Jiangu Granules Regulates Endoplasmic Reticulum Stress-Induced Apoptosis in UMR-106 Cells by Modulating the PERK/eIF2α/ATF4/CHOP Pathway by CHEN Sainan, ZHOU Fen, HUANG Yunmei, LIN Yanping

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Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice by Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi

“…Pirfenidone significantly reduced pro-inflammatory cytokines including interleukin-6, interleukin-1β, transforming growth factor-β, tumor necrosis factor- α, high-mobility group box-1, and toll-like receptor-4, elevated gamma-aminobutyric acid, decreased glutamate levels, modulated aspartate aminotransferase and alanine aminotransferase levels. …”
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Modulation of hormonal, metabolic, inflammatory and oxidative stress biomarkers in women with polycystic ovary syndrome following combined (resistant and endurance) training: a randomized controlled trail by Masoud Nasiri, Amirabbas Monazzami, Solmaz Alavimilani, Zatollah Asemi

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Phytochemical Profiles and Anticancer Effects of Calophyllum inophyllum L. Extract Relating to Reactive Oxygen Species Modulation on Patient-Derived Cells from Breast and Lung Cancers by Jetsada Ruangsuriya, Jirapast Sichaem, Apichat Tantraworasin, Somcharoen Saeteng, Phanchaporn Wongmaneerung, Angkhana Inta, Neal M. Davies, Kewalin Inthanon

“…Using antioxidants to modulate cellular ROS levels is a promisingstrategy for cancer prevention and treatment. …”
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A study on state dependent single server queue with Markov modulated arrival under hyper exponential service times using block matrix structured approach by Raghavendran. R, V. Vidhya

Subjects: “…Markov modulated arrival…”
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Optimization Configuration Model for Intelligent Measurement Multi-Core Modules Considering “Cloud-Edge-End-Core” Collaboration by Lai Zhou, Qinhao Li, Guoying Lin

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Cucumeropsis mannii seed oil shields against cyclophosphamide-induced hepatorenal toxicity by modulating redox imbalance and iNOS/IL-β1 signalling in rats by Amaka Cecilia Agbara, Ejike Daniel Eze, Christian Emeka Offor, Adam Moyosore Afodun, Ezebuilo Ugbala Ekpono, Peter Chinedu Agu, Chinyere Aloke, Nkeiru Nwaamaka Ezeani, Emmanuel Orire Ikuomola, Ekom Monday Etukudo, Ilemobayo Victor Fasogbon, Angela Mumbua Musyoka, Patrick Maduabuchi Aja

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Why are there discrepancies between depressed patients’ Global Rating of Change and scores on the Patient Health Questionnaire depression module? A qualitative study of primary care in England by Alice Malpass, Glyn Lewis, Jude Robinson, Christopher Dowrick, Naila Khan, Louise Fusco

“…Objectives Our aims were to investigate discrepancies between depressed patients’ GlobalRating of Change (GRC) and scores on the Patient Health Questionnaire depression module (PHQ-9). Our objectives were to ascertain patients’ views on the source and meaning of mismatches and assess their clinical significance.Design Qualitative study nested within a cohort, in a programme investigating the indications for prescribing antidepressants that will lead to a clinical benefit.Setting Primary care practices in north-west England.Participants We invited 32 adults with a recent diagnosis of depression and evidence of mismatch between GRC and PHQ-9 Scores to participate. …”
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Making up the planned initial cost of finishrd products at OJSC “BSW – Management Company of Holding “BMС” by means of the SAP ERP system controlling module by A. V. Potapenko, S. N. Astratov, I. I. Lavrish

“…The article reveals the process of making up the planned initial cost of finished products and detailing indirect costs on the long‑range production example by means of the “Controlling” module of the SAP ERP system. The problems of displaying indirect costs for product that practically do not depend on the quantity of products produced, and calculating direct costs through a specification mechanism based on a basic material records reference book have been solved. …”
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Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways by Yu Zhang, Hailong Lun, Naiqiang Zhu, Naiqiang Zhu, Ning Yang, Kaikai Ding, Bin Chen, Chengbing Chang, Haipeng Gu, Yanqi Liu

