Modeling Musculoskeletal Disorders in Zebrafish: Advancements in Muscle and Bone Research by Luca Dalle Carbonare, Michele Braggio, Arianna Minoia, Mattia Cominacini, Maria Grazia Romanelli, João Pessoa, Natascia Tiso, Maria Teresa Valenti

“…These models have provided significant insights into the molecular pathways involved in these diseases, helping to identify the key genetic and biochemical factors that contribute to their progression. …”
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Convergence of evolving artificial intelligence and machine learning techniques in precision oncology by Elena Fountzilas, Tillman Pearce, Mehmet A. Baysal, Abhijit Chakraborty, Apostolia M. Tsimberidou

“…By analyzing multi-dimensional, multiomic, spatial pathology, and radiomic data, these technologies enable a deeper understanding of the intricate molecular pathways, aiding in the identification of critical nodes within the tumor’s biology to optimize treatment selection. …”
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Molecular Pathogenesis of Cholangiocarcinoma by G. Fava, I. Lorenzini

“…This Paper describes the scientific progresses made in the last years in defining the molecular pathways implicated in the generation of this devastating disease.…”
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A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties by Floriane Lignet, Vincent Calvez, Emmanuel Grenier, Benjamin Ribba

“…In this paper, we propose a structural model of the main molecular pathways involved in the endothelial cells response to VEGF stimuli. …”
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Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming by Androniki Kretsovali, Christiana Hadjimichael, Nikolaos Charmpilas

“…Here we review the molecular pathways that are involved in the functions of HDAC inhibitors on stem cell differentiation and reprogramming of somatic cells into pluripotency. …”
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Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence by Nicola Alessio, Tiziana Squillaro, Giovanni Di Bernardo, Giovanni Galano, Roberto De Rosa, Mariarosa AB Melone, Gianfranco Peluso, Umberto Galderisi

“…We then analyzed how genotoxic stressors may promote the release of IGFBP-4 and the molecular pathways associated with the induction of senescence by this protein.…”
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Emerging Roles of Synapse Organizers in the Regulation of Critical Periods by Adema Ribic, Thomas Biederer

“…The synaptic specificity of these processes points towards the involvement of distinct molecular pathways. Attractive candidates are pre- and postsynaptic transmembrane proteins that form adhesive complexes across the synaptic cleft. …”
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Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting by GV Naveen Kumar, Rui-Sheng Wang, Ankit X. Sharma, Natalie L. David, Tânia Amorim, Daniel S. Sinden, Nandini K. Doshi, Martin Wabitsch, Sebastien Gingras, Asim Ejaz, J. Peter Rubin, Bradley A. Maron, Pouneh K. Fazeli, Matthew L. Steinhauser

“…Abstract Physiological adaptations to fasting enable humans to survive for prolonged periods without food and involve molecular pathways that may drive life-prolonging effects of dietary restriction in model organisms. …”
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Mucus production and chronic obstructive pulmonary disease, a possible treatment target: zooming in on N-acetylcysteine by Federico Baraldi, Tommaso Bigoni, Maria Pia Foschino Barbaro, Claudio Micheletto, Giulia Scioscia, Alessandro Vatrella, Alberto Papi

“…It exerts a direct and indirect (glutathione replenishment) antioxidant mechanism; it interferes with inflammatory molecular pathways, including inhibition of nuclear factor-kB activation in epithelial airway cells and reduction in the expression of cytokine tumor necrosis factor α, interleukin (IL)-6, and IL-10. …”
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Proteomic dataset of sorghum leaf and root responses to single and combined drought and heat stress by Ali Elnaeim Elbasheir Ali, Robert E. Sharp, Laura Greeley, Scott C. Peck, David L. Tabb, Ndiko Ludidi

“…GO and KEGG annotation revealed biological processes and molecular pathways associated with sorghum responses to these treatments. …”
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Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes by Gina Manda, Alexandru-Ionel Checherita, Maria Victoria Comanescu, Mihail Eugen Hinescu

