Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function by Gustavo Della-Flora Nunes, Lindsay A. Osso, Johana A. Haynes, Lauren Conant, Michael A. Thornton, Michael E. Stockton, Katherine A. Brassell, Amanda Morris, Yessenia I. Mancha Corchado, John A. Gaynes, Anthony R. Chavez, Michaelanne B. Woerner, Deidre A. MacKenna, Aryan Alavi, Anne Danks, Alon Poleg-Polsky, Rohan Gandhi, Jeffrey A. Vivian, Daniel J. Denman, Ethan G. Hughes

“…Abstract Myelin loss induces neural dysfunction and contributes to the pathophysiology of neurodegenerative diseases, injury conditions, and aging. Because remyelination is often incomplete, better understanding endogenous remyelination and developing remyelination therapies that restore neural function are clinical imperatives. …”
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Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus by Héctor Cañeque-Rufo, Teresa Fontán-Baselga, Milagros Galán-Llario, Agata Zuccaro, María Gracia Sánchez-Alonso, Esther Gramage, María del Pilar Ramos-Álvarez, Gonzalo Herradón

“…Obesity and metabolic disorders, such as metabolic syndrome (MetS) facilitate the development of neurodegenerative diseases and cognitive decline. Persistent neuroinflammation plays an important role in this process. …”
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Potential and Limitation of HLA-Based Banking of Human Pluripotent Stem Cells for Cell Therapy by Casimir de Rham, Jean Villard

“…Tissues or organs derived from hPS cells could be the best solution to cure many different human diseases, especially those who do not respond to standard medication or drugs, such as neurodegenerative diseases, heart failure, or diabetes. The origin of hPS is critical and the idea of creating a bank of well-characterized hPS cells has emerged, like the one that already exists for cord blood. …”
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Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy? by Anna R. Carta, Augusta Pisanu, Ezio Carboni

“…In the last decade, PPAR-γ agonists have received increasing attention for their neuroprotective properties displayed in a variety of neurodegenerative diseases, including Parkinson's disease (PD), likely related to the anti-infammatory activity of these compounds. …”
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Neural Induction, Neural Fate Stabilization, and Neural Stem Cells by Sally A. Moody, Hyun-Soo Je

“…The promise of stem cell therapy is expected to greatly benefit the treatment of neurodegenerative diseases. An underlying biological reason for the progressive functional losses associated with these diseases is the extremely low natural rate of self-repair in the nervous system. …”
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Therapeutic potential of cannabinoids in neurological conditions: a systematic review of clinical trials by Alqassem Y. Hakami, Alqassem Y. Hakami, Fahad S. Alshehri

“…OverviewCannabinoids have gained increasing attention for their therapeutic potential in treating several neurological conditions, including neurodegenerative diseases, chronic pain, and epilepsy. This review aims to assess the current clinical trials investigating cannabinoids, primarily Tetrahydrocannabinol and Cannabidiol, for neurological disorders. …”
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The roles of pleiotrophin in brain injuries: a narrative review of the literature by Yupeng Lei, Ruixi Zhou, Qian Mao, Xia Qiu, Dezhi Mu

“…Considering this, this review focuses on the roles and related regulatory pathways of PTN in brain injuries, what is known to date.Methods PubMed and Embase databases have been searched, and related studies are compiled and summarized.Results Our review has found PTN participates in the repairment of brain injuries, including hypoxic-ischemic brain injury, preterm white matter injury, traumatic brain injury, and neurodegenerative diseases, mainly based on animal data and small sample size studies. …”
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Brain Magnetic Resonance Imaging Findings in Developmentally Delayed Children by Ali Akbar Momen, Gholamreza Jelodar, Hamid Dehdashti

“…The finding includes nonspecific in 38 (6.6%), congenital and developmental anomalies of brain in 39 (6.7%), recognizable syndromes in 3 (0.5%), neurovascular diseases or trauma in 218 (37.6%), and metabolic or neurodegenerative diseases in 42 (7.2%) cases. Conclusion. Because 60% of all study groups showed abnormal brain MRI, using this method could be effective in diagnosis, management, and almost prognosis determination processes.…”
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Modulation of Second Messenger Signaling in the Brain Through PDE4 and PDE5 Inhibition: Therapeutic Implications for Neurological Disorders by Min Kyu Park, Hyun Wook Yang, Seo Young Woo, Dong Yeon Kim, Dae-Soon Son, Bo Young Choi, Sang Won Suh

“…Pharmacological modulation of these enzymes offers potential to enhance cognitive function and mitigate pathological mechanisms underlying brain injuries, neurodegenerative diseases, and psychiatric disorders. Further research into the regulation of PDE4 and PDE5 will advance therapeutic strategies for these conditions.…”
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Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration by Maj Schneider Thomsen, Serhii Kostrikov, Lisa Greve Routhe, Kasper Bendix Johnsen, Steinunn Sara Helgudóttir, Johann Mar Gudbergsson, Thomas Lars Andresen, Torben Moos

