Protocol to assess bottlenecks inhibiting the scaling up of evidence-based family planning practices in low-income and middle-income countries using mixed methods by James Kiarie, Moazzam Ali, Rita Kabra, Komal Preet Allagh, Kathryn Church, Abdulmumin Saad, Petrus Steyn

“…The protocol is structured in a modular format, with separate modules on postpregnancy FP, task sharing and SBC. …”
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Artemisia capillaris with two novel active compounds, Kawarayomogin I and II, inhibits HYBID (KIAA1199) expression as well as hyaluronic acid degradation by Kazal Boron Biswas, Yuka Kawai, Satoshi Nakagawa, Kyoko Kanai, Hiroyuki Kojima, Teruaki Masutani, Masayoshi Oyama, Arunasiri Iddamalgoda, Kotaro Sakamoto

“…Subsequent mechanism elucidation studies showed that ACFE epigenetically regulates the expression of HYBID by modulating the expression of a specific miRNA, miR-486-5p, which is known to directly target and inhibit HYBID expression. …”
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Oxidative stress and dysregulated long noncoding RNAs in the pathogenesis of Parkinson’s disease by Jialu Wang, Meitong Liu, Jiuhan Zhao, Pan Hu, Lianbo Gao, Shen Tian, Jin Zhang, Huayan Liu, Xiaoxue Xu, Zhenwei He

“…Oxidative stress and lncRNAs also affect other processes associated with neurodegeneration, including mitochondrial dysfunction and increased neuroinflammation that lead to neuronal death. Therefore, modulating the levels of specific lncRNAs may alleviate pathological oxidative damage and have neuroprotective effects. …”
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Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut by Xina Xiao, Meng Hu, Li Gao, Huan Yuan, Baochen Chong, Yu Liu, Rou Zhang, Yanqiu Gong, Dan Du, Yong Zhang, Hao Yang, Xiaohui Liu, Yan Zhang, Huiyuan Zhang, Heng Xu, Yi Zhao, Wenbo Meng, Dan Xie, Peng Lei, Shiqian Qi, Yong Peng, Tao Tan, Yang Yu, Hongbo Hu, Biao Dong, Lunzhi Dai

“…Crosstalk analysis revealed numerous age-related metabolites potentially involved in modulating oxidative stress and Cys modifications. Notably, we elucidated the role of fumarate in alleviating intestinal oxidative stress in a dextran sulfate sodium (DSS)-induced colitis mouse model. …”
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Super‐Enhancer‐Driven IRF2BP2 is Activated by Master Transcription Factors and Sustains T‐ALL Cell Growth and Survival by Juanjuan Yu, Zimu Zhang, Yanling Chen, Jianwei Wang, Gen Li, Yanfang Tao, Yongping Zhang, Yang Yang, Chenyue Zhang, Tiandan Li, Jia Cheng, Tongtign Ji, Zhongling Wei, Wenjuan Wang, Fang Fang, Wei Jiang, Peipei Chu, Hongli Yin, Di Wu, Xiaolu Li, Xiaodong Wang, Jun‐Jie Fan, Shaoyan Hu, Zhen‐Hong Zhu, Shuiyan Wu, Jun Lu, Jian Pan

“…Cleavage under targets and tagmentation (CUT&Tag) assays and immunoprecipitation revealed that IRF2BP2 cooperates with the master TFs of T‐ALL cells, targeting the enhancer of the T‐ALL susceptibility gene recombination activating 1 (RAG1) and modulating its expression. These findings provide new insights into the regulatory network within T‐ALL cells, identifying potential new targets for therapeutic intervention.…”
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Therapeutic Effects of BCG Vaccination on Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Yu-Chen Chang, Chien-Ju Lin, Yu-Hsuan Hsiao, Yu-Han Chang, Shu-Jung Liu, Hsin-Yin Hsu

