Androgen receptor dynamics in prostate cancer: from disease progression to treatment resistance by Caihong Li, Dongkai Cheng, Peng Li

“…The androgen receptor (AR) on the X chromosome is a central driver in this process, activating genes that govern proliferation and survival. Mutations and amplifications of the AR are closely associated with disease progression and treatment resistance. …”
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Les agglomérations de Nyon, Lausanne et Yverdon (Suisse) : trois exemples de l’ouest du plateau suisse entre Antiquité tardive et haut Moyen Âge by Clément Hervé

“…This contribution gives a first review of archaeological data on Late Antiquity and Early Middle Age of Nyon, Lausanne and Yverdon — three urban areas which illustrate different urban and territorial mutations which occured during those periods in the Western part of the “Plateau suisse”. …”
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Study on the Precursors of Coal-Rock Fracture Based on the Maximum Lyapunov Exponent of Acoustic Emission Parameters by Guoqiang Cheng, Xiaohui Sun, Jiangong Li

“…When the maximum Lyapunov exponent of AE event number time series mutates, it indicates that the specimen is about to be destroyed entirely, which can be used as a precursor criterion for coal-rock fracture.…”
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Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities by Jiarui Zhang, Jinan Zhang, Chen Yang

“…However, brain tumors contribute to high levels of both mortality and morbidity globally, with resistance to treatments being acquired due to genetic mutations and dysregulation of molecular mechanisms, among other factors. …”
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Supply chain risk transmission monitoring based on graphic evaluation and review technique by Jianlan Zhong, Fu Jia

“…In the supply chain context, risk events can accumulate, amplify, and mutate as they spread through the supply chain network structure. …”
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Progress in immune microenvironment, immunotherapy and prognostic biomarkers in pediatric osteosarcoma by Lin Zhang, Haoming Jiang, Haichao Ma

“…It examines the impact of immune checkpoints, genetic mutations, and inflammatory pathways on osteosarcoma progression, highlighting their contribution to tumor immune evasion and disease advancement. …”
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Implications of intratumoral microbiota in tumor metastasis: a special perspective of microorganisms in tumorigenesis and clinical therapeutics by Lei Zhang, Xichu Duan, Yanhua Zhao, Dejiu Zhang, Yuan Zhang

“…Intratumoral microbiota can modulate tumor progression through multiple mechanisms, including regulating immune responses, inducing genomic instability and gene mutations, altering metabolic pathways, controlling epigenetic pathways, and disrupting cancer-related signaling pathways. …”
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Pseudomonas Aeruginosa and Cystic Fibrosis: Antibiotic Therapy and the Science behind the Magic by Noni E MacDonald

“…Recent research has also shown that antimicrobial therapy in CF may be effective not through eradication of the organism but by decreasing bacterial density and exoproduct production in the lung and thus decreasing inflammatory stimulus; by protecting against the consequences of an overexhuberant host response and in patients with stop mutations, potentially by correcting the gene defect. …”
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From Science to Parliament: How Empathy Became a Political Concept in Finland by Martin Pettersson

“…This usage highlights how scientific concepts mutate when they are made to do rhetorical work.…”
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A Case of Essential Thrombocythemia and IgA Nephropathy with Literature Review of the Concurrence by Shoja Rahimian, Timothy Johnson, Ronald Herb

“…Pathological review of renal biopsy identified IgAN concurrently with newly diagnosed JAK2-mutated ET. The patient was started on aspirin therapy and closely monitored for his renal function. …”
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Targeting TRPM3 as a potential therapeutic approach for autosomal dominant polycystic kidney disease by Hüseyin Gül, Jamie A. Davies

“…Most ADPKD cases are caused by mutations in PKD1 or PKD2, encoding polycystin-1 (PC1) and polycystin-2 (PC2). …”
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Study on the Optimization of Hub-and-Spoke Logistics Network regarding Traffic Congestion by Wei Xu, JinCan Huang, YanZhao Qiu

“…Given the complexity of the problem, the congestion cost function is linearized, and the mutational particle swarm optimization (MPSO) is employed for the solution. …”
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The Short Dramatic Form in the Works of Kostas Ostrauskas and Juozas Erlickas by Neringa Klišienė

“…The question is whether (and how) such ‘mutations’ of dramatic writing maintain a specific theatrical mode of operation (the plot, the character etc.) when they enter the dynamic field of the short form. …”
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Genome-wide association data reveal a global map of genetic interactions among protein complexes. by Gregory Hannum, Rohith Srivas, Aude Guénolé, Haico van Attikum, Nevan J Krogan, Richard M Karp, Trey Ideker

“…Despite the immense potential of gene association studies, they have been challenging to analyze because most traits are complex, involving the combined effect of mutations at many different genes. Due to lack of statistical power, only the strongest single markers are typically identified. …”
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Advances in retina genetics: Progress, potential, and challenges by Mayank Bansal

“…We highlight key advancements such as the advent of next-generation sequencing, which has exponentially enhanced the discovery of genetic mutations, thus also enabling personalized medicine/therapeutic approaches. …”
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The Genetics of Alzheimer’s Disease by Robert C. Barber

“…It is inherited in Mendelian dominant fashion and is caused by mutations in three genes (APP, PSEN1, and PSEN2). …”
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KSHV hijacks the antiviral kinase IKKε to initiate lytic replication. by Xiaoqian Wang, Zhenshan Liu, Xue Xu, Xin Wang, Zizhen Ming, Chengrong Liu, Hang Gao, Tingting Li, Qiming Liang

“…Further experiments utilizing mutations on the SUMOylation sites of IKKε or inhibiting IKKε using BAY-985 showed that these actions no longer impact PML NBs and completely suppress the lytic replication of KSHV. …”
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Application of a macrocyclization strategy in kinase inhibitor development by Kun Xing, Shujun Li, Jinghuan Li, Dan Liu, Min Huang, Linxiang Zhao

“…The macrocyclization strategy is now widely used to enhance kinase inhibitory activity, overcome drug resistance caused by point mutations, improve kinase selectivity, and optimize drug-like properties. …”
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Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing. by Tiana M Scott, Lydia M Arnold, Jordan A Powers, Delaney A McCann, Ana B Rowe, Devin E Christensen, Miguel J Pereira, Wen Zhou, Rachel M Torrez, Janet H Iwasa, Philip J Kranzusch, Wesley I Sundquist, Jarrod S Johnson

“…Viral DNA could be "deprotected" by thermal stress, capsid mutations, or reduced concentrations of inositol hexakisphosphate (IP6) that destabilize the capsid. …”
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Clinical Study of De novo Histoid Leprosy by H Bangaru, Seema Afreen Kazi

“…A probable reason may be due to primary dapsone resistance by the folP1 gene, and another possibility could be due to other mutations in the Mycobacterium leprae. Early recognition of de novo cases with prompt institution of sufficient duration of WHO multibacillary multidrug therapy therapy under prolonged follow-up is important to ensure a favorable outcome.…”
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