Exploring novel and potent glycogen synthase kinase-3β inhibitors through systematic drug designing approach by Shabir Ahmad Ganai, Suma Mohan, Shahid Ahmad Padder

“…Abstract Significant implications of glycogen synthase kinase-3β (GSK-3β) have been reported in various neuronal disorders and malignant cancers. GSK-3β modulates diverse protein targets through phosphorylation, and its aberrant activity leads to neurological complications as well as tumour onset. …”
Get full text

Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord. by Alessandro Pazzaglia, Andrej Bicanski, Andrea Ferrario, Jonathan Arreguit, Dimitri Ryczko, Auke Ijspeert

“…Overall, this study highlights the beneficial role of proprioception in generating, modulating and stabilizing locomotion patterns, provided that it does not excessively override centrally-generated locomotor rhythms. …”
Get full text

Construction of Prompt Verbalizer Based on Dynamic Search Tree for Text Classification by Jinfeng Gao, Xianliang Xia, Ruxian Yao, Junming Zhang, Yu Zhang

“…Prompt tuning has shown impressive performance in the domain of few-shot text classification tasks, yet the coverage of its crucial module, i.e., the verbalizer, has a considerable effect on the results. …”
Get full text

B-doped nano-hydroxyapatite facilitates proliferation and differentiation of osteoblasts by Qiao Kang, Wenhao Wang, Shengtao Wu, Ganggang Hu

“…B-nHAp boosted the activity of the Wnt/β-catenin signaling pathway. Conclusion B-nHAp modulates the Wnt/β-catenin signaling pathway to significantly enhance the proliferative and differential abilities of osteoblasts, potentially as an efficient material for bone repair.…”
Get full text

Length and PKA Dependence of Force Generation and Loaded Shortening in Porcine Cardiac Myocytes by Kerry S. McDonald, Laurin M. Hanft, Timothy L. Domeier, Craig A. Emter

“…Overall, the bimodal distribution of myocyte length-tension relationships and the PKA-mediated changes in myocyte length-tension and power are likely important modulators of Frank-Starling relationships in mammalian hearts.…”
Get full text

The Association Between Physical Activity and The Development of Degenerative Spine Disease: A Review by Jakub Chodkowski, Urszula Korotko

“…Evidence highlights a dose-dependent relationship, where activity type, intensity, and duration critically modulate outcomes. Limited studies suggest potential genetic and biomechanical factors influencing individual responses to physical activity. …”
Get full text

Chi-miR-4110 promotes granulosa cell apoptosis by targeting Sma- and Mad-related protein 2 (Smad2) in the caprine ovary. by Xiaopeng An, Yuxuan Song, Jinxing Hou, Yue Zhang, Kaiwen Chen, Haidong Ma, Xinyan Zhao, Guang Li, Kexin Gao, Shan Wang, Binyun Cao, Yueyu Bai

“…The increase in Sp1 induces p53-upregulated modulator of apoptosis, which increases the relative abundance of Bax and causes caprine GC apoptosis. …”
Get full text

A novel transmission-augmented deep unfolding network with consideration of residual recovery by Zhijie Zhang, Huang Bai, Ljubiša Stanković, Junmei Sun, Xiumei Li

“…Based on the framework of our previous work PIPO-Net, the multi-channel transmission strategy is put forward to reduce the influence of critical information loss between modules and improve the reliability of data. Besides, in order to avoid the issues such as high information redundancy and high computational burden when too many channels are set, the attention based supervision scheme is presented to dynamically adjust the weight of each channel and remove the redundant information. …”
Get full text

Always Clear Days: Degradation Type and Severity Aware All-in-One Adverse Weather Removal by Yu-Wei Chen, Soo-Chang Pei

“…The proposed method can even restore previously unseen combined multiple degradation images, and modulate restoration level. Implementation code and pre-trained weights will be available at <uri>https://github.com/fordevoted/UtilityIR</uri>.…”
Get full text

Ecological status assessment of the rivers in Slovenia – an overview by Gorazd Urbanič

“…The Slovenian river classification system consists of three modules with pressure-specific assessment methods. …”
Get full text

DIGITALIZATION IN UNIVERSITY EDUCATION: DIDACTIC ASPECTS by Mariia A. Abysova, Mariia H. Kravchuk, Oksana M. Hurniak

