Therapeutic Potential of α-Synuclein Evolvability for Autosomal Recessive Parkinson’s Disease by Jianshe Wei, Gilbert Ho, Yoshiki Takamatsu, Eliezer Masliah, Makoto Hashimoto

“…Presumably, αS evolvability might benefit familial PD due to autosomal dominant genes and also sporadic PD during reproduction, which may manifest as neurodegenerative diseases through antagonistic pleiotropy mechanism in aging. …”
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Panoptosis – new frontier in research in head neck cancer by Shrikant B. Mali

“…It has been linked to the development of multiple systemic diseases in the human body, including infectious diseases, cancer, neurodegenerative diseases, and inflammatory diseases. The innate immune system provides the first line of defense against cellular perturbations, and inflammatory programmed cell death is elicited in response to microbial infections or alterations in cellular homeostasis. …”
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Role of Fractalkine/CX3CL1 and Its Receptor in the Pathogenesis of Inflammatory and Malignant Diseases with Emphasis on B Cell Malignancies by Elisa Ferretti, Vito Pistoia, Anna Corcione

“…Here we review the different effects of the CX3CL1/CX3CR1 axis in several inflammatory and neurodegenerative diseases and in cancer, with emphasis on human B cell lymphomas.…”
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NREM and REM sleep parasomnias: clinical cases and literature review by K. Teišerskytė, I. Čelpačenko, E. Pajėdienė

“…NREM parasomnias are often benign, self-limited, or resolved with non-pharmacological treatment, while REM sleep behaviour disorder (example of REM parasomnias) is much more likely to occur in adult age and is associated with neurodegenerative diseases. There are 3 types of parasomnias associated with REM sleep: REM sleep behaviour disorder (RBD), isolated sleep paralysis, and nightmare disorder. …”
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Circulating Stress Hormones, Brain Health, and Cognition in Healthy Older Adults: Cross-Sectional Findings and Sex Differences in Age-Well by Maxie Liebscher, Silke White, Simon Hass, Anne Chocat, Florence Mezenge, Brigitte Landeau, Marion Delarue, Oriane Hébert, Anne-Laure Turpin, Natalie L. Marchant, Gaël Chételat, Olga Klimecki, Géraldine Poisnel, Miranka Wirth, Claire André, Pierre Champetier, Léa Chauveau, Fabienne Collette, Sophie Dautricourt, Robin de Flores, Vincent De La Sayette, Harriet Demnitz-King, Séverine Fauvel, Francesca Felisatti, Victor Ferment, Eglantine Ferrand-Devouge, Julie Gonneaud, Antoine Garnier-Crussard, Anaïs Hamel, Sacha Haudry, Pierre Krolak-Salmon, Elizabeth Kuhn, Valérie Lefranc, Antoine Lutz, Valentin Ourry, Cassandre Palix, Anne Quillard, Géraldine Rauchs, Eric Salmon, Edelweiss Touron, Patrik Vuilleumier, Tim Whitfield

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Maximizing the neuroprotection from Citrus aurantium leaves: Optimization of a blended extract from a sequential extraction process with compressed fluids and NADES by Victor M. Amador-Luna, Miguel Herrero, Marta Jiménez de la Parra, Ángel Gómez Arribas, Elena Ibáñez, Lidia Montero

“…Due to the different nature and bioactivity of the obtained extracts, the mixture of the three fractions was optimized to enhance its overall preventive potential against neurodegenerative diseases. Finally, its scalability to a semi-pilot scale was evaluated, giving rise to increased bioactive values of the blended extract.…”
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Mitochondrial Fusion Proteins and Human Diseases by Michela Ranieri, Simona Brajkovic, Giulietta Riboldi, Dario Ronchi, Federica Rizzo, Nereo Bresolin, Stefania Corti, Giacomo P. Comi

“…While these disorders can still be considered rare, defective mitochondrial dynamics seem to play a significant role in the molecular and cellular pathogenesis of more common neurodegenerative diseases, for example, Alzheimer’s and Parkinson’s diseases. …”
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Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation by Dina Morshedi, Mahour Nasouti

“…It is believed that exposure to the factors which promote fibrillation may induce and progress such neurodegenerative diseases (NDs). Herein, the effects of some wildly used essential oils including Myrtus communis (M. communis) on α-Syn fibrillation were examined. …”
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Mutations in human prion-like domains: pathogenic but not always amyloidogenic by Andrea Bartolomé-Nafría, Javier García-Pardo, Salvador Ventura

“…To date, over 60 mutations targeting the LCDs of hnRNPs have been identified and associated with a spectrum of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease (AD). …”
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Coupling of mitochondrial state with active zone plasticity in early brain aging by Lu Fei, Yongtian Liang, Ulrich Kintscher, Stephan J. Sigrist

