NMDA Reduces Tau Phosphorylation in Rat Hippocampal Slices by Targeting NR2A Receptors, GSK3β, and PKC Activities by Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicotte

“…In the present study, pharmacological inhibitors were deployed to investigate potential processes by which the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors modulates Tau phosphorylation in rat hippocampal slices. …”
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Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial by Luz E. Gasca-Lozano, Silvia Lucano-Landeros, Héctor Ruiz-Mercado, Adriana Salazar-Montes, Ana Sandoval-Rodríguez, Jesus Garcia-Bañuelos, Arturo Santos-Garcia, Judith R. Davila-Rodriguez, José Navarro-Partida, Hiram Bojórquez-Sepúlveda, Juan Castañeda-Gomez, José Domínguez-Rosales, Myriam A. Ruiz-Arcos, María Guadalupe Sánchez-Parada, Juan Armendariz-Borunda

“…Pirfenidone (PFD) is a potent modulator of extracellular matrix. Modified diallyl disulfide oxide (M-DDO) is an antimicrobial and antiseptic agent. …”
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L-Theanine Extends the Lifespan of <i>Caenorhabditis elegans</i> by Reducing the End Products of Advanced Glycosylation by Zhihang Huang, Haiming Jing, Yan Pan, Hongxia Cai, Wenjing Zhang, Jingyuan Zhu, Nan Zhang, Dan Wu, Wentao Xu, Hexiang Qiu, Huihui Bao, Guojun Li, Junyu Ning, Bo Xian, Shan Gao

“…A further analysis demonstrated that L-theanine extends the lifespan of <i>Caenorhabditis elegans</i> by modulating the DAF-2/DAF-16 insulin-like signaling pathway and reducing the accumulation of advanced glycation end products (AGEs). …”
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Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells by Peng Wang, Haiyue Zhao, Wei Chen, Yuhui Guo, Shuo Zhang, Xin Xing, Shuai Yang, Fengkun Wang, Juan Wang, Zengwu Shao, Yingze Zhang

“…Subsequent miRNA sequencing reveals that ML-EVs exert their effects by delivering miR-27b-3p, which targets ROR1 mRNA in chondrocytes and suppresses downstream NF-κB pathways. By modulating the ROR1/NF-κB axis, miR-27b-3p effectively restrains ECM degradation and chondrocyte senescence. …”
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Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain? by Yanyuan Du, Yaoyuan Li, Jieqing Hu, Ruiying Fang, Yuming Liu, Liu Cai, Ying Song, Susu Ma, Jin Gao, Hanyue Zhang, Baihui Li, Hongtai Xiong, Huibo Yu, Shenglei Yang, Shuduo Zhu, Honggang Zheng

“…The analgesic mechanisms of rTMS include inhibiting nociceptive signal transmission in the spinal cord, modulating hemodynamic changes in brain regions, and promoting endogenous opioid release. …”
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Oncolytic Viruses and Immunotherapy for the Treatment of Uveal Melanoma and Retinoblastoma: The Current Landscape and Novel Advances by Merve Kulbay, Nicolas Tuli, Massimo Mazza, Armaan Jaffer, Sarinee Juntipwong, Emily Marcotte, Stuti Misty Tanya, Anne Xuan-Lan Nguyen, Miguel N. Burnier, Hakan Demirci

“…To overcome these obstacles, immunotherapy, which encompasses different treatment options such as oncolytic viruses, antibody-mediated immune modulations, and targeted immunotherapy, has shown great potential as a novel therapeutic tool for cancer therapy. …”
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Brain Hemodynamic Intermediate Phenotype Links Vitamin B12 to Cognitive Profile of Healthy and Mild Cognitive Impaired Subjects by Luca Cecchetti, Giada Lettieri, Giacomo Handjaras, Andrea Leo, Emiliano Ricciardi, Pietro Pietrini, Silvia Pellegrini, The Train the Brain Consortium

“…Despite this, no previous study directly investigated whether vitamin B12, folate, and homocysteine levels are sufficient to explain individual neuropsychological profiles or, alternatively, whether the activity of brain regions modulated by these compounds better predicts cognition in elders. …”
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Dietary supplementation with proanthocyanidins and rutin alleviates the symptoms of type 2 diabetes mice and regulates gut microbiota by Yue Gao, Yue Gao, Yue Gao, Binbin Huang, Yunyi Qin, Bing Qiao, Mengfei Ren, Liqing Cao, Yan Zhang, Maozhen Han, Maozhen Han

“…Importantly, several core microbes, particularly a series of probiotics, such as Akkermansia, Lactococcus, Odoribacter, Faecalibaculum, and Roseburia were identified, which were significantly correlated with the changes in BW and FBG.ConclusionOverall, our study highlights that rutin and PA can reduce BW, FBG, and inflammation by modulating the gut microbiota composition, providing novel perspectives for managing and treating weight and FBG concerns in obesity and T2DM patients through dietary supplements in clinical treatment.…”
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Approbation of the mechanism of economic reliability on the example of an industrial enterprise by A. R. Terentyeva

“…The analysis of the level of organization of ensuring economic reliability by organizational-managerial and productiontechnological modules revealed the bottlenecks of an industrial enterprise. …”
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Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels by Nathalie Idlin, Sivakumar Krishnamoorthy, Magdalena Wolczyk, Mouad Fakhri, Michal Lechowski, Natalia Stec, Jacek Milek, Pratik Kumar Mandal, Jaroslaw Cendrowski, Christos Spanos, Magdalena Dziembowska, Katarzyna Mleczko-Sanecka, Juri Rappsilber, Gracjan Michlewski

