Loss of H2A.Z Is Not Sufficient to Determine Transcriptional Activity of Snf2-Related CBP Activator Protein or p400 Complexes by Tamara A. Bowman, Madeline M. Wong, Linda K. Cox, Joseph J. Baldassare, John C. Chrivia

“…This conclusion is further supported by studies that demonstrate a SRCAPΔATP mutant unable to deposit H2A.Z has similar transcriptional activity as wild-type SRCAP.…”
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ANALYSIS OF CHANGES IN AFRICAN SWINE FEVER VIRUS GENETIC STRUCTURE AND BIOLOGICAL PROPERTIES DURING ADAPTATION TO CONTINUOUS CELL CULTURE by Ali Mazloum, N. G. Zinyakov, A. S. Pershin, I. V. Shevchenko, I. Yu. Zhukov, D. N. Fedoseyeva, D. V. Sharypova, A. S. Igolkin, N. N. Vlasova

“…Identifcation of such genes will enable preparation of deletion mutant ASF virus strains as well as development and testing of pilot safe vaccines based on the said virus strains. …”
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Nano-Azo Ligand and Its Superhydrophobic Complexes: Synthesis, Characterization, DFT, Contact Angle, Molecular Docking, and Antimicrobial Studies by Gehad G. Mohamed, Walaa H. Mahmoud, Ahmed M. Refaat

“…The binding between H2L and its Cd(II) complex with receptors of the crystal structure of S. aureus (PDB ID: 3Q8U), crystal structure of protein phosphatase (PPZ1) of Candida albicans (PDB ID: 5JPE), receptors of breast cancer mutant oxidoreductase (PDB ID: 3HB5), and crystal structure of Escherichia coli (PDB ID: 3T88) was predicted and given in detail using molecular docking.…”
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Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo. by Geelsu Hwang, Yuan Liu, Dongyeop Kim, Yong Li, Damian J Krysan, Hyun Koo

“…In turn, the GtfB amount on the fungal surface was significantly reduced, and the ability of C. albicans mutant strains to develop mixed-species biofilms with S. mutans was impaired. …”
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De Novo Transcriptome Sequencing of the Orange-Fleshed Sweet Potato and Analysis of Differentially Expressed Genes Related to Carotenoid Biosynthesis by Ruijie Li, Hong Zhai, Chen Kang, Degao Liu, Shaozhen He, Qingchang Liu

“…In this study, the transcriptome profiles of an orange-fleshed sweet potato cultivar “Weiduoli” and its mutant “HVB-3” with high carotenoid content were determined by using the high-throughput sequencing technology. …”
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Host 3' flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation. by Hu Zhang, Quanxin Long, Yuanjie Liu, Alexander L Marchetti, Cheng-Der Liu, Ning Sun, Haitao Guo

“…To address these questions, a mutant HBV cell line HepDES-C1822G was established with a C1822G mutation in the pgRNA coding sequence, altering the sequence of 3' TR of (-) strand DNA while the 5' TR remained wild type (wt). …”
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Epibrassinolide Regulates <i>Lhcb5</i> Expression Though the Transcription Factor of MYBR17 in Maize by Hui Li, Xuewu He, Huayang Lv, Hongyu Zhang, Fuhai Peng, Jun Song, Wenjuan Liu, Junjie Zhang

“…These results were validated using an Arabidopsis <i>mybr17</i> mutant. Our results offer a theoretical foundation for the application of BRs to enhance the photosynthetic efficiency of maize.…”
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Protease-activated receptor 1 in the pathogenesis of cystic fibrosis by Sarath Ranganathan, Philip Sutton, Sophie Day, Poshmaal Dhar, Kristy Azzopardi, Muhammad A Saeed, Sohinee Sarkar, Jia-Xi Han

“…While PAR1 is known to play an important role in regulating inflammation, nothing is known about any potential role of this receptor in CF pathogenesis.Methods PAR1 (PAR1-/-) and intestinal-corrected CFTR (Cftr-/-) deficient mice were crossed to generate double knock-out (DKO) mutants lacking both PAR1 and CFTR, as well as matching sibling single mutant and wildtype (WT) littermate controls. …”
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Minimization of the Bacillus subtilis divisome suggests FtsZ and SepF can form an active Z-ring, and reveals the amino acid transporter BraB as a new cell division influencing fact... by Ilkay Celik Gulsoy, Terrens N V Saaki, Michaela Wenzel, Simon Syvertsson, Taku Morimoto, Tjalling K Siersma, Leendert W Hamoen

“…Viability of the multiple deletion mutant was not greatly affected, although the frequency of cell division was considerably reduced. …”
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In-silico screening and analysis of missense SNPs in human CYP3A4/5 affecting drug-enzyme interactions of FDA-approved COVID-19 antiviral drugs by Amro A. Abdelazim, Mohamad Maged, Ahmed I. Abdelmaksoud, Sameh E. Hassanein

“…Our findings indicated that the CYP3A4 gene variants; R418T, I335T and R130P and the CYP3A5 gene variants; I335T, L133P and R130Q are considered the most deleterious missense SNPs. These mutants potentially affect drug-enzyme binding and hence may alter therapeutic response. …”
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AI allows pre-screening of FGFR3 mutational status using routine histology slides of muscle-invasive bladder cancer by Pierre-Antoine Bannier, Charlie Saillard, Philipp Mann, Maxime Touzot, Charles Maussion, Christian Matek, Niklas Klümper, Johannes Breyer, Ralph Wirtz, Danijel Sikic, Bernd Schmitz-Dräger, Bernd Wullich, Arndt Hartmann, Sebastian Försch, Markus Eckstein

