Subtilases: a major prospect to the genome editing in horticultural crops by Umashankar Chandrasekaran, Umashankar Chandrasekaran, Woo Jong Hong, Hyeran Kim, Hyeran Kim

“…Among these, SBTs (serine proteases) are a major class of proteolytic enzymes in plants and play key roles in various regulatory mechanisms, including plant immune response, fruit development and ripening, modulating root growth, seed development and germination, and organ abscission. …”
Get full text

Role of gut microbiota and fecal metabolites in the protective effect of soybean pulp-rich diet against estrogen-induced cholestasis in rats by Jiawei Wang, Qichao Hu, Jianying Wang, Liwei Lang, Shizhang Wei, Haotian Li, Manyi Jing, Xiao Ma, Yanling Zhao, Xuelin Zhou

“…Moreover, the soybean pulp-rich diet could modulate the abundances of Prevotella spp. and Tyzzerella, reducing EIC by regulating lipid metabolism and short-chain fatty acids synthesis. …”
Get full text

Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD by Fabrizio Termite, Sebastiano Archilei, Francesca D’Ambrosio, Lucrezia Petrucci, Nicholas Viceconti, Roberta Iaccarino, Antonio Liguori, Antonio Gasbarrini, Luca Miele

“…Gut microbiota plays a substantial role in modulating hepatic oxidative stress through multiple pathways: impairing the intestinal barrier, which results in bacterial translocation and chronic hepatic inflammation; modifying bile acid structure, which impacts signaling cascades involved in lipidic metabolism; influencing hepatocytes’ ferroptosis, a form of programmed cell death; regulating trimethylamine N-oxide (TMAO) metabolism; and activating platelet function, both recently identified as pathogenetic factors in MASH progression. …”
Get full text

An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass by E. Losanno, M. Badi, E. Roussinova, A. Bogaard, M. Delacombaz, S. Shokur, S. Micera

“…<italic>Objective:</italic> Brain-body interfaces (BBIs) have emerged as a very promising solution for restoring voluntary hand control in people with upper-limb paralysis. The BBI module decoding motor commands from brain signals should provide the user with intuitive, accurate, and stable control. …”
Get full text

Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo by Wei Li, Haihong Chen, Hongliang Chen, Ziyin Li, Wei Hu, Qinxuan Zhou, Bing Xu, Yi Wang, Xinhui Xing

“…In vitro results found that ADBP protected uric acid (UA)-induced HK-2 cells from damage by modulating urate transporters and antioxidant defense. …”
Get full text

Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats by Lei Zhang, Xingzhi Wang, Liang Chang, Yiqun Ren, Manshu Sui, Yuting Fu, Lei Zhang, Lirong Hao

“…Thus, our research underscores quercetin’s potential in DKD treatment by modulating the ferroptosis process via activating Nrf2 in a distinct DKD rat model, offering a fresh perspective on quercetin’s protective mechanisms.…”
Get full text

Veratrilla baillonii Franch alleviate the symptoms of diabetes in type 2 diabetic rats induced by high-fat diet and streptozotocin by Chunlan Yan, Zhihao Zhang, Liqun Ma, Xinyi Xu, Muhammad Azhar, Xianju Huang, Jianxun Shi, Jun Li

“…Further investigation suggested that WVBF modulates the signal transductions of the IRS1/PI3K/AKT/GLUT4 and AMPK pathways. …”
Get full text

INRNet: Neighborhood Re-Ranking-Based Method for Pedestrian Text-Image Retrieval by Kehao Wang, Yuhui Wang, Lian Xue, Qifeng Li

“…Finally, we input the restructured data into our Implicit Neighborhood Inference (INI) module, utilizing nearest neighbor intersection to optimize retrieval performance. …”
Get full text

WCMU-net: An Effective Method for Reducing the Impact of Speckle Noise in SAR Image Change Detection by Yu Duan, Kaimin Sun, Wangbin Li, Jinjiang Wei, Song Gao, Yingjiao Tan, Wanghui Zhou, Jun Liu, Junyi Liu

“…Subsequently, conventional convolutions are utilized to extract high-level semantic information from frequency-domain images, with the resulting feature maps serving as patch inputs to the ConvMixer module to acquire blended spatial and positional information. …”
Get full text

A Coupling Dynamics Analysis Method for Two-Stage Spur Gear under Multisource Time-Varying Excitation by Zizhen Qiao, Jianxing Zhou, Wenlei Sun, Xiangfeng Zhang

“…The continuous system is divided into four modules: shaft-shaft element, shaft-gear element, shaft-bearing element, and gear-gear element. …”
Get full text

