Activation of the periaqueductal gray controls respiratory output through a distributed brain network by Mitchell Prostebby, Jashan Saini, Vivian Biancardi, Vivian Biancardi, Vivian Biancardi, Clayton T. Dickson, Clayton T. Dickson, Clayton T. Dickson, Clayton T. Dickson, Silvia Pagliardini, Silvia Pagliardini, Silvia Pagliardini

“…Through cFOS mapping, we also identified key downstream brain regions which were likely modulated by PAG activation including the preBötzinger Complex (preBötC) and the lateral parafacial area (pFL). …”
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Immunotherapy in Recurrent Ovarian Cancer by Keyao Chen, Jingjing Wang, Meng Yang, Shaoqiong Deng, Li Sun

“…Immunotherapy offers potential advantages in modulating the immune response against tumor cells and has emerged as a promising strategy in ovarian cancer management. …”
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Resiquimod induces a mixed Th1 and Th2 response via STAT1 and STAT3 signalling in chickens by Deepthi Kappala, Saravanan Ramakrishnan, Patel Nikunjkumar Prakashbhai, Abinaya Kaliappan, Prasad Thomas, Jörg Linde, Mithilesh Singh, Sohini Dey, Madhan Mohan Chellappa

“…Resiquimod (R-848), a synthetic TLR7 agonist, modulates immune responses, primarily inducing Th1-biased immunity in mammals. …”
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AMINO-GRAFTED MESOPOROUS SILICA NANOPARTICLES: ASSESSMENT OF NEUROMODULATORY, MEMBRANOTROPIC AND ANTIOXIDANT PROPERTIES IN CORTEX NERVE TERMINALS by S. O. Sotnik, I. M. Pavliei, O.O. Pariiska, Y.I. Kurys, M.V. Dudarenko, A.А. Borysov, N. V. Krisanova, N. G. Pozdnyakova, L. M. Kalynovska, M. M. Driuk, A. O. Pastukhov, A. S. Tarasenko, V. G. Koshechko, S. V. Kolotilov, T. A. Borisova

“…The model of Cd2+/Pb2+/Hg2+-induced excitotoxicity was used to assess the capability of MSN-NH2 to adsorb xenobiotic heavy metals. MSN-NH2 did not modulate the Cd2+/Pb2+/Hg2+-induced increase in the extracellular synaptosomal level of L-[14C]glutamate. …”
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Antibacterial activity and impact on keratinocyte cell growth of Cutibacterium acnes bacteriophages in a Cutibacterium acnes IA1- colonized keratinocyte model by Juan C Farfán-Esquivel, María Victoria Gutiérrez, Alejandro Ondo-Méndez, John M González, Martha J Vives-Flórez

“…Moreover, bacteriophages (phages) may modulate the microbiota and immune responses. Some studies have shown the potential use of phages in the treatment of acne. …”
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GmERF57 negatively regulates root development and phosphate absorption in soybean by Hongqing Zhu, Dandan Hu, Yifei Yang, Xuhao Zhai, Shanshan Zhang, Mengshi He, Huifang Zuo, Lina Zhang, Mengjun Xu, Shanshan Chu, Haiyan Lü, Hengyou Zhang, Yu Zhang, Dan Zhang

“…We further uncovered that GmERF57 physically interacts with GmTUB1 (β-tubulin protein) and modulates soybean root architecture and Pi uptake capacity by downregulating GmTUB1 and other Pi starvation response genes. …”
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Unveiling the potential anticancer activity of Spirulina maxima extract-nanoemulsion through in vitro and in vivo studies by Mohammed Yasser Hussein, Merna Nasr, Veronia Emad, Julie Maged, Portia George, Amina Emad, Abeer Mahmoud Badr, Mehrez E. El-Naggar, Sayeda M. Abdo, Jihan Hussein

“…The study concludes that SMNE, with its anti-inflammatory and antioxidant properties and ability to modulate key miRNAs, enhances SME delivery and shows promise as an effective cancer treatment.…”
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Effect of Kinases in Extracellular Vesicles from HIV-1-Infected Cells on Bystander Cells by Gifty A. Mensah, Anastasia Williams, Pooja Khatkar, Yuriy Kim, James Erickson, Alexandra Duverger, Heather Branscome, Kajal Patil, Hafsa Chaudhry, Yuntao Wu, Olaf Kutsch, Fatah Kashanchi

“…These kinases were shown to be biologically active and capable of phosphorylating substrates, and they modulated changes in the cell cycle dynamics of exposed cells. …”
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Enhanced interannual variability of the terrestrial carbon sink in China under high emissions by Han Wu, Li Zhang, Honglin He, Xiaoli Ren, Mengyu Zhang, Dingjin Chu, Yuanhao Zheng

“…However, how these future changes will modulate the IAV of China’s terrestrial carbon sinks remains unclear. …”
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Enhancing soybean germination and vigor under water stress: the efficacy of bio-priming with sodium carboxymethyl cellulose and gum arabic by Aisha Almakas, Aisha Almakas, Ahmed S. Elrys, Ahmed S. Elrys, El-Sayed M. Desoky, Laila A. Al-Shuraym, Sadeq K. Alhag, Mohammed O. Alshaharni, Fawze Alnadari, Zhang NanNan, Zhang NanNan, Zunaira Farooq, Zunaira Farooq, Khaled A. El-Tarabily, Tuanjie Zhao, Tuanjie Zhao