“…We show that both HuR knockout and Eltrombopag treatment modulate iron metabolism by decreasing ferritin heavy chain (FTH1) and light chain (FTL) synthesis while increasing the expression of iron-regulatory protein 2 (IRP2), a key regulator of ferritin translation. …”
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Temporal Changes on the Risks and Complications of Posttransplantion Diabetes Mellitus Following Cardiac Transplantation by Nadia Iannino, Amine Nasri, Agnès Räkel, Anique Ducharme, Kim Lachance, Normand Racine, Simon de Denus, Maxime Tremblay-Gravel, Annik Fortier, Michel White

“…Recent changes in the demographic of cardiac donors and recipients have modulated the rate and risk, associated with posttransplant diabetes mellitus (PTDM). …”
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The Association of Serum Lactoferrin Level with Psychological Symptoms, Cognition, and Executive Function in Schizophrenia Patients by Niloufar Mahdavi Hezaveh, Soheila Kianpour Rad, Yousef Semnani, Maryam Mousavi Bazaz, Abdolreza Javadi

“…Conclusion: The study demonstrates a significant reduction in serum lactoferrin levels during the acute phase of schizophrenia, suggesting its potential role in modulating cognitive functions, particularly the executive function, rather than influencing positive or negative symptoms. …”
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Structural Characterization of Polygonum divaricatum L. Polysaccharide and Its Inhibitory Effect on Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells by CUI Yanyan, YUAN Yongxu, GUO Mingkun, HE Wenbing, LI Ming, PEI Shichun, LI Dajun

“…Conclusion: PSPDL exhibited anti-inflammatory activity, perhaps by regulating inflammatory mRNA expression and modulating the mitogen-activated protein kinases/nuclear factor kappa B (MAPK/NF-κB) signaling pathway. …”
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Multi-active phlorotannins boost antimicrobial peptide LL-37 to promote periodontal tissue regeneration in diabetic periodontitis by Cancan Li, Luowen Du, Yingying Xiao, Lei Fan, Quanli Li, Chris Ying Cao

“…Furthermore, PL/LL-37 effectively modulated macrophage polarization from a M1 phenotype to an M2 phenotype through NF-κB P-p65 inflammatory pathway, thereby reducing the release of pro-inflammatory cytokines and promoting the secretion of anti-inflammatory cytokines. …”
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Aurora kinase B inhibitor AZD1152: repurposing for treatment of lupus nephritis driven by the results of clinical trialsResearch in context by Yue Zhao, Zuguo Zheng, Xuexiao Jin, Shaoshan Liang, Changming Zhang, Mingchao Zhang, Yue Lang, Ping Li, Zhihong Liu

“…Findings: AZD1152 significantly attenuated systemic immune activation and renal injury in MRL/lpr mice, demonstrating efficacy comparable to MT regimens in animal studies. AZD1152 treatment modulated immune-inflammatory pathways in the kidney. …”
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A Synoptic- and Remote Sensing-based Analysis of a Severe Dust Storm Event over Central Asia by Parya Broomandi, Kaveh Mohammadpour, Dimitris G. Kaskaoutis, Aram Fathian, Sabur F. Abdullaev, Vladimir A. Maslov, Amirhossein Nikfal, Ali Jahanbakhshi, Bakhyt Aubakirova, Jong Ryeol Kim, Alfrendo Satyanaga, Alireza Rashki, Nick Middleton

“…The prevailing high-pressure system and temperature gradients over Kazakhstan modulated the dominant anticyclonic wind pattern generated from the south Balkhash basin toward the Caspian Sea, causing a huge dust storm that covered the southern half of Kazakhstan and large parts of Uzbekistan, Tajikistan and Turkmenistan. …”
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Plasma Fatty Acids in Zambian Adults with HIV/AIDS: Relation to Dietary Intake and Cardiovascular Risk Factors by Christopher K. Nyirenda, Edmond K. Kabagambe, John R. Koethe, James N. Kiage, Benjamin H. Chi, Patrick Musonda, Meridith Blevins, Claire N. Bosire, Michael Y. Tsai, Douglas C. Heimburger

“…Our data suggest that a single DR is inadequate for assessing PUFA intake and that plasma arachidonic acid levels may modulate HIV/AIDS progression and CVD risk.…”
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Multimessenger Probes of Supermassive Black Hole Spin Evolution by Angelo Ricarte, Priyamvada Natarajan, Ramesh Narayan, Daniel C. M. Palumbo

“…We show that the observed spin distribution is in agreement with a model that includes jet-driven spin-down, a key mechanism that acts to modulate spins across cosmic time at both high and very low specific accretion rates. …”
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Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow by Linghan Kong, Wei Jin, Yue Jiang, Fuhua Yan, Jun Liu, Eric C. Leuthardt, Guang-Zhong Yang, Yuan Feng

“…Conclusion: Non-invasive brain stimulation using TVS provided important implications for modulating brain physiology and showed prospective therapeutic benefits for neurological diseases.…”
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A fishy gut feeling – current knowledge on gut microbiota in teleosts by Ingvill Tolas, Ingvill Tolas, Zhigang Zhou, Zhen Zhang, Zhen Zhang, Tsegay Teame, Tsegay Teame, Rolf Erik Olsen, Einar Ringø, Ivar Rønnestad

“…Dietary additives, including probiotics, prebiotics, and antibiotics, effectively modulate GM. Probiotics enhance immunity and growth, prebiotics support beneficial bacteria, and antibiotics, though effective against pathogens, disrupt microbial diversity and may promote antibiotic resistance. …”
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