Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and Diagnosis by Rasanpreet Kaur, Saurabh Gupta, Sunanda Kulshrestha, Vishal Khandelwal, Swadha Pandey, Anil Kumar, Gaurav Sharma, Umesh Kumar, Deepak Parashar, Kaushik Das

“…., which, along with their high-throughput analysis, give insights into the metabolites and the molecular pathways involved. For instance, metabolome research has led to the discovery of the glutamate-to-glutamate ratio and aerobic glycolysis as biomarkers in breast cancer. …”
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Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal by Seyed Mohammad Doodmani, Payman Rahimzadeh, Najma Farahani, Seyedalireza Mirilavasani, Mina Alimohammadi, Noushin Nabavi, Elmira Alaei, Afshin Taheriazam, Maryam Abedi, Nadia Shafiee, Salman Daneshi, Mehrdad Hashemi

“…In conclusion, SFN shows significant promise in cancer therapy by targeting multiple molecular pathways, improving the efficacy of chemotherapy, and overcoming drug resistance, particularly when incorporated into advanced nanoparticle delivery systems.…”
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Current Treatment Regimens and Promising Molecular Therapies for Chronic Hepatobiliary Diseases by Marilena Durazzo, Arianna Ferro, Victor Manuel Navarro-Tableros, Andrea Gaido, Paolo Fornengo, Fiorella Altruda, Renato Romagnoli, Søren K. Moestrup, Pier Luigi Calvo, Sharmila Fagoonee

“…Drugs targeting molecular pathways involved in chronic hepatobiliary diseases, such as inflammation, hepatic stellate cell activation and proliferation, and extracellular matrix production, are being developed. …”
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Host RNA-Binding Proteins as Regulators of HIV-1 Replication by Sebastian Giraldo-Ocampo, Fernando Valiente-Echeverría, Ricardo Soto-Rifo

“…During HIV-1 infection, these proteins are key players in the fine-tuning of viral and host cellular and molecular pathways, including (but not limited to) viral entry, transcription, splicing, RNA modification, translation, decay, assembly, and packaging, as well as the modulation of the antiviral response. …”
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Hyodeoxycholic acid inhibits colorectal cancer proliferation through the FXR/EREG/EGFR axis by Qiang Pang, Shansong Huang, Xiaodong Li, Jiaqing Cao

“…Nonetheless, the antitumor effects and molecular pathways of HDCA in CRC remain largely unexplored.MethodsIn this study, we investigated how HDCA influences the growth potential of CRC cells using techniques such as flow cytometry, Edu assay, CCK-8, colony formation assay, Western blot analysis, and animal experiments.ResultsIt was found that HDCA treatment of CRC cells was able to significantly inhibit the proliferative capacity of the cells. …”
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Exploring the Molecular Modalities in the Pathogenesis of Diabetic Kidney Disease with a Focus on the Potential Therapeutic Implications by Lyubomir Gaydarski, Kristina Petrova, Ivan Angushev, Stancho Stanchev, Alexandar Iliev, Nikola Stamenov, Vidin Kirkov, Boycho Landzhov

“…This review explores the roles of key molecular pathways, including the apelinergic system, vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) axis, and nitric oxide (NO)/nitric oxide synthase (NOS) signaling, in DKD pathogenesis and potential therapeutic applications. …”
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Phytochemical Profiles and Anticancer Effects of Calophyllum inophyllum L. Extract Relating to Reactive Oxygen Species Modulation on Patient-Derived Cells from Breast and Lung Canc... by Jetsada Ruangsuriya, Jirapast Sichaem, Apichat Tantraworasin, Somcharoen Saeteng, Phanchaporn Wongmaneerung, Angkhana Inta, Neal M. Davies, Kewalin Inthanon

“…Overall, our findings highlight the anticancer potential of C. inophyllum extract, emphasize its ability to modulate cellular ROS levels and target key molecular pathways involved in cancer progression. This study sheds light on the promising therapeutic implications of C. inophyllum extract as a novel agent for cancer treatment, which is safe for normal cells.…”
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Nε-carboxyethyl-lysin influences atherosclerotic plaque stability through ZKSCAN3 acetylation-regulated macrophage autophagy via the RAGE/LKB1/AMPK1/SIRT1 pathway by Zhongwei Liu, Jing Liu, Xiqiang Wang, Yong Zhang, Yanpeng Ma, Gongchang Guan, Ya Yuwen, Ni He, Hanxiu Liu, Xingfeng Yu, Sen Ma, Junkui Wang, Jin Zhang, Ling Zhu, Yulian Zhang

“…These findings highlight CEL’s critical role in promoting plaque instability in T2DM by impairing key molecular pathways that regulate autophagy, offering potential therapeutic targets for managing atherosclerosis in diabetic patients.…”
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Formin protein DAAM1 positively regulates PD-L1 expression via mediating the JAK1/STAT1 axis in pancreatic cancer by Rui Xu, Mengyun Wan, Jiadong Pan, Jie Mei, Ji Zhou, Yan Shen, Jiayue Yang, Yichao Zhu, Jing Sun

