Nanostructured, Self-Assembling Peptide K5 Blocks TNF-α and PGE2 Production by Suppression of the AP-1/p38 Pathway by Woo Seok Yang, Yung Chul Park, Ji Hye Kim, Hye Ri Kim, Tao Yu, Se Eun Byeon, Larry D. Unsworth, Jaehwi Lee, Jae Youl Cho

“…First, we examined whether the K5 self-assembling peptide itself can modulate various cellular inflammatory responses. We found that peptide K5 significantly suppressed the release of tumor-necrosis-factor- (TNF-) α and prostaglandin E2 (PGE2) from RAW264.7 cells and peritoneal macrophages stimulated by lipopolysaccharide (LPS). …”
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2’-Fucosyllactose alleviate immune checkpoint blockade-associated colitis by reshaping gut microbiota and activating AHR pathway by Shikai Yan, Leilei Yu, Fengwei Tian, Jianxin Zhao, Wei Chen, Qixiao Zhai

“…These f indings suggest that 2’FL could serve as a potential protective strategy for ICB-associated colitis by modulating the intestinal microbiota and bacterial metabolites.…”
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Soil microbiome interventions for carbon sequestration and climate mitigation by Gwyn A. Beattie, Anna Edlund, Nwadiuto Esiobu, Jack Gilbert, Mette Haubjerg Nicolaisen, Janet K. Jansson, Paul Jensen, Marco Keiluweit, Jay T. Lennon, Jennifer Martiny, Vanessa R. Minnis, Dianne Newman, Raquel Peixoto, Christopher Schadt, Jan Roelof van der Meer

“…Direct interventions include the introduction of microbial strains, consortia, phage, and soil transplants, whereas indirect interventions include managing soil conditions or additives to modulate community composition or its activities. Approaches to increase soil carbon stocks using microbially catalyzed processes include increasing carbon inputs from plants, promoting soil organic matter (SOM) formation, and reducing SOM turnover and production of diverse greenhouse gases. …”
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The Effects of Destemming/Crushing and Pressing Conditions in Rosé Wine Production by Lorenzo Guerrini, Ferdinando Corti, Giulia Angeloni, Piernicola Masella, Agnese Spadi, Luca Calamai, Alessandro Parenti

“…Significance of the study: in rosé production, the capability to modulate the operational protocols allows selecting of different wines from the same grape batch. …”
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Mesenchymal Stromal Cells from Osteoarthritic Synovium Are a Distinct Population Compared to Their Bone-Marrow Counterparts regarding Surface Marker Distribution and Immunomodulati... by Sebastien Hagmann, Claudia Rimmele, Florin Bucur, Thomas Dreher, Felix Zeifang, Babak Moradi, Tobias Gotterbarm

“…Mesenchymal stromal cells (MSCs) play an important role in modulating inflammatory processes. Based on previous studies in an allogeneic T-cell coculture model, we aimed at further determining the role of synovial MSCs in OA pathogenesis. …”
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Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2 by Dandan Liu, Hewei Qin, Guanghua Liu, Yang Gao, Yu Guo

“…In addition, astragaloside IV has lipid-modulating and antioxidant pharmacological potential. …”
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Selective light olefin synthesis with high ethylene abundance via CO2 hydrogenation over (Ga-In)2O3/SSZ-13 catalysts by Yasemen Kuddusi, Laura Piveteau, Mounir Mensi, Daniel C. Cano-Blanco, Andreas Züttel

“…Therefore, the change in light olefin STY upon gallium incorporation could be ascribed to modulations in the structural and electronic properties, as well as alterations in the surface adsorption and acidic strengths. …”
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Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restriction by Liuke Sun, Xing Guo, Mengmeng Yu, Xue-Feng Wang, Huiling Ren, Xiaojun Wang

“…Such a SUMO-dependent recruitment of NS2 is mediated by its association with huANP32A/B via the SIM-SUMO interaction module, where K68/K153-SUMO in huANP32A or K68/K116-SUMO in huANP32B interacts with the NS2-SIM. …”
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Structural elucidation of mulberry leaf oligosaccharide and its selective promotion of gut microbiota to alleviate type 2 diabetes mellitus by Tenggen Hu, Yuanshan Yu, Jijun Wu, Yujuan Xu, Gengsheng Xiao, Kejing An, Erna Li, Sentai Liao, Yuxiao Zou

“…The in vitro fecal fermentation results showed that MLO 2-1 could modulate the composition of gut microbiota. Meanwhile, MLO 2-1 was effectively metabolized by fecal bacteria to produce lactate and short chain fatty acids, especially acetate and butyrate. …”
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p104 Binds to Rac1 and Reduces Its Activity during Myotube Differentiation of C2C12 Cell by Ki Young Choi, Min Sup Lee, Young Jun Cho, Myong Ho Jeong, Seung Jin Han, Seung Hwan Hong

“…Based on these results, we conclude that p104 is involved in muscle cell differentiation by modulating the Rac1 activity.…”
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Ultra‐Thin Strain‐Relieving Si1−xGex Layers Enabling III‐V Epitaxy on Si by Trevor R. Smith, Spencer McDermott, Vatsalkumar Patel, Ross Anthony, Manu Hedge, Sophie E. Bierer, Sunzhuoran Wang, Andrew P. Knights, Ryan B. Lewis

