Discussion on the mechanism of HER2 resistance in esophagogastric junction and gastric cancer in the era of immunotherapy by Yan Zhang, Wenxuan Fan, Fei Su, Xiaoling Zhang, Yunyi Du, Weiling Li, Yangjun Gao, Wenqing Hu, Jun Zhao

“…This review examines the mechanisms of drug resistance in HER2-positive G/GEJ cancer, the primary mechanisms of resistance explored include alterations in the HER2 receptor itself, such as mutations and changes in expression levels, as well as downstream signaling pathways, and interactions with the tumor microenvironment (TME). …”
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Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes by Ting-Hui Lin, Chang-Chun David Lee, Monica L. Fernández-Quintero, James A. Ferguson, Julianna Han, Xueyong Zhu, Wenli Yu, Jenna J. Guthmiller, Florian Krammer, Patrick C. Wilson, Andrew B. Ward, Ian A. Wilson

“…Despite some diversity in their VH and VK genes, the antibodies interact with the HA through germline-encoded residues in HCDR2 and LCDR3. Somatic mutations on HCDR3 also contribute hydrophobic interactions with the conserved HA epitope. …”
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Vasculopathy: a possible factor affecting hereditary angioedema by Anna Laura Colia, Alessandra Ranaldi, Rosa Santacroce, Giovanna D'Andrea, Angela Bruna Maffione, Maurizio Margaglione, Maria D'Apolito

“…This clinical subtype, distinguished by the absence of mutations in SERPING1, has a clinical picture similar to C1-INH-HAE but with normal C1-INH level and activity. …”
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ADATs: roles in tRNA editing and relevance to disease by Mao Xue-Ling, Eriani Gilbert, Zhou Xiao-Long

“…This review provides detailed information on A-to-I and C-to-U editing of tRNAs in different domains of life, presents recent new findings on ADATs for DNA editing, and finally comments on the association of mutations in the ADAT3 gene with intellectual disability.…”
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Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms by Stefan Bidula, Darren W. Sexton, Silke Schelenz

“…Moreover, there has been expanding evidence highlighting that mutations within these key immune proteins, or the possession of particular haplotypes, enhance susceptibility to colonization by pathogens and dysfunctional immune responses. …”
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Genomic analysis of antimicrobial resistant Escherichia coli isolated from manure and manured agricultural grasslands by C. Tyrrell, C. M. Burgess, F. P. Brennan, D. Münzenmaier, D. Drissner, R. J. Leigh, F. Walsh

“…Whole genome sequencing identified 31 antimicrobial resistance genes, and mutations in the gyrA, parC, and parE genes, conferring fluoroquinolone resistance. …”
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Classification of Colon Cancer Patients Based on the Methylation Patterns of Promoters by Wonyoung Choi, Jungwoo Lee, Jin-Young Lee, Sun-Min Lee, Da-Won Kim, Young-Joon Kim

“…Diverse somatic mutations have been reported to serve as cancer drivers. …”
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Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases by Lorena Martínez-Alcantar, Laura Hernández-Padilla, Alma Laura Díaz-Pérez, Lizbeth Guadalupe Villalón-Magallán, Mayra Xóchitl Durán-Maldonado, César Díaz-Pérez, Marlene E. Campos-Morales, Citlali Figueroa-Guzmán, Jesús Campos-García

“…Nevertheless, modifications in the expression due to mutations or their dysregulation can lead to diseases, including autoimmune disorders, cardiovascular problems, diabetes, neurological diseases, and cancers. …”
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A Therapeutic Challenge: Liddle’s Syndrome Managed with Amiloride during Pregnancy by Amelia Caretto, Liviana Primerano, Francesca Novara, Orsetta Zuffardi, Stefano Genovese, Maurizio Rondinelli

“…It is caused by gain-of-function mutations of the kidney epithelial sodium channel (ENaC) and it is classically associated with hypokalemia and suppression of renin and aldosterone. …”
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Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines by Lee Sherry, Mohammad W. Bahar, Claudine Porta, Helen Fox, Keith Grehan, Veronica Nasta, Helen M. E. Duyvesteyn, Luigi De Colibus, Johanna Marsian, Inga Murdoch, Daniel Ponndorf, Seong-Ryong Kim, Sachin Shah, Sarah Carlyle, Jessica J. Swanson, Sue Matthews, Clare Nicol, George P. Lomonossoff, Andrew J. Macadam, Elizabeth E. Fry, David I. Stuart, Nicola J. Stonehouse, David J. Rowlands

