Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice by Wanying Cheng, Cenzhu Wang, Meican Ma, Yu Zhou

“…Moreover, HU treatment significantly inhibited the mTOR signaling pathway in both in both in vivo and in vitro experiments.ConclusionThis study unveils a new role of HU in alleviating diabetic kidney disease by modulating inflammation and apoptosis through the mTOR-S6K pathway. …”
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Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion by Yao Liu, Qiong Zhou, Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue

“…Mechanistically, lactate modulated the gene transcription of transcription factor nuclear factor-κB p65 (NF-κB p65) through histone H3K18 lactylation (H3K18la), subsequently upregulating the gene expression of TNFR2 and expediting the progression of MPE. …”
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Distinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headache by Gurueswar Nagarajan, Yumin Zhang

“…Conclusions Transcriptomics analysis indicated that non-neuronal cells in peripheral TG and successive in situ assays revealed that glia in the central Sp5C are crucial in modulating headache-like symptoms. Thus, selective targeting of glia cells can be a therapeutic strategy for PTH attributed to repetitive mTBI.…”
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Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD+ metabolism by Markus Brüll, Selina Multrus, Michael Schäfer, Ivana Celardo, Christiaan Karreman, Marcel Leist

“…Various modifications of NAD+ metabolism known to modulate SARM1 activity showed the corresponding effects on ND. …”
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Melittin ameliorates schistosomiasis-induced liver fibrosis by suppressing signal transducer and activator of transcription 3 and nuclear factor kappa B by Ola I. Rozik, Manal M. Hussein, Ahmed S. El-elebiarie, Soad Nady

“…Conclusion According to the findings of this study, MEL alleviates the degree of hepatic inflammation in a mouse model of S. mansoni-induced liver fibrosis by modulating inflammation through suppression of STAT3 and NF-κB.…”
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TWIN-10: protocol for a 10-year longitudinal twin study of the neuroscience of mental well-being and resilience by Robin M Turner, Haeme R P Park, Leanne M Williams, Justine M Gatt

“…Genetic and/or environmental factors may also modulate these mechanisms. The aim of the TWIN-10 Study is to characterise the trajectories of well-being and resilience over 12 years across four timepoints (baseline, 1 year, 10 years, 12 years) in 1669 Australian adult twins of European ancestry (to account for genetic stratification effects). …”
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Implemetasi Komputasi Akar Kuadrat Resolusi Tinggi pada Field Programmable Gate Array (FPGA) by Muhammad Irfan, Hendra Setiawan

“…Proses verifikasi sistem dilakukan dalam dua tahap, yaitu verifikasi fungsional dengan aplikasi ModelSim-Altera dan verifikasi hardware menggunakan modul FPGA Cylcone IV EP4CE6E228N. Hasil verifikasi menunjukkan bahwa hasil perhitungan akar kuadrat memiliki resolusi sampai dengan 0,0039. …”
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Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities. by Alok Kafle, Sutas Suttiprapa, Mubarak Muhammad, Jan Clyden B Tenorio, Roshan Kumar Mahato, Norhidayu Sahimin, Shih Keng Loong

“…Promoter hypermethylation of specific genes suggests potential diagnostic biomarkers and dysregulation of Wnt/β-catenin-modulating genes contributes to pathway activation in Ov-CCA progression. …”
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IGAF: Incremental Guided Attention Fusion for Depth Super-Resolution by Athanasios Tragakis, Chaitanya Kaul, Kevin J. Mitchell, Hang Dai, Roderick Murray-Smith, Daniele Faccio

“…Our key contribution is the Incremental guided attention fusion (IGAF) module, which effectively learns to fuse features from RGB images and LR depth maps, producing accurate HR depth maps. …”
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The Response of Tissue Mast Cells to TLR3 Ligand Poly(I:C) Treatment by Piotr Witczak, Ewa Brzezińska-Błaszczyk, Justyna Agier

“…Our findings confirm that MCs may serve as active participants in the antiviral immune response. Presented data on modulated FcεRI-mediated MC secretion of mediators upon poly(I:C) treatment suggests that dsRNA-type virus infection could influence the severity of allergic reactions.…”
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The role of SASP in ischemic stroke: a deep dive into cellular mechanisms by Dong Xie, Yang Liu, Fang-Biao Xu, Jin-Sheng Zhang

