Astrocytic NLRP3 cKO mitigates depression-like behaviors induced by mild TBI in mice. by Hui-Tao Miao, Jun Wang, Jing-Jing Shao, Rong-Xin Song, Wen-Guang Li, Jian-Kai Sun, Shi-Yan Jia, Dong-Xue Zhang, Xiao-Ming Li, Jian-Yong Zhao, Li-Min Zhang

“…Our prior research suggests that Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)-related neuroinflammation, modulated by glial cells such as astrocytes, is likely to play a crucial role in the progression of anxiety and cognitive dysfunction. …”
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ApWD40a, a Member of the WD40-Repeat Protein Family, Is Crucial for Fungal Development, Toxin Synthesis, and Pathogenicity in the Ginseng Alternaria Leaf Blight Fungus <i>Alternari... by Jinling Lan, Shengjie Mei, Yingxue Du, Meili Chi, Jiayi Yang, Shuliu Guo, Mingliang Chu, Ronglin He, Jie Gao

“…Taken together, our findings highlight that <i>ApWD40a</i> played crucial roles in different biological processes and the pathogenicity of <i>A. panax</i> through modulating the expressions of genes involved in various primary and secondary metabolic processes.…”
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PPARα suppresses growth of hepatocellular carcinoma in a high-fat diet context by reducing neutrophil extracellular trap release by Banglun Pan, Zhu Zhang, Dongjie Ye, Xiaoxia Zhang, Yuxin Yao, Yue Luo, Haijie Hong, Xinran Cai, Yanling Chen, Nanhong Tang

“…Background &amp; Aims: The role of infiltrating neutrophils in hepatocellular carcinoma (HCC) is modulated by cellular metabolism, specifically lipid homeostasis. …”
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Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis by Mahsa Ranjbar, Mehran Rahimlou, Maryam Fallah, Kurosh Djafarian, Hamed Mohammadi

“…Evidence shows that Vitamin D modulates immunologic function and inflammation by affecting various immunological cells. …”
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Study protocol for Adaptive ChemoTherapy for Ovarian cancer (ACTOv): a multicentre phase II randomised controlled trial to evaluate the efficacy of adaptive therapy (AT) with carbo... by Michelle Lockley, Kathy Robinson, Rowan Miller, Charlie Gourley, Nicholas Counsell, Iain Mcneish, Trevor Graham, Uma Anne Mukherjee, Helen Hockings, Apini Patel, Priya Narayanan, Katie Wilkinson, Harjot Dhanda, Alexander R A Anderson

“…AT is a novel, evolutionarily informed approach to cancer treatment, which aims to exploit intratumoral competition between drug-sensitive and drug-resistant tumour subpopulations by modulating drug dose according to a patient’s own response to the last round of treatment. …”
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Effect of L-carnitine on lipid biomarkers of oxidative stress in chronic hemodialysis patients: a randomized controlled trial by Shokoh Shayanpour, Seyyed Seyfollah Beladi Mousavi, Hossain Karimpourian, Khojasteh Hoseinynejad, Kambiz Ahmadi Angali

“…Conclusion: Oral administration of L-carnitine in chronic hemodialysis patients may remarkably modulate lipid marker levels of oxidative stress and reduce the dose consumption of erythropoietin without any side effects.…”
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Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis by Flora Magno de Jesus Oliveira, Cassiano Felippe Gonçalves-de-Albuquerque, Isabel Matos Medeiros de Moraes, Patrícia Alves Reis, Vinicius Novaes Rocha, Patrícia Torres Bozza, Adriana Ribeiro Silva, Hugo Caire de Castro Faria Neto

“…Our results showed that posttreatment with simvastatin hampered organ dysfunction, increased local production of nitric oxide, improved bacterial clearance, and modulated inflammation in a relevant model of sepsis.…”
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Dye-based fluorescent organic nanoparticles made from polar and polarizable chromophores for bioimaging purposes: a bottom-up approach by Daniel, Jonathan, Dal Pra, Ophélie, Kurek, Eleonore, Grazon, Chloé, Blanchard-Desce, Mireille

