Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease by Giuseppe Verdile, Kevin N. Keane, Vinicius F. Cruzat, Sandra Medic, Miheer Sabale, Joanne Rowles, Nadeeja Wijesekara, Ralph N. Martins, Paul E. Fraser, Philip Newsholme

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Xixin Decoction’s novel mechanism for alleviating Alzheimer’s disease cognitive dysfunction by modulating amyloid-β transport across the blood–brain barrier to reduce neuroinflamma... by Chaokai Yang, Enlong Zhao, Hu Zhang, Liqi Duan, Xinyue Han, Hongli Ding, Yan Cheng, Dengkun Wang, Dengkun Wang, Dengkun Wang, Xiaojing Lei, Xiaojing Lei, Xiaojing Lei, Yongchang Diwu, Yongchang Diwu, Yongchang Diwu

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Interaction between 𝛼-Synuclein and Other Proteins in Neurodegenerative Disorders by Kurt A. Jellinger

“…Inclusions, characteristics of these disorders, also occurring in other neurodegenerative diseases, suggest interactions of pathological proteins engaging common downstream pathways. …”
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Editorial: Animal models of Alzheimer's disease and other dementias: past, present, and future by Ines Moreno-Gonzalez, Ines Moreno-Gonzalez, Ines Moreno-Gonzalez, Jesus Garcia-Martin, Roberta Marongiu, Roberta Marongiu, Roberta Marongiu

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Directional entropy based model for diffusivity-driven tumor growth by Marcelo E. de Oliveira, Luiz M. G. Neto

“…In our formulation, the tumor aggressiveness and morphological behavior is tissue-type dependent, i.e. alterations in white and gray matter regions (which can e.g. be induced by normal aging in healthy individuals or neurodegenerative diseases) affect both tumor growth rates and their morphology.The feasibility of this new conceptual approach is supported by previous observations that the fractal dimension, which correlates with the Shannon entropy we calculate, is a quantitative parameter that characterizes the variability of brain tissue, thus, justifying the further evaluation of this new conceptual approach.…”
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The structure, functions and clinical significance of the glymphatic system by Tansu Kuşat, Emrah Sur

“…Since the concept of the glymphatic system is a relatively new concept, we will evaluate its clinical significance in this review by looking at its basic structural elements, functions, and relationship with some certain neurodegenerative diseases. We will give information about some research showing that various diseases causing the functional impairment of the glymphatic system and also which diseases the functional impairment of the glymphatic system may cause.…”
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The Brain’s Aging Resting State Functional Connectivity by Ali F. Khan, Nada Saleh, Zachary A. Smith

“…By providing an overview of the current state of knowledge in this field, this review aims to guide future research endeavors aimed at promoting healthy brain aging and developing effective interventions for age-related cognitive impairment and neurodegenerative diseases.…”
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Neuroprotective Activity of (-)-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity by Jin-Biao Liu, Li Zhou, Yi-Zhong Wang, Xu Wang, Yu Zhou, Wen-Zhe Ho, Jie-Liang Li

“…Lipopolysaccharide- (LPS-) mediated systemic inflammation plays a critical role in neurodegenerative diseases. The present study was conducted to evaluate the protective effects of epigallocatechin gallate (EGCG), the major component in green tea, on LPS-mediated inflammation and neurotoxicity. …”
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Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free Treatment by Rohaina Che Man, Nadiah Sulaiman, Ruszymah Bt Hj Idrus, Shahrul Hisham Zainal Ariffin, Rohaya Megat Abdul Wahab, Muhammad Dain Yazid

“…All studies demonstrated that dental stem cell-derived factors promote neurotrophic effects that can mechanistically stimulate nerve regeneration in neurodegenerative diseases and nerve injury. This data collection will enable researchers to gather information to create a precise formulation for future prescribed treatments.…”
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Algebraic and topological indices of molecular pathway networks in human cancers by Peter Hinow, Edward A. Rietman, Sara Ibrahim Omar, Jack A. Tuszyński

“…Beyond that, we provide a unifying framework to study protein-protein interaction networks of families of related diseases (e.g. neurodegenerative diseases, viral diseases, substance abuse disorders).…”
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Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice by Sonja Mendritzki, Saskia Schmidt, Teresa Sczepan, Xin-Ran Zhu, Daniel Segelcke, Hermann Lübbert

“…Accumulation of α-synuclein is observed in neurodegenerative diseases like Parkinson's disease and Multiple System Atrophy. …”
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The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degener... by Lisa Schwarz, Grit Vollmer, Christiane Richter-Landsberg

