REDD1 mediates HDM-induced nuclear-cytoplasmic translocation and release of IL-33 in airway epithelial cells by downregulating Nrf2 by Tian Luo, Wentao Ji, Yuxin Gong, Lichang Chen, Chao Liu, Dandan Zhang, Xi Li, Yanhua Lv

“…Conclusion This study reveals the crucial regulatory role of the REDD1-Nrf2-IL-33 axis in the pathological process of bronchial asthma. REDD1 modulates the expression of IL-33 and other inflammatory factors through the Nrf2 signaling pathway, thereby influencing the onset and progression of asthma. …”
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The role of gut microbiota in disease management: Ayurvedic perspectives on metabolic diseases and health by Bhawana Jangra, Shreyanshi Kulshreshtha, Alok Goyal, Sanjay M. Jachak

“…While the phytoconstituents can modulate the growth of useful gut bacteria, such as Bifidobacterium and Lactobacillus, these microbes have enzymes that help in the transformation of plant moieties into active metabolites which have beneficial effects. …”
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Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024 by Congxu Zhu, Jingjing Yang, Lumei Liu, Bonan Li, Tiansong Sun, Wen Sheng, Qinghu He

“…Moreover, drugs targeting glycolytic inhibitors and natural products have exhibited therapeutic potential against this disease. By modulating glycolytic mechanisms, there is potential to increase resistance in PCa. …”
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Study on the effects of Massa Medicata Fermentata with different formulations on the intestinal microbiota and enzyme activities in mice with spleen deficiency constipation by Xuejuan Liang, Dan Wan, Xinliang Li, Yanmei Peng, Linglong Chen

“…Candidatus_Arthromitus in the CS3 group and Psychrobacter in the CS2 group were positive and negative correlations with 5-HT and VIP, respectively.ConclusionThe three formulations of MMF significantly alleviated spleen deficiency constipation symptoms by modulating intestinal enzyme activities, D-xylose, VIP, and 5-HT levels, and restoring intestinal microbiota balance. …”
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The Effect of Lithium on Inflammation-Associated Genes in Lipopolysaccharide-Activated Raw 264.7 Macrophages by Raymond T. Makola, Vusi G. Mbazima, Matlou P. Mokgotho, Vincent S. Gallicchio, Thabe M. Matsebatlela

“…It is shown here that lithium modulates the expression of several inflammatory genes including IκB-α, TRAF3, Tollip, and NF-κB1/p50 which are regulators of the NF-κB pathway. …”
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Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells by Jingwei Liu, Jingwei Liu, Tong Shu, Yiheng Mu, Wanlin Zheng, Xiaohuan Lu, Xiaohuan Lu, Hong Tao, Hong Tao

“…The expression of these inflammatory factors effectively promotes the migration and differentiation of T cells to the site of infection, completing the clearance of infected epithelial cells.ConclusionThe main components of Baofukang suppository, curdione and borneol, inhibit the progression of HPV infection and the occurrence of cervical cancer by modulating the communication between innate and adaptive immunity, promoting the recruitment and recognition of CD8+ T cells to eliminate HPV-infected epithelial cells.…”
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Electrical Properties of Cu-Based Coordination Complexes: Insights from In Situ Impedance Spectroscopy by Jana Pisk, Marko Dunatov, Martina Stojić, Nenad Judaš, Ivica Đilović, Marta Razum, Luka Pavić

“…This study underscores the pivotal role of ligand modifications in modulating the functional properties of coordination complexes, offering valuable insights for the advancement of materials chemistry.…”
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Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats by Xianbin Wang, Yingxue Fu, Xianglian Yang, Yan Chen, Ni Zeng, Shouxing Hu, Shuai Ouyang, Xiao Pan, Shuang Wu

“…Ultimately, the findings suggest that treadmill training may attenuate apoptosis in lung cells post-spinal cord injury by modulating the MAP3K3 protein through miR145-5p to regulate the MAPK/Erk signaling pathway.…”
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Development of a Solar-Powered Edge Processing Perimeter Alert System with AI and LoRa/LoRaWAN Integration for Drone Detection and Enhanced Security by Mateo Mejia-Herrera, Juan Botero-Valencia, José Ortega, Ruber Hernández-García

“…The monitoring system communicates with a second MCU integrated with a LoRa or LoRaWAN communication module, enabling information transmission over distances of up to several kilometers. …”
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Tinnitus Suppression with Electrical Stimulation at the Most Basal Contact of the Cochlear Implant Electrode as a Model for Round Window Stimulation by Kiana Kheirkhah, Valerie Van Kelecom, Marc Leblans, Joost van Dinther, Glynnis De Greve, Erwin Offeciers, Andrzej Zarowsk

“…Two types of stimulation were presented at the most basal CI contact: a constant pulse train and a modulated pulse train. The variation in pulse rates was low rate (100-300 pps) and high (≥900 pps), and the current level ranged from the C-level to less than the T-level for both stimulation types. …”
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Elucidating the Role of HIF-1α/YAP Signaling Pathway in Regulating Inflammation in Human Periodontal Stem Cells: An in vitro Study by Zhao HW, Liu ST, Wang XJ, Zhang XM, Ma X