“…Chronic neurodegenerative diseases are characterized by substantial inflammation with putative impairment of the brain vasculature also commonly observed. …”
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Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain by Chae-Jeong Lee, Seung Hyun Jang, Jiwoo Lim, Hyunju Park, So-Hee Ahn, Seon Young Park, Hyangmi Seo, Soo-Jin Song, Jung-A Shin, Chulhee Choi, Heon Yung Gee, Youn-Hee Choi

“…Abstract Neuroinflammation, a significant contributor to various neurodegenerative diseases, is strongly associated with the aging process; however, to date, no efficacious treatments for neuroinflammation have been developed. …”
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Study of the effect of the introduction of mitochondrial import determinants into the gRNA structure on the activity of the gRNA/SpCas9 complex in vitro by E. G. Zakirova, Y. V. Vyatkin, N. A. Verechshagina, V. V. Muzyka, I. O. Mazunin, K. E. Orishchenko

“…It has long been known that defects in the structure of the mitochondrial genome can cause various neuromuscular and neurodegenerative diseases. Nevertheless, at present there is no effective method for treating mitochondrial diseases. …”
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MRI-guided focused ultrasound for treating Parkinson’s disease with human mesenchymal stem cells by Sheng-Kai Wu, Chia-Lin Tsai, Aisha Mir, Kullervo Hynynen

“…Mesenchymal stem cell therapy may be a viable treatment option for neurodegenerative diseases such as Parkinson’s. Transcranial MRgFUS serves as an efficacious and safe method for targeted and minimally invasive stem cell homing.…”
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Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer by Giulia Casari, Brenda Romaldi, Andrea Scirè, Cristina Minnelli, Daniela Marzioni, Gianna Ferretti, Tatiana Armeni

“…Dysregulated epigenetic mechanisms are implicated in various diseases, including cardiovascular disorders, neurodegenerative diseases, obesity, and mainly cancer. Therefore, to develop innovative therapeutic strategies, research for compounds able to modulate the complex epigenetic landscape of cancer is rapidly surging. …”
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Targeting the epigenome with advanced delivery strategies for epigenetic modulators by Sonia Guha, Yogeswaran Jagadeesan, Murali Monohar Pandey, Anupama Mittal, Deepak Chitkara

“…Epigenetic drugs exhibit promising therapeutic efficacy against several epigenetically originated diseases including several cancers, neurodegenerative diseases, metabolic disorders, cardiovascular disorders, and so forth. …”
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The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease by Kemal Ugur Tufekci, Ezgi Civi Bayin, Sermin Genc, Kursad Genc

“…Mitochondrial dysfunction is a prominent feature of various neurodegenerative diseases as strict regulation of integrated mitochondrial functions is essential for neuronal signaling, plasticity, and transmitter release. …”
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Effects of Maillard reaction and its product AGEs on aging and age-related diseases by Huan Peng, Yuqi Gao, Chenye Zeng, Rui Hua, Yannan Guo, Yida Wang, Zhao Wang

“…On the other hand, pathological aging associated with autoimmune and inflammatory diseases, neurodegenerative diseases, diabetes and diabetic nephropathy, cardiovascular diseases and bone degenerative diseases have been mainly proposed. …”
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Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications by Wang Meng, Wang Chao, Zhao Kaiwei, Ma Sijia, Sang Jiajia, Xu Shijie

“…Furthermore, the synergistic effects of TCM formulations targeting multiple signaling pathways offer advantages over single-target therapies, especially in combating neurodegenerative diseases. The review also discusses the challenges and future directions for integrating these bioactive compounds into functional foods and dietary supplements, aiming to improve neurological health and enhance clinical outcomes. …”
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Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease by Dmitri Leonoudakis, Anand Rane, Suzanne Angeli, Gordon J. Lithgow, Julie K. Andersen, Shankar J. Chinta

“…These findings suggest that securinine may be a potential candidate for the treatment of neurodegenerative diseases related to neuroinflammation.…”
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7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents by Shuke Nie, Kai Ma, Mingkuan Sun, Matthew Lee, Yang Tan, Guiqin Chen, Zhentao Zhang, Zhaohui Zhang, Xuebing Cao

“…7,8-Dihydroxyflavone (7,8-DHF) is thought to be a promising therapeutic agent for various neurodegenerative diseases. The major purpose of this study was to investigate the neuroprotective effects of 7,8-DHF on the rotenone-induced motor deficit of Parkinson’s disease. …”
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