PGE2 Desensitizes β-Agonist Effect on Human Lung Fibroblast-Mediated Collagen Gel Contraction through Upregulating PDE4 by Qiuhong Fang, Yingmin Ma, Jing Wang, Joel Michalski, Stephen I. Rennard, Xiangde Liu

“…These findings suggest that long-acting β-agonist and PDE4 inhibitor have a synergistic effect in regulating fibroblast tissue repair functions and that PGE2 can modulate the effect of β-agonist and PDE4 inhibitor at least in part through the mechanism of regulating PDE4 expression.…”
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Shine on: Review of Laser- and Light-Based Therapies for the Treatment of Burn Scars by C. Scott Hultman, Renee E. Edkins, Clara N. Lee, Catherine T. Calvert, Bruce A. Cairns

“…We will demonstrate that laser- and light-based therapies can be combined with each other safely to yield superior results, often at lower cost, by reducing the need for reconstructive surgery. Modulating the burn scar, through minimally invasive modalities, may replace conventional methods of burn scar excision and yield outcomes not previously possible or conceivable.…”
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Sherlock-Genome: an R Shiny application for genomic analysis and visualization by Alyssa Klein, Jun Zhong, Maria Teresa Landi, Tongwu Zhang

“…Following FAIR principles, Sherlock-Genome provides a platform and guidelines for managing and sharing finalized sample-level WGS analysis results, enabling users to upload results, inspect analyses locally, and perform integrative analyses. It includes modules for major cancer genomic analyses, allowing interactive data visualizations and integrative analyses with other data types. …”
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ID-UNet: A densely connected UNet architecture for infrared small target segmentation by Diankun Chen, Feiwei Qin, Ruiquan Ge, Yong Peng, Changmiao Wang

“…Specifically, this research devises a feature extraction module, named Infrared Small Target Feature Extraction (ISTFE), that is embedded within the ID-UNet architecture to enable cross-layer and continuous interaction between deep high-level and shallow low-level features. …”
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Estimating Aggregate Capacity of Connected DERs and Forecasting Feeder Power Flow With Limited Data Availability by Amir Reza Nikzad, Amr Adel Mohamed, Bala Venkatesh, John Penaranda

“…Our proposal comprises: 1) ovel deep learning-based architecture with a few convolutional neural network and long short-term memory (CNN-LSTM) modules to represent feeder connected aggregate models of DERs and loads and associated training algorithms; 2) method for estimating aggregate capacities of connected renewables and loads; and 3) method for short-term (hourly) high-resolution forecasting. …”
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Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America by Gabriela Venicia Araujo Flores, Carmen Maria Sandoval Pacheco, Thaise Yumie Tomokane, Wilfredo Sosa Ochoa, Concepción Zúniga Valeriano, Claudia Maria Castro Gomes, Carlos Eduardo Pereira Corbett, Marcia Dalastra Laurenti

“…The data suggest that T regulatory FoxP3+ cells and the regulatory cytokines, especially TGF-β, play an important role in the immunopathogenesis of NUCL, modulating a cellular immune response in the skin, avoiding tissue damage, and leading to low tissue parasitic persistence.…”
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Naringenin, a Food Bioactive Compound, Reduces Oncostatin M Through Blockade of PI3K/Akt/NF-κB Signal Pathway in Neutrophil-like Differentiated HL-60 Cells by Na-Ra Han, Hi-Joon Park, Seong-Gyu Ko, Phil-Dong Moon

“…In the current work, we studied whether NAR modulates OSM release in neutrophil-like differentiated (d)HL-60 cells. …”
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Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model by Livia Aparecida Procópio Gomes, Lívia Mara Alves Figueiredo, Ana Luiza do Rosário Palma, Barbara Maria Corrêa Geraldo, Kelly Cristine Isler Castro, Luciana Ruano de Oliveira Fugisaki, Antônio Olavo Cardoso Jorge, Luciane Dias de Oliveira, Juliana Campos Junqueira

“…Punica granatum L. is an effective herbal extract with broad spectrum of action and bactericidal, antifungal, anthelmintic potential and being able to modulate the immune response. The aim was to evaluate the antimicrobial activity of pomegranate glycolic extract (PGE) against the periodontal pathogen Porphyromonas gingivalis by using Galleria mellonella as in vivo model. …”
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Effect of Alkaloids from Nelumbinis Plumula against Insulin Resistance of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice by Yong Xie, Yi Zhang, Zebin Guo, Hongliang Zeng, Baodong Zheng

