A single base pair substitution in zebrafish distinguishes between innate and acute startle behavior regulation. by Elelbin A Ortiz, Philip D Campbell, Jessica C Nelson, Michael Granato

“…We have previously identified a zebrafish mutant line (escapist) that displays a decreased baseline or innate acoustic startle threshold. …”
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Examination of Molecular Effects of MYLK Deletion in a Patient with Extensive Aortic, Carotid, and Abdominal Dissections That Underlie the Genetic Dysfunction by Sarah K. Macklin, Katelyn A. Bruno, Charitha Vadlamudi, Haytham Helmi, Ayesha Samreen, Ahmed N. Mohammad, Stephanie Hines, Paldeep S. Atwal, Thomas R. Caulfield

“…We also provide the electrostatics calculations from the wild type and mutant variant. Through a combined multiomic approach of clinical, functional, and protein informatics, we arrive at a data fusion for determination of pathogenicity embedded within the genetic code for this particular genetic variant, which, as a platform, continues to broaden its scope across the field of variants of uncertain significance classification.…”
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Herpes Simplex Virus-2 Glycoprotein Interaction with HVEM Influences Virus-Specific Recall Cellular Responses at the Mucosa by Sarah J. Kopp, Christopher S. Storti, William J. Muller

“…Mice were primed with attenuated HSV-2 expressing wild-type gD or mutant gD unable to engage HVEM and challenged 32 days later with virulent HSV-2 expressing wild-type gD. …”
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Leiomodin creates a leaky cap at the pointed end of actin-thin filaments. by Dmitri Tolkatchev, Garry E Smith, Lauren E Schultz, Mert Colpan, Gregory L Helms, John R Cort, Carol C Gregorio, Alla S Kostyukova

“…Data from experiments performed in cardiomyocytes provide additional support for the competition model; specifically, expression of a leiomodin mutant that is unable to interact with tropomyosin fails to displace tropomodulin at thin filament pointed ends and fails to elongate thin filaments. …”
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Fission yeast cells deficient in siderophore biosynthesis require Str2 for ferrichrome-dependent growth by Berthy Mbuya, Samuel Plante, Tobias Vahsen, Ariane Brault, Simon Labbé

“…Further analysis identified that conserved amino acids Tyr539 and Tyr553 in the last predicted loop of Str2 are required for supporting Fc-dependent growth of a sib1Δ sib2Δ mutant strain. Collectively, these findings indicate that the vacuolar Str2 protein plays a role in the consumption of Fc as an iron source, while also revealing the involvement of the vacuole in iron release from exogenous Fc after its assimilation.…”
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A two-strain HIV-1 mathematical model to assess the effects of chemotherapy on disease parameters by Tinevimbo Shiri, Winston Garira, Senelani D. Musekwa

“…We explore the effects of chemotherapy on the dynamics of two viral strains and T lymphocytes with one mutant strain phenotypically resistant to drug effects. …”
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Santa-maria is a glial phagocytic receptor that acts with SIMU to recognize and engulf apoptotic neurons by Reut Hilu-Dadia, Aseel Ghanem, Shelly Vogelesang, Malak Ayoub, Ketty Hakim-Mishnaevski, Estee Kurant

“…However, in simu;draper double-mutant embryos, some apoptotic neurons are still engulfed by the glia, suggesting the involvement of additional receptors. …”
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Congenital Oligodendroglioma: Clinicopathologic and Molecular Assessment with Review of the Literature by Hope Richard, Kimberly Stogner-Underwood, Christine Fuller

“…The mass was excised and the microscopic appearance was that of a classic low grade oligodendroglioma composed of cells with uniformly round nuclei, perinuclear halos, delicate branching capillaries, and an absence of high grade features. Mutant specific (R132H) isocitrate dehydrogenase-1 (IDH1) immunohistochemistry was negative, and the tumor lacked detectable 1p or 19q deletions by fluorescent in situ hybridization (FISH). …”
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The TIR Domain Containing Locus of Enterococcus faecalis Is Predominant among Urinary Tract Infection Isolates and Downregulates Host Inflammatory Response by Thomas Daniel Kraemer, Orlando Daniel Quintanar Haro, Eugen Domann, Trinad Chakraborty, Svetlin Tchatalbachev

