Safety and efficacy of omaveloxolone v/s placebo for the treatment of Friedreich's ataxia in patients aged more than 16 years: a systematic review by Ankita Umrao, Monika Pahuja, Nabendu Sekhar Chatterjee

“…Nrf2 is a regulator of FXN, which is a modulator of oxidative stress in animals and humans. …”
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Mexicanidad und Ironie durch die Revolution hindurch. Kompositionsstrategien in und diskursive Konstellationen um Revueltas’ Janitzio by Jonas Reichert

“…A method of composition with sound modules is identified, through which strong contrasts can be created. …”
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Discovery of Quinazolone Pyridiniums as Potential Broad-Spectrum Antibacterial Agents by Jie Dai, Qianyue Li, Ziyi Li, Zhonglin Zang, Yan Luo, Chenghe Zhou

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Gut colonization of Bacteroides plebeius suppresses colitis-associated colon cancer development by Hung-Lin Chen, Po-Yuan Hu, Chang-Shan Chen, Wei-Han Lin, Daniel K. Hsu, Fu-Tong Liu, Tzu-Ching Meng

“…Such findings underscore the potential of harnessing specific microbes, like B. plebeius shown in this study, to modulate the gut ecosystem and mitigate the risk of colitis-associated colon cancer.…”
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Gene expression analysis reveals mir-29 as a linker regulatory molecule among rheumatoid arthritis, inflammatory bowel disease, and dementia: Insights from systems biology approach... by Devi Soorya Narayana S, Vino Sundararajan

“…<h4>Conclusion</h4>Our study underscores the significant role of miR-29 in modulating the expression of hub genes and the associated transcription factors, which are crucial in the comorbidity status of RA, dementia, and IBD. …”
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Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners by Leroy Bondhus, Aileen A. Nava, Isabelle S. Liu, Valerie A. Arboleda

“…Finally, in the L1000 dataset, we identify drugs that can potentially be used to modulate expression of these genes. Conclusions Here we identify significant differences in isoform usage, disordered domain content, and variable binding partners between human epigenes and non-epigenes using various functional genomics datasets from Ensembl, ENCODE, GTEx, HPO, LINCS L1000, and BrainSpan. …”
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Decreased Hospital Length of Stay for ICH and PE after Adoption of an Artificial Intelligence-Augmented Radiological Worklist Triage System by Michael Petry, Charlotte Lansky, Yosef Chodakiewitz, Marcel Maya, Barry Pressman

“…Pre-AI and post-AI time periods were defined around the deployment dates of the ICH and PE modules, respectively. The reduction in LOS was 1.30 days (95% C.I. 0.1–2.5), resulting in an observed percentage decrease of 11.9% (p value = 0.032), for ICH and 2.07 days (95% C.I. 0.1–4.0), resulting in an observed percentage decrease of 26.3% (p value = 0.034), for PE when comparing the pre-AI and post-AI time periods. …”
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Ge-gen decoction alleviates primary dysmenorrhoea symptoms in a rat model by Yazhen Xie, Haifeng Xu, Zhijuan Gu

“…Additionally, GGD increased β-EP content and inhibited ERK1/2 activation and ERα expression in uterine tissues.Conclusions The results of this study suggest that GGD alleviates PD in rats by suppressing the COX-2-mediated release of PGE2 and PGF2α, modulating the ERα/ERK1/2/COX-2 pathway, and increasing β-EP content. …”
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The Effects of Noxious Electrical Stimulation and Eccentric Exercise on Mechanical and Thermal Pain Sensitivity in Recreational Runners with Achilles Tendinopathy by Scott K. Stackhouse, Brian J. Eckenrode, Kathleen C. Madara

“…Both exercise and electrical stimulation have the potential to modulate the nervous system’s sensitivity to painful stimuli…”
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Daclatasvir and Sofosbuvir Therapy Enhance Monocyte Phenotypic Changes in Naive Chronic Hepatitis C Patients: A Prospective Cohort Study by Hanan M. Fayed, Ali A. Ghweil, Mona M. AbdelMeguid

“…SOF/DCV therapy efficiently decreases viral load, reduces fibrosis potentials, attenuates monocyte activation, normalizes monocytes phenotypic abnormalities, and modulates monocyte subsets recruitment and differentiation later in the liver.…”
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Role of Cerebellum in the Treatment of Dystonia and Application of Cerebellum Transcranial Magnetic Stimulation by WENG Yajing, WU Yi, LIU Gang, CHENG Huilan, XIE Hongyu, TIAN Shan

