A Dynamic Adaptive Ensemble Learning Framework for Noninvasive Mild Cognitive Impairment Detection: Development and Validation Study by Aoyu Li, Jingwen Li, Yishan Hu, Yan Geng, Yan Qiang, Juanjuan Zhao

“… BackgroundThe prompt and accurate identification of mild cognitive impairment (MCI) is crucial for preventing its progression into more severe neurodegenerative diseases. However, current diagnostic solutions, such as biomarkers and cognitive screening tests, prove costly, time-consuming, and invasive, hindering patient compliance and the accessibility of these tests. …”
Get full text

Assessment of clinical prognosis in autoimmune encephalitis: Girona score by Gary Álvarez Bravo, Giuseppe Guglielmini, Ana Quiroga Varela, Almudena Boix Lago, Ariadna Gifreu Fraixinó, Daniele Urso, Daniele Urso, Daniele Urso, Daniele Urso, Giancarlo Logroscino, Giancarlo Logroscino, Giancarlo Logroscino, Giancarlo Logroscino, Lluís Ramió-Torrentà

Get full text

Distinct patterns of prion strain deposition and toxicity in a novel whole brain organotypic slice culture system by Hailey Pineau, Valerie L. Sim

“…Abstract Prion diseases are fatal transmissible neurodegenerative diseases that affect many mammals, including humans, caused by the templated misfolding of the prion protein. …”
Get full text

Cookware as source of toxic metals: An overview by Okunola Alabi, Amos Tomiwa Afolabi

“…Aluminum used in cookware, has raised health concerns because of its possible associations with neurodegenerative diseases. Metal leaching is influenced by various factors, including acidity, cooking duration, and temperature. …”
Get full text

A Review on the Antimutagenic and Anticancer Effects of Cysteamine by Chun-Man Lee

“…It has been safely used in humans for the treatment of several pathologies including cystinosis and neurodegenerative diseases. Cysteamine has been shown to be a potent antimutagenic, anticarcinogenic, and antimelanoma in various in vitro and in vivo studies, but a review on these aspects of cysteamine’s use in medicine is lacking in the current literature. …”
Get full text

Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases by Xinyu Yang, Xiangyu Gao, Xiaofan Jiang, Kangyi Yue, Peng Luo

“…Owing to their therapeutic properties and ability to cross the blood–brain barrier, extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions, including ischemic stroke, traumatic brain injury, neurodegenerative diseases, glioma, and psychosis. However, the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the body. …”
Get full text

Profile of STING agonist and inhibitor research: a bibliometric analysis by Xuemei Wang, Qian Wang, Yidan Gao, Lijuan Jiang, Lingli Tang

“…BackgroundSTING is a core signaling hub molecule in the innate immune system, involved in various diseases, including infectious diseases, autoimmune diseases, tumors, aging, organ fibrosis, and neurodegenerative diseases. Its activation has shown great potential in anti-tumor and anti-infective therapies, with STING agonists emerging as a promising approach in cancer immunotherapy in recent years. …”
Get full text

Mechanism of Inflammation in Age-Related Macular Degeneration by Francesco Parmeggiani, Mario R. Romano, Ciro Costagliola, Francesco Semeraro, Carlo Incorvaia, Sergio D’Angelo, Paolo Perri, Paolo De Palma, Katia De Nadai, Adolfo Sebastiani

“…In the aging retina, free radicals and oxidized lipoproteins are considered to be major causes of tissue stress resulting in local triggers for parainflammation, a chronic status which contributes to initiation and/or progression of many human neurodegenerative diseases such as AMD. Experimental and clinical evidences strongly indicate the pathogenetic role of immunologic processes in AMD occurrence, consisting of production of inflammatory related molecules, recruitment of macrophages, complement activation, microglial activation and accumulation within those structures that compose an essential area of the retina known as macula lutea. …”
Get full text

Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity by Dwaine F. Emerich, Jeffrey H. Kordower, Yaping Chu, Chris Thanos, Briannan Bintz, Giovanna Paolone, Lars U. Wahlberg

“…Because GDNF has been effective in animal models of Parkinson’s disease, stroke, epilepsy, and Huntington’s disease, among other debilitating neurodegenerative diseases, encapsulated cell-based delivery of GDNF might represent one innovative means of slowing the neural degeneration seen in a myriad of currently untreatable neurological diseases.…”
Get full text

Halloysite clay nanotubes as platforms for loading of aptamers and antisense oligonucleotides by Maria Rita Caruso, Martina Maria Calvino, Giuseppe Cavallaro, Jussara Amato, Simona Marzano, Federica D'Aria, Concetta Giancola, Giuseppe Lazzara, Stefana Milioto, Bruno Pagano

“…The knowledge achieved represents the first step towards the development of hybrid nanomaterials with therapeutic applications towards neurodegenerative diseases.…”
Get full text

Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy by Tjaša Goričan, Simona Golič Grdadolnik

