Differential impact of TIM-3 ligands on NK cell function by Xin Zhang, Lazar Vujanovic, Riyue Bao, Robert L Ferris, Tullia C Bruno, Aditi Kulkarni, Hridesh Banerjee, Housaiyin Li, Juncheng Wang, Lawrence P Kane, Pragati Upadhyay, Jennifer L Anderson, Onyedikachi Victor Onyekachi, Lidia M R B Arantes

“…In vitro killing, proliferation and cytokine production assays were implemented to evaluate whether the four TIM-3 ligands differentially modulate TIM-3+ NK cell functions, and whether disruption of TIM-3/ligand interaction can enhance NK cell-mediated antitumor effector mechanisms. …”
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DEVELOPING INFORMATION AND TECHNOLOGICAL COMPETENCE OF PROSPECTIVE MILITARY SAILORS by Ruslan Shevchenko, Oleh Cherniavskyi, Vasyl Shemchuk, Olena Zlobina, Natalia Benkovska, Nataliia Terentieva, Андрій Гуралюк

“…In the framework of our research we understand this competence as an integral quality of a person which combines motivation, knowledge, skills, experience in the use of modern information technologies during professional activities related to the performance of duties of future officers of the Ukrainian Navy of the Armed Forces of Ukraine (including  management of combat modules, unmanned aerial vehicles, digital weapons, the possibility of using artificial intelligence in combat systems, ensuring cyber security of weapons and military equipment, etc.). …”
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Chemopreventative potential of Salsola tuberculatiformis Botch and Compound A in the differential regulation of IL-1Ra:IL-1α in UVB exposed skin keratinocytes by T. Magcwebeba, L. McEvoy, S. Hayward, T. Tait, J.L Quanson, L. Kelbe, WCA Gelderblom, M. Lilly, A.C Swart, P. Swart

“…Background: Salsola tuberculatiformis Botsch, commonly known as Gannabos, is a Namibian shrub known for its contraceptive properties in rats and its ability to modulate adrenal steroidogenesis both in vitro and in vivo. …”
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PRACTICAL TRAINING OF OFFICERS OF THE STATE FIRE SERVICE THROUGH GAME-BASED LEARNING by V. V. Bulgakov, A. A. Lazarev, E. P. Konovalenko, T. A. Mochalova

“…The proposed methodological tool has shown promise in more rational redistribution of teaching time and expansion of the base of practical modules for designing business games for the purpose of development of new relevant professional competencies in students.…”
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ADAPTIVE COMFORT PADA GRAND STUDIO PROGRAM STUDI ARSITEKTUR FAKULTAS TEKNIK UNIVERSITAS MALIKUSSALEH by Atthaillah Atthaillah, Eri Saputra, Muhammad Iqbal

“…Dalam penggunaannya, dirasakan kondisi termal yang tidak nyaman baik bagi mahasiswa maupun tenaga pengajar.Studi ini melakukan investigasi untuk membuktikan sensasi ketidaknyamanan subjektif tersebut dengan data sehingga bisa dipertanggung jawabkan secara objektif dengan pengukuran adaptive comfort.Tujuannya adalah untuk memberikan data sensasi termal sehingga pihak prodi arsitektur dapat mengambil langkah yang benar untuk penyelesaian masalah tersebut.Metode yang dipakai adalah metode simulasi komputer dengan teknik parametrik menggunakan Rhinoceros, Grasshopper dan Ladybug & Honeybee.Ruang GS-PAFT dibagi menjadi sembilan zona berdasarkan orientasi dan modul bangunan untuk memudahkan analisis.Simulasi dilakukan dari pukul 08.00 sampai 17.00 yang merupakan waktu pemakaian ruang pada hari kerja.Hasil menunjukkan kurang dari 40% waktu sepanjang tahun dirasakan nyaman.Zona yang paling nyaman dan paling tidak nyaman secara berurutan adalah zona 8 (Timur, tidak terpapar matahari) dan zona 20 (Barat Daya, terekspos matahari) dengan persentase waktu nyaman tahunan 39.23% dan 33.53%. …”
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Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis by Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xiao

“…Genetic or pharmacological inhibition of HDAC7 effectively enhanced astrocytic clearance of tau with improved cognitive functions in PS19 mice. HDAC7 could modulate astrocytic uptake and lysosomal degradation of tau proteins through a transcriptional factor EB (TFEB) acetylation-dependent manner. …”
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The model of intermediate assessment of future teachers’ professional competencies by I. V. Golovina, Kh.-Akh. S. Khaladov, T. Yu. Medvedeva, G. A. Paputkova, A. V. Milekhin