“…The Bacillus Calmette–Guerin (BCG) vaccine can modulate the immune response and decelerate disease progression. …”
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Cis‐Regulation of an m6A Eraser by an Insertion Variant Associated with Survival of Patients With Non‐Small Cell Lung Carcinoma by Lei Cheng, Qiangsheng Hu, Yanan Wang, Wei Nie, Haijiao Lu, Bo Zhang, Genming Zhao, Shiyun Ding, Feng Pan, Yinchen Shen, Runbo Zhong, Ruoxin Zhang

“…Triggered by an insertion variant, this remote cis‐regulation of m6A eraser and the downstream molecular events modulate the survival of NSCLC patients.…”
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Reduction of IL-17A Might Suppress the Th1 Response and Promote the Th2 Response by Boosting the Function of Treg Cells during Silica-Induced Inflammatory Response In Vitro by Wen Tang, Fangwei Liu, Ying Chen, Laiyu Song, Wujing Dai, Chao Li, Dong Weng, Jie Chen

“…Blocking the function of IL-1 signal pathway could suppress the level of IL-17A, which played the major role in modulating silica-induced Th responses in vitro.…”
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Multi-Task Learning for Alzheimer’s Disease Diagnosis and Mini-Mental State Examination Score Prediction by Jin Liu, Xu Tian, Hanhe Lin, Hong-Dong Li, Yi Pan

“…Then, we propose feature sharing module to obtain shared features from candidate features and return shared features to task branches, which can promote the learning of each task. …”
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The Roles of MicroRNAs in the Regulation of Rice–Pathogen Interactions by Yanfeng Jia, Kai Wei, Jiawang Qin, Wenxue Zhai, Quanlin Li, Yalan Li

“…Among these strategies, plant microRNAs (miRNAs), endogenous single-stranded short non-coding RNA molecules, have emerged as promising candidates in coordinating plant–pathogen interactions. MiRNAs can modulate target gene expression at the post-transcriptional level through mRNA cleavage and/or translational inhibition. …”
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DeepGlioSeg: advanced glioma MRI data segmentation with integrated local-global representation architecture by Ruipeng Li, Yuehui Liao, Yueqi Huang, Xiaofei Ma, Guohua Zhao, Yanbin Wang, Chen Song

“…First, a CTPC (CNN-Transformer Parallel Combination) module leverages parallel branches of CNN and Transformer networks to fuse local and global features of glioma images, enhancing feature representation. …”
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Adaptive cognitive control in 4 to 7-year-old children and potential effects of school-based yoga-mindfulness interventions: an exploratory study in Italy by Lisa Toffoli, Giulia Stefanelli, Giulia Manca, Fiorella Del Popolo Cristaldi, Gian Marco Duma, Michele Guidi, Francesca Incagli, Luca Sbernini, Luca Sbernini, Vincenza Tarantino, Giovanni Mento, Giovanni Mento

“…Moreover, they successfully modulate interference control as a function of environmental contingencies, displaying more optimal conflict resolution when proactive control is engaged. …”
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Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study by Zhao Qing, Weiping Li, Zuzana Nedelska, Wenbo Wu, Fangfang Wang, Renyuan Liu, Hui Zhao, Weibo Chen, Queenie Chan, Bin Zhu, Yun Xu, Jakub Hort, Bing Zhang

“…We also demonstrated that the MCI versus NC group difference can modulate activity-behavior relationship, that is, the correlation slopes between ReHo and allocentric SN task total errors were significantly different between NC and MCI groups in the right hippocampus (interaction F=4.44, p=0.05), pallidum (F=8.97, p=0.005), and thalamus (F=5.95, p=0.02), which were negative in NC (right hippocampus, r=−0.49; right pallidum, r=−0.50; right thalamus, r=−0.45; all p<0.05) but absent in MCI (right hippocampus, r=0.21; right pallidum, r=0.32; right thalamus r=0.28; all p>0.2). …”
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Mesenchymal stem cell-derived extracellular vesicles enriched with miR-124 exhibit anti-inflammatory effects in collagen-induced arthritis by Guo Zhonghua, He Mengyuan, Shi Dongliang, Zhang Zhongbo, Wang Lisha, Ren Bowen, Wang Yunfei, Wang Junjie, Yang Shaoxiang, Yu Hongchao

