Chronic Lymphocytic Leukemia and Myelofibrosis by Fares Darawshy, Arieh Ben-Yehuda, Karine Atlan, Deborah Rund

“…Etiologic and pathogenic associations—the role of t (1; 6) and JAK-2 V617F mutation—are discussed.…”
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Intestinal Type of Lung Adenocarcinoma in Younger Adults by Jelena Stojsic, Milica Kontic, Dragan Subotic, Marko Popovic, Dragana Tomasevic, Jelena Lukic

“…More investigations are needed for further understanding of ILADC in purpose of personalized lung carcinoma therapy particularly introducing detection of mutation status, especially in younger patients.…”
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Spatio-temporal Distribution Characteristics and Future Trend Analysis of Extreme Climate Indices in Nenjiang River Basin over the Past 60 Years by GONG Xiao, DAI Changlei, LI Shuling, XIAO Yue

“…Meanwhile, methods like the linear fitting, Mann-Kendall mutation test, and sliding T-test are adopted to analyze the spatio-temporal variation characteristics of extreme temperature and precipitation in the basin. …”
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Molar Tooth Sign with Deranged Liver Function Tests: An Indian Case with COACH Syndrome by Rama Krishna Sanjeev, Seema Kapoor, Manisha Goyal, Rajiv Kapur, Joseph Gerard Gleeson

“…We report the first genetically proven case of COACH syndrome from the Indian subcontinent in a 6-year-old girl who presented with typical features of Joubert syndrome along with hepatic involvement. Mutation analysis revealed compound heterozygous missense mutation in the known gene TMEM67 (also called MKS3).…”
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The Hereditary Hyperferritinemia-Cataract Syndrome in 2 Italian Families by Katia Perruccio, Francesco Arcioni, Carla Cerri, Roberta La Starza, Donatella Romanelli, Ilaria Capolsini, Maurizio Caniglia

“…Genetic investigation revealed two distinct mutations in iron haemostasis genes; homozygosity for the HFE gene H63D mutation in the younger and heterozygosity in the elder. …”
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Association between P2X7 Receptor Polymorphisms and Bone Status in Mice by Susanne Syberg, Peter Schwarz, Solveig Petersen, Thomas H. Steinberg, Jens-Erik Beck Jensen, Jenni Teilmann, Niklas Rye Jørgensen

“…Macrophages from mouse strains with the naturally occurring mutation P451L in the purinergic receptor P2X7 have impaired responses to agonists (1). …”
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IKEChecker: grammar-guided stateful fuzzer for IKE protocol implementions by ZHENG Yonghui, ZHAO Dongliang, GU Chunxiang, ZHANG Xieli

“…Additionally, an evolutionary strategy-based mutation scheduling scheme was introduced, which automatically optimized the probability distribution of mutation operators, further increasing the likelihood of generating high-quality test cases. …”
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Self-adaptive fuzzing optimization method based on distribution divergence by XU Hang, JI Jiangan, MA Zheyu, ZHANG Chao

“…The selection for the focused mutation block of a seed file was defined as an action, and the distribution divergence of the approximate distributions of the random fields before and after the action was defined as the reward. …”
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An Improved Grasshopper Optimizer for Global Tasks by Hanfeng Zhou, Zewei Ding, Hongxin Peng, Zitao Tang, Guoxi Liang, Huiling Chen, Chao Ma, Mingjing Wang

“…Firstly, a probabilistic mutation mechanism is introduced into the basic GOA, which makes full use of the strong searchability of Cauchy mutation and the diversity of genetic mutation. …”
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A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia by Andrew Chu, Thu Thu Aung, Minni Shreya Arumugam, Mauricio Danckers, Mohi Mitiek, Jonathan Leslie

“…FVL mutation associated with right heart thrombus is a rare entity. …”
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Comparison of molecular analysis results determined by next-generation sequencing to immunohistochemical indicators and clinicopathological parameters in prostate adenocarcinomas by Merve Çırak Balta, İbrahim Halil Erdoğdu, Esin Oktay, Nil Çulhac

“…In all cases with a pathogenic mutation in the androgen receptor gene, a pathogenic mutation in the Protein Tyrosine Phosphatase and Tensin Homolog gene was also observed and a significant relationship was found between them. …”
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BRAF V600E-Negative Hairy Cell Leukaemia by Stephen E. Langabeer, David O'Brien, Anthony M. McElligott, Michelle Lavin, Paul V. Browne