Reducing M2 macrophage in lung fibrosis by controlling anti-M1 agent by Fatemeh Bahram Yazdroudi, Alaeddin Malek

“…The results highlight the potential of the proposed optimal control approach in modulating tissue repair processes and mitigating the progression of IPF. …”
Get full text

Multifunctional nanoparticles confers both multiple inflammatory mediators scavenging and macrophage polarization for sepsis therapy by Wenjie Xi, Weijie Wu, Lili Zhou, Qi Zhang, Shushu Yang, Lihong Huang, Yijun Lu, Jing Wang, Xinjin Chi, Yang Kang

“…Briefly, the effective treatment of sepsis can be achieved by multiple strategies of effectively capturing the inflammatory triggering factor cfDNA, modulating the polarization of M1 macrophage to M2 macrophage and scavenging ROS, which has a promising clinical application.…”
Get full text

AlgaeClass&#x005F;Net: Optimizing Few-Shot Marine Microalgae Classification With Multi-Scale Feature Enhancement Network by Dan Liu, Guihong Yuan, Huachao Tan, Yanbo Jiang, Hai Bi, Yuan Cheng

“…In this paper, an AlgaeClass&#x005F;Net algorithm that combines an improved multi-scale feature fusion with a feature enhancement module is proposed for the fine-grained features of microalgae. …”
Get full text

Expression of CD24 in Human Bone Marrow-Derived Mesenchymal Stromal Cells Is Regulated by TGFβ3 and Induces a Myofibroblast-Like Genotype by Luisa Marilena Schäck, Manuela Buettner, Alexander Wirth, Claudia Neunaber, Christian Krettek, Andrea Hoffmann, Sandra Noack

“…We demonstrate that CD24 is an important modulator in transforming growth factor beta 3 (TGFβ3) signaling with a reciprocal regulatory relationship between these two proteins.…”
Get full text

Palmitoylethanolamide supplementation for human health: A state-of-the-art systematic review of Randomized Controlled Trials in patient populations by R. Bortoletto, C. Comacchio, M. Garzitto, F. Piscitelli, M. Balestrieri, M. Colizzi

“…Also, alongside symptom improvement, PEA demonstrated to modulate biomarkers early altered in the initial phases of an illness or contributing to its progression, suggesting a disease-modifying potential. …”
Get full text

Toward the calibration of 2D thermomechanical simulations of magma poor passive continental margins: method, validation and case example by Perron, Paul, Le Pourhiet, Laetitia, Jourdon, Anthony, Cornu, Tristan, Gout, Claude

“…This method integrates a new kinematic module into the pTatin2D code, allowing for calibrating numerical simulations with regional geological and geophysical dataset over time while solving for mechanical balance using Stokes flow to ensure that crustal deformation remains consistent with mantle dynamics. …”
Get full text

Phosphodiesterase 10A Is a Mediator of Osteogenic Differentiation and Mechanotransduction in Bone Marrow-Derived Mesenchymal Stromal Cells by Sigrid Müller-Deubert, Carolin Ege, Melanie Krug, Jutta Meißner-Weigl, Maximilian Rudert, Oliver Bischof, Franz Jakob, Regina Ebert

“…We conclude that PDE10A is a modulator of osteogenic differentiation as well as mechanotransduction in hMSCs. …”
Get full text

Diffusion Behaviors of Hydrogen Isotopes in Incoloy 800H: A First-Principles Study by Hongyu Chen, Hong Li, Chuan Li, Jianzhu Cao, Chao Fang

“…Incoloy 800H is one of the main stainless steel materials used in steam generators with High Temperature Reactor Pebble-bed Modules (HTR-PM). In this study, the diffusion behaviors of hydrogen isotopes in Incoloy 800H were investigated with first-principle calculations. …”
Get full text

Impact of Organ Donor Pretreatment With Anti-Thymocyte Globulin in a Murine Model of Allogenic Kidney Transplantation by An He, An He, Yiren Yang, Katja Kotsch, Arne Sattler

“…To improve transplantation outcomes, particularly of “marginal” organs from extended criteria donors (ECD), attempts have been made to therapeutically modulate donor or graft pre-transplantation. Anti-thymocyte globulin (ATG) has a history as lymphocyte-depleting, immunosuppressive drug for treating rejection episodes post transplantation. …”
Get full text

Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans by Andrea Guerra, Matteo Bologna, Giulia Paparella, Antonio Suppa, Donato Colella, Vincenzo Di Lazzaro, Peter Brown, Alfredo Berardelli

“…These findings demonstrate that tACS modulates finger tapping in a frequency-dependent manner with no concurrent changes in corticospinal excitability. …”
Get full text