Cannabidiol Modulates Neuroinflammatory and Estrogen-Related Pathways in a Sex-Specific Manner in a Chronic Stress Model of Depression by Uri Bright, Irit Akirav

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How close is autophagy-targeting therapy for Alzheimer's disease to clinical use? A summary of autophagy modulators in clinical studies by Sofia Miranda Fernandes, Johanna Mayer, Per Nilsson, Makoto Shimozawa

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Capsaicin Modulates Ruminal Fermentation and Bacterial Communities in Beef Cattle with High-Grain Diet-Induced Subacute Ruminal Acidosis by Wei You, Haijian Cheng, Xin Hu, Enliang Song, Fugui Jiang

“…In summary, these results suggest that dietary capsaicin supplementation can limit the adverse effects of SARA through the modulation of bacterial communities within the rumen, thus altering ruminal fermentation in beef cattle.…”
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Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization by Cuicui Guo, Hui Sun, Yulei Du, Xiaodong Dai, Yu Pang, Zhen Han, Xinhui Xiong, Shaowei Li, Junhua Zhang, Qingbing Zheng, Xun Gui

“…Targeting αvβ8 with a blocking antibody significantly inhibits tumor growth by modulating macrophage polarization and enhancing immune cell infiltration. …”
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Protocol for visualizing the chromatin assembly properties of epigenetic protein complexes via an HTM module-mediated artificial tethering system by Shanli Guan, Jiajia Tang, Cuixia Di, Bo Cheng

“…Here, we present a protocol utilizing heterochromatin-targeting module (HTM) module-mediated chromatin tethering followed by microscopy-based visualization to detect the recruitment priority between two components in Polycomb repressive complex 1 (PRC1). …”
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Hei-Gu-Teng Zhuifenghuoluo Granule Modulates IL-12 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis by Kang Zheng, Zexu Chen, Wen Sun, Bin Liu, Danping Fan, Qingqing Guo, Hui Luo, Jiawen Shen, Li Li, Xiaojuan He, Shuang Kou, Xiaoya Li, Guoming Pang, Hongchuan Zhao, Cheng Lu

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DNA methylation modulates nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos by Grigorios Fanourgakis, Laura Gaspa-Toneu, Pavel A. Komarov, Panagiotis Papasaikas, Evgeniy A. Ozonov, Sebastien A. Smallwood, Antoine H. F. M. Peters

“…Failing de novo DNAme in Dnmt3a/Dnmt3b double deficient spermatogonia is associated with increased nucleosome occupancy in mature sperm, preferentially at sites with higher CpG content, supporting the model that DNAme modulates nucleosome retention in sperm. To assess the impact of altered sperm chromatin in formatting embryonic chromatin, we measure H3K4me3 occupancy at paternal and maternal alleles in 2-cell embryos using a transposon-based tagging approach. …”
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Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks in Aspergillus nidulans by Erzsébet Orosz, Károly Antal, Zoltán Gazdag, Zsuzsa Szabó, Kap-Hoon Han, Jae-Hyuk Yu, István Pócsi, Tamás Emri

“…Our model suggests that an important function of AtfA is to modulate the transduction of stress signals. Although it may regulate directly only a limited number of genes, these include elements of the signaling network, for example, members of the two-component signal transduction systems. …”
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Cardioprotective effects of hUCMSCs-Exosi-EGR1 MN patch in MI/RI by modulating oxidative stress and mitophagy by Chen Huang, Xun Zhang, Shi-Xiong Wu, Qing Chang, Zhi-Kun Zheng, Jing Xu

“…Noteworthy outcomes from in vivo experiments included significant improvements in cardiac function, reduced cardiac fibrosis, and decreased apoptosis rates in MI/RI mice, emphasizing the potential therapeutic value of the Exosi-EGR1 MN patch in mitigating MI/RI through modulation of oxidative stress and mitophagy mechanisms.…”
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Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion by Flaminia Cavallaro, Lorena Duca, Laura Francesca Pisani, Roberta Rigolini, Luisa Spina, Gian Eugenio Tontini, Nadia Munizio, Elena Costa, Maria Domenica Cappellini, Maurizio Vecchi, Luca Pastorelli

