miR-26a-5p/ADAM17-Mediated Proteolysis of TREM2 Regulates Neuroinflammation in Hypertensive Mice Following Lead Exposure by Yuran Wang, Zeming Wang, Han Hao, Yuwei Zhao, Jian Wang, Weixuan Wang

“…As a traditional neurotoxic heavy metal, Pb exposure results in neuroinflammation as well as neurodegenerative diseases. The current study aimed to investigate the mechanisms of neuroinflammation in hypertensive mice exposed to Pb. …”
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Evaluating Dose- and Time-Dependent Effects of Vitamin C Treatment on a Parkinson’s Disease Fly Model by Huynh Man Anh, Dao My Linh, Vuu My Dung, Dang Thi Phuong Thao

“…Oxidative stress is considered as a major cause of neurodegenerative diseases, and there is increasing evidence for the association between PD and oxidative stress. …”
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Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects by Zi-Han Xu, Ming-Min Xie, Chun-Lan Xie, Xian-Wen Yang, Jun-Song Wang

“…Neuroinflammation and neuronal cell death are leading causes of death in the elderly and underlie various neurodegenerative diseases. These diseases involve complex pathophysiological mechanisms, including inflammatory responses, oxidative stress, and ferroptosis. …”
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Exploring the Antioxidant and Neuroprotective Potential of Muscari armeniacum: Phenolic Profiling and Enzyme Inhibition by Fevzi Topal, Firat Yılmaz, Meryem Topal, Ahmed Menevşeoğlu

“…In addition to its antioxidant properties, the enzymatic activity assays revealed that the extract significantly inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, which are associated with neurodegenerative diseases such as Alzheimer’s. The IC₅₀ values were determined to be 54.14 mg/mL (R² = 0.9695) for AChE and 58.73 mg/mL (R² = 0.9609) for BChE, indicating moderate enzyme inhibition. …”
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A systematic screening assay identifies efficient small guide RNAs for CRISPR activation by Elin Arvidsson, Diana Duarte Lobo, Diana Duarte Lobo, Ermelinda Sabarese, Fabio Duarte, Rui Jorge Nobre, Rui Jorge Nobre, Rui Jorge Nobre, Luis Quintino, Cecilia Lundberg

“…The overall workflow was validated using therapeutically relevant genes for neurodegenerative diseases, including Tfeb, Adam17, and Sirt1. …”
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Protein palmitoylation is involved in regulating mouse sperm motility via the signals of calcium, protein tyrosine phosphorylation and reactive oxygen species by Yuping Xiong, Chenchen Yi, Haixia Zheng, Ya Ni, Yamei Xue, Kun Li

“…It is also implicated in the pathogenesis of diseases, such as cancer, neurological disorders, inflammation, metabolic disorders, infections, and neurodegenerative diseases. However, its regulatory effects on sperm physiology, particularly motility, remain unclear. …”
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Instationary metabolic flux analysis reveals that NPC1 inhibition increases glycolysis and decreases mitochondrial metabolism in brain microvascular endothelial cells by Bilal Moiz, Matthew Walls, Viviana Alpizar Vargas, Anirudh Addepalli, Callie Weber, Andrew Li, Ganesh Sriram, Alisa Morss Clyne

“…Brain microvascular endothelial cells (BMEC) are thought to play a critical role in the pathogenesis of several neurodegenerative diseases; however, little is known about how these cells are altered in NP-C. …”
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In vitro neuroprotective potentials of aqueous and methanol extracts from Heinsia crinita leaves by Ganiyu Oboh, Esther E. Nwanna, Sunday I. Oyeleye, Tosin A. Olasehinde, Opeyemi B. Ogunsuyi, Aline A. Boligon

“…Therefore, H. crinita leaves could be used as a functional food and dietary intervention for the management of some neurodegenerative diseases. Nevertheless, the aqueous extracts exhibited better neuroprotective properties.…”
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Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies by Liu S, Li H, Xi S, Zhang Y, Sun T

“…These disorders, ranging from neurodegenerative diseases to psychiatric conditions, not only impact individuals but also place a substantial burden on healthcare systems and society. …”
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Effects of Maillard reaction and its product AGEs on aging and age-related diseases by Huan Peng, Yuqi Gao, Chenye Zeng, Rui Hua, Yannan Guo, Yida Wang, Zhao Wang

“…On the other hand, pathological aging associated with autoimmune and inflammatory diseases, neurodegenerative diseases, diabetes and diabetic nephropathy, cardiovascular diseases and bone degenerative diseases have been mainly proposed. …”
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TDP-43 nuclear retention is antagonized by hypo-phosphorylation of its C-terminus in the cytoplasm by Célia Rabhi, Nicolas Babault, Céline Martin, Bénédicte Desforges, Alexandre Maucuer, Vandana Joshi, Serhii Pankivskyi, Yitian Feng, Guillaume Bollot, Revital Rattenbach, David Pastré, Ahmed Bouhss