“…The efficient strain relaxation results from the high oxidation temperature, producing a periodic network of dislocations at the substrate interface, coinciding with modulations of the Ge content in the Si1−xGex layer and indicating the presence of defect‐mediated diffusion of Si through the layer. …”
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Platelet‐derived apoptotic vesicles ameliorate nonalcoholic fatty liver disease by regulating lipid metabolism via apolipoprotein A‐II by Yuhe Jiang, Yike Liao, Zeying Wang, Lei Zhu, Yunsong Liu, Ping Zhang, Yuan Zhu, Wenyue Li, Yongsheng Zhou, Xiao Zhang

“…This underscores the need for improved therapeutic approaches that can modulate lipid metabolism and halt the transition from liver steatosis to chronic liver disease. …”
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Advanced Microgrid: Containerized Development Platform by João Marcus S. Callegari, Danilo Iglesias Brandao, Luís Guilherme Monteiro Oliveira, Sidelmo Magalhães Silva, Braz J. Cardoso Filho

“…All these devices are commercially available off-the-shelf equipment. Photovoltaic modules and different battery technologies are installed outside and inside the container, respectively, with cabling extending to the container to connect these components to the inverters. …”
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How do age and sex influence pain threshold and tolerance among Santal tribal people living in West Bengal, India? by Arpita Santra, Subrata Kumar Roy, Monali Goswami, Diptendu Chatterjee

“…Notably, age and sex have consistently emerged as pivotal determinants in modulating pain perception. The study aimed to examine age and sex differences in pain threshold and tolerance levels. …”
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Beneficial Roles of 1-MCP on Regulation of Photosynthetic Electron Transport and Energy Dissipation in Chrysanthemum Under Heat Stress by Runtian Miao, Xiaoman Liu, Yilin Zhao, Yanli Zhao, Han Dong, Gan Huang, Yonghua Li

“…Here, the chlorophyll a fluorescence and modulated 820 nm reflection transients were analyzed in heat-tolerant and heat-sensitive chrysanthemum plants. …”
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Pharmacological Characterization of the Mechanisms Involved in Delayed Calcium Deregulation in SH-SY5Y Cells Challenged with Methadone by Sergio Perez-Alvarez, Maria E. Solesio, Maria D. Cuenca-Lopez, Raquel M. Melero-Fernández de Mera, Carlos Villalobos, Hanna Kmita, Maria F. Galindo, Joaquin Jordán

“…Only those compounds targeting mitochondria such as oligomycin, FCCP, CGP 37157, and cyclosporine A were able to amend methadone-induced Ca2+ dyshomeostasis suggesting that methadone induces DCD by modulating the ability of mitochondria to handle Ca2+. …”
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Flexible modular dwelling for rural environments; specific case: Cebadas – Ecuador [version 2; peer review: 2 approved] by Karina Elizabeth Cajamarca Dacto, Maikol Josueé González Espinosa, Dany Marcelo Tasan Cruz, Erick Fabricio Nieto Páez, Jean Carlos Montero Riofrio

“…Conclusions The flexible modular dwelling project for rural environments addresses complex housing needs, highlighting the flexibility and adaptability of an expandable module. It includes income generation with a duplex apartment, fosters communal and cultural life with public and commercial spaces, promotes tourism and rural development with landscape design and crops. …”
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Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study by Jijo Francis, Honey Sebastian, Saley Daniel, Leyon Varghese, Sareena Gilvaz, Ragitha Thenkattil Sankarankutty, Siji Susan George, Pulikkottil Raphael Varghese, Suresh Kumar Raveendran

“…Genetic variations in the MCP-1 gene may modulate MCP-1 expression. Although the association of theMCP-1 promoter polymorphism (-2518A/G) was extensively studied in different inflammatory conditions, there isonly one report in PCOS conditions. …”
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Research progress in the role of β-arrestin 1 in the regulation of inflammatory response by YI Wenjing, FAN Yixuan, QIU Jiatai, FU Xiaoyan, LIU Meifang

“…Therefore, it is particularly important to effectively modulate the extent and scope of the inflammatory response. β-arrestin 1 (ARRB1) is a multifunctional regulatory protein that plays a key role in G protein-coupled receptor (GPCR) and non-GPCR-mediated signal transduction. …”
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PcWRKY1 Represses Transcription of Yellow Stripe‐Like 3 (PcYSL3) to Negatively Regulate Radial Cadmium Transport in Poplar Stems by Xin Chen, Yuhong Zhang, Yao Cheng, Wenjian Yu, Lingyu Yang, Peiqi Shu, Jing Zhou, Payam Fayyaz, Zhi‐Bin Luo, Shurong Deng, Wenguang Shi

“…Here, a Cd radial transport pathway in poplar stems and a previously unrecognized PcWRKY1‐Yellow Stripe‐Like 3 (PcYSL3) module that regulates Cd transport are identified in Populus × canescens (Aiton) Sm. …”
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