“…Errors in the process of the chaperone cycle can lead to diseases such as cancer and neurodegenerative diseases. Therefore, the activity of Hsp90 must be carefully regulated. …”
Get full text

Review on dietary supplements as an effective improvement of Alzheimer’s disease: focus on structures and mechanisms by Sheng Li, Yinling Wei, Zhenzhen Liang, Lingli Guo, Xiaojiang Hao, Yu Zhang

“…Alzheimer’s disease (AD), the major form of neurodegenerative diseases that can severely impede normal cognitive function, makes it one of the most common fatal diseases. …”
Get full text

New Insights into Chemical Profiles and Health-Promoting Effects of Edible Mushroom <i>Dictyophora indusiate</i> (Vent ex. Pers.) Fischer: A Review by Yogesh Kumar, Baojun Xu

“…DIP shows neuroprotective effects by reducing oxidative damage, improving mitochondrial function, and regulating apoptosis, making them beneficial for neurodegenerative diseases. They also activate immune responses through TLR4 and NF-κB pathways. …”
Get full text

Impact of Time Delay in Perceptual Decision-Making: Neuronal Population Modeling Approach by Urszula Foryś, Natalia Z. Bielczyk, Katarzyna Piskała, Martyna Płomecka, Jan Poleszczuk

“…Impairments in decision-making are frequently observed in neurodegenerative diseases, but the mechanisms underlying such pathologies remain elusive. …”
Get full text

Noradrenergic Modulation of Cognition in Health and Disease by Olga Borodovitsyna, Matthew Flamini, Daniel Chandler

“…Due to its role in mediating normal cognitive function, it is reasonable to expect that noradrenergic transmission becomes dysfunctional in a number of neuropsychiatric and neurodegenerative diseases characterized by cognitive deficits. …”
Get full text

Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin by Jeonghyun Oh, Christy Catherine, Eun Seon Kim, Kwang Wook Min, Hae Chan Jeong, Hyojin Kim, Mijin Kim, Seung Hae Ahn, Nataliia Lukianenko, Min Gu Jo, Hyeon Seok Bak, Sungsu Lim, Yun Kyung Kim, Ho Min Kim, Sung Bae Lee, Hyunju Cho

“…Abstract Toxic protein aggregates are associated with various neurodegenerative diseases, including Huntington’s disease (HD). …”
Get full text

Aging-associated sensory decline and Alzheimer’s disease by Suji Hong, Seung-Hyun Baek, Mitchell K. P. Lai, Thiruma V. Arumugam, Dong-Gyu Jo

“…This approach underscores the significance of sensory health in addressing neurodegenerative diseases, particularly AD.…”
Get full text

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity by Gabriel Olmos, Jerònia Lladó

“…This review summarizes the current knowledge of the cellular and molecular mechanisms by which TNF-α links the neuroinflammatory and excitotoxic processes that occur in several neurodegenerative diseases, but with a special emphasis on amyotrophic lateral sclerosis (ALS). …”
Get full text

Possible impact of use of a ketogenic diet in pregnancy on the fetus: Review of animal and human studies by Agata Miłosz, Justyna Michalczyk, Iwona Morawik, Klaudia Długoborska, Monika Gesek

“…It is an effective form of treatment for many diseases including epilepsy, obesity, neurodegenerative diseases and some metabolic disorders.In women with Polycystic Ovary Syndrome ketogenic diet has a positive effect on fertility by reducing weight, insulin resistance and hormonal regulation [4–7]. …”
Get full text

Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection by Gabriela Gonzalez Aleman, George D. Vavougios, George D. Vavougios, Carmela Tartaglia, Carmela Tartaglia, Nalakath A. Uvais, Alla Guekht, Alla Guekht, Akram A. Hosseini, Akram A. Hosseini, Vincenzina Lo Re, Vincenzina Lo Re, Catterina Ferreccio, Catterina Ferreccio, Giovanni D'Avossa, Hernan P. Zamponi, Mariana Figueredo Aguiar, Agustin Yecora, Agustin Yecora, Mohammad Zia Ul Haq Katshu, Vasileios T. Stavrou, Vasileios T. Stavrou, Stylianos Boutlas, Konstantinos I. Gourgoulianis, Camila Botero, Francisco González Insúa, Santiago Perez-Lloret, Mikhail Zinchuk, Anna Gersamija, Sofya Popova, Yulia Bryzgalova, Ekaterina Sviatskaya, Giovanna Russelli, Giovanna Russelli, Federica Avorio, Federica Avorio, Sophia Wang, Sophia Wang, Paul Edison, Paul Edison, Yoshiki Niimi, Hamid R. Sohrabi, Elizabeta B. Mukaetova Ladinska, Elizabeta B. Mukaetova Ladinska, Daria Neidre, Gabriel A. de Erausquin, Gabriel A. de Erausquin, Gabriel A. de Erausquin

Get full text