“…This effect appears to be related to the modulation of the cytokine network and specifically IL-6 leading to a relevant decrease of hepcidin, a master regulator of ACD.…”
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Point of Common Coupling Voltage Modulated Direct Power Control of Grid-Tied Photovoltaic Inverter for AC Microgrid Application by Shameem Ahmad, Hamza Mubarak, Umme Kulsum Jhuma, Tofael Ahmed, Saad Mekhilef, Hazlie Mokhlis

“…The proposed PCC voltage modulated (PVM) theory-based DPC method (PVMT-DPC) is composed of nonlinear PVM, nonlinear damping, conventional feedforward, and feedback PI controllers. …”
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Ultrahigh average zT realized in polycrystalline SnSe0.95 materials through Sn stabilizing and carrier modulation by Xing Yang, Tian-En Shi, Wang-Qi Bao, Zi-Yuan Wang, Jun Wang, Peng Wu, Yi-Xin Zhang, Jing Feng, Zhen-Hua Ge

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Design and simulation of a simple greenhouse solar dryer and peltier thermoelectric module under independent and combined operating conditions by A GokulRaj, S Padma, R Mohan

“…At 40 K temperature difference the Peltier thermo electric module attained optimal performance. From the analysis using EJS tool, the maximum and average air temperatures inside the dryer were found to be 65 °C and 57 °C, the COP and cooling capacity of the Peltier thermoelectric model were high at 800 W/m ^2 solar radiation.…”
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Multiscale Modeling Indicates That Temperature Dependent [Ca2+]i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity by Niko Komin, Mahsa Moein, Mark H. Ellisman, Alexander Skupin

“…Changes in the cytosolic Ca2+ concentration ([Ca2+]i) are the most predominant active signaling mechanism in astrocytes that can modulate neuronal activity and is assumed to influence neuronal plasticity. …”
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Enhanced Optical Modulation Properties via Two-step Annealing of Sol–Gel Deposited Vanadium Dioxide Thin Films by Zhencheng Li, Jiacheng Yu, Yongde Xia, Zhuxian Yang, Yunbin He, Nannan Wang, Yanqiu Zhu

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Theaflavin Ameliorates Cerebral Ischemia-Reperfusion Injury in Rats Through Its Anti-Inflammatory Effect and Modulation of STAT-1 by Fei Cai, Cai-Rong Li, Ji-Liang Wu, Jian-Guo Chen, Chao Liu, Qing Min, Wei Yu, Chang-Han Ouyang, Jin-He Chen

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Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs by Felipe Beccaria Casagrande, Sabrina de Souza Ferreira, Fernanda Peixoto Barbosa Nunes, Lavínia Maria Dal’Mas Romera, Suelen Silvana dos Santos, Fernando Henrique Galvão Tessaro, Paula Regina Knox de Souza, Sandro Rogério Almeida, Joilson Oliveira Martins

“…The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection.…”
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Orthogonal Nano‐Engineering (ONE): Modulating Nanotopography and Surface Chemistry of Aluminum Oxide for Superior Antibiofouling and Enhanced Chemical Stability by Hanyu Chen, Felicia Fianu, Carmen I. Moraru, Rong Yang, Yifan Cheng

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MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways by Xueting Guo, Wenqi Wang, Liting Lin, Jie Shan, Junyao Zhu, Shipeng Ning, Hanmei Li, Xianwen Wang, Decheng Lu

“…RNA sequencing of mouse skin tissue further revealed that MnGA significantly reduces inflammation by modulating the nuclear factor kappa-B (NF-κB), Toll-like receptor (TLR), and NOD-like receptor (NLR) signaling pathways and promotes skin regeneration. …”
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Single-cell mitophagy patterns within the tumor microenvironment modulate intercellular communication, impacting the progression and prognosis of hepatocellular carcinoma by Zhengyan Li, Wei Chen, Shu Yao, Zuxiang Peng, Hongming Liu, Yongliang Tang, Yi Feng

“…However, mitophagy did not seem to affect the effectiveness of immunotherapy.ConclusionThis study provides evidence that mitophagy within the HCC TME modulates intercellular communication, influencing tumor progression and patient prognosis. …”
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