“…This study investigated the effects of the prolyl hydroxylase (PHD) inhibitor DMOG on pro-inflammatory cytokine expression in human periodontal ligament stem cells (hPDLSCs) and examined the involvement of the HIF-1α/YAP signaling path ay in modulating inflammation.Materials and Methods: hPDLSCs were cultured and treated with lipopolysaccharide (LPS) to induce inflammation, followed by DMOG treatment. …”
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Role of Aging in Ulcerative Colitis Pathogenesis: A Focus on ETS1 as a Promising Biomarker by Ni M, Peng W, Wang X, Li J

“…After identifying UC-related ARGs, consistent clustering was performed to screen aging-related molecular subtypes, followed by the exploration of differences in the immune microenvironment and pathways between distinct subtypes. Next, core module genes were screened using WGCNA and then the hub genes were characterized using LASSO and random forest methods. …”
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WKB ameliorates DSS-induced colitis through inhibiting enteric glial cells activation and altering the intestinal microbiota by Qi Sun, Bai-Rong Li, Dong-Hao Li, Xiao-Ying Wang, Qian-Yi Wang, Zhi-Meng Jiang, Shou-Bin Ning, Tao Sun

“…This effect was linked to enhanced mucosal barrier integrity, seen through increased tight junction protein and Muc2 expression, accompanied by favorable ultrastructural changes. WKB modulated EGCs activity via TNF-like cytokine 1 A inhibition, resulting in reduced glial fibrillary acidic protein expression. …”
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Different expression of circulating microRNA profile in tibetan OSAHS with metabolic syndrome patients by Xue-feng Shi, Xiang He, Ze-rui Sun, Jie Duo, Hao Yang

“…We also revealed that IKBKB, PIK3R1, and MAP2K1 are mostly associated with metabolic disorder in OSAHS, and miR-503-5p and miR-497-5p may regulate the development of MetS associated with OSAHS by modulating IKBKB, PIK3R1, and MAP2K1.…”
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The relationship between gallstone disease and the genetic variants of the sterol transporter adenosine triphosphate–binding cassette G8 and G5 in Egyptians by Menna A. Hassan, Salwa M. Abo El-Khair, Noha M. Mesbah, Dina M. Abo-Elmatty, Asmaa R. Abdel-Hamed

“…Additionally, the study aimed to examine the impact of these genetic variations on serum lipid profile to understand their role in modulating biochemical markers associated with GSD. …”
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Çocuk Kütüphanelerinde Yaşam Becerileri Geliştirmek: Bir Kütüphane Programı Modeli by Bülent Yılmaz, Ph.d., Nihan Temiz

“…Uzmanlardan gelen dönütler doğrultusunda yapılan düzenlemelerin ardından programa son hâli verilerek uygulamaya hazır duruma getirilmiştir. Sonuç: Üç farklı modül hâlinde geliştirilen kütüphane programı modeli, alan uzmanlarının görüşleri ile son şeklini almıştır. …”
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Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice by Shiyue Sun, Tongtong Yu, Joo Young Huh, Yujie Cai, Somy Yoon, Hafiz Muhammad Ahmad Javaid

“…Mechanistically, AGH modulated the AKT/FOXO1 pathway, decreasing myogenin and Foxo1 while increasing MyoD. …”
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The Campylobacter jejuni BumS sensor phosphatase detects the branched short-chain fatty acids isobutyrate and isovalerate as direct cues for signal transduction by Nestor Ruiz, Jiawei Xing, Igor B. Zhulin, Chad A. Brautigam, David R. Hendrixson

“…In this work, we expanded the repertoire of lower intestinal metabolites that are cues sensed by BumS that modulate the expression of genes required for colonization to include the branched short-chain fatty acids isobutyrate and isovalerate. …”
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Impact of Amarogentin on Gastric Carcinoma Cell Multiplication, Apoptosis and Migration via circKIF4A/miR-152-3p by Zhi Tan, Weining Wang, Jin Peng, Zhen Zhou, Jia Pan, Aiming Peng, Hui Cao, Wenling Fan

“…AG can decrease GC multiplication, clone formation and migration and induce apoptosis via modulating circKIF4A/miR-152-3p expression.…”
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Distinct dynamic regulation of pectoralis muscle metabolomics by insulin and the promotion of glucose-lipid metabolism with extended duration by Xiangli Zhang, Pengfei Du, Ziyang Wang, Yao Zhu, Xuemeng Si, Wen Chen, Yanqun Huang

“…Metabolomic analysis revealed that insulin promotes the downregulation of 63 out of 71 metabolites at 15 min and the upregulation of 101 out of 134 metabolites at 120 min, mainly associated with lysine degradation and thyroid hormone signaling pathways, respectively. 7 metabolites were dynamically modulated in the same manner over time (2 up-up and 5 down-down). …”
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