Dual‐Enhanced SERS Satellite Immuno‐Nanocomplex for Multiple PSA‐Mediated PHI Assay Toward Clinical Prostate Cancer Screening by Dong Chen, Yilin Ma, Annan Yang, Liping Hu, Hanlin Zhou, Jun Xu, Shanze Chen, Dingmeng Nie, Weifeng Feng, Huaihong Cai, Yanguang Cong, Jiang Pi, Lang Rao, Xueqin Huang, Pinghua Sun, Haibo Zhou

“…Unlike the previous studies focus on the tPSA and fPSA/tPSA ratio (f/t PSA%), this work introduces a multiple PSA‐mediated Prostate Health Index (PHI) assay with significantly increased the predictive accuracy and specificity of PCa, especially the patients with a tPSA level in the “diagnostic gray zone”. …”
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Electroacupuncture Improves Baroreflex and γ-Aminobutyric Acid Type B Receptor-Mediated Responses in the Nucleus Tractus Solitarii of Hypertensive Rats by Qi Zhang, Ying-Ying Tan, Xiao-hua Liu, Fan-Rong Yao, Dong-Yuan Cao

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Notch Signaling Mediates TNF-α-Induced IL-6 Production in Cultured Fibroblast-Like Synoviocytes from Rheumatoid Arthritis by Zhijun Jiao, Wenhong Wang, Jie Ma, Shengjun Wang, Zhaoliang Su, Huaxi Xu

“…The aim of this paper was to investigate whether Notch signaling mediated TNF-α-induced cytokine production of cultured fibroblast-like synoviocytes (FLSs) from RA. …”
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Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by reducing CCL2-mediated macrophage infiltration in sensory ganglia and sciatic nerve by Yuanyuan Li, Ruoyao Xu, Muyan Chen, Kaige Zheng, Huimin Nie, Chengyu Yin, Boyu Liu, Yan Tai, Junying Du, Jie Wang, Jianqiao Fang, Boyi Liu

“…Conclusions These findings suggest EA alleviates PIPN by reducing CCL2/CCR2 mediated-pro-inflammatory macrophage infiltration into sensory ganglia as well as the sciatic nerve. …”
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Exploring the mediating role of blood metabolites in the relationship between gut microbiota and gastric cancer risk: a Mendelian randomization study by Xiaocheng Li, Xiaocheng Li, Huapeng Lin, Huapeng Lin, Huapeng Lin, Jing Peng, Jianping Gong

“…Additionally, we conducted mediation analysis (two-step MR) to identify potential metabolite mediators in the GM-GC relationship.ResultsWe identified twelve negative and seven positive associations between specific GM taxa and GC risk. …”
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Enhanced silk production and pupal weight in Bombyx mori through CRISPR/Cas9-mediated circadian Clock gene disruption. by Daniel J Brady, Alessio Saviane, Matteo Battistolli, Irene Varponi, Federica Barca, Kunihiro Shiomi, Silvia Cappellozza, Federica Sandrelli

“…This study investigates the role of the circadian clock gene Clock in B. mori using CRISPR/Cas9-mediated mutagenesis to establish the ClkΔ29 knock-out mutant strain. …”
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Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension by Justin H. Berger, Yuji Shi, Timothy R. Matsuura, Kirill Batmanov, Xian Chen, Kelly Tam, Mackenzie Marshall, Richard Kue, Jiten Patel, Renee Taing, Russell Callaway, Joanna Griffin, Attila Kovacs, Dinesh Hirenallur-Shanthappa, Russell Miller, Bei B. Zhang, Rachel J. Roth Flach, Daniel P. Kelly

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Toll-like receptor 2-mediated ERK activation significantly upregulates interleukin-6 expression in M2-polarized macrophages by Jo Wol Soon, Kim Sung Dae, Jeong Soo Kyung, Oh Su Jung, Baik Ji Sue, Seo Ji An, Baek Jeong-Hwa, Lee Chang Geun, Kang Young-Rok, Jeong Min Ho, Park Moon-Taek

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The mediating role of accelerated biological aging in the association between household air pollution from solid cooking fuels and neuropsychiatric disorders by Rui Tang, Haisheng Wu, Ling Jiang, Jie Zhou, Xia Gao, Jiazhen Zheng, Ya-Ping Tang, Mingxi Tang

“…Results: Compared to consistent use of cleaner fuels, consistent solid fuel use was associated with a 0.12 (95 % CI: 0.05, 0.18) year increase in KDM-BAA, a 25 % higher risk of neurological disease (HR = 1.25, 95 % CI: 1.03, 1.54), and a 34 % increased risk of psychiatric disorders (HR = 1.34, 95 % CI: 1.02, 1.78). Mediation analysis revealed that KDM-BAA significantly mediated the association between solid cooking fuel and neuropsychiatric diseases, with mediated proportions of 5.96 % (P = 0.006) for neurological disease and 5.71 % (P = 0.024) for psychiatric disease. …”
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The Influence of Brand Image and Electronic Word of Mouth on Purchase Intention of the Originote Products by Tiktok Users with Brand Trust as a Mediator by Falasifatul Falah, Muzakar Isa

