Altered Viral Replication and Cell Responses by Inserting MicroRNA Recognition Element into PB1 in Pandemic Influenza A Virus (H1N1) 2009 by Xiaoyue Shen, Wenkui Sun, Yi Shi, Zheng Xing, Xin Su

“…MicroRNAs (miRNAs) are endogenous noncoding RNAs that spatiotemporally modulate mRNAs in a posttranscriptional manner. Engineering mutant viruses by inserting cell-specific miRNA recognition element (MRE) into viral genome may alter viral infectivity and host responses in vital tissues and organs infected with pandemic influenza A virus (H1N1) 2009 (H1N1pdm). …”
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6‐Nitrodopamine potentiates catecholamine‐induced contractions of human isolated vas deferens by Antonio Tiago Lima, Sami Jabbour, José Britto‐Júnior, Demétrio Martinho Ramos deCarvalho, Adriano Fregonesi, Fernanda V. Mariano, Valéria Barbosa deSouza, Andre Almeida Schenka, Edson Antunes, Gilberto De Nucci

“…The results clearly demonstrate that epithelium‐derived 6‐ND is a major modulator of human vas deferens contractility.…”
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A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas by Kun Xiao, Yan Cao, Zhihai Han, Yuxiang Zhang, Laurence Don Wai Luu, Liang Chen, Peng Yan, Wei Chen, Jiaxing Wang, Ying Liang, Xin Shi, Xiuli Wang, Fan Wang, Ye Hu, Zhengjun Wen, Yong Chen, Yuwei Yang, Haotian Yu, Lixin Xie, Yi Wang

“…Together, these findings highlight potential therapeutic targets for modulating immune responses and improving clinical outcomes in bacterial pneumonia.…”
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STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines by Pan Jiang, Huai Huang, Zilong Liu, Guiling Xiang, Xiaodan Wu, Shengyu Hao, Shanqun Li

“…STAT6 is crucial in the signaling pathway that modulates immune response. However, the status of phosphorylated STAT6 (p-STAT6) in an OSA-induced PH mouse model remains largely unexplored. …”
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Effects of Artemisia argyi leaf water extract (AWE) on growth performance, muscle quality, intestinal microbial, and metabolomics of common carp (Cyprinus carpio) by Di Sun, Nanyang Zeng, Yingjia Pan, Qingsong Shu, Jixing Zou, Yingshi Huang, Guoxia Wang, Jun Shi

“…Analysis of intestinal microbiota revealed that Cetobacterium and Aeromonas may play crucial roles as genus-level microorganisms in modulating metabolic processes associated with AWE in carp intestines. …”
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Arbuscular mycorrhizal colonization defines root ecological strategies in an extreme arid environment by Cristian A. Delpiano, Cristian A. Delpiano, Cristian A. Delpiano, Rodrigo S. Rios, Rodrigo S. Rios, Rodrigo S. Rios, Claudia E. Barraza-Zepeda, Melissa J. Pozo, Lorgio E. Aguilera, Andrea P. Loayza, Andrea P. Loayza, Andrea P. Loayza

“…These findings emphasize the critical importance of colM in modulating plant ecological strategies and highlight the need to further investigate how AM enhances root lifespan and optimizes resource uptake in extreme environments.…”
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Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis by Huann-Cheng Horng, Jin-Wei Xu, Yi-Shan Kuo, Yu-Sin Chen, Yu-Hsuan Chiu, Kuan-Hao Tsui, Yu-Tang Tung

“…This study underscores the potential of microbiome-modulating strategies in managing vaginal infections, paving the way for more targeted and side-effect-free VVC treatments.…”
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3D Point Cloud from Millimeter-wave Radar for Human Action Recognition: Dataset and Method by Biao JIN, Kangsheng SUN, Hao WU, Zixuan LI, Zhenkai ZHANG, Yan CAI, Rongmin LI, Xiangqun ZHANG, Genyuan DU

