Adaptation of an additively manufactured reactor concept for catalytic methanation with in-situ tar co-reforming of biogenic syngas by Jakob Müller, Alexander Feldner, Simon Markthaler, Peter Treiber, Jürgen Karl

“…ADDmeth3.1 uses a dedicated internal channel structure that serves as a counter-current heat exchanger for the feed gas, whereas ADDmeth3.2 is optimized to fill the triangular footprint of a scalable reactor module as best as possible. Both designs were subject to a preliminary feasibility study, to ensure sufficient heat removal and a finite element analysis regarding structural stability was performed. …”
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Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression by Li Xiang, Wenxu Pan, Huan Chen, Wenjun Du, Shuping Xie, Xinhua Liang, Fangying Yang, Rongwei Niu, Canxin Huang, Minan Luo, Yuxin Xu, Lanlan Geng, Sitang Gong, Wanfu Xu, Junhong Zhao

“…Real-time polymerase chain reaction, immunofluorescence, and western blotting were performed to analyze the effect of sorbitol-regulated M-cell differentiation in vivo and in vitro, and luciferase and chromatin Immunoprecipitation were used to reveal the mechanism through which sorbitol-modulated M-cell differentiation. Results. Herein, in comparison to the mannitol group (control group), we found that intestinal M-cell development was inhibited in response to sorbitol treatment as evidenced by impaired enteroids accompanying with decreased early differentiation marker Annexin 5, Marcksl1, Spib, sox8, and mature M-cell marker glycoprotein 2 expression, which was attributed to downregulation of receptor activator of nuclear factor kappa-В ligand (RANKL) expression in vivo and in vitro. …”
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Bidirectional approach of Punica granatum natural compounds: reduction in lung cancer and SARS-CoV-2 propagation by Md. Abul Barkat, Afreen Fatima, Bushra Riaz, Mohd. Zaheen Hassan, Tanveer Ahamad, Abdulkareem A. Alanezi, Harshita Barkat, Afaf F. Almuqati, Yahya I. Asiri, Sahabjada Siddiqui

“…Cytotoxicity was analyzed using MTT dye, followed by apoptosis, ROS generation, and cell cycle phase detection in human lung cancer cells (A549). The glide module of Maestro software was used to investigate the molecular-docking interaction of the constituents against main protease (Mpro) and papain-like protease (PLpro) of SARS-CoV-2. …”
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Insights from the single-cell level: lineage trajectory and somatic-germline interactions during spermatogenesis in dwarf surfclam Mulinia lateralis by Yajuan Li, Huilan Wei, Xiaoting Dai, Lijing Zhang, Liangjie Liu, Xiaomei Chen, Tian Liu, Ya Shu, Yaxin Yang, Shi Wang, Zhenmin Bao, Lingling Zhang

“…Weighted gene coexpression network analysis (WGCNA) identified four modules corresponding to the four types of germ cells, as well as key transcription factors (e.g., MYC, SREBF1, SOXH) that may play a critical role in these cell types. …”
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Resveratrol Alleviates NEFA-Induced Oxidative Damage in Bovine Mammary Epithelial Cells by Restoring Mitochondrial Function by Longwei Sun, Junpeng Huang, Xiangyang Dou, Zhenyu Dong, Yuan Li, Shujing Tan, Ran Yu, Chengmin Li, Weiguo Zhao

“…Overall, these findings suggested that RES could alleviate NEFA-induced oxidative damage in BMECs by modulating mitochondrial function, thereby contributing to the prevention and treatment of oxidative damage in perinatal dairy cows with a negative energy balance.…”
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Classification of Cigarette Types Using Computer Vision: An Analysis of Smoke Aggregation Features by Shishuan Guan, Lei Jiao, Zengyu Wang, Xiaofei Ji, Hongwei Zheng, Cunfeng Yu, Hongtao Li, Liwen Zheng, Shuaishuai Sun, Qiang Sun, Jun Li, Guangwei Jiang, Kezhi Wu, Erge Lin, Xinlong Zhang