“…Infection of mouse RAW264.7 macrophages with a tcpF knock-out mutant led to elevated cytokine response compared to the isogenic wild type E. faecalis strain. …”
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Validation of Customized Cancer Panel for Detecting Somatic Mutations and Copy Number Alterations by Su-Hye Choi, Seung-Hyun Jung, Yeun-Jun Chung

“…In terms of the limit of detection, more than 86% of target mutations with a mutant allele frequency (MAF) <1% can be identified, and any mutation with >3% MAF can be detected. …”
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Organophosphorus Nerve Agents: Types, Toxicity, and Treatments by Sudisha Mukherjee, Rinkoo Devi Gupta

“…Hence, studies have been conducted to create mutants with an enhanced rate of hydrolysis and high specificity. …”
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A hybrid differential evolution particle swarm optimization algorithm based on dynamic strategies by Huarong Xu, Qianwei Deng, Zhiyu Zhang, Shengke Lin

“…Finally, the mutation crossover operator of DE is applied to PSO, selecting the appropriate mutation strategy based on particle improvement, which generates a mutant vector. This vector is then combined with the current particle’s best position through crossover, aiding particles in escaping local optima. …”
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Identification and functional analysis of light-responsive unique genes and gene family members in rice. by Ki-Hong Jung, Jinwon Lee, Chris Dardick, Young-Su Seo, Peijian Cao, Patrick Canlas, Jirapa Phetsom, Xia Xu, Shu Ouyang, Kyungsook An, Yun-Ja Cho, Geun-Cheol Lee, Yoosook Lee, Gynheung An, Pamela C Ronald

“…We then screened collections of rice T-DNA insertional mutants to identify rice lines with mutations in the strongly light-induced genes. …”
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Random Mutagenesis of the Aspergillus oryzae Genome Results in Fungal Antibacterial Activity by Cory A. Leonard, Stacy D. Brown, J. Russell Hayman

“…To randomly generate A. oryzae mutant strains, spores were treated with ethyl methanesulfonate (EMS). …”
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Novel approaches in myelofibrosis by Steffen Koschmieder

“…Also, extracellular targeting using interferon, calreticulin mutant‐specific antibodies, and other immunotherapeutic approaches are discussed, as well as various antifibrotic strategies. …”
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Comparison of natural and artificial vasopressin deficiency: why the latter is lethal? by D. Zelena

“…It is surprising take into consideration the viability of the AVP mutant Brattleboro rats. Thus, AVP is essential for survival, but which of its ubiquiter role is the most important. …”
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PAI-1 Expression Is Required for HDACi-Induced Proliferative Arrest in ras-Transformed Renal Epithelial Cells by Stephen P. Higgins, Craig E. Higgins, Paul J. Higgins

“…The addition of a stable, long half-life, recombinant PAI-1 mutant to PAI-1-deficient v-K-ras-/c-Ha-ras-transformants or to PAI-1 functionally null, NaB-resistant, 4HH cells (engineered by antisense knockdown of PAI-1 mRNA transcripts) resulted in marked cytostasis in the absence of NaB. …”
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Targeting KRAS: from metabolic regulation to cancer treatment by Yanyan Shi, Huiling Zheng, Tianzhen Wang, Shengpu Zhou, Shiqing Zhao, Mo Li, Baoshan Cao

“…Here, we review the metabolic reprogramming of glucose, glutamine, and lipids regulated by oncogenic KRAS, with an emphasis on recent insights into the relationship between changes in metabolic mechanisms driven by KRAS mutant and related advances in targeted therapy. We also focus on advances in KRAS inhibitor discovery and related treatment strategies in colorectal, pancreatic, and non-small cell lung cancer, including current clinical trials. …”
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SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development. by Marissa Baccas, Vanathi Ganesan, Amy Leung, Lucas R Pineiro, Alexandra N McKillop, Jun Liu

“…Detailed analyses of mutant animals harboring this point mutation uncovered new functions of SEM-2 in the M lineage. …”
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Le grotesque en science-fiction by Istvan Csicsery-Ronay (Jr.)

“…Il renonce en général à appréhender ces anomalies dans un mode intellectuel, pour plutôt plonger dans un univers de corps qui souvent encodent en mutant sans relâche une mise en cause féminine de la rationalité scientifique, phallocratique. …”
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