Positively charged specificity site in cyclin B1 is essential for mitotic fidelity by Christian Heinzle, Anna Höfler, Jun Yu, Peter Heid, Nora Kremer, Rebecca Schunk, Florian Stengel, Tanja Bange, Andreas Boland, Thomas U. Mayer

“…HeLa cells expressing pocket mutant cyclin B1 are strongly delayed in anaphase onset due to multiple defects in mitotic spindle function and timely activation of the E3 ligase APC/C. …”
Get full text

Pediatric Case of Li–Fraumeni Syndrome in Honduras by R. Martínez-Beckerat, C. Alas-Pineda, M. Melgar-Gonzales, B. Mejía-Raudales, N. Andino-Paz, S. Bejarano-Cáceres, J. Chiang

“…An intraventricular tumor was identified in the occipital of the left lateral ventricle, which turned out to be a TP53-mutant choroidal plexus carcinoma.…”
Get full text

A Review of the Progress in the Development of Leishmaniasis Vaccines by Narges Khaghanzadeh, Fatemeh Javadi, Afshin Samiei

“…The LeishChim vaccine, designed using immunoinformatics and molecular docking techniques, has shown promising efficacy results in mouse studies. Additionally, the mutant gene-centered LmCen-/- vaccine has completed Phase 1 clinical trials in humans. …”
Get full text

A Conserved Di-Lysine Motif in the E2 Transactivation Domain Regulates MmuPV1 Replication and Disease Progression by Jessica Gonzalez, Marsha DeSmet, Elliot J. Androphy

“…Furthermore, mutation of the second lysine residue, K113, to the potential acetyl-lysine mimic glutamine (Q) abrogated E2 transcription and decreased transient replication in vitro, while the acetylation defective arginine (R) mutant remained functional. Both K113 mutants were able to induce wart formation in vivo, though disease progression appeared to be delayed in the K113Q group. …”
Get full text

Halp Score: A Simple and Easily Accessible Index for Predicting Prognosis in Colorectal Cancer Patients by Zeynep Güç

“…Univariate analysis showed that patients with low BMI, high ECOG score, and tumors located in the right colon, and RAS mutant patients, and those with a low HALP score were associated with worse survival rates. …”
Get full text

Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models by Everardo Macias, Dharanija Rao, John DiGiovanni

“…Further studies using a transgenic mouse model with a gain of function mutant of Stat3 (Stat3C) expressed in the basal layer of the epidermis revealed a novel role for Stat3 in skin tumor progression. …”
Get full text

Pathogenicity Assay of Vibrio harveyi in Tiger Shrimp Larvae Employing Rifampicin-Resistant as A Molecular Marker by . Widanarni, D. Meha, Sri Nuryati, . Sukenda, A. Suwanto

“…Two groups of shrimp post-larvae (PL5) were immersed for 30 min in 106 CFU/ml of mutants and wild type of V. harveyi, respectively; and then placed in a 2 liter shrimp rearing tank for five days. …”
Get full text

Hsp90 and cochaperones have two genetically distinct roles in regulating eEF2 function. by Melody D Fulton, Danielle J Yama, Ella Dahl, Jill L Johnson

“…In addition, these results provide further evidence that yeast Hsp90 mutants have distinct in vivo effects that correlate with defects in subsets of cochaperones.…”
Get full text

RNase Y mediates posttranscriptional control of the virulence-associated CncR1 small-RNA in Helicobacter pylori by Federico D’Agostino, Eva Pinatel, Alexandra Meynhardt, Vincenzo Scarlato, Andrea Vannini, Davide Roncarati

“…The observation that the RNAse Y-mutant strain showed deregulation of several members of the CncR1 regulon suggests this ribonuclease has an important role in H. pylori posttranscriptional regulation.…”
Get full text

Understanding Rifampicin Resistance in Tuberculosis through a Computational Approach by Satish Kumar, Lingaraja Jena

“…In this study, we modeled two resistant mutants of rpoB (S450L and H445Y) using Modeller9v10 and performed a docking analysis with RIF using AutoDock4.2 and compared the docking results of these mutants with the wild-type rpoB. …”
Get full text

AT2 Receptor-Interacting Proteins ATIPs in the Brain by Sylvie Rodrigues-Ferreira, Erwann le Rouzic, Traci Pawlowski, Anand Srivastava, Florence Margottin-Goguet, Clara Nahmias

“…We summarize here current knowledge on the ATIP family of proteins, and we present new experimental evidence showing interaction defects between ATIP1 and two mutant forms of the AT2 receptor identified in cases of mental retardation. …”
Get full text