“…To further investigate their contribution to neurodegenerative diseases, we have analyzed the association of HSP27 with pathological lesions of tauopathies. …”
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Neuroplasticity in Alzheimer's disease: a therapeutic alternative at the molecular level by Noel Jesús Niebla Gómez, Rodolfo Javier Rivero Morey, Víctor René Navarro Machado, Mariangel González León, Amanda Martínez Pérez

“…The neuroplasticity mechanisms of the organism form the basis of dissimilar therapies that seek to potentiate such effects to achieve relative improvement in a large number of neurodegenerative diseases. Included within this high number of conditions, Alzheimer's disease stands out, due to its direct relationship with the alarming figures of population aging in Cuba and the world. …”
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RIPK1 in necroptosis and recent progress in related pharmaceutics by Kunhou Yao, Zhihao Shi, Fengya Zhao, Cong Tan, Yixin Zhang, Hao Fan, Yingzhe Wang, Xingwang Li, Jun Kong, Qun Wang, Dingxi Li

“…RIPK1-mediated necroptosis further promotes cell death and inflammation in the pathogenesis of liver injury, skin diseases, and neurodegenerative diseases. The N-terminal kinase domain of RIPK1 is significant in the induction of cell death and can be used as a vital drug target for inhibitors. …”
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Genomic exploration of pediatric neurological disorders: a case series by Naresh Tayade, Gautham Manoj, Akshay Kewat, Anjali Krishna A, Rajiv Devulapalli, Somesh Kumar, Sunil Kumar Polipalli, Bipin G. Nair, Obul Reddy Bandapalli, Prashanth Suravajhala

“…Abstract Background Pediatric neurological disorders include neurodegenerative diseases causing cognitive impairment and vision loss. …”
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Examining Specific Theory-of-Mind Aspects in Amnestic and Non-Amnestic Mild Cognitive Impairment: Their Relationships with Sleep Duration and Cognitive Planning by Areti Batzikosta, Despina Moraitou, Paschalis Steiropoulos, Georgia Papantoniou, Georgios A. Kougioumtzis, Ioanna-Giannoula Katsouri, Maria Sofologi, Magda Tsolaki

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Peripheral Expression of IL-6, TNF-α and TGF-β1 in Alzheimer's Disease Patients by Gamze Güven, Pınar Köseoğlu, Ebba Lohmann, Bedia Samancı, Erdi Şahin, Başar Bilgiç, Haşmet Ayhan Hanağası, Hakan Gürvit, Nihan Erginel-Ünaltuna

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Wide field imaging biomarkers: A different perspective by Sakshi Shiromani, Niveditha Pattathil, Elham Sadeghi, Netan Choudhry, Jay Chhablani

“…We discuss quantitative biomarkers, including ischemic index, nonperfusion area and more, and their application in diabetic retinopathy, central retinal vein occlusion, neurodegenerative diseases, and more. In addition, we outline qualitative biomarkers such as choroidal venous hyperpermeability and intervortex anastomoses. …”
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Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases by Robbin Romijnders, Arash Atrsaei, Rana Zia Ur Rehman, Lea Strehlow, Jèrôme Massoud, Chloe Hinchliffe, Victoria Macrae, Kirsten Emmert, Ralf Reilmann, C. Janneke van der Woude, Geert Van Gassen, Frédéric Baribaud, Teemu Ahmaniemi, Meenakshi Chatterjee, Bruno Kusznir Vitturi, Clémence Pinaud, Jérôme Kalifa, Stefan Avey, Wan-Fai Ng, Clint Hansen, Nikolay V. Manyakov, Walter Maetzler

“…Abstract Fatigue is prevalent in immune-mediated inflammatory and neurodegenerative diseases, yet its assessment relies largely on patient-reported outcomes, which capture perception but not fluctuations over time. …”
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Splicing accuracy varies across human introns, tissues, age and disease by S. García-Ruiz, D. Zhang, E. K. Gustavsson, G. Rocamora-Perez, M. Grant-Peters, A. Fairbrother-Browne, R. H. Reynolds, J. W. Brenton, A. L. Gil-Martínez, Z. Chen, D. C. Rio, J. A. Botia, S. Guelfi, L. Collado-Torres, M. Ryten

“…We find that age is positively correlated with a global decline in splicing fidelity, mostly affecting genes implicated in neurodegenerative diseases. We find support for the latter by observing a genome-wide increase in splicing inaccuracies in samples affected with Alzheimer’s disease as compared to neurologically normal individuals. …”
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