cAMP analogues downregulate the expression of granulocyte macrophage colony-stimulating factor (GM-CSF) in human bone marrow stromal cells in vitro by G. Bug, J. Aman, C. Huber, C. Peschel, H. G. Derigs

“…Our results provide evidence that the previously described inhibitory effect of cAMP agonist PGE2 on haematopoietic progenitor cells in vivo is, at least in part, mediated by modulating the expression of GMCSF in bone marrow stromal cells.…”
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2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: inv... by Wei Dong, Yujia Peng, Guijie Chen, Zhiyong Xie, Weiqi Xu, Wangting Zhou, Jia Mi, Lu Lu, Yi Sun, Xiaoxiong Zeng, Youlong Cao, Yamei Yan

“…The present study provided the evidence that AA-2βG could improve indices of cognition and neuroinflammmation via modulating gut dybiosis and preventing leaky gut. As a potential functional food ingredient, AA-2βG may be applied to attenuate neuroinflammation associated with Western-style diets.…”
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Dihydrotanshinone I Alleviates Crystalline Silica-Induced Pulmonary Inflammation by Regulation of the Th Immune Response and Inhibition of STAT1/STAT3 by Yiting Zhang, Chao Li, Siyi Li, Yiping Lu, Sitong Du, Xinning Zeng, Xi Chen, Jie Chen

“…Taken together, our findings indicated that DHI could modulate Th responses and alleviate CS-induced pulmonary inflammation, suggesting a novel application of DHI in CS-induced pulmonary disease.…”
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METTL16 is Required for Meiotic Sex Chromosome Inactivation and DSB Formation and Recombination during Male Meiosis by Lisha Yin, Nan Jiang, Wenjing Xiong, Shiyu Yang, Jin Zhang, Mengneng Xiong, Kuan Liu, Yuting Zhang, Xinxin Xiong, Yiqian Gui, Huihui Gao, Tao Li, Yi Li, Xiaoli Wang, Youzhi Zhang, Fengli Wang, Shuiqiao Yuan

“…Collectively, this study identified METTL16 as a key regulator of male meiosis and demonstrated that it modulates meiosis by interacting with MSCI‐related factors and regulating m6A levels and translational efficiency (TE) of meiosis‐related genes.…”
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Novel adaptive immune systems in pristine Antarctic soils by Marc W. Van Goethem, Oliver K. I. Bezuidt, Rian Pierneef, Surendra Vikram, David W. Hopkins, Thomas Aspray, Grant Hall, Stephan Woodborne, Ian D. Hogg, Trent R. Northen, Weidong Kong, Daniele Daffonchio, Don A. Cowan, Yves Van de Peer, Manuel Delgado-Baquerizo, Thulani P. Makhalanyane

“…Notably, a Class 2 system featuring type V variants lacks CRISPR arrays, encodes Cas1 and Cas2 adaptation module genes. Phylogenetic analysis of Cas12 effector proteins hints at divergent evolutionary histories compared to classified type V effectors and indicates that TnpB is likely the ancestor of Cas12 nucleases. …”
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The Plant-Derived Bauhinia bauhinioides Kallikrein Proteinase Inhibitor (rBbKI) Attenuates Elastase-Induced Emphysema in Mice by Bruno Tadeu Martins-Olivera, Rafael Almeida-Reis, Osmar Aparecido Theodoro-Júnior, Leandro Vilela Oliva, Natalia Neto dos Santos Nunes, Clarice Rosa Olivo, Marlon Vilela de Brito, Carla Máximo Prado, Edna Aparecida Leick, Mílton de Arruda Martins, Maria Luiza Vilela Oliva, Renato Fraga Righetti, Iolanda de Fátima Lopes Calvo Tibério

“…Our study evaluated the ability of the recombinant plant derived Bauhinia bauhinioides Kallikrein proteinase Inhibitor (rBbKI) to modulate elastase-induced pulmonary inflammation. Methods. …”
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Spatio-Temporal Feature Aware Vision Transformers for Real-Time Unmanned Aerial Vehicle Tracking by Hao Zhang, Hengzhou Ye, Xiaoyu Guo, Xu Zhang, Yao Rong, Shuiwang Li

“…NT-Track also incorporates a spatial neighborhood feature extraction module, which focuses on identifying and extracting features within the neighborhood of the target in each frame, ensuring continuous focus on the target during inter-frame processing. …”
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A multi-dimensional validation strategy of pharmacological effects of Radix Isatidis Mixtures against the co-infection of Mycoplasma gallisepticum and Escherichia coli in poultry by Xiaodi Jin, Jinhai Huo, Yecheng Yao, Rui Li, Mengqing Sun, Jichang Li, Zhiyong Wu

“…The experimental results indicated that, compared to the co-infection group, the RIM treatment group significantly modulated the expression of select genes and proteins, particularly MMP2 and TLR4, with a high level of statistical significance (p < 0.01). …”
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Decoding nature: multi-target anti-inflammatory mechanisms of natural products in the TLR4/NF-κB pathway by Yue Zhao, Yue Zhao, Jiacai Wu, Xiaolan Liu, Xiaolan Liu, Xu Chen, Xu Chen, Juan Wang, Juan Wang

“…Research has demonstrated that many natural products exert notable anti-inflammatory effects by modulating the Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) signaling pathways. …”
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Bifidobacterium animalis ssp. lactis BX-245-fermented milk alleviates tumor burden in mice with colorectal cancer by Chengcong Yang, Musu Zha, Lu Li, Jiaqi Qiao, Lai-Yu Kwok, Dandan Wang, Yongfu Chen

