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241
Manganese Inhalation as a Parkinson Disease Model
Published 2011-01-01“…Our data provide evidence that Mn2+/Mn3+ mixture inhalation produces similar morphological, neurochemical, and behavioral alterations to those observed in PD providing a useful experimental model for the study of this neurodegenerative disease.…”
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242
Association of serum neurofilament light chain with cognitive impairment: findings from the National Health and Nutrition Examination Survey
Published 2025-01-01“…BackgroundSerum Neurofilament Light chain (NfL) is a promising biomarker of neuronal damage, used to assess the extent of neuronal injury and neurodegeneration, and it is widely applied in the diagnosis of neurodegenerative disease and monitoring disease progression. …”
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243
iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study
Published 2016-01-01“…Photoreceptors rely heavily on the RPE, and death or dysfunction of RPE is characteristic of age-related macular degeneration (AMD), a very common neurodegenerative disease for which no cure exists. RPE replacement is a promising therapeutic intervention for AMD, and large numbers of RPE cells can be generated from pluripotent stem cells. …”
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244
Improvement of Blood Plasmalogens and Clinical Symptoms in Parkinson’s Disease by Oral Administration of Ether Phospholipids: A Preliminary Report
Published 2020-01-01“…Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD). With the ageing of population, the frequency of PD is expected to increase dramatically in the coming decades. …”
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245
The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway
Published 2023-05-01“…Abstract Alzheimer's disease (AD) is a neurodegenerative disease with high incidence and widespread attention. …”
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246
Artificial intelligence empowered voice generation for amyotrophic lateral sclerosis patients
Published 2025-01-01“…Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that can result in a progressive loss of speech due to bulbar dysfunction, which can have significant negative impact on the patient’s mental well-being. …”
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247
The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils
Published 2018-09-01“…Development of an α-synuclein (α-Syn) positron emission tomography agent for the diagnosis and evaluation of Parkinson disease therapy is a key goal of neurodegenerative disease research. BF-227 has been described as an α-Syn binder and hence was employed as a lead to generate a library of α-Syn-binding compounds. [ 3 H]BF-227 bound to α-Syn and amyloid β peptide (Aβ) fibrils with affinities (K D ) of 46.0 nM and 15.7 nM, respectively. …”
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248
Psychological experience of inpatients with acute pancreatitis: a qualitative study
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249
Developing non-invasive molecular markers for early risk assessment of Alzheimer's disease
Published 2025-06-01“…Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease, with no standard biomarker(s) to detect or confirm its risk at an early stage. …”
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250
The Role of Virtual Reality in Postural Rehabilitation for Patients with Parkinson’s Disease: A Scoping Review
Published 2024-12-01“…Parkinson’s disease is the second most common neurodegenerative disease worldwide, characterized by bradykinesia, rigidity, tremor, and postural instability. …”
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251
Daily Assistance for Amyotrophic Lateral Sclerosis Patients Based on a Wearable Multimodal Brain-Computer Interface Mouse
Published 2025-01-01“…Amyotrophic lateral sclerosis (ALS) is a chronic, progressive neurodegenerative disease that mainly causes damage to upper and lower motor neurons. …”
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252
Adolescent mice exposed to TBI developed PD-like pathology in middle age
Published 2025-01-01“…Abstract Traumatic brain injury (TBI) is identified as a risk factor for Parkinson’s disease (PD), which is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN). …”
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253
Study on influencing factors of age-adjusted Charlson comorbidity index in patients with Alzheimer's disease based on machine learning model
Published 2025-01-01“…BackgroundAlzheimer's disease (AD) is a widespread neurodegenerative disease, often accompanied by multiple comorbidities, significantly increasing the risk of death for patients. …”
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254
Antiparkinsonian activity of selective MAO-B inhibitors of different chemical structures
Published 2024-12-01“…Introduction: Parkinson’s disease (PD) is a chronic neurodegenerative disease of the central nervous system, the pathogenesis of which is associated with the death of dopaminergic neurons of the midbrain substantia nigra. …”
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255
A human-induced pluripotent stem cell (iPSC) line (SMUSHi006-A) from an ALS patient carrying a mutation c.1126C > T in the FUS gene
Published 2025-02-01“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Four major genes associated with ALS—SOD1, TARDBP, FUS, and C9orf72—have been identified, with the fused in sarcoma (FUS) gene demonstrating considerable genetic heterogeneity. …”
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256
Impact of MMP2 rs243865 and MMP3 rs3025058 Polymorphisms on Clinical Findings in Alzheimer’s Disease Patients
Published 2021-01-01“…Alzheimer’s disease (AD) is a chronic neurodegenerative disease of the central nervous system with higher prevalence in elderly people. …”
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257
Brain health in Norwegian female former top-level football players: a protocol for a longitudinal cohort study
Published 2025-01-01“…Recent studies have identified an association between playing football at the top level and an elevated risk of cognitive impairment and neurodegenerative disease. However, these were conducted on men, and there is a knowledge gap regarding these risks in female athletes. …”
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258
Novel method for classification of prion diseases by detecting PrPres signal patterns from formalin-fixed paraffin-embedded samples
Published 2024-12-01“…Prion disease is an infectious and fatal neurodegenerative disease. Western blotting (WB)-based identification of proteinase K (PK)-resistant prion protein (PrPres) is considered a definitive diagnosis of prion diseases. …”
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259
Identification of Potential miRNA-mRNA Regulatory Network Contributing to Parkinson’s Disease
Published 2022-01-01“…Parkinson’s disease (PD) is a common neurodegenerative disease, and the mechanism underlying PD pathogenesis is not completely understood. …”
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260
Elevation of ganglioside degradation pathway drives GM2 and GM3 within amyloid plaques in a transgenic mouse model of Alzheimer's disease
Published 2025-02-01“…Alzheimer's disease (AD) is a progressive neurodegenerative disease that accounts for two-thirds of all dementia cases, and age is the strongest risk factor. …”
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