“…Currently, the system for assessing educational results in teacher education programmes is most often aimed at assessing the degree of mastery of disciplines (modules, practices), i.e. it has a disciplinary basis. …”
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Pengaruh Pemberian Glutamin pada Kemampuan Fagositosis Makrofag terhadap Pseudomonas Aeruginosa by Daslina , Eryati Darwin, Aziz Djamal

“…Glutamine is an amino acid  in the body that able to modulate the body's immune function. The objective of this study was to determine the potential of glutamine in enhancing the ability of the immune system against infection of P.aeruginosa. …”
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Modelling the air quality impacts of a zero emission zone scenario in the city of Milan by Andrea Piccoli, Valentina Agresti, Marco Bedogni, Giovanni Lonati, Guido Pirovano

“…The assessment of the environmental and health effects is done thanks to a modelling suite composed of a road traffic, an emission, a hybrid air quality models, plus a fourth module for human health impacts. In this specific case study, the modelling chain is applied to the metropolitan city of Milan for the reference year 2017 first, and then for two hypothetical mobility scenarios referred to 2030: the temporal evolution of baseline simulation as planned by the NEC (National Emission reduction Commitments) directive and by local emission containment measures (BAS30) and the BAS30 scenario with the implementation of the mobility policy (ZEZ30). …”
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Integrated transcriptomic hypothalamic-pituitary-ovarian axis network analysis reveals the role of energy availability on egg production in layers by Jianling Peng, Yong Cui, Haiping Liang, Shenyijun Xu, Linjian Weng, Meng Ru, Ramlat Ali, Qing Wei, Jiming Ruan, Jianzhen Huang

“…The hypothalamic-pituitary-ovarian (HPO) axis is an energy-sensitive functional axis for follicle development, synthesis, and secretion of reproductive hormones, and plays a key role in modulating sustained ovulation in layers. To investigate the mechanism of integrated network regulation of the HPO axis under energy fluctuation, ninety Hy-line brown layers (265-day-old, 1.92 ± 0.02 kg) were randomly divided into three groups for a 17-day experiment: a control group (Con group) fed ad libitum from days 1 to 17, an energy-deprived group (ED group) that was fed ad libitum from days 1 to 12 and then underwent a fasting period from days 13 to 17 to induce a pause in laying, and a re-fed group (Rf group) that fasted for seven days (specifically, days 1 to 5, day 7, and day 9), had ad libitum access to feed on days 6 and 8, and was continuously fed from days 10 to 17. …”
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Gut microbiota influence on lung cancer risk through blood metabolite mediation: from a comprehensive Mendelian randomization analysis and genetic analysis by Yizhao Du, Qin Wang, Zongmei Zheng, Hailun Zhou, Yang Han, Ao Qi, Lijing Jiao, Lijing Jiao, Yabin Gong

“…BackgroundGut microbiota (GM) and metabolic alterations play pivotal roles in lung cancer (LC) development and host genetic variations are known to contribute to LC susceptibility by modulating the GM. However, the causal links among GM, metabolite, host genes, and LC remain to be fully delineated.MethodThrough bidirectional MR analyses, we examined the causal links between GM and LC, and utilized two-step mediation analysis to identify potential mediating blood metabolite. …”
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Dietary Solid-state-fermentation product of Bacillus velezensis T23 alleviate hepatic steatosis, oxidative stress, gut barrier damage, and microbiota dysbiosis in juvenile genetica... by Qiang Hao, Rolf Erik Olsen, Einar Ringø, Qianwen Ding, Tsegay Teame, Yuanyuan Yao, Chao Ran, Yalin Yang, Zhen Zhang, Zhigang Zhou

“…Therefore, a 0.2 g/kg dose is suggested to supplement the diet of Nile tilapia to improve liver health and modulate the gut microbiota profile of the fish positively. …”
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Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease by Weigang Shu, Yongheng Wang, Mengfan Chen, Xiaoli Zhu, Fangtao Wang, Chunqiu Chen, Peng Du, Alexandra Bartolomucci, Xin Su, Xiaolei Wang

