Blind super-resolution network based on local fuzzy discriminative loss for fabric data augmentation by Ning Dai, Xiaohan Hu, Kaixin Xu, Xudong Hu, Yanhong Yuan, Bo Cao, Luhong Shi

“…The model is based on Real-ESRGAN and has been optimized specifically for the resolution degradation module to better adapt to the resolution degradation process in fabric images. …”
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Boosting the human antiviral response in conjunction with natural plant products by Rashmi Srivastava, Neeraj Kumar Dubey, Megha Sharma, Harsha Kharkwal, Rajesh Bajpai, Rakesh Srivastava

“…Various plant natural products (PNPs) known for their antiviral properties have been evaluated for their ability to modulate immune responses and inhibit viral infections. …”
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Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies by Hongping Wan, Xinyi Zhong, Shinong Yang, Jiarong Deng, Xu Song, Yong Liu, Yuanfeng Li, Zhongqiong Yin, Xinghong Zhao

“…These systems utilize bacteriophage receptor‐binding proteins conjugated to loading modules, enabling efficient targeting of bacterial pathogens. …”
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Exploring the Potential of SGLT-2 Inhibitors in Cancer Treatment: Mechanisms, Preclinical Findings, and Clinical Implications by Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła, Michał Mazur, Dorota Waz, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak

“… Introduction Sodium-glucose co-transporter 2 (SGLT-2) inhibitors, originally developed for the treatment of type 2 diabetes, have recently attracted attention for their potential applications in oncology. Their potential to modulate tumor metabolism and enhance responses to cancer therapies is an area of increasing interest. …”
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Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease by Ana R. Pérez, Ana R. Pérez, Oscar A. Bottasso, Oscar A. Bottasso, Oscar A. Bottasso, Natalia E. Santucci, Natalia E. Santucci

“…Evidence indicates that in infectious diseases, cancer, and autoimmunity, NRs modulate immune and endocrine responses, altering the transcriptional profile of cells and organs and influencing disease progression. …”
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Versatile Click Chemistry-based Approaches to Illuminate DNA and RNA G-Quadruplexes in Human Cells by Angélique Pipier, David Monchaud

“…Among them, G4 imaging ranks high because of its reliability and practical convenience, which now makes cellular G4 detection quick and easy; also, because this technique is sensitive and responsive to any G4 modulations in cells, which thus allows gaining precious insights into G4 biology. …”
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Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway by Ruina Han, Dongyang Zhou, Ning Ji, Zhifeng Yin, Jian Wang, Qin Zhang, Hao Zhang, Jinlong Liu, Xinru Liu, Han Liu, Qinglin Han, Jiacan Su

“…Our in vitro findings indicate that FA-GDEVs promote the polarization towards a reparative M2 macrophage phenotype by modulating the PI3K-AKT pathway. Further corroboration comes from in vivo studies, which demonstrate that FA-GDEVs not only concentrate efficiently in the affected joints but also markedly reduce the manifestations of RA. …”
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Integration of ordered porous materials for targeted three-component gas separation by Xue Jiang, Yu Wang, Hui Wang, Lu Cheng, Jian-Wei Cao, Jin-Bo Wang, Rong Yang, Dong-Hui Zhang, Run-Ye Zhang, Xiu-Bo Yang, Su-Hang Wang, Qiu-Yu Zhang, Kai-Jie Chen

“…Thermodynamic and dynamic simulation results explained that the pre-designed pore modules can perform specific target functions independently in the pore-integrated materials.…”
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Self-Supervised Chinese Ontology Learning from Online Encyclopedias by Fanghuai Hu, Zhiqing Shao, Tong Ruan

“…We explore the three largest online Chinese encyclopedias for ontology learning and describe how to transfer the structured knowledge in encyclopedias, including article titles, category labels, redirection pages, taxonomy systems, and InfoBox modules, into ontological form. In order to avoid the errors in encyclopedias and enrich the learnt ontology, we also apply some machine learning based methods. …”
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Remimazolam Combined with Andrographolide Improve Postoperative Cognitive Dysfunction in Rats after Cardiopulmonary Bypass through the AMPK/SIRT1 Signaling Pathway by Chong Chen, Lixia Lan, Kai Xu

“…Methods: We hypothesized that the combination of Re and AP could improve postoperative cognitive dysfunction (POCD) in rats after CPB by modulating nervous system inflammation. Cognitive function was assessed using the Morris Water Maze test, and the concentrations of tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) in serum were measured by enzyme-linked immunosorbent assay (ELISA). …”
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Meta-atoms: From Metamaterials to Metachips by Hao Chi Zhang, Sen Gong, Le Peng Zhang, Yaxin Zhang, Tie Jun Cui