“…The variety of forms of organization of educational activities in the digital educational environment is increasing significantly, they are becoming a dynamic open system of educational modules. The educators are being faced with new theoretical tasks due to the active modernization of university educational practice, including the need to find ways to implement continuity between traditional and innovative methods of organizing the educational process while taking into account specific cognitive, motivational, and need-based characteristics of the digital generation. …”
Get full text

Plant Growth Promoting Rhizobacteria (PGPR): Reports on Their Colonization, Beneficial Activities, and Use as Bioinoculant by Dew Biswas, Amit Kumar Chakraborty, Vikas Srivastava, Arunava Mandal

“…Responding to the external environmental stimuli, they often modulate the expression of genes responsible for the transport of nutrients. …”
Get full text

Mini meta-analysis of anticholinesterase actions of atorvastatin, simvastatin and rosuvastatin, and in silico identification of their protein targets in Mus musculus by Fouad Kasim Mohammad, Rawnaq Faris Al-Shalchi

“…The findings highlight statin effects in mice by reducing blood and brain ChE activities, in a dose/concentration-dependent manner, that would potentially modulate the cholinergic system. This anti-ChE effect together with in silico protein targets recognized could be the basis of further experimental explorations of adverse effects of statins.…”
Get full text

Studies on the Association of GCK and GCKR Polymorphisms with Susceptibility to Gestational Diabetes Mellitus: A Meta-Analysis by Hongxia Tu, Youyi Zhang, Mingyi Wang

“…Polymorphisms in the glucokinase (GCK) and glucokinase regulatory protein (GCKR) genes, which are crucial for glucose homeostasis, may modulate susceptibility to GDM. Hence, this meta-analysis aimed to assess the relationship between GDM and polymorphisms in GCK (rs1799884, rs4607517) and GCKR (rs780094, rs1260326). …”
Get full text

GIS BASED DECISION SUPPORT SYSTEM FOR SEISMIC RISK IN BUCHAREST. CASE STUDY – THE HISTORICAL CENTRE by DIANA GHEORGHE, IULIANA ARMAS

“…For the present paper, the SMCE Module for ILWIS 3.4 was used. The method included the following steps: structuring the problem in a decision tree, applying standardization and weighting methods to the criteria, finding suitable alternatives and choosing one of the alternatives. …”
Get full text

Analyses of Total Alkaloid Extract of Corydalis yanhusuo by Comprehensive RP × RP Liquid Chromatography with pH Difference by Xiaodong Wei, Hongling Shen, Lijun Wang, Qingyan Meng, Wenjie Liu

“…The performance of pH modulated 2D LC is demonstrated with 8 alkaloid standards which resulted in orthogonal separation. …”
Get full text

Training Technologies as Means for Forming the Professional Identity of Police Officers during Professional Genesis by O. Y. Shlomin

“…It is noted that the developed and worked out program of comprehensive training to optimize the professional genesis of the employees of preventive units of the National Police consists of three modules and allows participants to solve problems (professional and life) situations during training exercises. …”
Get full text

Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness by Sahithi Attaluri, Raghavendra Upadhya, Maheedhar Kodali, Leelavathi N. Madhu, Dinesh Upadhya, Bing Shuai, Ashok K. Shetty

“…Therefore, drugs capable of modulating LT signaling may reduce neuroinflammation and improve cognitive function in GWI. …”
Get full text

PROJECT DESIGN OF LEARNING ACTIVITY CYCLE FROM THE PERSPECTIVE OF ACTIVITY AND COMPETENCE APPROACH by E. O. Pokhomchikova

“…The project provides a rationale for choosing a topic that reflects the core competence towards which the educational process is directed. The chosen topic is module involving the complete cycle of competence development including stages “Know”, “Able to”, “Master” and “Be”. …”
Get full text

Zigbee Wireless Sensor Networks: Performance Study in an Apartment-Based Indoor Environment by Biswajit Kumar Dash, Jun Peng

“…The experiments were done in a XBee module-based Zigbee network for measuring the received signal strength indicator (RSSI), packet drop rate (PDR), and loopback throughput with and without nearby Wi-Fi traffic introduced on purpose. …”
Get full text