“…Structural analyses of these recombinant VLPs provide a rational understanding of the stabilizing mutations and the role of potential excipients. Collectively, we have established these poliovirus stabilized VLPs as viable next-generation vaccine candidates for the future.…”
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Delivery of Prime editing in human stem cells using pseudoviral NanoScribes particles by Thibaut Halegua, Valérie Risson, Julien Carras, Martin Rouyer, Laurent Coudert, Arnaud Jacquier, Laurent Schaeffer, Théophile Ohlmann, Philippe Emmanuel Mangeot

“…Abstract Prime Editing can rewrite genes in living cells by allowing point mutations, deletions, or insertion of small DNA sequences with high precision. …”
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Dynamics of Feline Coronavirus and FIP: A Compartmental Modeling Approach by Ayse Peker Dobie, Alper Bayrakal, Mehmet Erman Or, Ayse Humeyra Bilge

“…We incorporate the concept of mutations from FCoV to FIP to enrich our analysis. …”
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L’écriture après l’écriture : Öyvind Fahlström, au prisme de la pensée de Vilém Flusser by Ludovic Bernhardt

“…The radical thought of Vilém Flusser regarding mutations of the alphabet linked to apparatuses, cannot escape from a perspective of art and poetry. …”
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COEVOLUTION IN «A PREDATOR–PREY» SYSTEM: AN ECOGENETIC MODEL by Yu. S.

“…Another important result was that the speciation of predators follows prey speciation when the probability of mutational changes in adaptive traits of predators exceeds that in the prey.…”
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The Role of Mitochondria from Mature Oocyte to Viable Blastocyst by Scott Chappel

“…The combination of lower number and increased frequency of mutations and deletions may result in inadequate mitochondrial activity necessary for continued embryo development and cause pregnancy failure. …”
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Multiobjective Particle Swarm Optimization Based on Ideal Distance by Shihua Wang, Yanmin Liu, Kangge Zou, Nana Li, Yaowei Wu

“…Additionally, to prevent the algorithm from falling into a local optimum, the cosine factor is introduced to mutate the position of the particles during the exploitation and exploration process. …”
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Reverse Genetic Strategies in Caenorhabditis elegans: Towards Controlled Manipulation of the Genome by Howard A. Baylis, Rafael P. Vázquez-Manrique

“…We describe methods that use random mutagenesis to isolate mutations in specific genes. We then focus on techniques that allow controlled manipulation of the genome: gene modification by transposon mobilisation, gene knock-out mediated by zinc-finger nucleases, and gene targeting by biolistic transformation.…”
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Pèleriner, faire du commerce et visiter les lieux saints : Le tourisme religieux sénégalais au Maroc by Nazarena Lanza

“…The discourses and temporalities that characterize such organized groups of pilgrims, feed particular imaginaries and reveal a multiplicity of dimensions, including social, political and religious dimensions of Senegalese society.The present article emphasizes two aspects: firstly, the meanings and motivations of those travels to Morocco, which allow to understand number of mutations in contemporary Senegalese society (the concept of family, death, belief, leisure, etc.); secondly, the discourses and counter-discourses about the nature of the links between Senegalese and Moroccan peoples, qualified by the governments as «exceptional and fraternal», but which are often differently experienced and reported by many Senegalese residents in Morocco.…”
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Erat simplicis ingenii: A deposição de Garcia da Galiza vista pelos cronistas dos séculos XII e XIII by Maria Joana Gomes

“…It aims at understanding the relation between the discursive mutations of this episode and the writers’ political and ideological conceptions.…”
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Trichoscopy in Unveiling the Triad of Netherton Syndrome by H Bangaru, D Ashwini

“…Netherton syndrome (NS) is a rare autosomal recessive disorder characterized by the triad of congenital ichthyosiform erythroderma or ichthyosis linearis circumflexa (ILC), hair shaft abnormalities, and atopic diathesis (elevated serum IgE) caused by mutations in serine protease-inhibitor (SPINK5) gene located on chromosome 5q31–32. …”
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