“…Our findings indicate that intragastric administration of BX245-fermented milk effectively modulated the intratumor microbiota, as well as the gut microbiota and its metabolism. …”
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The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy by Wenhua Xia, Wenhua Xia, Yuanhao Lv, Yuanhao Lv, Yan Zou, Zhanting Kang, Zhaoyi Li, Jiaqi Tian, Hongyan Zhou, Wei Su, Wei Su, Jiateng Zhong, Jiateng Zhong, Jiateng Zhong, Jiateng Zhong

“…Meanwhile, traditional Chinese medicine therapies promote antitumor immunity by modulating the TME and inducing ferroptosis. Additionally, advances in nanotechnology have facilitated precise therapy by enabling targeted delivery of ferroptosis inducers or immunomodulators, transforming “cold” tumors into “hot” tumors and further boosting ICI efficacy. …”
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Reducing off-target expression of mRNA therapeutics and vaccines in the liver with microRNA binding sites by Brian J. Parrett, Satoko Yamaoka, Michael A. Barry

“…Lipid nanoparticles (LNPs) are often liver tropic, presenting challenges for LNP-delivered mRNA therapeutics intended for other tissues, as off-target expression in the liver may increase side effects and modulate immune responses. To avoid off-target expression in the liver, miR-122 binding sites have been used by others in viral and non-viral therapeutics. …”
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An effective vessel segmentation method using SLOA-HGC by Zerui Liu, Junliang Du, Weisi Dai, Wenke Zhu, Ziqing Ye, Lin Li, Zewei Liu, Linan Hu, Lin Chen, Lixiang Sun

“…The ghost fully convolutional Rectified Linear Unit (GFCReLU) module in the output convolutional layer captures deep semantic information for better vessel localization. …”
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Fluorine‐Induced Lattice Oxygen Participation in 2D Layered Double Hydroxide/MXene Hybrids for Efficient Oxygen Evolution by Chengang Pei, Min‐Cheol Kim, Unbeom Baeck, Won Tae Hong, Jong Hun Kim, Hyungu Han, Jaekyum Kim, Sung Min Cho, Xu Yu, Jongwook Park, Ho Seok Park, Jung Kyu Kim

“…Owing to the synergistic effects of the 2D/2D hierarchical structure and the modulated active surface, F‐LDH/MX possesses excellent electrochemical performances, including a low overpotential of 251 mV at 10 mA cm−2, a low Tafel slope of 40.28 mV dec−1, and robust stability. …”
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New Role of Adult Lung c-kit+ Cells in a Mouse Model of Airway Hyperresponsiveness by Giuseppe Spaziano, Donato Cappetta, Konrad Urbanek, Elena Piegari, Grazia Esposito, Maria Matteis, Manuela Sgambato, Gioia Tartaglione, Rosa Russo, Raffaele De Palma, Francesco Rossi, Antonella De Angelis, Bruno D’Agostino

“…In conclusion, intratracheally administered c-kit+ cells reduce inflammation, positively modulate airway remodeling, and improve function. These data document previously unrecognized properties of c-kit+ cells, able to impede pathophysiological features of experimental airway hyperresponsiveness.…”
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Early transcriptomic changes at the skin interface during Powassan virus transmission by Ixodes scapularis ticks by Dakota N. Paine, Dakota N. Paine, Meghan Hermance, Saravanan Thangamani, Saravanan Thangamani, Saravanan Thangamani

“…Tick feeding and salivary factors modulate the host’s immunological responses, facilitating blood feeding and pathogen transmission. …”
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Automatic Multitarget Detection Method Based on Distributed Through-wall Radar by Xiao LIANG, Shengbo YE, Chenyang SONG, Yubing YUAN, Qunying ZHANG, Xiaojun LIU, Hejun JIANG, Hong LI

“…Finally, a positioning module is employed to determine the radar’s location, enabling rapid and automatic detection of the target’s location. …”
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The landscape of cell regulatory and communication networks in the human dental follicle by Jia-Ning Liu, Jia-Ning Liu, Jiong-Yi Tian, Lu Liu, Lu Liu, Yuan Cao, Yuan Cao, Xiao Lei, Xiao Lei, Xiao-Hui Zhang, Xiao-Hui Zhang, Zi-Qi Zhang, Zi-Qi Zhang, Jun-Xi He, Jun-Xi He, Chen-Xi Zheng, Chao Ma, Sheng-Feng Bai, Bing-Dong Sui, Fang Jin, Ji Chen, Ji Chen

“…Gene regulatory networks (GRNs) were established and defined four regulon modules underlying dental tissue development and microenvironmental regulation, including vascular and immune responses. …”
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Trust Region Policy Learning for Adaptive Drug Infusion with Communication Networks in Hypertensive Patients by Mai The Vu, Seong Han Kim, Ha Le Nhu Ngoc Thanh, Majid Roohi, Tuan Hai Nguyen

“…The automated closed-loop infusion of vasoactive drugs for the purpose of modulating blood pressure (BP) in patients suffering from acute hypertension has been the focus of rigorous investigation in recent years. …”
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An Efficient Frequency Encoding Scheme for Optical Convolution Accelerator by Gongyu Xia, Jiacheng Liu, Qilin Hong, Pingyu Zhu, Ping Xu, Zhihong Zhu

“…For one-dimensional optical convolution accelerators, existing methods can fully utilize the working bandwidth of electro-optic modulators and the frequency resources of light sources. …”
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