“… This research explores the effect of brand image and electronic word of mouth (e-WOM) on the purchase intention of Originote products among TikTok users, with brand trust as a mediating factor. Data were collected using an online survey distributed through Google Forms from October 5th, 2024, to December 5th, 2024, yielding 195 valid responses. …”
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The impact of attitude towards an e-tax system on tax compliance of Vietnamese enterprises: Adoption of an e-tax system as a mediator by Ha Thi Hai Do, Yen Thi Hai Mac, Hoa Thi Van Tran, Thuy Thi Le Nguyen

“…This mediating effect positively consolidates the impact of attitude towards an e-tax system and tax compliance. …”
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MSC-derived exosome ameliorates pulmonary fibrosis by modulating NOD 1/NLRP3-mediated epithelial-mesenchymal transition and inflammation by Wei Chen, Jie Peng, Xiangyi Tang, Shao Ouyang

“…Conclusion: MSC-derived exosome ameliorates pulmonary fibrosis by modulating NOD 1/NLRP3-mediated epithelial-mesenchymal transition and inflammation.…”
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MiR-128-3p mediates MRP2 internalization in estrogen-induced cholestasis through targeting PDZK1 by Yue Zu, Qianyan Gao, Yisheng He, Qiao Deng, Guodong Li, Xiping Li, Tianze Shang, Xinwei Cheng, Chenglong Zhu, Jianqiao Wang, Dong Liu, Chengliang Zhang

“…Emerging evidence indicates that PDZ domain containing 1 (PDZK1) regulates localization of MRP2; however, PDZK1’s role and regulatory machinery in MRP2-mediated estrogen-induced cholestasis (EIC) remain unclear. …”
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A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial by Xiaorong Wu, Alvin Surya Tjahyo, Vera Sergeyevna Brok Volchanskaya, Long Hui Wong, Xianning Lai, Yi Ning Yong, Farhana Osman, Shia Lyn Tay, Priya Govindharajulu, Shalini Ponnalagu, Rachel Tso, Hwee Sze Teo, Kaijie Khoo, Huan Fan, Chew Chan Goh, Clara Poh Lian Yap, Melvin Khee-Shing Leow, Christiani Jeyakumar Henry, Sumanto Haldar, Kevin Junliang Lim

“…A legume-enriched, multicomponent intervention diet can improve metabolic health in a prediabetes population, in addition to benefits obtained from calorie restriction alone, partially mediated through changes in gut microbial composition and function. …”
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Mediating or moderating? Innovative approach to the role of flexibility in the relationship between entrepreneurial orientation and firm growth under different market conditions by Marcin Suder, Rafał Kusa, Joanna Duda, Małgorzata Okręglicka

“…Specifically, FLEX impacts FG and mediates the EO→FG relationship in a stable market, whereas it does not impact FG nor mediate the EO→FG relationship in a hostile market. …”
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The relationship between discriminatory work environment and psychological distress in Italian organizations: Are lack of supervisor support and economic stress mediating factors? by Giorgia BONDANINI, Gabriele GIORGI, Francesco CHIRICO, Amelia RIZZO, Hicham KHABBACHE, Francesca ROMANA TESTA, Giulia FOTI, Federico ALESSIO, Valerio VINCIARELLI, Georgia Libera FINSTAD

“…This research aims to demonstrate how the perception of a discriminatory work environment can affect workers’ perceived well-being, considering supervisor support and economic stress as potential mediators. Methods:A parallel mediation analysis was conducted on 170 managers to examine the associations between a discriminatory work environment, psychological distress, supervisor support, and economic stress. …”
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Mediating Role of Islamic Social Reporting on the Nexus Between Sharia Supervisory Board Characteristics and Islamic Banks' Financial Performance in Indonesia by Chitra Yuliashri Katili, Rifadli D. Kadir, Asma Polapa, Ritfiani Gobel

“…However, SSB characteristics significantly affect ISR, which in turn has a significant impact on financial performance. The mediation analysis shows that ISR fully mediates the relationship between SSB characteristics and financial performance. …”
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AFP shields hepatocellular carcinoma from macrophage phagocytosis by regulating HuR-mediated CD47 translocation in cellular membrane by Yinglian Pan, Qiushi Yin, Zhaoliang Wang, Gang Wu, Kun Liu, Xiaowei Li, Jinchen Liu, Jiangzheng Zeng, Bo Lin, Wei Li, Mingyue Zhu, Mengsen Li

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ADOPTION OF ARTIFICIAL INTELLIGENCE AND DIGITAL SUPPLY CHAIN FOR ENHANCING SUPPLY CHAIN PERFORMANCE: MEDIATING ROLE OF GREEN SUPPLY CHAIN PROCESS by Abdulaziz Aljoghaiman, Sanjar Mirzaliev

“… : Research empirically tested the impact of artificial intelligence adoption and digital supply chains on supply chain performance with the mediating effect of green supply chain process of manufacturing companies in Saudi Arabia. …”
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Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo. by Geelsu Hwang, Yuan Liu, Dongyeop Kim, Yong Li, Damian J Krysan, Hyun Koo

“…Here, we report that mannans located on the outer surface of C. albicans cell-wall mediates GtfB binding, enhancing glucan-matrix production and modulating bacterial-fungal association within biofilms formed in vivo. …”
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