“…Conversely, the overexpression of miR-34a-5p mitigated these stimulatory effects, suggesting a regulatory role in modulating OS progression.DiscussionOur research emphasizes the critical role of C1QTNF1-AS1 in the pathogenesis of osteosarcoma (OS). …”
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Sustained Interleukin-1β Exposure Modulates Multiple Steps in Glucocorticoid Receptor Signaling, Promoting Split-Resistance to the Transactivation of Prominent Anti-Inflammatory Genes by Glucocorticoids by Pedro Escoll, Ismael Ranz, Norman Muñoz-Antón, Ana van-den-Rym, Melchor Alvarez-Mon, Carlos Martínez-Alonso, Eva Sanz, Antonio de-la-Hera

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LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer Cell Invasion and Migration via Modulating Transcription Factor DDX17 by Chanjiao Yao, Lingjuan Zeng, Qin Liu, Xiaoxin Qiu, Chunyan Chen

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Sargassum plagiophyllum Ethanolic Extract Enhances Wound Healing by Modulating FAK/Src/Akt/p38 and Rac1 Signaling in Keratinocytes HaCaT Cells by Furoida Moolsup, Wanida Sukketsiri, Wipawadee Sianglum, Jirawat Saetan, Nattakanwadee Khumpirapang, Supita Tanasawet

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The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling by Fangzhen Xia, Ziteng Zhang, Zhen Qian, Xiaoyu Fang, Junxue Wang, Yan Wang, Guoting Sun, Yuefeng Yu, Ninjian Wang, Junke Zhen, Yan Liu, Yingli Lu

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Agathisflavone Inhibits Viability and Modulates the Expression of miR-125b, miR-155, IL-6, and Arginase in Glioblastoma Cells and Microglia/Macrophage Activation by Karina Costa da Silva, Irlã Santos Lima, Cleonice Creusa dos Santos, Carolina Kymie Vasques Nonaka, Bruno Solano de Freitas Souza, Jorge Mauricio David, Henning Ulrich, Ravena Pereira do Nascimento, Maria de Fátima Dias Costa, Balbino Lino dos Santos, Silvia Lima Costa

“…Exposure of human microglia/macrophage to the secretome from GL-15 GMB cells modulated proliferation and morphology, effects that were modulated by agathisflavone treatment. …”
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Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/β-catenin pathway modulation by Wenta Tan, Shuo Fu, Yufei Wang, Bojun Hu, Guiquan Ding, Li Zhang, Wen Zhang, Guanhua Du, Junke Song

“…Transcriptomic and metabolomic analyses indicated that AIRE regulated the Wnt signaling pathway in CIRI and modulated metabolites associated with mitochondrial energy metabolism, such as citrate and succinate. …”
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Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice by Wanxiu Cao, Fang Liu, Robert W. Li, Yaoxian Chin, Yuming Wang, Changhu Xue, Qingjuan Tang

“…It is unclear how docosahexaenoic acid (DHA) improves insulin resistance via modulating gut microbiome in obese individuals. We used diet-induced obesity (DIO) mice as a model to study the effects of DHA-rich fish oil (DHA-FO) on host metabolic disorders and colonic microbiome. …”
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PENGARUH MODUL AJAR IPA BERBASIS PROBLEM BASED LEARNING TERHADAP KEMAMPUAN PEMECAHAN MASALAH SISWA KELAS IX SMP NEGERI 4 MANDREHE UTARA by Lusia Zebua, Agnes Renostini Harefa, Desman Telaumbanua, Toroziduhu Waruwu

Subjects: “…Modul Ajar…”
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Short bouts and long-term exercise reduce sedentary-induced bone loss and microstructural changes by modulating bone formation and resorption in healthy young male rats by L.Y. Wang, L.M. Liang, X.X. Zhang, H. Chi, F. L. Peng

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Jussara (Euterpe edulis Mart.) Supplementation during Pregnancy and Lactation Modulates the Gene and Protein Expression of Inflammation Biomarkers Induced by trans-Fatty Acids in the Colon of Offspring by Carina Almeida Morais, Lila Missae Oyama, Juliana Lopez de Oliveira, Márcia Carvalho Garcia, Veridiana Vera de Rosso, Laís Sousa Mendes Amigo, Claudia Maria Oller do Nascimento, Luciana Pellegrini Pisani

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