“…It highlights key molecular pathways and new hypothesis in diabetic nephropathy, related to the interferences of metabolic, oxidative, and inflammatory stresses. …”
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Beyond Hormone Receptors: liquid biopsy tools to unveil new clinical meanings and empower therapeutic decision-making in Luminal-like metastatic breast cancer by Brenno Pastò, Riccardo Vida, Arianna Dri, Lorenzo Foffano, Serena Della Rossa, Lorenzo Gerratana, Fabio Puglisi

“…The present work aims to summarize the current evidence regarding the clinical meanings of hormone receptors and their downstream molecular pathways, alongside their implications for therapeutic decision-making in Luminal-like mBC.…”
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Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens by Paras Famta, Saurabh Shah, Biswajit Dey, Kondasingh Charan Kumar, Deepkumar Bagasariya, Ganesh Vambhurkar, Giriraj Pandey, Anamika Sharma, Dadi A. Srinivasarao, Rahul Kumar, Santosh Kumar Guru, Rajeev Singh Raghuvanshi, Saurabh Srivastava

“…This review provides a holistic picture of BC biology, molecular pathways, and recent advances in therapeutic strategies.…”
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Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7) in Smooth Muscles by Marcio Augusto Fressatto de Godoy, Larissa Pernomian, Ana Maria de Oliveira, Satish Rattan

“…This paper provides an overview of the functional role and the molecular pathways involved in the biosynthesis and activity of Ang-(1–7) in diverse systems.…”
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Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 by Chuangjiang Chen, Chenlong Wang, Hui Jiang, Mengya Wang, Sajid Ur Rahman, Changjiang Chen, Hongyan Ding, Chang Zhao, Wanyue Huang, Xichun Wang

“…This study investigates the molecular pathways by which rutin alleviates ZEA-induced ESC apoptosis, focusing on the role of Nrf2. …”
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Nanocurcumin in myocardial infarction therapy: emerging trends and future directions by Mei Lv, Qing Sun, Yilin Yu, Jinwei Bao

“…Curcumin nanoparticles have been observed to successfully reduce infarct size, maintain heart function by modulating essential molecular pathways in MI. Its liposomal formulations provide sustained release and higher tissue penetration with improved pharmacokinetics and enhanced therapeutic efficacy. …”
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Transcriptomic Approaches to Investigate the Anti-Aging Effects of Blueberry Anthocyanins in a Caenorhabditis Elegans Aging Model by Jie Ding, Jiahui Liu, Qingqi Guo, Na Zhang

“…Transcriptomic analysis was conducted to explore the regulatory effects of BA on anti-aging molecular pathways and key genes in <i>C. elegans</i>. Results showed a significant, dose-dependent extension of lifespan, improvement in locomotion and pharyngeal pumping rate, and reduction in lipofuscin and ROS accumulation. …”
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Whole blood transcriptome profile identifies motor neurone disease RNA biomarker signatures by Sulev Kõks, Sulev Kõks, Karin Rallmann, Mari Muldmaa, Mari Muldmaa, Jack Price, Abigail L. Pfaff, Abigail L. Pfaff, Pille Taba

“…In addition to the formal differential analysis, we performed functional annotation of the genomics data and identified the molecular pathways that are differentially regulated in MND patients. …”
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Cerebral Cavernous Malformation: From Genetics to Pharmacotherapy by Zhuangzhuang Zhang, Jianwen Deng, Weiping Sun, Zhaoxia Wang

“…Results Germline and somatic mutations mediate the onset and development of CCM through several molecular pathways. Medications such as statins, fasudil, rapamycin, and propranolol can alleviate CCM symptoms or hinder its progression by specifically modulating the corresponding targets. …”
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MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury by Mingming Cao, Wenjing Song, Runyu Liang, Lili Teng, Mei Zhang, Jiyao Zhang, Luwen Zhu

“…With growing evidence that microRNAs (miRNAs) play an important role as posttranscription gene silencing mediators in many I/R injury, in this review, we highlight the microRNAs that are related to I/R injury and their regulatory molecular pathways. In addition, we discussed the potential role of miRNA as a biomarker and its role as a target in I/R injury treatment. …”
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