“…However, the regulating roles of ADSC‐EVs in CrF (CrF‐EVs) in CD, especially in modulating lymphatic function and mitigating the progression of mesenteritis and colitis, remains elusive. …”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…The role of USP7 in modulating SEL sensitivity was analyzed in MM cell lines, primary CD138+ cells, and xenograft mouse models. …”
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Dental and oral health assessments in the German National Cohort (NAKO) by Stefanie Samietz, Katrin Borof, Katrin Hertrampf, Ghazal Aarabi, Antonio Ciardo, Hannah Finke, Daniel Hagenfeld, Jan Kühnisch, Maurice Rütters, Sebastian-Edgar Baumeister, Stefan Lars Reckelkamm, Ti-Sun Kim, Thomas Kocher, Wolfgang Ahrens, Hermann Brenner, Carina Emmel, Beate Fischer, Amand Führer, Karin Halina Greiser, Jasmin Grischke, Kathrin Günther, Volker Harth, Stefanie Jaskulski, André Karch, Thomas Keil, Yvonne Kemmling, Alexander Kluttig, Lilian Krist, Oliver Kuss, Michael Leitzmann, Claudia Meinke-Franze, Karin B. Michels, Nadia Obi, Anette Peters, Nicole Pischon, Tobias Pischon, Sabine Schipf, Börge Schmidt, Henning Teismann, Stefan Rupf, Birte Holtfreter

“…As part of the Level 2 program that was offered to 20% randomly selected participants, each study centre selected one of three modules, one of them being the Level 2 oral examination. …”
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Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma by Iasmina Marcovici, Iasmina Marcovici, Raul Chioibas, Raul Chioibas, Istvan Zupko, Iulia Pinzaru, Iulia Pinzaru, Alina Moaca, Alina Moaca, Adriana Ledeti, Adriana Ledeti, Lucian Barbu-Tudoran, Lucian Barbu-Tudoran, Andreea Geamantan, Andreea Geamantan, Iasmina Predescu, Iasmina Predescu, Cristina Adriana Dehelean, Cristina Adriana Dehelean

“…Additionally, MEL-NPs accumulated within the intracellular space of CM cells, forming a perinuclear coating, inhibited their motility and clonogenic potential, increased intracellular oxidative stress, targeted the epithelial-to-mesenchymal transition, and induced apoptosis by altering cell morphology, nuclear aspect, F-actin and tubulin distribution, and by modulating the expression of pro- and anti-apoptotic markers. …”
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Dosimetric Comparison of Noncoplanar VMAT Without Rotating the Patient Couch Versus Conventional Coplanar/Noncoplanar VMAT for Head and Neck Cancer: First Report of Dynamic Swing A... by Kouta Hirotaki, MS, Kento Tomizawa, MD, PhD, Satoe Kitou, BS, Shunta Jinno, MS, Shunsuke Moriya, PhD, Takeshi Fujisawa, MD, Sadamoto Zenda, MD, PhD, Takeji Sakae, PhD, Masashi Ito, BS

“…Purpose: This retrospective planning study aimed to verify the usefulness of a clinically available method, dynamic swing arc (DSA), a noncoplanar volumetric modulated arc therapy (VMAT) technique, of the new accelerator OXRAY for head and neck squamous cell carcinoma (HNSCC). …”
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Time-restricted feeding improves metabolic syndrome by activating thermogenesis in brown adipose tissue and reducing inflammatory markers by Yueling Gong, Yueling Gong, Honghui Zhang, Jiang Feng, Li Ying, Mengmeng Ji, Shiyin Wei, Shiyin Wei, Qiming Ma

“…The study provides mechanistic insights into the beneficial effects of TRF, highlighting its potential in modulating lipid metabolism and exerting anti-inflammatory effects.…”
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Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

“…Exploratory transcriptomic analyses suggest that tumors of males with BRAF mutated MSI-H metastatic CRC are characterized by an enrichment of androgen receptor signature and an immune-depleted microenvironment, with a reduction in memory B cells, activated natural killer cells, and activated myeloid dendritic cells.Conclusions Overall, our findings suggest a complex interplay between sex and BRAF mutational status that may modulate the activity of ICIs in patients with MSI-H mCRC and pave the way to novel tailored strategies.…”
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Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trial by Jiajun Weng, Junbo Ge, Jiajia Liu, Juying Qian, Xiao Huang, Yuanyuan Li, Juan Peng, Yan'e Lu, Dong Huang, Pingyuan Yang, Shikun Xu, Lihua Guan, Qibing Wang, Zexin Zhao, Yabin Wei

“…VR-CBT consisted of four modules and was delivered at the bedside over a 1-week period. …”
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