“…In order to further improve the performance, we build SmokeSeqNetV2 model to continue the experiment, which introduces Swin-Transformer feature extraction module and attention mechanism, and the final accuracy rate reaches 88.9%. …”
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Preclinical evaluation of the potential PARP-imaging probe [carbonyl-11C]DPQ by Katarína Benčurová, Theresa Balber, Victoria Weissenböck, Lukas Kogler, Joachim Friske, Verena Pichler, Markus Mitterhauser, Marcus Hacker, Cécile Philippe, Marius Ozenil

“…Results [carbonyl-11C]DPQ was synthesised in a GE TracerLab FXC2 module, yielding sufficient activity (940 ± 410 MBq), molar activity (53 ± 16 GBq/µmol) and radiochemical purity (> 97%) for subsequent preclinical evaluation. …”
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The Combination of Shading and Potassium Application Regulated the Bulb Active Ingredients Accumulation in <i>Fritillaria thunbergii</i> Miq. by Affecting Rhizosphere Microecology by Leran Wang, Bingbing Liang, Jia Liu, Huizhen Jin, Zixuan Zhu, Siyu Hao, Shumin Wang, Xiaoxiao Sheng, Xinshu Zhou, Honghai Zhu, Ning Sui

“…</i> The combination of shading and K application may regulate the accumulation of medicinal substances in <i>F. thunbergii</i> by modulating the structure of the soil microbial community. …”
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Maladaptive changes in the homeostasis of AEA-TRPV1/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury by JiaQi Hu, WenYong Fan, Yue Xu, XiaoFei Li, HaoYang Zhang, Shun Li, Lei Xue

“…Anandamide (AEA) has been reported to modulate neuronal excitability and synaptic transmission through activation of cannabinoid type-1 receptors (CB1Rs) and transient receptor potential vanilloid 1 (TRPV1). …”
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Characterization of MADS-Box Gene Family in <i>Isatis indigotica</i> and Functional Study of <i>IiAP1</i> in Regulating Floral Transition and Formation by Yanqin Ma, Yanhong Lan, Ju Li, Haicheng Long, Yujie Zhou, Zhi Li, Mingjun Miao, Jian Zhong, Haie Wang, Wei Chang, Ziqin Xu, Liang Yang

“…<i>APETALA1</i> (<i>AP1</i>) encodes a MADS-box transcription factor which plays a pivotal role in determining floral meristem identity and also modulates developmental processes within the perianth. …”
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Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA by Tobias Solli Iveland, Lars Hagen, Mirta Mittelstedt Leal de Sousa, Nina Beate Liabakk, Per Arne Aas, Animesh Sharma, Bodil Kavli, Geir Slupphaug

“…The potential of HDACis to modulate pyrimidine metabolism and DNA damage responses offers novel strategies for improving NSCLC outcomes.…”
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HBV and HBsAg strongly reshape the phenotype, function, and metabolism of DCs according to patients’ clinical stage by Lucile Dumolard, Theophile Gerster, Florent Chuffart, Thomas Decaens, Marie-Noelle Hilleret, Sylvie Larrat, Philippe Saas, Evelyne Jouvin-Marche, David Durantel, Patrice N. Marche, Zuzana Macek Jilkova, Caroline Aspord

“…Methods:. We explored DC modulations by HBV and HBsAg by exposing blood-derived cDC1s, cDC2s, and plasmacytoid DCs from healthy donors to HBV or HBsAg and stimulating them with toll-like receptor ligand. …”
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Effects of Macleaya cordata extract supplementation in low-protein, low-fishmeal diets on growth, hematology, intestinal histology, and microbiota in largemouth bass (Micropterus s... by Wenyuan Xu, Ruijun Zhu, Dianyu Huan, Xiaoqin Li, Xiangjun Leng

“…In summary, supplementing MCE in low-protein diet significantly improved the weight gain (P < 0.05), and MCE supplementation in low-protein or low-fishmeal diet could modulate the intestinal microbiota composition and reduce the inflammation factors expression in largemouth bass.…”
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Chronic Inhibition of FAAH Reduces Depressive-Like Behavior and Improves Dentate Gyrus Proliferation after Chronic Unpredictable Stress Exposure by A. R. Tejeda-Martínez, J. M. Viveros-Paredes, G. V. Hidalgo-Franco, E. Pardo-González, V. Chaparro-Huerta, R. E. González-Castañeda, M. E. Flores-Soto