“…Intriguingly, the implemented strategy also enables modulating and improving the dFONs colloidal and structural stability as well as their photostability. …”
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Enhancement of systemic and lung-localized CD4⁺ T-cell immune responses by truncation of NS1 protein of a seasonal live influenza vaccine strain by Polina I. Prokopenko, Ekaterina A. Stepanova, Victoria A. Matyushenko, Alexandra Ya. Rak, Anna K. Chistyakova, Arina D. Kostromitina, Tatyana S. Kotomina, Igor V. Kudryavtsev, Artem A. Rubinstein, Alexey S. Komlev, Larisa G. Rudenko, Irina N. Isakova-Sivak

“…One such approach is to modulate the immunogenic properties of live attenuated influenza vaccine (LAIV) by truncating the open reading frame of influenza virus non-structural protein 1 (NS1). …”
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Detection of alteration in carotid artery volumetry using standard-of-care computed tomography surveillance scans following unilateral radiation therapy for early-stage tonsillar s... by Efstratios Koutroumpakis, Mohamed A. Naser, Abdallah Sherif Radwan Mohamed, Salman A. Eraj, Andrea Jarre, Jay C. Shiao, Mona Kamal, Subha Perni, Jack P. Phan, William H. Morrison, Steven J. Frank, G.Brandon Gunn, Adam S. Garden, Anita Deswal, Jun-ichi Abe, David I. Rosenthal, Elie Mouhayar, Clifton D. Fuller

“…Methods: Disease-free cancer survivors (>3 months since therapy and age > 18 years) treated with intensity modulated RT for early (T1-2, N0-2b) tonsillar cancer with pre- and post-therapy contrast-enhanced CT scans available were included. …”
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A method to estimate the water storage of on-farm reservoirs by detecting slope gradients based on multi-spectral drone data by Yixuan Wang, Nana Yan, Weiwei Zhu, Zonghan Ma, Bingfang Wu

“…Once the OFR morphology was fully constructed, the water storage was calculated based on area-storage and depth-storage methods using the 3D volume module in Arcpy. The derived water storage agrees well with in situ observation (R2: 0.99) using slope gradients, reaching an overall accuracy of 95.2 %, with a root mean square error (RMSE) and a mean absolute error (MAE) of 2785 m3 and 1820 m3, respectively. …”
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Parasitic infections during pregnancy in Gabon affect glycosylation patterns of maternal and child antibodies by Yabo J. Honkpehedji, Anna O. Kildemoes, Koen A. Stam, Dieu L. Nguyen, Tom Veldhuizen, Angela van Diepen, Meral Esen, Peter G. Kremsner, Manfred Wuhrer, Ayôla A. Adegnika, Cornelis H. Hokke, Maria Yazdanbakhsh

“…During pregnancy, maternal antibodies can be transferred through the placenta and contribute to modulating both the mother’s and her child’s immune responses. …”
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Derivation and Verification of the Relationship between Ablation Index and Baseline Impedance by Zheng Cai, Sainan Li, Qi Zhang, Chenyuan Wang, Zhen Jin, Ming Fu, Shuai Zhang, Ming Liang, Zulu Wang, Yaling Han

“…Results. (1) Higher baseline impedances were related to smaller lesion dimensions at similar AIs. (2) The lesion dimensions were roughly the same after modulating the baseline impedance and power to keep the electric current relatively constant. …”
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Metabolic response to burn injury: a comprehensive bibliometric study by Yixu Li, Yixu Li, Yifan Liu, Sujie Xie, Sujie Xie, Yushu Zhu, Yushu Zhu, Xinran Ding, Xinran Ding, Wei Zhang, Wei Zhang, Shuyuan Xian, Shuyuan Xian, Guosheng Wu, Guosheng Wu, Hanlin Sun, Hanlin Sun, Jiale Yan, Bingnan Lu, Yuntao Yao, Weijin Qian, Yuwei Lu, Yiting Yang, Dayuan Xu, Dayuan Xu, Runzhi Huang, Runzhi Huang, Shizhao Ji, Shizhao Ji