“…The LinkedOmics platform was employed to perform enrichment analysis of DAAM1-associated molecular pathways in pancreatic cancer. Subsequently, a series of in vitro and in vivo experiments were conducted to evaluate the biological roles of DAAM1 in pancreatic cancer cells and its effects on intratumoral T cells. …”
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Selective Immunomodulation of Inflammatory Pathways in Keratinocytes by the Janus Kinase (JAK) Inhibitor Tofacitinib: Implications for the Employment of JAK-Targeting Drugs in Psor... by Martina Morelli, Claudia Scarponi, Laura Mercurio, Francesco Facchiano, Sabatino Pallotta, Stefania Madonna, Giampiero Girolomoni, Cristina Albanesi

“…Finally, we found that tofacitinib mimics SOCS1 or SOCS3 activities, as it impaired the same molecular pathways in IFN-γ or IL-22-activated keratinocytes.…”
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MSC-derived exosome ameliorates pulmonary fibrosis by modulating NOD 1/NLRP3-mediated epithelial-mesenchymal transition and inflammation by Wei Chen, Jie Peng, Xiangyi Tang, Shao Ouyang

“…Classic molecular biology approaches such as RT-qPCR, Western blot, immunofluorescence, and ELISA were used to examine molecular pathways. Histopathological examination was performed using HE and Masson staining. …”
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Drought Tolerance in Modern and Wild Wheat by Hikmet Budak, Melda Kantar, Kuaybe Yucebilgili Kurtoglu

“…This paper focuses on recent advances on drought related gene/QTL identification, studies on drought related molecular pathways, and current efforts on improvement of wheat cultivars for drought tolerance.…”
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Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/β-catenin pathway modulat... by Wenta Tan, Shuo Fu, Yufei Wang, Bojun Hu, Guiquan Ding, Li Zhang, Wen Zhang, Guanhua Du, Junke Song

“…Transcriptomic and metabolomic analyses were conducted to explore the molecular pathways and metabolites affected by AIRE. ATP level was measured using an ATP assay kit. …”
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Deciphering the role of epigenetics in plant pathogen resistance: Strategies for sustainable sugarcane management by Faisal Mehdi, Yuanli Wu, Shuzhen Zhang, Yimei Gan, Zhengying Cao, Shuting Jiang, Limei Zan, Benpeng Yang

“…By clarifying these molecular pathways, the review lays a foundation for future research that seeks to strengthen sugarcane against biotic stressors and ensure the sustainability of sugar and bioenergy production.…”
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The burden of group A Streptococcus (GAS) infections: The challenge continues in the twenty-first century by Aswin Thacharodi, Saqib Hassan, Avadh Vithlani, Tawfeeq Ahmed, Sanjana Kavish, Nicole-Mae Geli Blacknell, Ali Alqahtani, Arivalagan Pugazhendhi

“…Despite substantial research on GAS infections, it is still unclear what molecular pathways are responsible for their emergence and how to best manage them. …”
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Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome by Gema Mondéjar-Parreño, Ana I. Moreno-Manuel, Juan Manuel Ruiz-Robles, José Jalife

“…We review some molecular pathways and mechanisms involved in cardiac ion channel trafficking. …”
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Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature by Sandra Maria Barbalho, Beatriz Leme Boaro, Jéssica da Silva Camarinha Oliveira, Jiří Patočka, Caroline Barbalho Lamas, Masaru Tanaka, Lucas Fornari Laurindo

“…Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by the dysregulation of molecular pathways and activation of the brain’s immune system, resulting in the release of pro-inflammatory and oxidative molecules. …”
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In vitro high-content screening reveals miR-429 as a protective molecule in photoreceptor degeneration by Georgios Petrogiannakis, Irene Guadagnino, Santiago Negueruela, Martina Di Guida, Elena Marrocco, Mariateresa Pizzo, Annalaura Torella, Mariateresa Zanobio, Marianthi Karali, Diego Luis Medina, Sabrina Carrella, Sandro Banfi

“…Given their ability to simultaneously modulate multiple molecular pathways, miRNAs represent promising therapeutic tools for disorders with high genetic heterogeneity, such as IRDs. …”
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Development of a spontaneous model of renal interstitial fibrosis in NOD/SCID mice: Aging-induced pathogenesis. by Lihua Qiu, Zhaoxia Ma, Jinyan Li, Zhen Wu, Longmei Dai, Ruimin Long, Linlin Hu, Jianxiu Sun, Min Hu, Yanjiao Li

“…In this comprehensive investigation, we successfully developed a spontaneous mouse model of renal interstitial fibrosis and revealed the molecular pathways contributing to increased susceptibility to kidney injury and renal fibrosis in elderly individuals.…”
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MicroRNA-219 in the central nervous system: a potential theranostic approach by Nahal Shamaeizadeh, Mina Mirian

“…Exploring the miR-219 molecular pathways and their therapeutic effects on central nervous system disorders and the mechanisms involved, the present review study aims to illustrate how this information may change the future of gene therapy.…”
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