“…Based on the theory of cerebellar-brain inhibition, TMS can improve symptoms by modulating cerebellar-brain inhibition. Stimulation of the cerebellar cortex by iTBS can inhibit the development of subsequent associative plasticity in the motor cortex, whereas inhibition of the cerebellar cortex by cTBS can enhance subsequent plasticity in the motor cortex. …”
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Spatio-Temporal Dynamics of Sediment Transport Pathways: Sand Apron Bars and Islands of Tokelau and Kiribati, Central Pacific by Eugene C. Rankey, Tion Uriam, Mika Perez

“…Although sea-level change likely plays a modulating role, much of the considerable spatial and temporal variability relates to differences in energy controlled by seasonal change in swell direction and climate shifts. …”
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Exploring Heat-Response Mechanisms of MicroRNAs Based on Microarray Data of Rice Post-meiosis Panicle by Yan Peng, Xianwen Zhang, Yuewu Liu, Xinbo Chen

“…Finally, a heat-induced miRNA-PPI (protein-protein interaction) network was constructed, and three miRNA coregulatory modules were discovered.…”
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Automated Phenotypic Analysis of Mature Soybean Using Multi-View Stereo 3D Reconstruction and Point Cloud Segmentation by Daohan Cui, Pengfei Liu, Yunong Liu, Zhenqing Zhao, Jiang Feng

“…This network enhances feature extraction capabilities through the integration of point cloud and voxel convolution, as well as an orientation-encoding (OE) module. Finally, phenotypic parameters such as stem diameter, pod length, and pod width are extracted and validated against manual measurements. …”
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Seed priming and abiotic stress tolerance in carrot: Unraveling the mechanisms of improved germination. by Marcin Nowicki, Marzena Nowakowska, Katarzyna Nowak, Wojciech Szczechura, Piotr Kaminski

“…Seed priming agents were hypothesized to enhance stress tolerance by modulating specific cellular and biochemical pathways, such as improving osmotic balance, enhancing antioxidant defense mechanisms, and activating stress-responsive genes. …”
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Use of the LCM Model in the prospective simulation of land use in the Nafoun watershed (Northern Ivory Coast) by Kamagate Anzoumanan, Koffi Ehouman Serge, Koffi Yao Blaise

“…The Land Change Modeler (LCM) was therefore used. LCM is a module integrated into a Geographic Information System (GIS) and TerrSet geospatial modeling system, assimilated to the Multi- Layer Perceptron (MLP) and the CA_Markov chain for analysis and prediction of land use change and assessment of environmental implications. …”
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LncRNA GAS5 reduces blood glucose levels and alleviates renal fibrosis in diabetic nephropathy by regulating the miR-542-3p/ERBB4 axis by Qinghua Yin, Na Guo, Ruoxi Liao

“…LncRNA GAS5 could bind to miR-542-3p and miR-542-3p further modulating ERBB4 expression. Up-regulation of miR-542-3p neutralized the suppressive effect of lncRNA GAS5 overexpression and down-regulation of ERBB4 also counteracted the inhibitory impact of down-regulation of miR-542-3p on renal fibrosis in DN mice. …”
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The antibiotic procurement saga: a long-neglected stewardship target to combat antimicrobial resistance in Pakistan by Shairyar Afzal, Mishal Bajwa, Nabeel Ahmed, Jawaria Jabeen, Mian Shahzeb Haroon, Rana Muhammad Zahid Mushtaq, Zikria Saleem

“…However, flawed procurement modules result in poor antibiotic supply management within health facilities of low- and middle-income countries (LMICs), including Pakistan, exacerbating antimicrobial resistance (AMR). …”
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Prevention and Control of Losses of Gaseous Nitrogen Compounds in Livestock Operations: A Review by A.A. Jongebreur, G.J. Monteny

“…Monteny[3] has built an NH3 production model with separate modules for the emission of the manure storage under the dairy house and the floor in the house. …”
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Combined effects of topography, soil moisture, and snow cover regimes on growth responses of grasslands in a low- mountain range (Vosges, France) by P.-A. Herrault, A. Ullmann, D. Ertlen

“…Through the use of winter habitat indices, we noted high responsiveness of low-mountain grasslands to differences in intra-seasonal snow regimes, partly modulated by topographic features. Prolonged and time-continuous snow cover promotes higher peak productivity and shortened green-up periods. …”
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