Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer by Wan-Xin Peng, Pratirodh Koirala, Huaixiang Zhou, Jiahong Jiang, Ziqiang Zhang, Liu Yang, Yin-Yuan Mo

“…Abstract Selective estrogen receptor modulators (SERMs) such as tamoxifen have proven to be effective in the treatment of estrogen receptor (ER) positive breast cancer. …”
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Neural activity responsiveness by maturation of inhibition underlying critical period plasticity by Ibuki Matsumoto, Sou Nobukawa, Sou Nobukawa, Sou Nobukawa, Sou Nobukawa, Takashi Kanamaru, Takashi Kanamaru, Yusuke Sakemi, Yusuke Sakemi, Nina Sviridova, Nina Sviridova, Tomoki Kurikawa, Nobuhiko Wagatsuma, Kazuyuki Aihara, Kazuyuki Aihara

“…In the present study, we aimed to investigate neuronal activity responsiveness with respect to the maturation of inhibition at gamma-band frequencies.MethodWe calculated inter-trial phase coherence (ITPC), which quantifies event-related phase modulations across trials, using a biologically plausible spiking neural network that generates gamma oscillations through interactions between excitatory and inhibitory neurons.ResultsOur results demonstrated that the neuronal response coherence to external periodic inputs exhibits an inverted U-shape with respect to the maturation of inhibition. …”
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RED-Net: A Neural Network for 3D Thyroid Segmentation in Chest CT Using Residual and Dilated Convolutions for Measuring Thyroid Volume by Min-Ji Kim, Jin-A Kim, Naae Kim, Yul Hwangbo, Hyun Jeong Jeon, Dong-Hwa Lee, Ji Eun Oh

“…Its fundamental structure comprises a residual downsampling and upsampling pathway, complemented by a parallel dilated convolution module. This combination allows the model to extract features at multiple scales and capture contextual information to effectively segment even tiny thyroid glands in the complex anatomical structures observed in chest CT scans. …”
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Melanocortin Peptide Therapy for the Treatment of Arthritic Pathologies by S. J. Getting, M. Kaneva, Y. Bhadresa, D. Renshaw, Giovanna Leoni, H. B. Patel, M. J. P. Kerrigan, I. C. Locke

“…Melanocortins exhibit their biological efficacy by modulating proinflammatory cytokines and subsequent leukocyte extravasation. …”
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The biogenesis, regulation and functions of transitive siRNA in plants by Tan Huijun, Liu Yuelin, Guo Hongwei

“…Small RNA (sRNA)-mediated RNA interference (RNAi) is a sequence-specific gene silencing mechanism that modulates gene expression in eukaryotes. …”
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The multifaceted anti-atherosclerotic properties of herbal flavonoids: A comprehensive review by Meiwen Huang, Xuena Xie, Rong Yuan, Qiqi Xin, Shudong Ma, Hongai Guo, Yu Miao, Chunyu Hu, Yizhun Zhu, Weihong Cong

“…Researches on natural compounds derived from herbal medicines, such as flavonoids, hold significant promise in combating AS by regulating lipid metabolism, reducing oxidative stress and inflammation, inhibiting the proliferation of vascular smooth muscle cells, modulating autophagy and additional pathways. Various targets participate in these physiological processes, encompassing acyl-CoA: cholesterol acyltransferase (ACAT), ATP citrate lyase (ACLY), nuclear factor erythroid 2-related factor 2 (Nrf2), krüppel-like factor 2 (KLF2), NOD-like receptor protein 3 (NLRP3), transcription factor EB (TFEB) and so on. …”
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pH‐Dependent Assembly and Stability of Toll‐Like Receptor 3/dsRNA Signaling Complex: Insights from Constant pH Molecular Dynamics and Metadynamics Simulations by Penghui Li, Mingsong Shi, Yibo Wang, Qiong Liu, Xiubo Du, Xiaohui Wang

“…The findings demonstrate that system pH regulates complex assembly and stability by modulating the protonation and charge states of histidines. …”
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Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects by Zi-Han Xu, Ming-Min Xie, Chun-Lan Xie, Xian-Wen Yang, Jun-Song Wang

“…Additionally, <b>17</b> suppresses TLR4, reducing p38 MAPK phosphorylation, and inhibits ferroptosis by decreasing lipid peroxidation and modulating mitochondrial membrane potential. Metabolomic analysis showed that <b>17</b> rescues alterations in multiple metabolic pathways induced by RSL3 and increases levels of antioxidant metabolites, including glutamine, glutamate, and glutathione. …”
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Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses by Hongyu Yu, Shaoyuan Cui, Yan Mei, Qinggang Li, Lingling Wu, Shuwei Duan, Guangyan Cai, Hanyu Zhu, Bo Fu, Li Zhang, Zhe Feng, Xiangmei Chen

“…Mesangial cells can present antigen and modulate CD4+ T lymphocyte proliferation and differentiation. …”
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Stepwise Adipogenesis of Decellularized Cellular Extracellular Matrix Regulates Adipose Tissue-Derived Stem Cell Migration and Differentiation by Ziang Zhang, Rongmei Qu, Tingyu Fan, Jun Ouyang, Feng Lu, Jingxing Dai