“…Data collection is conducted using Texas Instruments (TI)’s IWR1443-ISK and Vayyar’s vBlu radio imaging module, covering 12 common human actions, including walking, waving, standing, and falling. …”
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Optimized Gross Primary Productivity Over the Croplands Within the BEPS Particle Filtering Data Assimilation System (BEPS_PF v1.0) by Xiuli Xing, Mousong Wu, Huajie Zhu, Wenzhuo Duan, Weimin Ju, Xiaorong Wang, Youhua Ran, Yongguang Zhang, Fei Jiang

“…Abstract Agricultural ecosystems play an important role in modulating the global carbon balance by taking up atmospheric carbon dioxide, while large differences and uncertainties exist in the estimated crop gross primary productivity (GPP) by terrestrial ecosystem models (TEMs). …”
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Comprehensive analysis of the succinylome in Vero cells infected with peste des petits ruminants virus Nigeria 75/1 vaccine strain by Xuelian Meng, Xueliang Zhu, Xiangwei Wang, Rui Zhang, Zhidong Zhang, Yuefeng Sun

“…Protein-protein interaction networks of the identified proteins provided further evidence that various ATP synthase subunits and carbon metabolism were modulated by succinylation, while the overlapped proteins between succinylation and acetylation are involved in glyoxylate and dicarboxylate metabolism. …”
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LiDAR point cloud denoising for individual tree extraction based on the Noise4Denoise by Xiangfei Lu, Zongyu Ye, Liyong Fu, Huaiyi Wang, Kaiyu Wang, Yaquan Dou, Dongbo Xie, Xiaodi Zhao

“…The processing of LiDAR point cloud data is of critical importance in the context of forest resource surveys, as well as representing a pivotal element in the realm of forest physiological and ecological studies.Nonetheless, conventional denoising algorithms frequently exhibit deficiencies with regard to adaptability and denoising efficacy, particularly when employed in relation to disparate datasets.To address these issues, this study introduces DEN4, an unsupervised, deep learning-based point cloud denoising algorithm designed to improve the accuracy of single tree segmentation in LiDAR point clouds.DEN4 introduces a multilevel noise separation module that effectively distinguishes between signal and noise, thereby improving the signal-to-noise ratio (SNR) and reducing the error.The experimental results demonstrate that DEN4 significantly outperforms traditional denoising methods in several key metrics, including mean square error (MSE), SNR, Hausdorff distance, and structural similarity index (SSIM).In the 60 sample dataset, DEN4 achieved the best mean and standard deviation on all metrics: Specifically, the MSE mean was found to be 0.0094, with a standard deviation of 0.0008, the SNR mean was 149.1570, with a standard deviation of 0.5628, the Hausdorff mean was 0.8503, with a standard deviation of 0.0947, and the SSIM mean was 0.8399, with a standard deviation of 0.0054. …”
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HIV-Envelope–Dependent Cell-Cell Fusion: Quantitative Studies by Leonor Huerta, Nayali López-Balderas, Evelyn Rivera-Toledo, Guadalupe Sandoval, Guillermo Gómez-Icazbalceta, Carlos Villarreal, Edmundo Lamoyi, Carlos Larralde

“…We have shown that such a flow-cytometry assay is appropriate for the screening of compounds that have the potential to modulate HIV-Env–mediated cell fusion. Even those syncytia that are small or few in numbers can be detected. …”
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MSF-GhostNet: Computationally Efficient YOLO for Detecting Drones in Low-Light Conditions by Maham Misbah, Misha Urooj Khan, Zeeshan Kaleem, Ali Muqaibel, Muhamad Zeshan Alam, Ran Liu, Chau Yuen

“…To address these challenges, we present an improved YOLOv5 architecture named multiscale feature map GhostNet (MSF-GhostNet) by introducing GhostConv and C3Ghost modules to reduce the redundant operations in the head and neck. …”
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Milk fat globule membrane supplementation protects against β-lactoglobulin-induced food allergy in mice via upregulation of regulatory T cells and enhancement of intestinal barrier... by Han Gong, Tiange Li, Dong Liang, Jingxin Gao, Xiaohan Liu, Xueying Mao