Trehalose Ameliorates Zebrafish Emotional and Social Deficits Caused by CLN8 Dysfunction by Rosario Licitra, Stefania Della Vecchia, Lorenzo Santucci, Rachele Vivarelli, Sara Bernardi, Filippo M. Santorelli, Maria Marchese

“…Our findings show that trehalose, an autophagy enhancer, ameliorates anxiety, and modestly improves social behavior and predator avoidance in mutant zebrafish. This finding aligns animal models with clinical reports suggestive of behavioral improvements in NCL patients. …”
Get full text

Placode and neural crest origins of congenital deafness in mouse models of Waardenburg-Shah syndrome by Jaime Tan, Alicia Duron, Henry M. Sucov, Takako Makita

“…On an outbred strain background, we find a normal representation of melanocytes in hearing-impaired mutant mice. Instead, our results in neural crest-specific Ednrb mutants implicate a previously unrecognized role for glial support of synapse assembly between auditory neurons and cochlear hair cells. …”
Get full text

Comparative Evaluation of the Adsorption Performance of Citric Acid-Treated Peels of Trapa natans and Citrullus lanatus for Cationic Dyes Degradation from Water by Muhammad Sadiq Hussain, Rabia Rehman, Muhammad Imran

“…Thermodynamic parameters such as ΔG0, ΔS0, ΔH0, and ΔE0 are determined statistically for the adsorption performance of both novel chemically mutant biosorbents, which reflect that biosorption mechanisms are exothermic as well as spontaneous.…”
Get full text

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. by Tammie Bishop, Kah Weng Lau, Andrew C R Epstein, Stuart K Kim, Min Jiang, Delia O'Rourke, Christopher W Pugh, Jonathan M Gleadle, Martin S Taylor, Jonathan Hodgkin, Peter J Ratcliffe

“…However, persisting differential gene expression in hif-1 versus hif-1; vhl-1 double mutant worms clearly distinguished HIF-1-independent effects of VHL-1 inactivation. …”
Get full text

Design, Expression, and Inhibitory Effects of Antagonistic Single-Chain Platelet-Derived Growth Factor on Lung Cancer Cells by Salim Alhafyan

“…Molecular dynamics simulations of the designed antagonistic sc-PDGF showed a noteworthy reduction in binding affinity at the mutant interface, indicating a reduced capability to effectively bind the receptor. …”
Get full text

Structural Predictive Model of Presenilin-2 Protein and Analysis of Structural Effects of Familial Alzheimer’s Disease Mutations by Alejandro Soto-Ospina, Pedronel Araque Marín, Gabriel de Jesús Bedoya, Andrés Villegas Lanau

“…These relationships allow for studying the system from a structural approach with the determination of small distance changes, potential surfaces, electrostatic maps, and angle changes, which favor the comparison between wild-type and mutant systems. With the results obtained, it is expected to complement experimental data reported in the literature from models that would allow us to understand the effects of the selected mutations.…”
Get full text

Pathogenesis of Myeloproliferative Neoplasms: Role and Mechanisms of Chronic Inflammation by Sylvie Hermouet, Edith Bigot-Corbel, Betty Gardie

“…Moreover, the JAK inhibitor clinical trials showed that the reduction of symptoms linked to inflammation was beneficial to patients even in the absence of significant decrease in the JAK2-V617F mutant load. These observations suggested that part of the inflammation observed in patients with JAK2-mutated MPNs may not be the consequence of JAK2 mutation. …”
Get full text

CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions by Lei Huang, Yalei Wen, Qin Guo, Caishi Zhang, Xiao Yang, Mei Li, YiXia Liu, Xinying Li, Jiaxin Tang, Xiaofeng Zhou, Qi Qi, Haoxing Zhang, Tongzheng Liu

“…On the contrary, the loss of Thr495 phosphorylation by the phosphorylation-defective mutant DUB3 T495A, the cancer-related mutant DUB3 D496H and CK2 inhibition failed to deubiquitinate and stabilize YAP1 effectively. …”
Get full text

Identification of SLC35A1 as an essential host factor for the transduction of multi-serotype recombinant adeno-associated virus (AAV) vectors by Xiujuan Zhang, Siyuan Hao, Zehua Feng, Kang Ning, Cagla Aksu Kuz, Shane McFarlin, Donovan Richart, Fang Cheng, Ander Zhang-Chen, Richenda McFarlane, Ziying Yan, Jianming Qiu

“…Furthermore, the T128A mutant significantly decreased SIA expression but still supported rAAV transduction and nuclear import. …”
Get full text