“…The role of propranolol, insulin, oxandrolone, and nutritional interventions in modulating the hypermetabolic state was discussed. Additionally, our study underscored the challenges of managing sepsis and drug-resistant infections in burn patients as an important future area of research.…”
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Quantifying the impact of fermented liquid bio formulations, biofertilizers and organic amendments on horticultural and soil nutrient traits of garden pea ( Pisum sativum L.) by Vandana Thakur, Praveen Sharma, Pradeep Kumar, Payal Sharma, Sartaj Ahmad Bhat, Sunny Sharma, Rehan Azmi, Shivender Thakur

“…Among varieties, treatments, and their interactions, variety GS-10 and PB-89 treatment modules, viz., Jeevmurta 20% + Phosphorus solubilizing bacteria 100% + Farmyard manure, and their interaction were found to be best for improving the various horticultural and soil traits i.e. shelling percentage, protein content, effective nodules per plant, available nitrogen and phosphorus content. …”
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Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation by Yu Tang, Ruizhi Zhang, Gan Mao, Chong Li, Yisong Gao, Xuebing Zhou, Wenxiang Nie, Tianyu Song, Suao Liu, Kaixiong Tao, Peng Zhang, Wei Li

“…Conclusion Gastric cancer with ARID1A mutations modulates immune cell chemotaxis within the tumor microenvironment by influencing histone acetylation. …”
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PPARG2 Pro12Ala and TNFα -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting by Izabela Wojtkowska, Tomasz A. Bonda, Andrzej Tysarowski, Katarzyna Seliga, Janusz A. Siedlecki, Maria M. Winnicka, Janina Stępińska

“…TNFα and PPARγ are important modulators of metabolism, inflammation, and atherosclerosis. …”
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Language function improvement and cortical activity alteration using scalp acupuncture coupled with speech-language training in post-stroke aphasia: A randomised controlled study by Bingbing Lin, Jinglei Ni, Xiao Xiong, Lanlan Zhang, Jian Song, Mengxue Wang, Linsong Chai, Yunshi Huang, Jia Huang

“…Additionally, it may modulate cortical activation in the left frontopolar area, left fusiform gyrus, left pars opercularis, and right superior temporal gyrus, and induces different cortical alteration patterns in global and non-global aphasia.…”
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Can oral caffeine decrease postoperative opioid consumption following posterior spinal fusion in adolescent idiopathic scoliosis? A randomized placebo-controlled trial by Anne Stuedemann, MSN, RN, CPNP, Richard M Schwend, MD FAAP FAOA, Kenneth A. Shaw, MD, Nicolette Saddler, MSN, APRN, FNP-C, Michon Huston, PA-C, Michael Benvenuti, MD, Julia Leamon, MSN, RN, CPN, Ashley K. Sherman, MA, John Anderson, MD

“…Caffeine's ability to modulate pain following posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS) has not been previously assessed. …”
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Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial by Jinzhao Ji, Jinzhao Ji, Xiaoqing Ding, Xiaoqing Ding, Chuanli Liu, Chuanli Liu, Lingling Dai, Lingling Dai, Junting Yu, Junting Yu, Linghao Li, Linghao Li, Shaobing Wan, Shaobing Wan, Yangyang Song, Junqing Zhao, Zhetong Su, Kun Jia, Kun Jia, Shoujun Li, Shoujun Li

“…Anemoside B4 (AB4), derived from the traditional Chinese medicine Pulsatilla, has shown promise in preclinical studies for modulating inflammatory responses and improving clinical symptoms of pneumonia. …”
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