“…Information metamaterials break the inherent barriers between the EM and digital domains, providing a physical platform for controlling EM waves and modulating digital information simultaneously. The concepts of meta-atoms and metamaterials are also introduced to high-frequency integrated circuit designs to address issues that cannot be solved by traditional methods, since lumped-parameter models become unsustainable at microscopic scales. …”
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Decoding SFRP2 progenitors in sustaining tooth growth at single-cell resolution by Tianyuan Zhao, Qing Zhong, Zewen Sun, Xiaoyi Yu, Tianmeng Sun, Zhengwen An

“…Mechanistically, we found that the transcription factor Twist1, regulated via MAPK phosphorylation, binds to the Sfrp2 promoter and modulates Wnt signaling activation to maintain stem cell identity. …”
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A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis by Aleksandar R. Zivkovic, Sebastian O. Decker, Anne C. Zirnstein, Annette Sigl, Karsten Schmidt, Markus A. Weigand, Stefan Hofer, Thorsten Brenner

“…Anti-inflammatory nonneuronal cholinergic signaling modulates the magnitude of an immune response. Serum cholinesterase (BChE), an enzyme that hydrolyzes acetylcholine, plays an important role during inflammatory response and serves as an accurate index of cholinergic activity. …”
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Glucocorticoid receptor: translocation from the cytoplasm to the nuclei, chromatin and intranuclear chaperone cycles by V. M. Merkulov, N. V. Klimova, T. I. Merkulova

“…Upon ligand binding, GR dissociates from chaperon complex and translocates into the nucleus, where it interacts with specific DNA sequences (GREs) in the regulatory regions of target genes and modulates their expression. Then unliganded GR is exported to the cytoplasm, completing the nuclear-cytoplasmic cycle. …”
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Low-Resolution Target Detection with High-Frequency Information Preservation by Feng Zhang, Hongyang Bai, Wenlong Yin, Ze Li, Hailong Ma, Lei Chen

“…It is composed of two key components: (1) the decoupled high-frequency learning component, which extracts the high-frequency information along the vertical and horizontal directions separately, and (2) the dilated frequency-aware channel correlation component, which decomposes the input feature map into multiple smaller ones in a dilated manner, concatenates them by channel, and then correlates the combined channels in the frequency space. Our module can generally be integrated into existing network architectures for target detection (e.g., YOLO, HRNet). …”
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Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights by Akhil Hegde, Yung-Hua Koh, Shabbir M. Moochhala, Madhav Bhatia

“…We conclude that substance P acting via neurokinin-1 receptor in sepsis initiated signaling cascade mediated mainly by protein kinase C-α, led to NF-κB and activator protein-1 activation, and further modulated proinflammatory mediators.…”
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Effect of Vitronectin Bound to Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 on Porcine Enamel Organ-Derived Epithelial Cells by Yoshinori Shinohara, Shuhei Tsuchiya, Kazuo Hatae, Masaki J. Honda

“…The aim of this paper was to determine whether the interaction between IGF, IGFBP, and VN modulates the functions of porcine EOE cells. Enamel organs from 6-month-old porcine third molars were dissociated into single epithelial cells and subcultured on culture dishes pretreated with VN, IGF-I, and IGFBP-3 (IGF-IGFBP-VN complex). …”
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Chemical Characterization and Biological Activities of Essential Oil Obtained from Mint Timija Cultivated under Mineral and Biological Fertilizers by Ayoub Kasrati, Chaima Alaoui Jamali, Robert Spooner-Hart, Laurent Legendre, David Leach, Abdelaziz Abbad

“…Overall, we conclude that cultivation using complete mineral fertilizer and VAM inoculation could be useful in modulating the chemical composition and enhancing the antioxidant activity of the EO of this endemic Moroccan species.…”
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Verification of CENDL-3.2 Nuclear Data on VENUS-3 Shielding Benchmark by ARES Transport Code by Jiaju Hu, Bin Zhang, Zhiwei Zong, Cong Liu, Yixue Chen

“…To verify the applicability of the library to the shielding calculation of PWR and analyze the influence of multigroup cross-section parameters on the shielding calculation, ARES-MACXS module is used to process the MATXS format multigroup library based on CENDL-3.2 to generate multigroup working cross sections for PWR shielding calculation. …”
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Therapeutic Doses of Nonsteroidal Anti-Inflammatory Drugs Inhibit Osteosarcoma MG-63 Osteoblast-Like Cells Maturation, Viability, and Biomineralization Potential by E. De Luna-Bertos, J. Ramos-Torrecillas, O. García-Martínez, A. Guildford, M. Santin, C. Ruiz

“…Short-term treatment with therapeutic doses of NSAIDs modulated differentiation, antigenic profile, and phagocyte activity of osteoblast-like cells. …”
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