“…Also, JNK and IRS phosphorylation were suggested for their involvement in the modulating of IR during NAFLD progression. Therefore, NPA may serve as a potential natural remedy against IR in NAFLD.…”
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Comparative transcriptomics and metabolomics provide insight into degeneration‐related physiological mechanisms of Morchella importuna after long‐term preservation by Ying Chen, Xuelian Cao, Liyuan Xie, Jie Tang, Lixu Liu, Di Wang, Xiang Wu, Tianhai Liu, Yang Yu, Yong Wang, Francis Martin, Weihong Peng, Hao Tan

“…Repeated subculturing triggered dissimilar changes in the functional modules under nutrient‐rich and nutrient‐limited conditions. …”
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Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice by Mario Rodriguez-Canales, Ruben Jimenez-Rivas, Maria Margarita Canales-Martinez, Ana Judith Garcia-Lopez, Nelly Rivera-Yañez, Oscar Nieto-Yañez, Yadira Ledesma-Soto, Luvia Enid Sanchez-Torres, Miriam Rodriguez-Sosa, Luis Ignacio Terrazas, Marco Aurelio Rodriguez-Monroy

“…The results suggested the protective potential of AaEE in DSS-induced colitis and this might be attributed to its phytochemicals compounds that have been found to induce a wide spectrum of activities such as reduction in oxidative stress, suppression of inflammation, modulating numerous signal transduction pathways, and induction of apoptosis. …”
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Timing of Acupuncture during LTP-Like Plasticity Induced by Paired-Associative Stimulation by Xiao-kuo He, Qian-qian Sun, Hui-hua Liu, Xin-yi Guo, Cheng Chen, Li-dian Chen

“…Our results indicated that acupuncture modulated the excitability of M1, and the synaptic plasticity was time-dependent. …”
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Case study of natural convection topology optimization based on finite volume method by Honglei Liu, Shuzhe Guo, Ce Liu, Fei Du, Baotong Li, Jun Hong

“…Notably, finite element method has long been used as the analysis module of the topology optimization since early studies, which is different from most computational fluid dynamics software that uses finite volume method (FVM). …”
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Step-necking growth of silicon nanowire channels for high performance field effect transistors by Lei Wu, Zhiyan Hu, Lei Liang, Ruijin Hu, Junzhuan Wang, Linwei Yu

“…In this work, we demonstrate that ultrathin and short silicon nanowires channels can be created through a local-curvature-modulated catalytic growth, where a planar silicon nanowires is directed to jump over a crossing step. …”
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Gender-Related Effects of Sex Steroids on Histamine Release and FcεRI Expression in Rat Peritoneal Mast Cells by Samira Muñoz-Cruz, Yolanda Mendoza-Rodríguez, Karen E. Nava-Castro, Lilián Yepez-Mulia, Jorge Morales-Montor

“…In conclusion, MCs degranulation is modulated by sex hormones in a gender-selective fashion, with MC from females being more susceptible than MC from males to the effects of sex steroids.…”
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Encapsulated Fe3C boosted electrocatalytic performance for oxygen reduction reaction of N-doped carbon nanotube by Jun Dong, Qiqi Jiao, Hao Wang, Hong Wang, Yi-ke Ren

“…The additional electric field between Fe3C and N-CNT modulated the C-N bond of surface N-CNT and enhanced the catalytic performance for ORR. …”
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Regulator of Calcineurin 1 in Periodontal Disease by Ulrike Peters, Eleni Solominidou, Yüksel Korkmaz, Stefan Rüttermann, Astrid Klocke, Thomas Frank Flemmig, Thomas Beikler

“…During an acute infection, however, rcan1 seems to be upregulated in endothelial cells, indicating a modulating role in immune homeostasis of periodontal tissues.…”
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Activity of Phosvitin in Hydroxyapatite Acid-Damage Immersion and Antimicrobial Assays by Richard D. Shipman, Sean D. Doering, Jack R. Hemsath, Eun Joo Lee, Jennifer E. Grant

“…SEM, AFM, and FAAS analyses revealed that pretreatment of discs with phosvitin modulated the damage-induced morphology and topography changes associated with acid-damaged discs.…”
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Impaired Glucose Metabolism Is Associated with Visit-to-Visit Blood Pressure Variability in Participants without Cardiovascular Disease by Nobuo Sasaki, Ryoji Ozono, Saeko Fujiwara, Ryo Maeda, Yasuki Kihara

“…In participants without CVD, impaired glucose metabolism may modulate visit-to-visit BP variability.…”
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The evolutionary dynamics of plastic foraging and its ecological consequences: a resource-consumer model by Ledru, Léo, Garnier, Jimmy, Guillot, Océane, Faou, Erwan, Noûs, Camille, Ibanez, Sébastien

“…Yet little is known about the ecological conditions that favor the evolution of PF, and how the evolutionary dynamics of PF may modulate its effects on community stability. In order to address these questions, we constructed an eco-evolutionary model in which resource and consumer niche traits underwent evolutionary diversification. …”
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