“…Microenvironmental factors can modulate the cellular status of adipose tissue-derived stem cells (ASCs). …”
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Edaphic factors mediate the response of nitrogen cycling and related enzymatic activities and functional genes to heavy metals: A review by Tracy Opande, Mengru Kong, Di Feng, YuHong Wen, Nathan Okoth, Ali Mohd Yatoo, Fatma Mohamed Ameen Khalil, Ahmed S. Elrys, Lei Meng, Jinbo Zhang

“…Environmental factors like soil organic carbon, soil texture, water content, temperature, soil pH, N fertilization, and redox status play significant roles in modulating the response of soil N cycling to HM contamination. …”
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Manipulating polarization attenuation in NbS2–NiS2 nanoflowers through homogeneous heterophase interface engineering toward microwave absorption with shifted frequency bands by Yiru Fu, Yuping Wang, Junye Cheng, Yao Li, Jing Wang, Yongheng Jin, Deqing Zhang, Guangping Zheng, Maosheng Cao

“…Such regulation on the interfaces is effective in modulating electromagnetic wave absorbing materials. …”
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Tailor-Made, Linear, and “Comb-Like” Polyester-Based Copolymers: Synthesis, Characterization, and Thermal Behavior of Potential 3D-Printing/Electrospinning Candidates by Franco L. Redondo, Mario D. Ninago, Augusto G. O. de Freitas, Cristiano Giacomelli, Andrés E. Ciolino, Marcelo A. Villar

“…All polymers exhibited narrow molar masses distributions (Mw/Mn<1.54), and their thermal properties were analyzed by isothermal crystallization kinetics (Avrami’s theory, by using differential scanning calorimetry (DSC)) and by employing modulated thermogravimetric analysis (MTGA). The macromolecular structure exerts a noticeable effect on the PCL block behavior when compared to the PCL homopolymer, at least for the temperature range studied (16–24°C): less differences in thermal properties were observed for linear block copolymers, whereas for “comb-like” graft copolymers their final crystallization capacity strongly depends on the presence of branches. …”
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The potential impact of glycine supplementation on the process of aging by Michalina Wójcikiewicz, Julia Kulbacka, Witold Czyż, Julia Kacperczyk, Karol Dziedzic, Marta Chuncia-Ileczko, Maciej Wojszczyk, Damian Zys, Piotr Pasek, Julia Ryniecka, Wiktor Czaja, Michał Krzciuk

“…Glycine, the simplest amino acid, has recently gained attention as a potential nutritional and therapeutic intervention to modulate various pathways implicated in aging. Beyond its structural role in collagen and other proteins, glycine is a critical precursor for glutathione- an essential intracellular antioxidant- plays a role in neurotransmission, and is involved in the synthesis of heme, creatine, and bile acids. …”
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Carrageenan-induced acute inflammation in the mouse air pouch synovial model. Role of tumour necrosis factor by M. Romano, R. Faggioni, M. Sironi, S. Sacco, B. Echtenacher, E. Di Santo, M. Salmona, P. Ghezzi

“…Carrageenan-induced inflammation was modulated by anti-inflammatory drugs. Pretreatment with dexamethasone (DEX) or indomethacin (INDO) inhibited cell migration and reduced the concentration of TNF in the exudate. …”
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Inducible Fgf13 ablation alleviates cardiac fibrosis via regulation of microtubule stability by Wang Cong, Wang Xiangchong, Zhang Yiyi, Mi Yuan, Han Yanxue, Zhi Yaxin, Zhao Ran, Cui Nanqi, Ma Qianli, Zhang Huaxing, Xue Dazhong, Qiao Ruoyang, Han Jiabing, Yu Yulou, Li Jiaxuan, Shaiea Mohammed, Liu Demin, Gu Guoqiang, Wang Chuan

“…Collectively, cardiac Fgf13 knockdown protects the heart from fibrosis in response to haemodynamic stress by modulating microtubule stabilization and ROCK signaling pathway.…”
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Enhanced oracle bone corrosion detection using attention-guided YOLO with ghost convolution by Feng Gao, Ziheng Yang, Qiyu Liu, Zhan Zhang, Bang Li, Han Zhang

“…To tackle this challenge, this study incorporates advanced attention mechanisms, including Squeeze-and-Excitation Networks (SE), Coordinate attention, and Convolutional Block Attention Module (CBAM), into the YOLOv5 detection architecture. …”
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Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI3K/mTOR Signaling Pathway by Dandan Chai, Guoyu Wang, Ziyu Zhou, Hanyan Yang, Zhiwen Yu

“…Furthermore, SESN2 via modulating PTEN plays a negative feedback role in insulin signaling.…”
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Complementarity-Oriented Feature Fusion for Face-Phone Trajectory Matching by Changfeng Cao, Wenchuan Zhang, Hua Yang, Dan Ruan

“…The latent features from both transforming directions are concatenated in the Feature Unifying (FU) module and fed into a binary face-phone trajectory matching discriminator (FPTPMD) to infer whether a face-phone trajectory pair corresponds to the same underlying motion trajectory. …”
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Hypertrophic cardiomyopathy: insights into pathophysiology and novel therapeutic strategies from clinical studies by Samuel Oluwadare Olalekan, Olalekan Olanrewaju Bakare, Patrick Godwin Okwute, Ifabunmi Oduyemi Osonuga, Muinat Moronke Adeyanju, Victoria Biola Edema

“…The review also explored the impact of targeted therapeutic approaches aimed at modulating these proteins to improve patient outcomes. …”
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