“…Levels of the endocannabinoid anandamide (AEA) seem to affect these depression-by-stress-related features and could be modulated by fatty acid amide hydrolase (FAAH). We aimed to evaluate the effects of FAAH inhibitor, URB597, on depressive-like behavior and neural proliferation of mice subjected to a model of CUS. …”
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Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line by Mohammed Nihal Hasan, Syed Shoeb Razvi, Hani Choudhry, Mohammed A. Hassan, Said Salama Moselhy, Taha Abduallah Kumosani, Mazin A. Zamzami, Khalid Omer Abualnaja, Majed A. Halwani, Abdulrahman Labeed Al-Malki, Jiannis Ragoussis, Wei Wu, Christian Bronner, Tadao Asami, Mahmoud Alhosin

“…Several epigenetic modulators such as UHRF1, HDAC7, and DNMT1 were also considerably downregulated, and this effect was associated with significant upregulation of various proapoptotic genes including CASP3, TNF-α, CASP7, and CDKN1A (p21). …”
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Evaluating the Constructive Alignment of Learning Objectives Within Haptics Simulation in the Dental Undergraduate Curriculum by Susha Rajadurai, Tapan Hebballi, Zahra Sharif, Guneet Kaur Kukreja, Ithar Derdour

“…Method: The study incorporated a mixed methods approach to evaluate a module already taking place, which was completed from the perspectives of both the investigators and the students themselves through the triangulation of noninterventional classroom observational data, anonymous Likert-scale questionnaire data, and a literature review. …”
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Transparent Celadon with Phase-Separated Structure: Study on the Technological Characteristics and Coloring Mechanism of Celadons from the Lieshan Kiln by Qijiang Li, Jingyun Wang, Chao Chen, Tao Fang, Chenyi Gao, Jinwei Li

“…Glaze coloration was modulated by the interaction of Fe³⁺ and Fe²⁺ ions, and chemical coloration by Fe ions prevailed when phase-separated particles were minute enough to avoid Rayleigh or Mie scattering. …”
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Predicting hepatocellular carcinoma outcomes and immune therapy response with ATP-dependent chromatin remodeling-related genes, highlighting MORF4L1 as a promising target by Chao Xu, Litao Liang, Guoqing Liu, Yanzhi Feng, Bin Xu, Deming Zhu, Wenbo Jia, Jinyi Wang, Wenhu Zhao, Xiangyu Ling, Yongping Zhou, Wenzhou Ding, Lianbao Kong

“…Conclusion ACRRGs, particularly MORF4L1, play crucial roles in modulating HCC progression, offering new insights into the molecular mechanisms driving HCC and potential therapeutic targets. …”
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HIV and the gut microbiome: future research hotspots and trends by Zhen Wu, Zhan-Peng Xie, Xin-Xin Cui, Xiang-Bin Sun, Fang-Yi Zhao, Nuo Wang, Yu Li, Yu Li, Yu Li, Haixia Wang, Haixia Wang, Haixia Wang, Li Zhang, Li Zhang, Li Zhang, Jing Shen, Fulei Chen, Haogang Sun, Jia He, Jia He, Jia He

“…BackgroundThe use of highly active antiretroviral therapy has transformed AIDS into a chronic infectious disease, but issues of chronic inflammation and immune system activation persist. Modulating the gut microbiome of patients may improve this situation, yet the specific association mechanisms between HIV and the gut microbiome remain unclear. …”
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Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells by Zhen Yu, Xianfeng Wang, Yusen Hu, Xinfa Wang, Zhenghuan Zhu, Xu Xu, Yiming Wang, Ailiang Zhang

“…Results: High glucose decreased the viability and induced ER stress-related apoptosis in NP cells. Quercetin modulated ER stress through the PERK-eIF2α-ATF4 pathway, thereby alleviating the apoptosis rank in NP cells. …”
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