolamine and 2-amino-2-methylpropanol solutions via response surface methodology and artificial neural network by Zohreh Khoshraftar

“…The multilayer perceptron (MLP) architecture demonstrated strong correlation capabilities, featuring one hidden layer with 10 and 5 neurons, respectively. Its topology was structured as 4-10-1 for predicting CO2 solubility and 4-5-1 for predicting CO2 partial pressure. …”
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Hyperthermia and targeting heat shock proteins: innovative approaches for neurodegenerative disorders and Long COVID by David M. Smadja, David M. Smadja, M. Marc Abreu, M. Marc Abreu

“…Neurodegenerative diseases (NDs) and Long COVID represent critical and growing global health challenges, characterized by complex pathophysiological mechanisms including neuronal deterioration, protein misfolding, and persistent neuroinflammation. …”
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Propofol Ameliorates Microglia Activation by Targeting MicroRNA-221/222-IRF2 Axis by Xi Xiao, Yuanyuan Hou, Wei Yu, Sihua Qi

“…Propofol is a widely used intravenous anesthetic drug with potential neuroprotective effect in diverse diseases of neuronal injuries such as traumatic brain injury and ischemic stroke. …”
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Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions by Jeremy Matthew Bohl, Abdul Rhman Hassan, Zachary J. Sharpe, Megi Kola, Angela Shehu, Deborah Langrill Beaudoin, Tomomi Ichinose

“…The intrinsically photosensitive retinal ganglion cells (ipRGCs) in the retina are neurons that are critical to generating the PLR, receiving rod/cone photoreceptor signals and directly sensing light through melanopsin. …”
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Evaluating the predictive potential of RSM and ANN models in treatment of greywater-syrup mixture using Ekowe clay-PEM microbial fuel cell by Livinus A. Obasi, Cornelius O. Nevo

“…The ANN gave the best prediction with n = 10 neurons. The response variables (power density generation (mW/m2) and chemical oxygen demand (COD) removal efficiency (%)) were measured against four process input variables: mass of the clay component of the proton exchange membrane (PEM) (g), PEM preparation temperature (PPT), anolyte pH, and concentration. …”
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Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson’s Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo by Chien-Wei Feng, Nan-Fu Chen, Te-Fu Chan, Wu-Fu Chen

“…Our study showed that suramin, an inhibitor of PTP1B, could improve neuronal damage. It could significantly attenuate the interferon-gamma-induced upregulation of proinflammatory cytokines, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). …”
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Electroacupuncture-Regulated miR-34a-3p/PDCD6 Axis Promotes Post-Spinal Cord Injury Recovery in Both In Vitro and In Vivo Settings by Lili Ma, Lizhong Ma, Yu Yang, Ting Chen, Limin Wang, Qilong Deng

“…Notably, in the post-SCI rat model, exogenous miR-34a-3p agomir obviously inhibited the expression of PDCD6 at the protein level and promoted neuronal proliferation, motoneurons regeneration, and axonal myelination. …”
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