“…Neurodegenerative diseases typically emerge after an extended prodromal period, underscoring the critical importance of initiating interventions during the early stages of brain aging to enhance later resilience. …”
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Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration by Jialiu Zeng, Jialiu Zeng, Lenny Yi Tong Cheong, Chih Hung Lo, Chih Hung Lo

“…These disruptions impair normal neuronal function and subsequently lead to cognitive decline and motor deficits, similar to the pathologies observed in major neurodegenerative diseases, including Alzheimer’s disease, multiple sclerosis, and Parkinson’s disease. …”
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Effects of Intravenous Administration of Human Umbilical Cord Blood Stem Cells in 3-Acetylpyridine-Lesioned Rats by Lucía Calatrava-Ferreras, Rafael Gonzalo-Gobernado, Antonio S. Herranz, Diana Reimers, Teresa Montero Vega, Adriano Jiménez-Escrig, Luis Alberto Richart López, Eulalia Bazán

“…Cell replacement strategies using human umbilical cord blood mononuclear cells (HuUCBMCs) have emerged as a promising approach for restoration of function in neurodegenerative diseases. The aim of this work was to investigate the potential therapeutic activity of HuUCBMCs in the 3-acetylpyridine (3-AP) rat model of cerebellar ataxia. …”
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Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases by Van-Long Truong, Woo-Sik Jeong

“…High intake of tea polyphenols has been described to prevent and/or attenuate a variety of chronic pathological conditions like cardiovascular diseases, neurodegenerative diseases, diabetes, and cancer. This review focuses on established antioxidant and anti-inflammatory properties of tea polyphenols and underlying mechanisms of their involvement in inflammatory bowel diseases (IBD). …”
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Dental Mesenchymal Stem/Stromal Cells and Their Exosomes by Peter Stanko, Ursula Altanerova, Jana Jakubechova, Vanda Repiska, Cestmir Altaner

“…The therapeutic applicability of these cells and exosomes in dental practice, neurodegenerative diseases, and many other difficultly treatable diseases, like myocardial infarction, focal cerebral ischemia, acute lung or brain injury, acute respiratory distress syndrome, acute inflammation, and several others is concisely covered. …”
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A systematic screening assay identifies efficient small guide RNAs for CRISPR activation by Elin Arvidsson, Diana Duarte Lobo, Diana Duarte Lobo, Ermelinda Sabarese, Fabio Duarte, Rui Jorge Nobre, Rui Jorge Nobre, Rui Jorge Nobre, Luis Quintino, Cecilia Lundberg

“…The overall workflow was validated using therapeutically relevant genes for neurodegenerative diseases, including Tfeb, Adam17, and Sirt1. …”
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Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review by Ubaid Ansari, Jimmy Wen, Burhaan Syed, Dawnica Nadora, Romteen Sedighi, Denise Nadora, Vincent Chen, Forshing Lui

“…Emerging research suggests that NP2 is implicated in the pathogenesis of various neurological disorders, including neurodegenerative diseases, neuropsychiatric disorders, and neuropathies. …”
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Patient-Specific Pluripotent Stem Cells in Neurological Diseases by Serpen Durnaoglu, Sermin Genc, Kursad Genc

“…Patient-specific iPSC-based modeling of neurogenetic and neurodegenerative diseases is an emerging efficient tool for in vitro modeling to understand disease and to screen for genes and drugs that modify the disease process. …”
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A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases by Claudia-Andreea Moldoveanu, Maria Tomoaia-Cotisel, Alexandra Sevastre-Berghian, Gheorghe Tomoaia, Aurora Mocanu, Csaba Pal-Racz, Vlad-Alexandru Toma, Ioana Roman, Madalina-Anca Ujica, Lucian-Cristian Pop

“…This review explores cellular and molecular current aspects, of curcumin-based effects with an emphasis on curcumin’s metabolism and its impact on pathological conditions, such as neurodegenerative diseases, schizophrenia, and cerebral angiopathy. …”
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PET Quantification of Cerebral Oxygen Metabolism in Small Animals by Takashi Temma, Kazuhiro Koshino, Tetsuaki Moriguchi, Jun-ichiro Enmi, Hidehiro Iida

“…Since small animals such as rats are widely used to study various diseases including cerebral ischemia, cerebrovascular diseases, and neurodegenerative diseases, the development of a noninvasive in vivo measurement method of cerebral oxygen metabolic parameters such as oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) as well as cerebral blood flow (CBF) and cerebral blood volume (CBV) has been a priority. …”
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Microbial phenolic metabolites are associated with better frontal lobe cognition by Inés Domínguez-López, Isabella Parilli-Moser, Anna Vallverdú-Queralt, Anna Tresserra-Rimbau, Cinta Valls-Pedret, Zenaida Vázquez-Ruiz, Olga Castañer, Ramon Estruch, Emili Ros, Rosa M. Lamuela-Raventós

“…With increasing life expectancy, neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. …”
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