The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes w... by Rehana Akter, Alexander Zhyvoloup, Bingqian Zheng, Surita R Bhatia, Daniel P Raleigh

“…The triphenylmethane dye, brilliant blue G (BBG, Sodium;3-[[4-[(E)-[4-(4-ethoxyanilino)phenyl]-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]-2-methylcyclohexa-2,5-dien-1-ylidene]methyl]-N-ethyl-3-methylanilino]methyl]benzenesulfonate) has been shown to modulate Aβ amyloid formation and inhibit Aβ induced toxicity. …”
Get full text

Team Assembly Mechanisms and the Knowledge Produced in the Mexico’s National Institute of Geriatrics: A Network Analysis and Agent-Based Modeling Approach by Carmen García-Peña, Luis Miguel Gutiérrez-Robledo, Augusto Cabrera-Becerril, David Fajardo-Ortiz

“…The main result of these experiments is that by modulating just one variable (homophily), we could successfully reproduce the current situation of INGER (homophily of 79%) and simulate alternative scenarios in which interdisciplinary (46%) and transdisciplinary (14%) research could be done.…”
Get full text

Evaluation of Mast Cells in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma by Ashish Shrestha, Shashi Keshwar, Toniya Raut

“…Mast cell is a key immune modulating cell which is primarily involved in initiation and propagation of inflammation. …”
Get full text

Thesis Overview: Oscillating wave surge converters – Large eddy simulation modelling of wave farms hydrodynamics and its related energy potential by Guilherme Fuhrmeister Vargas, Alexandre Beluco

“…In this context, a detailed study of a wave farm composed of several OWSCs is necessary, which represents a case closer to reality, since most renewable systems include several modules of the same converter. Considering the complexity of the existing hydrodynamics in these cases, a numerical modeling methodology based on the Large Eddy Simulation (LES) methodology is applied to correctly represent the oscillation of the structure and the observed flow fields. …”
Get full text

Assessing the Impact of Inclusive Education on Children with Disabilities in Kisoro Municipality. by Tusingwire, Hope

“…The government should include a module on Special needs in the training of all teachers so that they all know what to do. …”
Get full text

Quel Français Pour Les Etudiants De La Faculte De Genie De L’universite De Kabale? by Ayebare, Boniface Martial

“…Notre recherche recommande l’élaboration d’un module détaillé de français sur objectifs spécifiques (FOS) spécialisé en français de l’Ingénierie. …”
Get full text

Investigating the effect of synthetic cobalt and nickel oxide nanoparticles on the growth and physiology of Mungbean (Vigna radiata L.) seedlings, and exploring tunable magnetism s... by Anjali Joshi, Simranjeet Kaur, Pargat Singh, Havneet Singh, Keya Dharamvir, Harsh Nayyar, Gaurav Verma

“…The interaction of CoO and NiO nanoparticles with plant systems revealed significant modifications in magnetic properties, offering potential avenues for modulating plant growth through external magnetic fields. …”
Get full text

Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs by Wei Li, Wei Li, Wei Li, Peiyue Luo, Peiyue Luo, Peiyue Luo, Qi Chen, Qi Chen, Qi Chen, Le Cheng, Le Cheng, Le Cheng, Lifeng Gan, Lifeng Gan, Lifeng Gan, Fangtao Zhang, Fangtao Zhang, Fangtao Zhang, Haidong Zhong, Haidong Zhong, Haidong Zhong, Liying Zheng, Biao Qian, Biao Qian

“…Research has demonstrated that DNA methylation not only directly influences the expression of miRNA genes but also indirectly affects the maturation and functionality of miRNAs by modulating the methylation status of miRNA promoter regions. …”
Get full text

Impact of Thermospheric Mass Density on the Orbit Prediction of LEO Satellites by Changyong He, Yang Yang, Brett Carter, Kefei Zhang, Andong Hu, Wang Li, Florent Deleflie, Robert Norman, Suqin Wu

“…The present study investigates the quantitative impact of periodic spatiotemporal TMD variations modulated by the empirical DTM2013 model. Also considered are two small‐scale variations, that is, the equatorial mass anomaly and the midnight density maximum, which are reproduced by the Thermosphere‐Ionosphere‐Electrodynamics General Circulation Model. …”
Get full text

Exploration of the shared diagnostic genes and molecular mechanism between obesity and atherosclerosis via bioinformatic analysis by Wenrong An, Kegong Tang, Juan Liu, Wenfei Zheng, Guoxia Li, Yunsheng Xu

“…By intersecting the key module genes of WGCNA with DEGs in OB and AS, 56 shared genes with the same expression trend were identified. …”
Get full text

mTOR downregulation promotes anti-inflammatory responses via the CCL3-CCR5 axis in hypoxic retinopathy by Tae Kwon Moon, Im Kyeung Kang, Kyoung Jin Lee, Ji Hyun Kim, Hee Jong Kim, A. Reum Han, Ha-Na Woo, Joo Yong Lee, Jun-Sub Choi, Keerang Park, Heuiran Lee

“…Previously, we demonstrated that AAV2-shmTOR, effective across distinct species, holds therapeutic promise by modulating the activated mTOR pathway, yet its mechanisms for reducing inflammation remain largely unexplored. …”
Get full text

Enhanced precise therapy of ROS-sensitive dual-layer shell nanoparticles loading quercetin on DSS-induced ulcerative colitis mice by Yang Bai, Danling Jiang, Boda Wu, Jiao Peng, Ji Wang, Yuhui Chen, Xi Li

