Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro by Gang Shen, Haiyun Wen, Huijuan Li, Xuetao Zhang, Bowen Lan, Xuanchi Dong, Peng Ge, Yalan Luo, Hailong Chen

“…Conclusions Our results demonstrated that EMO effectively inhibited ferroptosis both in vivo and in vitro, while also modulating the Nrf2/HO-1/GPX4 signaling pathway to provide protection against SAP-ALI.…”
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Rationale, design, and methodology of My Body Is Fit and Fabulous at school (MyBFF@school) study: a multi-pronged intervention program to combat obesity among Malaysian schoolchild... by Abdul Halim Mokhtar, Ruziana Mona Wan Mohd Zin, Abqariyah Yahya, Fuziah Md. Zain, Rusidah Selamat, Zahari Ishak, Muhammad Yazid Jalaludin

“…The intervention schools underwent MyBFF@school program, whereas the control followed standard school curriculum for a duration of six months. The intervention modules replaced the existing two physical education classes and one co-curriculum activity per week. …”
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A network analysis of depression and anxiety symptoms among Chinese elderly living alone: based on the 2017–2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS) by Ze Chang, Yunfan Zhang, Xiao Liang, Yunmeng Chen, Chunyan Guo, Xiansu Chi, Liuding Wang, Xie Wang, Hong Chen, Zixuan Zhang, Longtao Liu, Lina Miao, Yunling Zhang

“…Betweenness centrality results highlighted GAD1 (Nervousness or anxiety) and GAD2 (Uncontrollable worry) as critical bridge nodes facilitating information flow between different symptoms, while CESD3 (Feeling depressed) demonstrated a bridging role across modules. Weighted analyses further confirmed the central importance of GAD2 (Uncontrollable worry) and GAD4 (Trouble relaxing). …”
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A Randomized, Placebo-Controlled, Single-Center, Crossover Study to Evaluate the Effects of Pre-Meal Whey Protein Microgel on Post-Prandial Glucometabolic and Amino Acid Response i... by Ian J Neeland, Luiz H de Gregório, Roberto Zagury, Bo Ahrén, Joel Neutel, Christian Darimont, John Corthesy, Yohan Grzywinski, Emilie Perrin, Maximilian von Eynatten, Odd Erik Johansen

“…WPM may therefore serve as a metabolic modulator in people with T2D living with overweight or obesity.…”
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Influence of substrate bias on the properties of CrAlN wear-resistant coating prepared by arc/magnetron composite technology by Xiaoyan NIU, Mingze LIU, Guoqiang DONG, Yujiang WANG, Haoliang TIAN

“…In addition, substrate bias, a key process parameter, was found to affect particle activity and sputtering yield, thereby modulating element distribution in the coating and coating properties. …”
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FKBP5 as a key regulator of metabolic processes in birds: Insights from chicken pectoral muscle by Pengfei Du, Xiangli Zhang, Yao Zhu, Ziyang Wang, Xuemeng Si, Huaiyong Zhang, Yanqun Huang, Wen Chen

“…The FKBP5 levels in birds are dramatically modulated during development in insulin-sensitive tissues, with the highest expression observed in striated muscle and liver at embryonic day 19 (E19) (P < 0.01). …”
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A pharmacoinformatic approach for studying Atractylodes Lancea DC’s anticancer potential and control ROS-mediated apoptosis against prostate cancer cells by Chi-Hoon Ahn, Ji Soo Myong, Kazi Rejvee Ahmed, Md Ataur Rahman, Md. Maharub Hossain Fahim, Min Choi, Muntajin Rahman, Jinwon Choi, Kiryang Kim, Seungjoon Moon, Seungjoon Moon, Mohammed Dalli, Mohammed Dalli, Rony Abdi Syahputra, Sang-Won Shin, Abdel Halim Harrath, Moon Nyeo Park, Bonglee Kim, Hwa-Seung Yoo

