Targeting KRAS G12C and G12S mutations in lung cancer: In silico drug repurposing and antiproliferative assessment on A549 cells by Mansour S. Alturki, Nada Tawfeeq, Amal Alissa, Zahra Ahbail, Mohamed S. Gomaa, Abdulaziz H. Al Khzem, Thankhoe A. Rants'o, Mohammad J. Akbar, Waleed S. Alharbi, Bayan Y. Alshehri, Amjad N. Alotaibi, Fahad A. Almughem, Abdullah A. Alshehri

“…The computational studies involved virtual screening, induced fit, and covalent docking, and molecular dynamics simulations, and identified five promising candidates, the antibiotics; capreomycin, cefadroxil, and Cefdinir, the antifungal; natamycin, and the anti-inflammatory, cortisone. …”
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Uncovering the Mechanisms of BaBaoWuDanYaoMo Against Influenza A Virus and Virus-Induced Inflammation Based on Network Pharmacology and Pharmacological Evaluation by Lei B, Su Y, Chen R, Chen Z, Liu B, Chen Y, Zhou M, Wang X, Ma Q

“…To predict its therapeutic targets via network pharmacology and verify the therapeutic effect and the mechanism of BB against influenza virus in vitro and in vivo.Material and Methods: The potential active and underlying mechanism of BB in the treatment of influenza virus was predicted through network pharmacological strategies and Molecular Docking. The protective and anti-inflammatory effects of BB were determined by cytopathic effect (CPE), quantitative real-time PCR, mitochondrial membrane potentials and Western blotting assay in vitro. …”
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Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice by Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Ayami Saga, Hiroshi Sawabe, Hiroyasu Inui, Takeshi Okada, Tohru Ohama, Daisuke Okuzaki, Yoshihiro Kamada, Masafumi Ono, Makoto Nishida, Mikio Watanabe, Yasushi Sakata

“…We previously demonstrated hepatic, cardiac, and skin inflammation in a high-fat diet-induced steatotic liver disease (SLD) model. However, the molecular mechanism in the kidneys in this model remains unclear. …”
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Modern perspective of the Rice Diet for hypertension and other metabolic diseases by Anthony Kuo, Pao-Hwa Lin, Yi-Ju Li, Friedrich C Luft, David López, Romeo Sommerfeld, Paul Ermler, Jana Fehr, Benjamin Bergner, Scott Sanoff, Francis Neelon, William McDowell, Smilla Fox, Abdullatif Ghajar, Elena Gensch, Cedric Lorenz, Martin Preiss, Tom Richter, Philip Klemmer, Anastacia Bohannon, Christoph Lippert

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Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus by Jian Ji, Yongli Ye, Lina Sheng, Jiadi Sun, Qianqian Hong, Chang Liu, Jun Ding, Shuxiang Geng, Deping Xu, Yinzhi Zhang, Xiulan Sun

“…Subsequently, a metabolomics approach of the serum, basal ganglia, hypothalamus, and hippocampus as well as the gut microbiota was undertaken to unravel the underlying molecular mechanisms of sleep promotion. Our data reveal that HIBA can regulate the metabolism of basal ganglia (sphingolipids, acylcarnitines, etc.), possibly in relation to HIBA’s influence on the gut microbiome (Muribaculum, Bacteroides, Lactobacillus, etc.). …”
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Synthesis and Antifungal Activity of Fmoc-Protected 1,2,4-Triazolyl-α-Amino Acids and Their Dipeptides Against <i>Aspergillus</i> Species by Tatevik Sargsyan, Lala Stepanyan, Henrik Panosyan, Heghine Hakobyan, Monika Israyelyan, Avetis Tsaturyan, Nelli Hovhannisyan, Caterina Vicidomini, Anna Mkrtchyan, Ashot Saghyan, Giovanni N. Roviello

“…Our mechanistic studies based on molecular docking revealed that compounds <b>3a</b> and <b>7a</b> bind to the same region of the sterol 14-α demethylase as fluconazole. …”
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Green Tea Extract (<i>Theaceae</i>; <i>Camellia sinensis</i> L.): A Promising Antimicrobial, Anti-Quorum Sensing and Antibiofilm Candidate Against Multidrug-Resistant <i>Campylobac... by Mona S. Emara, Ahmed M. Ammar, Ashraf M.O. Abdelwahab, Attia A. Elgdawy, Adel Abdelkhalek, Elena Pet, Gabi Dumitrescu, Mirela Ahmadi, Norhan K. Abd El-Aziz

“…Methods: This study investigated the antimicrobial and antibiofilm activities of some herbal extracts against multidrug-resistant (MDR) <i>Campylobacter</i> species recovered from different sources using phenotypic and molecular techniques. Results: The overall <i>Campylobacter</i> species prevalence was 21.5%, representing 15.25% and 6.25% for <i>C. jejuni</i> and <i>C. coli</i>, respectively. …”
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PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction by Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren

“…Immunoprecipitation, western blotting and immunofluorescence analysis were performed to elucidate the molecular mechanisms involved. Results We determined that PINK1 and Prdx2 were downregulated in the HFpEF mouse model. …”
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Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasticity after ischemic stroke in rats by transcranial direct current stimulation by Yu Chen, Lin Mao, Qinxiang Zhou, Dingqun Bai, Yuhan Kong

“…However, to use this technology more rationally in clinical practice, a deepened understanding of the molecular mechanisms behind its therapeutic effects is needed. …”
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Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models by Andrea Mancini, Alessandro Colapietro, Loredana Cristiano, Alessandra Rossetti, Vincenzo Mattei, Giovanni Luca Gravina, Giovanni Luca Gravina, Héctor Perez-Montoyo, Marc Yeste-Velasco, Jose Alfon, Carles Domenech, Claudio Festuccia