“…MSC-EVs overexpressed with inflammation-modulating miRNAs offer a promising cell-free approach for treating inflammatory arthritis.…”
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Experimental and Modeling Study for the Solar-Driven CO₂ Electrochemical Reduction to CO by Matteo Agliuzza, Roberto Speranza, Andrea Lamberti, Candido Fabrizio Pirri, Adriano Sacco

“…COMSOL^® Multiphysics 6.3 was used to develop a detailed finite element method model of the electrochemical cell integrated with a photovoltaic module, validated with the experimental results that demonstrated a strong correlation. …”
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Quaternary ammoniums activate human dendritic cells and induce a specific T-cell response in vitro by Marine Peyneau, Mathilde Zeller, Virginie Paulet, Benoît Noël, Marie-Hélène Damiens, Natacha Szely, Andreas Natsch, Marc Pallardy, Sylvie Chollet-Martin, Luc de Chaisemartin, Saadia Kerdine-Römer

“…Results: Amongst the seven molecules tested, four could modulate activation markers on DCs, and thus can be classified as chemical sensitizers (polyquaterniums-7 and -10, ethylhexadecyldimethylammonium and benzethonium). …”
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The Manufacture of GMP-Grade Bone Marrow Stromal Cells with Validated In Vivo Bone-Forming Potential in an Orthopedic Clinical Center in Brazil by Rhayra B. Dias, João A. M. Guimarães, Marco B. Cury, Leonardo R. Rocha, Elaine S. da Costa, Liebert P. Nogueira, Camila Hochman-Mendez, Anneliese Fortuna-Costa, Anna Karoline F. Silva, Karin S. Cunha, Sergio A. L. de Souza, Maria Eugênia L. Duarte, Rafaela C. Sartore, Danielle C. Bonfim

“…In vitro-expanded bone marrow stromal cells (BMSCs) have long been proposed for the treatment of complex bone-related injuries because of their inherent potential to differentiate into multiple skeletal cell types, modulate inflammatory responses, and support angiogenesis. …”
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Reduction of Scarce Materials in Silicon Heterojunction Solar Cells and Implications on the Performance in the Field by Sebastian Pingel, Ioan Voicu Vulcanean, Timo Wenzel, Winfried Wolke, Vasileios Georgiou-Sarlikiotis, Philipp Schmid, Henning Nagel, Ulli Kräling, Martin Bivour, Anamaria Steinmetz

“…Considering low light conditions TCO-precursor type with differences in passivation have a strong impact. On module level similar irradiation dependence of the efficiency was found and in temperature-dependent IV-measurements a positive impact of high-quality passivation on the temperature coefficients was found while an increase of the series resistance had a negative impact on the temperature dependence. …”
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LINC01355 Contributes to Malignant Phenotype of Oral Squamous Cell Carcinoma and Cytotoxic T Cell Infiltration via Activating Notch Signaling Pathway by Chen Zou, Siyuan Wu, Haigang Wei, Hailing Luo, Zhe Tang, Xia Li, Xiaozhi Lv, Yilong Ai

“…In conclusion, it was implied that LINC01355 might induce the development of OSCC via modulating the Notch signal pathway, which could provide a candidate therapeutic target for OSCC.…”
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Deformed wing virus coopts the host arginine kinase to enhance its fitness in honey bees (Apis mellifera) by Andrea Becchimanzi, Giovanna De Leva, Rosanna Mattossovich, Serena Camerini, Marialuisa Casella, Giovanni Jesu, Ilaria Di Lelio, Sabrina Di Giorgi, Joachim R. de Miranda, Anna Valenti, Silvia Gigliotti, Francesco Pennacchio

“…Conclusions In summary, these data indicate that DWV modulates the host ArgK through transcriptional regulation and cooptation to enhance its fitness in honey bees. …”
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