“…The stained results indicated that Que@Gel-DA NPs attenuate inflammation by promoting the polarization of M2 macrophages to reduce apoptosis and modulate immunity. Therefore, Que@Gel-DA NPs, a ROS-sensitive nano-drug delivery system, represent a novel therapeutic approach for the clinical intervention of UC.…”
Get full text

Biotin's protective effects against nicotine withdrawal-induced anxiety and depression: Mechanistic insights into serotonin, inflammation, BDNF, and oxidative stress in male rats by Dawood Hossaini, Mohammad Jalal Nazari, Khan Baba Ghazanfar, Mohammad Edris Amiri, Mohammad Tariq Anwary, Mohammad Jawad Jawad, Murtaza Haidary

“…Given the complex neurobiological mechanisms underlying withdrawal symptoms, biotin's ability to modulate critical signaling pathways such as serotonin metabolism, neuroinflammation, and oxidative stress could provide a multifaceted treatment approach.…”
Get full text

Interleukin‐37 promotes DMBA/TPA skin cancer through SIGIRR‐mediated inhibition of glycolysis in CD103+DC cells by Fan‐lian Zeng, Xiao‐yan Wang, Ya‐wen Hu, Zhen Wang, Ya Li, Jing Hu, Jia‐dong Yu, Pei Zhou, Xiu Teng, Hong Zhou, Hua‐ping Zheng, Fu‐lei Zhao, Lin‐na Gu, Cheng‐cheng Yue, Shu‐wen Chen, Juan Cheng, Yan Hao, Qi‐xiang Zhao, Chen Zhang, Song Zou, Zhong‐lan Hu, Xiao‐qiong Wei, Xiao Liu, Guo‐lin Li, Nong‐yu Huang, Wen‐ling Wu, Yi‐fan Zhou, Wei Li, Kaijun Cui, Jiong Li

“…In a word, our results highlight that IL‐37 as an inhibitor of tumor immune surveillance through modulating CD103+DCs and establishing an important link between metabolism and immunity as a therapeutic target for skin cancer.…”
Get full text

Genome-Wide Expression Difference of MicroRNAs in Basal Cell Carcinoma by Hai-Peng Wei, Song Zhan, Qing-An Zhu, Zhen-Juan Chen, Xian Feng, Jun-Yuan Chen, Qi-Lin Zhang, Jingjie Zhao, Lingzhang Meng

“…These results revealed the association between BCCs and abundant miRNA molecules that regulate target genes, functional modules, and signaling pathways in carcinogenesis.…”
Get full text

Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult... by Stuart I. Hodgetts, Jun Han Yoon, Alysia Fogliani, Emmanuel A. Akinpelu, Danii Baron-Heeris, Imke G. J. Houwers, Lachlan P. G. Wheeler, Bernadette T. Majda, Sreya Santhakumar, Sarah J. Lovett, Emma Duce, Margaret A. Pollett, Tylie M. Wiseman, Brooke Fehily, Alan R. Harvey

“…In some animals, viable or nonviable F344 rat mesenchymal precursor cells (rMPCs) were injected into the lesion site two weeks after SCI to modulate the inhibitory environment. Treatment with AAV-CNTFmCherry, as well as with AAV-CNTFmCherry combined with rMPCs, yielded functional improvements over AAV-GFP alone, as assessed by open-field and Ladderwalk analyses. …”
Get full text

A numerical investigation of heat transfer performance in a prismatic battery cooling system using hybrid nanofluids by B. Venkateswarlu, Santosh Chavan, Sang Woo Joo, Sung Chul Kim, Kottakkaran Sooppy Nisar

“…This research highlights the potential of hybrid nanofluids as an effective coolant for enhancing the heat transfer performance of battery modules in electric vehicles and energy storage applications.…”
Get full text

Effectiveness of a family customised online FOCUS programme aimed on building resiliency in dyad relationship to support dyadic illness management in persons with heart failure and... by Xin Zhang, Xiaonan Zhang, Yongjun Cao, Weiling Yang, Yanting Li, Xuedong Li, Sixuan Jiang, Qingyun LV, Mei Cheng, Xiaoying Zang

“…Given the key role and limited evidence of dyad illness management in improving dyad health in the context of HF, we developed a customisable, relationship focused, family online dynamic disease management programme—FOCUS programme—to improve dyad health for HF patients and their informal caregivers in China.Methods and analysis Based on the Theory of Dyadic Illness Management and the Systemic Transactional Model of Stress and Coping, the family customised online FOCUS programme has five modules: (1) family participatory; (2) open communication; (3) coping effectiveness; (4) uncertainty reduction and 5) shared dyad life stories. …”
Get full text

G Protein-Coupled Receptor 17 Inhibits Glucagon-like Peptide-1 Secretion via a Gi/o-Dependent Mechanism in Enteroendocrine Cells by Jason M. Conley, Alexander Jochim, Carmella Evans-Molina, Val J. Watts, Hongxia Ren

“…We previously showed that G protein-coupled receptor 17 (GPR17) is expressed in intestinal enteroendocrine cells (EECs) and modulates nutrient-induced GLP-1 secretion. However, the GPR17-mediated molecular signaling pathways in EECs have yet to be fully deciphered. …”
Get full text

Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGE2-EP2 mediated microglia-neuron signaling by Kunlin Guo, Lei Gao, Ping Li, Shanwu Feng, Liping Zhao, Xian Wang

“…Neurosteroid allopregnanolone is suggested to modulate the expression of various receptors or enzymes that involved in pain perception, presenting an analgesic potential. …”
Get full text