“…As previously shown in other cancer types, we demonstrated that the molecular mechanism of action of ABTL0812 in glioblastoma involves the inhibition of Akt/mTORC1 axis by overexpression of TRIB3, and the activation of endoplasmic reticulum (ER) stress/unfolded protein response (UPR). …”
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Kloning gen virulen Streptococcus agalactiae sebagai bahan dasar vaksin rekombinan by , Sutanti, Retno Damayanti Soejoedono, Irvan Faizal

“…The goals of this study were to isolate and molecular characterize the mga gene of local isolate of S. agalactiae to support the development of DNA vaccine. …”
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Observational study on the current status of thalassaemia in Malaysia: a report from the Malaysian Thalassaemia Registry by Hishamshah Mohd Ibrahim, Zulaiha Muda, Ida Shahnaz Othman, Mohamed Najib Mohamed Unni, Kok Hoi Teh, Asohan Thevarajah, Kogilavani Gunasagaran, Gek Bee Ong, Seoh Leng Yeoh, Aisyah Muhammad Rivai, Che Hadibiah Che Mohd Razali, Nazzlin Dizana Din, Zarina Abdul Latiff, Rahman Jamal, Norsarwany Mohamad, Hany Mohd Ariffin, Hamidah Alias

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Microsatellite analyses reveal genetic diversity and population structure of Cipangopaludina chinensis in Guangxi, China by Xiao-kai Wei, Kang-qi Zhou, Xin-xi Zou, Xue-ling Zhang, Yu-Sen Li, Hui Luo, Yin Huang, Xue-song Du, Jun-qi Qin, Zhong Chen, Yong Lin, Xian-hui Pan, Hua Ye

“…However, the large amount of fishing and the invasion of other species have severely impacted the natural resources of C. chinensis in China. Moreover, the molecular-level population structure of C. chinensis remains poor. …”
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Optimising Xpert-Ultra and culture testing to reliably measure tuberculosis prevalence in the community: findings from surveys in Zambia and South Africa by Richard Hayes, Sarah Fidler, Sian Floyd, María Rupérez, Helen Ayles, Redwaan Vermaak, Kwame Shanaube, Albertus Schaap, Eveline Klinkenberg, Petra de Haas, Barry Kosloff, Thomas Gachie, Pete J Dodd, Chali Wapamesa, Michael J Burnett, Nico Kalisvaart, Tila Mainga, Linda Mureithi

“…Challenges with using culture (the reference standard) for TB diagnosis in prevalence surveys have led to increasing use of molecular tests (Xpert assays), but discordance between these two tests has created problems for deciding which individuals have TB. …”
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Rapid detection of Vibrio alginolyticus in seafood using the flgL gene and real-time polymerase chain reaction by Muktiningsih Nurjayadi, Gladys Indira Putri, Jefferson Lynford Declan, Ismaya Krisdawati, Dandy Akbar Juliansyah, Maharanianska Azzahra, Irvan Maulana, Irma Ratna Kartika, Fera Kurniadewi, Tiara Fahriza, Adinda Myra Amalia Putri, Ayu Berkahingrum, Atikah Nur Rahmawati, Rosita Gio Anggraeni, Dalia Sukmawati, Sri Rahayu, Vira Saamia, I Made Wiranatha, Bassam Abomoelak, Hesham Ali El-Enshasy

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SEC61 translocon gamma subunit is correlated with glycolytic activity, epithelial mesenchymal transition and the immune suppressive phenotyp... by Zhou Changshuai, Cui Huanhuan, Yang Yuechao, Chen Lei, Feng Mingtao, Gao Yang, Li Deheng, Li Liangdong, Chen Xin, Li Xiaoqiu, Cao Yiqun

“…In this study, we use a multifaceted approach, combining bioinformatics analysis with experimental validation, to elucidate the pivotal role of SEC61G and its associated molecular mechanisms in LUAD. Our integrated analyses reveal a significant positive correlation between SEC61G expression and the glycolytic activity of LUAD, as evidenced by increased fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET)/CT scans. …”
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KEMAMPUAN LITERASI SAINS SISWA SMA DI KOTA KENDARI: DESKRIPSI & ANALYSIS by Erniwati Erniwati, Istijarah istijarah, La Tahang, Hunaidah Hunaidah, Vivi Hastuti Rufa Mongkito, Suritno Fayanto

“…As for the energy supply molecular indicator, it s a percentage of 33.75% with a very low category. …”
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The CYP4/20-HETE/GPR75 axis in the progression metabolic dysfunction-associated steatosis liver disease (MASLD) to chronic liver disease by James P. Hardwick, Byoung-Joon Song, Paul Rote, Charles Leahy, Yoon Kwang Lee, Alexandra Rudi Wolf, Danielle Diegisser, Victor Garcia

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Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3 by Peipei Li, Zhini Zhu, Yong Wang, Xuyuan Zhang, Chuanhui Yang, Yalan Zhu, Zixuan Zhou, Yulin Chao, Yonghui Long, Yina Gao, Songqing Liu, Liguo Zhang, Pu Gao, Qianhui Qu

“…Despite their physiological and pharmacological significance, the molecular underpinnings of substrate and drug recognition remain unknown. …”
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Endothelial calcium firing mediates the extravasation of metastatic tumor cells by Marina Peralta, Amandine Dupas, Annabel Larnicol, Olivier Lefebvre, Ruchi Goswami, Tristan Stemmelen, Anne Molitor, Raphael Carapito, Salvatore Girardo, Naël Osmani, Jacky G. Goetz

“…In this work, we dissect the cellular and molecular mechanisms driving endothelial remodeling. …”
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