“…Ccl3 and Lcp1 might potentially modulate IS progression by influencing SASP, proffering novel prospects for IS clinical diagnosis and treatment.…”
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Multi-view knowledge representation learning for personalized news recommendation by Chao Chang, Feiyi Tang, Peng Yang, Jingui Zhang, Jingxuan Huang, Junxian Li, Zhenjun Li

“…The MKRL framework innovatively integrates convolutional neural networks with multi-head attention modules to capture intricate contextual information from both user history and candidate news, allowing the model to recognize fine-grained patterns. …”
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Evidence from NHANES 2011–2014: a correlation between the weight-adjusted-waist index and cognitive abilities in the United States by Chan Zhao, Xintian Xu, Chunyan Hao

“…Three cognitive assessments were administered: the Animal Fluency Test (AFT), the Digit Symbol Substitution Test (DSST), and the Word Learning and Recall Module from the Coalition to Establish a Registry for Alzheimer’s Disease (CERAD). …”
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A Morphometric Approach to Bozkurt (Kastamonu-Türkiye) Flood by Vedat Avci, Ömer Ünsal

“…The Digital Elevation Model (DEM) of the study area was created with a cell size of 10*10 m using topography maps, and the boundaries of the basins to be analyzed with the ArcGIS-Archydro Module were determined. 30 indices were applied to these basins within the scope of shape (geometric), areal and relief morphometric features of the basins. …”
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Criteria for Detecting Turn-To-Turn Short Circuit in Stator Windings Using Vector Analysis of Electric Motor Phase Currents by I. V. Zhezhelenko, V. E. Kryvonosov, S. V. Vasilenko

“…Analytical results of the dependence of the sensitivity coefficient for turn-to-turn short circuit on the absolute increment of the modules of phase currents and the corresponding phase angles have been obtained.…”
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Employing ICTS: Teaching & Learning through Literature Digital Reading (LDR) by Aba-Carina Pârlog

“…It was made available for training participants as part of Project Result 2, Module 5 (Creating Digital Stories: Story Writing Toolkit for Teachers) on the project platform. …”
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Accounting treatment of tax credits arising from the exclusion of ICMS from the PIS and COFINS calculation base of publicly traded companies by Douglas Willian Nascimento Schmidt, José Antonio Cescon, Antônio Carlos Brunozi Junior, Julio César Ferreira

“… Purpose: The objective of the study was to demonstrate the accounting treatment adopted by companies listed on B3, Novo Mercado, regarding the dispute over the exclusion of ICMS from the PIS and COFINS calculation basis, as well as demonstrating the change in accounting treatment, following the decision of the Federal Supreme Court, favorable to companies in 2017, modulated in 2021. Methodology: This research has a descriptive, documentary, and qualitative nature. …”
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m6A-modified lncRNA GAS5 promotes M1-polarization of microglia in alcohol use disorder by Shuang Zhu, Peng Wang, Jian Hu

“…Long noncoding RNA (lncRNA) are essential for modulating the onset and progression of alcohol use disorder (AUD). …”
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Nitrogen and water additions with or without mowing altered soil microbial community characteristics in a semi-arid steppe by Hao Liu, Feirong Ren, Shiqiang Wan, Shijie Han, Junqiang Zheng

“…Combination effects of N with precipitation or clipping on module aggregation of meta-networks were also observed between uC and CL, as well as aP and eP meta-networks. …”
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Mixture of MMP-2, MLC, and NOS Inhibitors Affects NO Metabolism and Protects Heart from Cardiac I/R Injury by Anna Krzywonos-Zawadzka, Aleksandra Franczak, Grzegorz Sawicki, Iwona Bil-Lula

“…The aim of the current study was to provide an important insight into understanding the interaction of iNOS, eNOS, and ADMA during oxidative stress and to propose the beneficial therapy to modulate this interaction. Material and Methods. Pathogen-free Wistar rats were used in this study as a surrogate heart model ex vivo. …”
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