“…Abstract Pathogenic activating mutations in the fibroblast growth factor receptor 3 (FGFR3) drive disease maintenance and progression in urothelial cancer. 10–15% of muscle-invasive and metastatic urothelial cancer (MIBC/mUC) are FGFR3-mutant. Selective targeting of FGFR3 hotspot mutations with tyrosine kinase inhibitors (e.g., erdafitinib) is approved for mUC and requires FGFR3 mutational testing. …”
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Conducting and automating the water Morris maze test in SPF conditions by N. V. Khotskin, V. A. Kulikov, E. L. Zavyalov, D. V. Fursenko, A. V. Kulikov

“…It is a part of a series of tests necessary for behavioral phenotyping of mutant and transgenic mice. At the same time, conducting this test in SPF conditions must comply with very strict regulations concerning pathogen control. …”
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EXPRESSION AND CLINICAL CORRELATION OF PD-1/PD-L1 AND VE1(BRAFP.V600E) IN PEDIATRIC LANGERHANS CELL HISTIOCYTOSIS by sneha tandon, Sheila Weitzman, Brooklyn Joyce, Bryan Maguire, Derek Stephens, James Whitlock, Cynthia Hawkins, Bo-Yee Ngan, Oussama Abla

“…Methods: A total of 111 samples were tested for PD-1/PD-L1 and 109 for VE1(BRAFp.V600E) mutant protein by immunohistochemistry. Results: PD-1, PD-L1 and VE1(BRAFp.V600E) positivity was observed in 40.5%, 31.53% and 55%, respectively.  …”
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MOBILIZATION OF VEGETABLE AND CUCURBIT CROP GENETIC RESOURCES IN THE 21^st CENTURY by A. M. Artemyeva, O. A. Zvereva, T. N. Kozhanova, D. L. Kornyukhin, T. M. Piskunova, T. N. Smekalova, I. G. Chukhina, L. V. Bagmet

“…Currently, the completion of the collection is conducted in the following areas: collection of wild species and local forms with a high level of resistance to biotic and abiotic stresses, and with valuable biochemical composition; replenishment of the collection with accessions missing in the evolutionary series of vegetable crops from their ancestral forms to modern varieties and lines, including those needed for the analysis of domestication processes; introduction of crops and types of varieties novel for Russia; mobilization of the world’s best achievements in modern breeding, first of all in the newest breeding trends; mobilization of new genetic material -mutant lines, double haploid lines, and mapping populations.…”
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Identification and characterization of CONSTANS-like (COL) gene family in upland cotton (Gossypium hirsutum L.). by Darun Cai, Hui Liu, Na Sang, Xianzhong Huang

“…Transgenic study in the Arabidopsis co-2 mutant demonstrated that GhCOL1-A and GhCOL1-D fully rescued the late-flowering phenotype, whereas GhCOL3-A, GhCOL3-D, GhCOL7-A, and GhCOL7-D partially rescued the late-flowering phenotype, and the other five homoeologous pairs in Group I did not promote flowering. …”
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Extended UVB Exposures Alter Tumorigenesis and Treatment Efficacy in a Murine Model of Cutaneous Squamous Cell Carcinoma by Erin M. Burns, Kathleen L. Tober, Judith A. Riggenbach, Donna F. Kusewitt, Gregory S. Young, Tatiana M. Oberyszyn

“…Vehicle-treated mice in the 25-week UVB exposure model exhibited an increased tumor burden and a higher percentage of malignant tumors compared to mice in the 10-week exposure model, which correlated with increases in total and mutant p53-positive epidermal cells. Only topical diclofenac decreased tumor number and burden in both sexes regardless of UVB exposure length. …”
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OsSLI1, a Homeodomain Containing Transcription Activator, Involves Abscisic Acid Related Stress Response in Rice (Oryza sativa L.) by Xi Huang, Min Duan, Jiakai Liao, Xi Yuan, Hui Chen, Jiejie Feng, Ji Huang, Hong-Sheng Zhang

“…Further, it was found that OsSLI1 expression was enhanced in an ABI5-Like1 (ABL1) deficiency rice mutant abl1 under stress conditions, suggesting that ABL1 probably negatively regulates OsSLI1 gene expression. …”
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Second-Generation Triple Reporter for Bioluminescence, Micro–Positron Emission Tomography, and Fluorescence Imaging by Aparna H. Kesarwala, Julie L. Prior, Jinwu Sun, Scott E. Harpstrite, Vijay Sharma, David Piwnica-Worms

“…To exploit the combined strengths of each and facilitate multimodality imaging, we engineered a dual-reporter construct in which firefly luciferase (FLuc) and a 12–amino acid nonstructural linker were fused in frame to the N-terminus of a mutant herpes simplex virus thymidine kinase (mNLS-SR39TK) kinetically enhanced for positron emission tomography (PET). …”
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The modulating effect of coat color mutations on the generation and neutralization of reactive oxygen species in the Аmerican mink (Neovison vison) as a model by S. N. Sergina, V. A. Ilyukha, I. V. Baishnikova, T. N. Ilyina

“…The study was conducted with standard dark brown (+/+), monorecessive royal pastel (b/b) and silver-blue (р/р), and direcessive sapphire (a/a р/р) mutant minks. It was found that the functioning of both RO S generation and neutralization systems was genotypespecific. …”
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Identifying novel heterozygous PI4KA variants in fetal abnormalities by Chen Cheng, Fan Yang, Xinlin Chen, Sheng Zhao

“…Subsequently, both wild-type and mutant PI4KA protein fragments were purified, and their enzymatic activities were quantitatively assessed. …”
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