Stem Cell Hierarchy and Clonal Evolution in Acute Lymphoblastic Leukemia by Fabian Lang, Bartosch Wojcik, Michael A. Rieger

“…In the clonal evolution model, a consecutive accumulation of mutations starting in a single cell results in competitive growth of subclones with divergent fitness in either a linear or a branching succession. …”
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Late-Onset Isolated Corticotrope Deficiency in a Woman with Down Syndrome by Ibtissem Oueslati, Marwa Ben Jemaa, Meriem Yazidi, Fatma Chaker, Melika Chihaoui

“…Genetic analysis showed no mutations and no copy number variants of the TBX19 and NFKB2 genes. …”
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Resolution of Mild Ganciclovir-Resistant Cytomegalovirus Disease with Reduced-Dose Cidofovir and CMV-Hyperimmune Globulin by Samir J. Patel, Samantha A. Kuten, Richard J. Knight, Dana M. Hong, A. Osama Gaber

“…All patients initially developed “breakthrough” viremia while still receiving valganciclovir prophylaxis after transplant and were later confirmed to exhibit UL97 mutations after failing to eradicate virus on adequate dosages of valganciclovir. …”
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Clinicopathological and molecular characterization of astrocytoma by Xiaoyan Wu, Wenfeng Peng, Xu Zhang, Tao Tang, Ling Deng, Yuxia Xu, Xiaoyun Liu, Fang Wang, Wujian Peng, Jianrong Huang, Xiaoni Zhong

“…Three cases experienced tumour recurrences at the spinal cord site, with multiple recurrences in case 4.DiscussionOur study unveiled the distinctive clinicopathological and molecular mutational characteristics of astrocytoma, while also identifying rare mutated genes. …”
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A Large PROP1 Gene Deletion in a Turkish Pedigree by Suheyla Gorar, Doga Turkkahraman, Kanay Yararbas

“…This finding is in line with the fact that patients with PROP1 mutations may have different phenotype/genotype correlation.…”
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SPERMATOGENESIS INDICES IN INBRED STRAINS DD/HE AND BALB/CLAC AND THEIR F1 RECIPROCAL CROSSES by M. A. Kleshchev, L. V. Osadchuk, A. V. Osadchuk

“…It is known that Y chromosome genes are important for spermatogenesis. Thus, Y chromosome mutations may be responsible for interstrain differences in spermatogenic parameters. …”
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Implications of noncoding RNAs for cancer therapy: Are we aiming at the right targets? by Amil Shah

“…Modifications of the ncRNA network due to altered ncRNAs can cause the cell to shift towards to neoplastic phenotype; this is cancer initiation. Mutations in the well-known cancer driver genes provide the incipient cancer cell with a selective growth advantage and fuel its consequent clonal expansion. …”
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Machine learning models for water safety enhancement by Fatemeh Ranjbar, Hossein Sadeghi, Reza Pourimani, Soraya Khanmohammadi

“…These radionuclides can infiltrate the human body through various pathways, potentially leading to cancer and genetic mutations. A study was conducted using random sampling to assess the concentrations of radioactive isotopes and heavy metals in mineral water from Iran, consumable at Arak City. …”
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MsDpo4—a DinB Homolog from Mycobacterium smegmatis—Is an Error-Prone DNA Polymerase That Can Promote G:T and T:G Mismatches by Amit Sharma, Deepak T. Nair

“…Overall, our data show that MsDpo4 has the capacity to facilitate transition mutations and can potentially impart plasticity to the genome.…”
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The Effect Of Andaliman Fruit (Zanthoxylum Acanthopodium) Extract On Oxidative Stress In The Pancreas Of Rats (Ratus Norvegicus) Induced By D-Galactose by Felix Hartanto, Chrismis Novalinda Ginting, Linda Chiuman

“…The cause of aging is believed to be due to an increase in reactive oxygen species (ROS) which are oxidative, resulting in cell membrane damage and DNA mutations. One of the organs most frequently damaged is the pancreas which functions in maintaining the function of sugar in the individual's body. …”
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ATM in immunobiology: From lymphocyte development to cancer immunotherapy by Ji-Hoon Lee

“…Ataxia Telangiectasia Mutated (ATM) is a protein kinase traditionally known for its role in DNA damage response and cell cycle regulation. …”
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Facioscapulohumeral muscular dystrophy: a review of pathogenesis, clinical symptoms, and treatment by T. Mikalauskas, B. Burnytė

“…The first type is characterised by a reduction in D4Z4 repeats, while the second type is characterised by mutations in genes encoding epigenetic regulators such as SMCHD1. …”
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Post-COVID Mucormycosis: An Emerging Threat in Developing Countries - A Prospective Review by Debpratim Chakraborty, Sudipa Adhikary

“… COVID-19, with its rapidly mutating strains, poses a significant global health challenge. …”
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Therapeutic Potential of α-Synuclein Evolvability for Autosomal Recessive Parkinson’s Disease by Jianshe Wei, Gilbert Ho, Yoshiki Takamatsu, Eliezer Masliah, Makoto Hashimoto

“…The remaining are familial PD associated with gene mutations of either autosomal dominant or recessive inheritances. …”
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Biomarker testing in lung cancer: from bench to bedside by Ullas Batra, Shrinidhi Nathany

“…NGS enables the identification of point mutations, insertions, deletions, copy number alterations, fusion genes, and microsatellite instability information needed to guide the potential use of targeted therapy. …”
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Principal component analysis (PCA) as a genetic diversity tool to understand the variation of rice mutant culture by S. Palaniyappan1, P. Arunachalam1*, S. Banumathy1 and S. Muthuramu2

“…More precisely, the grouping revealed that the EMS mutants of Anna (R) 4 were potentially mutated not only for the grain type and also for yield related traits such as flag leaf length and breadth, panicle length, plant height. …”
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Marfan Syndrome and Autosomal Dominant Polycystic Kidney Disease: A Case of Rare Co-occurrence or Coincidence? by Arjun Sekar

“…ADPKD and MFS are caused by totally different mutations. However, the literature review showed that vascular abnormalities and connective tissue diseases may be more common with ADPKD. …”
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A novel metal transporter mediating manganese export (MntX) regulates the Mn to Fe intracellular ratio and Neisseria meningitidis virulence. by Frédéric J Veyrier, Ivo G Boneca, Mathieu F Cellier, Muhamed-Kheir Taha

“…In the Neisseria genus, this exporter is present and functional in all Nm isolates but it is mutated in a majority of Ng strains and commonly absent in nonpathogenic species. …”
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Hybrid Genetic Grey Wolf Algorithm for Large-Scale Global Optimization by Qinghua Gu, Xuexian Li, Song Jiang

“…Finally, the elite individuals in the population are mutated to prevent the algorithm from falling into local optimum. …”
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Statistical - Spatial Analysis of the Core of Siberian High Pressure System Period 1955-2014) by daryosh yarahmdi, asadollah khoshkish, Mustafa Karampour, Ismail Ahmadi

“…Unlike the months of October and January, in March the central pressure had few mutations but no trend was observed. However, during this month the Earth's surface temperature has increased significantly during thementioned period.…”
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