“…Results demonstrated that MFGM alleviated food allergy symptoms, decreased serum levels of lipopolysaccharide, pro-inflammatory cytokines, immunoglobulin (Ig) E, IgG1, and Th2 cytokines including interleukin (IL)-4, while increased serum levels of Th1 cytokines including interferon-γ and regulatory T cells (Tregs) cytokines including IL-10 and transforming growth factor-β. MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice, as evidenced by decreased relative abundance of Desulfobacterota, Rikenellaceae, Lachnospiraceae, and Desulfovibrionaceae, while increased relative abundance of Bacteroidetes, Lactobacillaceae and Muribaculaceae, and enhanced expressions of tight junction proteins including Occludin, Claudin-1 and zonula occludens-1. …”
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Estimation of the drift velocity of Equatorial Plasma Bubbles using GNSS and digisonde data by Navas-Portella Víctor, Altadill David, Blanch Estefania, Altadill Mar, Segarra Antoni, de Paula Víctor, Timoté Cristhian Camilo, Juan José Miguel

“…Equatorial Plasma Bubbles (EPBs) play a crucial role in modulating plasma density and electron content within the equatorial ionosphere. …”
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Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications by Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase

“…Intestinal microbiota can be modulated by changing one’s lifestyle but also by antibiotic, probiotic, prebiotic, and fecal transplantation. …”
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A Lightweight YOLO Model for Rice Panicle Detection in Fields Based on UAV Aerial Images by Zixuan Song, Songtao Ban, Dong Hu, Mengyuan Xu, Tao Yuan, Xiuguo Zheng, Huifeng Sun, Sheng Zhou, Minglu Tian, Linyi Li

“…Additionally, we integrate a Normalization-based Attention Module (NAM) and introduce a Minimum Point Distance-based IoU (MPDIoU) loss function to further improve the detection capability. …”
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A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms by David Trombley McSwiggen, Helen Liu, Ruensern Tan, Sebastia Agramunt Puig, Lakshmi B Akella, Russell Berman, Mason Bretan, Hanzhe Chen, Xavier Darzacq, Kelsey Ford, Ruth Godbey, Eric Gonzalez, Adi Hanuka, Alec Heckert, Jaclyn J Ho, Stephanie L Johnson, Reed Kelso, Aaron Klammer, Ruchira Krishnamurthy, Jifu Li, Kevin Lin, Brian Margolin, Patrick McNamara, Laurence Meyer, Sarah E Pierce, Akshay Sule, Connor Stashko, Yangzhong Tang, Daniel J Anderson, Hilary P Beck

“…Kinetic htSMT experiments were capable of distinguishing between on-target and on-pathway modulators of ER signaling. Integrated pathway analysis recapitulated the network of known ER interaction partners and suggested potentially novel, kinase-mediated regulatory mechanisms. …”
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Prospects for mine geological work in the intelligence age: Architecture of the intelligent geological guarantee technology system for mine exploitation by Yucheng XIA, Xueyang SUN, Lintian MIAO, Chen GUO, Rongjun DU

“…., the intelligent management subsystem for fundamental geological survey information, the intelligent prediction and early warning subsystem for geologic hazards in mines, the intelligent monitoring, prediction, and early warning subsystem for ecosystems in mining areas, the intelligent identification subsystem for favorable mining blocks, and the transparent mining face subsystem), as well as their core modules. ConclusionsNotably, with the constant advancements in technologies for geological explorations and detections, the effectiveness of the technology system depends on the accuracy and reliability of original data, ultimately relying on the number and professional quality of personnel engaged in geological surveys. …”
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Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2 by Jiaqi Sheng, Depei Wu, Jingzhe Shang, Xiaodan Fu, He Gao, Jianjie Rong, Jun Wang, Jiancheng Hu, Xiaofei Qi

“…In conclusion, Usp11 played a crucial role in modulating immune system damage induced by ionizing radiation, primarily through ubiquitination of Notch ligands. …”
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