“…Western blot analysis showed that ALD modulates critical survival pathways, leading to apoptotic cell death.DiscussionThese findings demonstrate that ALD exerts potent anticancer effects against metastatic prostate cancer cells through ROS-mediated apoptosis and mitochondrial dysfunction, while exhibiting minimal cytotoxicity toward normal prostate cells. …”
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Effect of chemoradiotherapy on the dynamics of circulating lymphocyte subsets in patients with non-metastatic nasopharyngeal carcinoma by Lilan Yi, Lilan Yi, Yinfang Gu, Yinfang Gu, Longhua Guo, Longhua Guo, Xiaofang Zou, Xiaofang Zou, Guowu Wu, Guowu Wu

“…BackgroundChemoradiotherapy (CRT) is the primary and most effective treatment for non-metastatic nasopharyngeal carcinoma (NPC), exerting antitumor effects by modulating immune cells. Distinct subpopulations of immune cells exhibit specific sensitivity to CRT. …”
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Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils by Yixiang Jiang, Ning Wang, Jingyi Liu, Haoran Ren, Wenkang Jiang, Yanting Lei, Xidan Fu, Miao Hao, Xiujuan Lang, Yumei Liu, Xijun Liu, Rui Li, Hulun Li

“…While the cytokines secreted by stem cells show promise in modulating post-stroke inflammation, the direct application of these supernatants in ischemic stroke treatment and the underlying mechanisms are still unclear. …”
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gga-miR-6634-5p Affects the proliferation and steroid hormone secretion of chicken (Gallus Gallus) granulosa cells by targeting MMP16 by Yixiang Tian, Xing Wu, Zihao Zhang, Yijie Li, Meng Hou, Ruirui Jiang, Donghua Li, Yanhua Zhang, Yulong Guo, Guoxi Li, Xiaojun Liu, Xiangtao Kang, Yadong Tian, Wenting Li, Yuetao Li

“…Therefore, this study demonstrates that gga-miR-6634-5p modulates the proliferation of chicken GCs and the secretion of steroid hormones by targeting MMP16, which may contribute to a better understanding of the functional mechanisms of miRNAs in the ovarian development of laying hens.…”
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A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity by Wen Wang, Wen Wang, Meiting Wang, Huanbai Wang, Weifeng Xu, Conggang Wang, Jie Pei, Xiaodan Li, Dongting Zhangsun, Dongting Zhangsun

“…This study first proposed that [D1G, ΔQ14] LvIC could modulate mice’s locomotor activity. However, further investigation is needed to understand the therapeutic effects of [D1G, ΔQ14] LvIC.…”
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Sdd3 regulates the biofilm formation of Candida albicans via the Rho1-PKC-MAPK pathway by Li Mei Pang, Guisheng Zeng, Eve Wai Ling Chow, Xiaoli Xu, Ning Li, Yee Jiun Kok, Shu Chen Chong, Xuezhi Bi, Jiaxin Gao, Chaminda Jayampath Seneviratne, Yue Wang

“…Taken together, our studies identify a new biofilm regulator, Sdd3, in C. albicans that modulates Rho1 activity through its inhibitory interaction with Bem2, thereby regulating the PKC-MAPK pathway to control chitin biosynthesis, which is critical for biofilm formation. …”
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Mesenchymal stem cells from perinatal tissues promote diabetic wound healing via PI3K/AKT activation by Jiawei Huang, Qingwen Deng, Lai Ling Tsang, Guozhu Chang, Jinghui Guo, Ye Chun Ruan, Chi Chiu Wang, Gang Li, Hon Fai Chan, Xiaohu Zhang, Xiaohua Jiang

“…Mesenchymal stem cell (MSC) therapies have emerged as a promising alternative, given their potential to modulate various pathways involved in wound healing. …”
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Immunomodulatory and growth-promoting effects of Rauwolfia serpentina root powder in broiler chicks challenged with Salmonella Gallinarum by Yingyu Zhang, Hiba Rehman, Farina Khattak, Maryam Tariq, Bushra Nisar Khan, Sadia Chaman, Ayaesha Riaz, Muhammad Ovais Omer, Aqib Ali, Qamar un Nisa, Muhammad Muddassir Ali, Gulbeena Saleem