“…Since the initial report of the BRAF V600E mutation in hairy cell leukemia, numerous investigators have demonstrated the presence of this activating mutation in nearly all cases of this disease. …”
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Dynamic spectrum allocation for cognitive radio sensor networks based on improved genetic algorithm by Chang CAI, Yafang WANG, Bingmei MIAO, Hui JIANG

“…ISM (industrial scientific and medical) bands where wireless sensor network works faced with the shortage of spectrum resources problems.Aimed at this case,dynamic spectrum allocation in cognitive radio technology was applied in wireless sensor network.A dynamic frequency spectrum allocation scheme was proposed.The algorithm was a modified adaptive genetic algorithm which was based on graph coloring model.In addition,the objective functions of the algorithm were maximum bandwidth gains and minimum spectrum handoff,besides,in the crossover and mutation process,adaptive crossover probability and mutation probability was used instead of the fixed.Experimental results confirm that compared with the traditional genetic algorithm and color sensitive graph coloring algorithm,the proposed algorithm can achieve the expected goal of improving the spectral efficiency and reducing energy consumption.…”
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Generation and propagation of high fecundity gene edited fine wool sheep by CRISPR/Cas9 by Xuemei Zhang, Meiyu Qiu, Bing Han, Li Liao, Xinrong Peng, Jiapeng Lin, Ning Zhang, Lati Hai, Long Liang, Yila Ma, Wenrong Li, Mingjun Liu

“…The FecB allele in sheep is a mutation in the BMPRIB gene, recognized as the first major gene responsible for the high fecundity trait in sheep, leading to an increased ovulation rate in ewe. …”
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Impact of Bone-Modifying Agents on Post-Bone Metastasis Survival Across Cancer Types by Hironari Tamiya, Kazumi Nishino, Yuji Kato, Reina Nakahashi-Kato, Yurika Kosuga-Tsujimoto, Shota Kinoshita, Rie Suzuki, Makiyo Watanabe, Toru Wakamatsu, Shigeki Kakunaga, Satoshi Takenaka

“…In non-small cell lung cancer (NSCLC), the log-rank test demonstrated that the epidermal growth factor receptor (EGFR) mutation was a significant factor for post-bone metastasis survival: EGFR mutation (−) <i>n</i> = 67, median post-bone metastasis survival 11.5 months (95% CI: 6.0–15.2); EGFR mutation (+) <i>n</i> = 39, median post-bone metastasis survival 28.8 months (95% CI: 18.1–35.7) (<i>p</i> < 0.05). …”
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Clinical And Molecular-Genetic Features Of Congenital Aniridia by T.A. Vasilieva, Voskresenskaya A. A, V.V. Kadyshev, N.A. Pozdeeva, A.V. Marakhonov, R.A. Zinchenko

“…Patients were divided into the groups according to the type/location of mutation. Phenotypic traits were referred to the type/location of mutation. …”
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Characteristics of Siblings with Familial Mediterranean Fever: A Single-Center Experience by Elif Arslanoglu Aydin, Esra Baglan, İlknur Bagrul, Emine Nur Sunar Yayla, Nesibe Gokce Kocamaz, Semanur Ozdel

“…Seventy-two percent of the patients had the same genetic mutation as their siblings. Despite having the same genetic mutation, 59% of the patients had different attack symptoms from their siblings. …”
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Management of asynchronous multifocal adult glioblastoma with loss of BRAFV600E -mutant clonality: a case report by Hannah Haile, Pavan S. Upadhyayula, Esma Karlovich, Michael B. Sisti, Brian J. A. Gill, Laura E. Donovan

“…Abstract Glioblastoma (GBM) classification involves a combination of histological and molecular signatures including IDH1/2 mutation, TERT promoter mutation, and EGFR amplification. …”
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Biofilm-associated metabolism via ERG251 in Candida albicans. by Liping Xiong, Nivea Pereira De Sa, Robert Zarnowski, Manning Y Huang, Caroline Mota Fernandes, Frederick Lanni, David R Andes, Maurizio Del Poeta, Aaron P Mitchell

“…Under those conditions, the erg251Δ/Δ mutation causes defects in growth and hyphal extension. …”
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Primary Hyperoxaluria Type 1 in 18 Children: Genotyping and Outcome by Mohamed S. Al Riyami, Badria Al Ghaithi, Nadia Al Hashmi, Naifain Al Kalbani

“…It results from genetic mutations of the AGXT gene, which is more common due to higher consanguinity rates in the developing countries. …”
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