“…Seed priming can significantly enhance the tolerance of soybean against different environmental stresses by improving seed water uptake and modulating stress-response mechanisms. In particular, seed priming with sodium carboxymethylcellulose (SCMC) and gum Arabic (GA) can support seeds to withstand extreme conditions better, promoting more consistent germination and robust seedling establishment, which is crucial for achieving stable agricultural yields. …”
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Molecular insights into the functional role of PbNRT2.4 in potassium homeostasis and nutrient transport in Pyrus ussuriensis by Han Yang, Hao Xu, Yujie Shi, Liyan Chen, Lijuan Zhang, Liping Kan, Yumeng Jin, Xinlan Mei, Yangchun Xu, Nazir Ahmed, Caixia Dong

“…Interactions among PbNRT2.4, PbHAK11, and PbSDH1 proteins, elucidated using yeast two-hybrid, BiFC, and Co-IP assays, are crucial for modulating carbon and nitrogen metabolic processes, thereby harmonizing K+ absorption and transport. …”
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The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis by Paulina Marona, Rafał Myrczek, Iga Piasecka, Judyta Gorka, Oliwia Kwapisz, Ewelina Pospiech, Janusz Rys, Jolanta Jura, Katarzyna Miekus

“…These findings highlight the critical role of MCPIP1 RNase activity in modulating the c-Met/CD44 axis, thereby influencing stemness and tumorigenesis.…”
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Techno-economic analysis of cutting-edge PV systems deployment and reconfigurations on rooftop industrial building in Saudi Arabia’s eastern region by Abdulrhman Klifa Al-Hanoot, Hazlie Mokhlis, Saad Mekhilef, Mohammad Alghoul, Hussain Shareef, Zaid Alotaibi

“…By meticulously simulating and comparing five advanced PV technologies across various configurations, the research identifies the N-type Mono BIFACIAL module in the third configuration scenario as the most effective. …”
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STAT3-Inducible Mouse ESCs: A Model to Study the Role of STAT3 in ESC Maintenance and Lineage Differentiation by Yu Qian Wong, Hongyan Xu, Qiang Wu, Xinyu Liu, Chengchen Lufei, Xiu Qin Xu, Xin-Yuan Fu

“…Studies have demonstrated that STAT3 is essential in maintaining self-renewal of embryonic stem cells (ESCs) and modulates ESC differentiation. However, there is still lack of direct evidence on STAT3 functions in ESCs and embryogenesis because constitutive STAT3 knockout (KO) mouse is embryonic lethal at E6.5–E7.5, prior to potential functional role in early development can be assessed. …”
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Effects of Different Stand Densities on the Composition and Diversity of Soil Microbiota in a <i>Cunninghamia lanceolata</i> Plantation by Zuyuan Xu, Fei Fan, Qinmin Lin, Shengzhou Guo, Shumao Li, Yunpeng Zhang, Zhiyi Feng, Xingxing Wang, Christopher Rensing, Guangqiu Cao, Linkun Wu, Shijiang Cao

“…The present study demonstrated that reduced stand densities modulated soil nutrient content and enhanced bacterial diversity, thereby contributing to a more complex and stable soil ecosystem structure. …”
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The endocannabinoid system’s genetic polymorphisms in sickle cell anemia patients by Amanda Cristina Meneguetti Berti, Vanessa da Silveira Ramos de Castro, Gabriela Silva Arcanjo, Aderson da Silva Araujo, Antonio Roberto Lucena-Araujo, Marcos André Cavalcanti Bezerra, Lucas Gazarini, Danilo Grünig Humberto da Silva, Edis Belini-Júnior

“…The endocannabinoid system (ECS) could be a candidate for modulating SCA complications, such as priapism, as it has demonstrated an essential role in hematopoiesis, platelet aggregation, and immune responses. …”
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Type 2 Cytokine–Dependent Skin Barrier Regulation in Personalized 2-Dimensional and 3-Dimensional Skin Models of Atopic Dermatitis: A Pilot Study by Hila Emmert, Franziska Rademacher, Matthias Hübenthal, Regine Gläser, Hanne Norsgaard, Stephan Weidinger, Jürgen Harder

“…Similar to the 2-dimensional cultures, IL-4/IL-13 stimulation of 3-dimensional skin models generated with AD-derived KCs modulated the expression of several AD-relevant factors. …”
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Immunomodulatory Effects of Aerobic Training in Obesity by Thomas Nickel, Henner Hanssen, Ingrid Emslander, Verena Drexel, Gernot Hertel, Arno Schmidt-Trucksäss, Claudia Summo, Zeljka Sisic, Marius Lambert, Eva Hoster, Martin Halle, Michael Weis

“…We hereby describe new immune modulatory effects, which—through regular aerobic exercise—modulate innate immunity and pro-inflammatory cytokines in obesity.…”
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Weakened Effective Connectivity Related to Electroacupuncture in Stroke Patients with Prolonged Flaccid Paralysis: An EEG Pilot Study by Yi-Fang Lin, Xin-Hua Liu, Zheng-Yu Cui, Zuo-Ting Song, Fei Zou, Shu-Geng Chen, Xiao-Yang Kang, Bin Ye, Qiang Wang, Jing Tian, Jie Jia

“…These findings may help us to modulate the formulation of electroacupuncture treatment according to different durations of the flaccid upper extremity.…”
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Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein by Rui Tong Quek, Cyna R. Shirazinejad, Christina L. Young, Kierra S. Hardy, Samuel Lim, Phillip J. Elms, David T. McSwiggen, Timothy J. Mitchison, Pamela A. Silver

“…There is great interest in identifying condensate modulators (CMODs), which are small molecules that alter the dynamics and functions of phase-separated condensates, as a potential therapeutic modality. …”
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