“…We anticipate that reducing TDP-43 C-terminus self-assembly in the cytoplasm may be an interesting strategy to reverse TDP-43 nuclear depletion in neurodegenerative diseases.…”
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Co-occurrence of behavioural risk factors for non-communicable diseases and mortality risk in Spain: a population-based cohort study by Iñaki Galán, Cristina Ortiz, Carmen Rodriguez-Blazquez, Teresa López-Cuadrado, Ana Ayuso-Álvarez

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Brown rice: a missing nutrient-rich health food by Xiuxiu Wu, Tianyi Guo, Feijun Luo, Qinlu Lin

“…In this review, we systemically summarized the efficacy of BR on cardiovascular diseases (CVDs), hyperlipidemia, hypertension, diabetes, obesity, osteoporosis, neurodegenerative diseases, cancer, immune disorders, inflammation, anxiety, liver and stomach damage, etc. …”
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Reactivation of mTOR signaling slows neurodegeneration in a lysosomal sphingolipid storage disease by Hongling Zhu, Y. Terry Lee, Colleen Byrnes, Jabili Angina, Danielle A. Springer, Galina Tuymetova, Mari Kono, Cynthia J. Tifft, Richard L. Proia

“…These findings imply that enhancing mTOR signaling could be a potential therapeutic strategy for lysosomal-based neurodegenerative diseases.…”
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Identification of the Highly Polymorphic Prion Protein Gene (<i>PRNP</i>) in Frogs <i>(Rana dybowskii</i>) by Chang-Su Han, Sae-Young Won, Sang-Hun Park, Yong-Chan Kim

“…Prion diseases are fatal neurodegenerative diseases that can be transmitted by infectious protein particles, PrP^Scs, encoded by the endogenous prion protein gene (<i>PRNP</i>). …”
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A thorny pathway of macrophage activating factor (GcMAF): from bench to bedside by A. A. Ostanin, S. S. Kirikovich, E. V. Dolgova, А. S. Proskurina, E. R. Chernykh, S. S. Bogachev

“…Besides its anti-tumor activity, GcMAF exerts a potential against a number of viral and neurodegenerative diseases associated with increased activity of N-acetylgalactosaminidase (nagalase) in the blood serum of patients. …”
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Quantifying human genome parameters in aging by V. P. Volobaev, S. S. Kunizheva, L. I. Uralsky, D. A. Kupriyanova, E. I. Rogaev

“…The review considers the relationship between quantitative characteristics of the mitochondrial genome and aging, longevity, and age-related neurodegenerative diseases, such as the frequency of extensive mitochondrial DNA (mtDNA) deletions, mtDNA half-life, the frequency of A&gt;G replacements in the mtDNA heavy chain, the number of mtDNA copies; special attention is paid to the mtDNA methylation sign. …”
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Consequences of Repetitive Head-Impact Exposure in Sports - literature review by Wiktoria Gajek-Flanczewska, Sebastian Flanczewski, Małgorzata Wirkijowska, Katarzyna Wójtowicz, Jakub Wirkijowski, Agata Walczak, Paulina Woźniak, Ewa Wietrzykowska, Dominika Sobolewska, Katarzyna Michalczyk-Fraszka, Martyna Śliwińska, Anna Podraza

“… Repetitive head impacts (RHIs), common in contact sports, have raised concerns about their long-term effects on brain health, potentially leading to conditions like concussions, Chronic Traumatic Encephalopathy (CTE), and other neurodegenerative diseases. CTE, a progressive tauopathy, is associated with cognitive and psychological symptoms, including memory loss and depression. …”
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Parkinson’s Disease Prediction: An Attention-Based Multimodal Fusion Framework Using Handwriting and Clinical Data by Sabrina Benredjem, Tahar Mekhaznia, Abdulghafor Rawad, Sherzod Turaev, Akram Bennour, Bourmatte Sofiane, Abdulaziz Aborujilah, Mohamed Al Sarem

“…Background: Neurodegenerative diseases (NGD) encompass a range of progressive neurological conditions, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), characterised by the gradual deterioration of neuronal structure and function. …”
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Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels by Nathalie Idlin, Sivakumar Krishnamoorthy, Magdalena Wolczyk, Mouad Fakhri, Michal Lechowski, Natalia Stec, Jacek Milek, Pratik Kumar Mandal, Jaroslaw Cendrowski, Christos Spanos, Magdalena Dziembowska, Katarzyna Mleczko-Sanecka, Juri Rappsilber, Gracjan Michlewski

“…Elevated HuR levels are associated with multiple disorders, including cancer and neurodegenerative diseases. Despite the identification of small molecule inhibitors targeting HuR, their detailed characterization remains limited. …”
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