“…In contrast, the RSP-1 and RSP-2 groups showed significantly lower SOCS3 and P20K expression (p &lt; 0.001), alongside improved gut morphology, weight gain, and FCR compared to the SGC group, with these benefits increasing over time.ConclusionIn conclusion, these findings suggest that Rauwolfia serpentina supplementation modulates key immune-related gene expression (SOCS3, P20K, and MHC class IIβ), enhances intestinal health, and improves growth performance in broilers challenged with Salmonella Gallinarum.…”
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Bisphenol B restrains rat leydig cell function via H3K27me3/H3K9me3 histone modifications by Jiayi He, Huiqian Zhang, Hehua Quan, Qingyuan Wang, Congcong Wen, Yiyan Wang, Yang Zhu, Ren-Shan Ge, Xiaoheng Li

“…BPB could potentially hinder the growth and function of Leydig cells by modulating H3K27me3 and H3K9me3. The findings of the study indicate the involvement of histone methylation (H3K27me3) in BPB-induced steroidogenic dysfunction, emphasizing the correlation between histone modifications and male reproductive toxicity.…”
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MiR-3664-3p through suppressing ABCG2, CYP3A4, MCL1, and MLH1 increases the sensitivity of colorectal cancer cells to irinotecan by Elham Farrokhnazar, Sahar Moghbelinejad, Reza Najafipour, Ladan Teimoori-Toolabi

“…Conclusion: It can be concluded that miR-3664-3p can be considered a regulator of resistance to irinotecan by modulating the expression of ABCG2, CYP3A4, MCL1, and MLH1 genes.…”
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Development of the DO₃SE-Crop model to assess ozone effects on crop phenology, biomass, and yield by P. Pande, S. Bland, N. Booth, J. Cook, Z. Feng, L. Emberson

“…Here we extend the DO<span class="inline-formula">₃</span>SE model (designed to estimate total and stomatal O<span class="inline-formula">₃</span> deposition for risk assessment) to incorporate a coupled <span class="inline-formula"><i>A</i>_net</span>–<span class="inline-formula"><i>g</i>_sto</span> model to estimate O<span class="inline-formula">₃</span> uptake; an O<span class="inline-formula">₃</span> damage module (that impacts instantaneous <span class="inline-formula"><i>A</i>_net</span> and the timing and rate of senescence); and a crop phenology, carbon allocation, and growth model based on the JULES-crop model. …”
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An integrated microbiome- and metabolome-genome-wide association study reveals the role of heritable ruminal microbial carbohydrate metabolism in lactation performance in Holstein... by Chenguang Zhang, Huifeng Liu, Xingwei Jiang, Zhihong Zhang, Xinfeng Hou, Yue Wang, Dangdang Wang, Zongjun Li, Yangchun Cao, Shengru Wu, Sharon A. Huws, Junhu Yao

“…Collectively, these findings offer compelling evidence for the host-microbe interactions, wherein cows actively modulate their rumen microbiota through SNP variants to regulate their own lactation performance. …”
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Makro-Mikro Düzeylerde Edimbilim: Taha Abdurrahman ve Ahmed el-Mütevekkil Örneği by Hüseyin Çiçek

“…Onun İslami pragmatik anlayışına göre iletişimsel ve etkileşimsel nitelikteki kullanım; dil, inanç ve bilgi alanlarında gerçekleşir. Bu üç bileşen, modüler İslami pragmatik alanı tamamlar ve bunların her birinin özünde eylem ve fayda yer alır. …”
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Exploring the Mechanism of Canmei Formula in Preventing and Treating Recurrence of Colorectal Adenoma Based on Data Mining and Algorithm Prediction by Xiaoling Fu, Yimin Xu, Xinyue Han, Xiangying Lin, Jingnan Wang, Guanhong Li, Xiaochen Fu, Min Zhang

“…CMF prevents and treats colorectal adenomas by modulating the renin-angiotensin signaling pathway and the inflammatory response.…”
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