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Design, theoretical approaches and new framework of pyrazolo[3,4-d]pyrimidine as potent anticancer agents: Efficient synthesis, ADME-T and molecular docking
Published 2025-03-01“…Additionally, the anchoring function of the 1,3,4-thiadiazole-substituted pyrazolo[3,4-d]pyrimidine moiety in interacting with anticancer targets and hydrophobic interaction with the essential amino acid residues has been highlighted by molecular modeling studies. The study shows how certain residues from the colorectal cancer mutant (1WCH) interact with each other in a way that is stable. …”
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Molecular imprinted polymer-based potentiometric approach for the determination of carvedilol and ivabradine hydrochloride in dosage form, spiked human plasma and in presence of their oxidative degradates
Published 2025-02-01“…Precipitation polymerization was used to create molecular imprinted polymers (MIPs) for each drug. …”
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Synthesis, crystal structure, hirshfeld study, DFT analysis, molecular docking study, antimicrobial activity of β-enaminonitrile bearing 1H-pyran
Published 2025-01-01“…The dominant forces in the crystal were explained by energy framework calculations and density functional theory analyses, which also show the geometric optimization aspects and molecular reactivity indicators. The focus is on the investigation of frontier molecular orbitals, aromaticity, and π–π stacking abilities. …”
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RAB3GAP2 dysregulation in adult T-cell leukemia/lymphoma (ATLL) compared to acute lymphoblastic leukemia (ALL): a molecular perspective
Published 2025-01-01“…This proposes that the underlying molecular mechanisms governing ATLL and ALL may largely overlap concerning these cellular processes. …”
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Patterns of variations in lipid molecular profile during larval development of red king crab, Paralithodes camtschaticus, and Japanese mitten crab, Eriocheir Japonica
Published 2025-01-01“…To extend our knowledge of crustacean biochemistry and provide a more comprehensive model of lipidomic patterns during embryonic and larval development of these crab species, we studied the dynamics of molecular species profiles of reserve lipids such as triacylglycerols (TG) and membrane lipids such as glycerophospholipids (PL). …”
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Transcriptome analysis and cytochrome P450 monooxygenase reveal the molecular mechanism of Bisphenol A degradation by Pseudomonas putida strain YC-AE1
Published 2023“…Conclusion: In this study we propose the molecular basis and the potential role of YC‑AE1cytochrome P450 monooxygenase in BPA catabolism…”
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Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species
Published 2025-02-01Subjects: Get full text
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Protocol for generating splice isoform-specific mouse mutants using CRISPR-Cas9 and a minigene splicing reporter
Published 2025-03-01Subjects: Get full text
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Polymorphism of the <i>Rca2</i> anthracnose resistance gene in strawberry cultivars (<i>Fragaria × ananassa</i>)
Published 2019-06-01Subjects: Get full text
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Anticancer activity of Ilex khasiana, a rare and endemic species of holly in Northeast India, against murine lymphoma
Published 2025-01-01Subjects: Get full text
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Revealing Mucilage Event-Linked Community Composition in the Sea of Marmara from eDNA Metabarcoding Data
Published 2024-03-01Subjects: Get full text
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Shivasia gen. nov. for the Australasian smut Ustilago solida that historically shifted through five different genera
Published 2012-12-01Subjects: Get full text
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Causality-driven feature selection and domain adaptation for enhancing chemical foundation models in downstream tasks
Published 2025-01-01Subjects: Get full text
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Mathematical Analysis Of A Modular Network Coordinating The Cell Cycle And Apoptosis
Published 2005-07-01Subjects: Get full text
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Selenium’s Role in Plant Secondary Metabolism: Regulation and Mechanistic Insights
Published 2024-12-01Subjects: Get full text
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