Association between long-term exposure to air pollution and immune-mediated diseases: a population-based cohort study by Giovanni Adami, Angelo Fassio, Giovanni Orsolini, Davide Gatti, Maurizio Rossini, Ombretta Viapiana, Camilla Benini, Elena Fracassi, Giorgio Cattani, Marco Pontalti, Eugenia Bertoldo

“…The primary aim of the present study was to describe the association between long-term exposure to air pollution and risk of developing immune-mediated conditions.Methods We conducted a retrospective observational study on a nationwide dataset of women and men. …”
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CD36-Mediated Lipid Accumulation and Activation of NLRP3 Inflammasome Lead to Podocyte Injury in Obesity-Related Glomerulopathy by Jing Zhao, Hong-liang Rui, Min Yang, Li-jun Sun, Hong-rui Dong, Hong Cheng

“…Mediators of Inflammation…”
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The association of visceral and subcutaneous fat areas with phenotypic age in non-elderly adults, mediated by HOMA-IR and HDL-C by Yuanhong Liu, Min Xu, Liqing Wang, Linyun Meng, Mengran Li, Shumin Mu

“…Conversely, HDL-C had a greater mediating effect in individuals aged 45–59 years, accounting for 21.7% of the relationship between VFA and PhenoAgeAccel and 11.6% of the relationship between abdominal SFA and PhenoAgeAccel. …”
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ENHANCING WORKPLACE SAFETY BEHAVIOUR THROUGH SAFETY CULTURE AMONG BREWERY WORKERS: THE MEDIATING ROLE OF WORK-LIFE BALANCE by Abimbola A. AKANNI, Choja A. ODUARAN

“…This study investigates the mediating effect of work-life balance in the link between safety culture and workplace safety behavior among brewery workers. …”
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Examination of the Mediating Role of Attachment Dimensions in the Link between Suicide Probability and Cognitive Distortions about Relationships in University Students by Gulin Yazici-Celebiİ, Muge Yilmaz, Muhammed Enes Karacoskun, Aybuke Irem Sahin

“…It was shown that there were low and moderate positive correlations between cognitive distortion scores, and avoidance and anxiety scores. The results of the mediation analyses showed that anxiety and avoidance had a partial mediating role in the relationship between cognitive distortion and suicide probability. …”
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ROS anchor PAMPs-mediated extracellular HMGB1 self-association and its dimerization enhances pro-inflammatory signaling by Man Sup Kwak, Myeonggil Han, Yong Joon Lee, Seoyeon Choi, Jeonghwa Kim, In Ho Park, Jeon-Soo Shin

“…In this study, we investigated the immunological significance of Cys106-mediated HMGB1 homo-dimerization. In the extracellular environment, LPS and LTA induced HMGB1 self-association leading to H2O2 anchoring Cys106–Cys106-mediated HMGB1 intermolecular disulfide bond formation. …”
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NaHS alleviates neuropathic pain in mice by inhibiting IL-17-mediated dopamine (DA) neuron necroptosis in the VTA by Jun Wang, Nan Zhang, Hong-Zheng Liu, Jin-Liang Wang, Yong-Bo Zhang, Dong-Dong Su, Li-Min Zhang, Bao-Dong Li, Hui-Tao Miao, Jun Miao

“…Previous research has suggested that the analgesic effects of NP are mediated by dopamine (DA) neurons in the ventral tegmental region (VTA) through projections to various brain regions. …”
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The Protective Effect of Naringenin on Airway Remodeling after Mycoplasma Pneumoniae Infection by Inhibiting Autophagy-Mediated Lung Inflammation and Fibrosis by Yan Lin, Dan Tan, Qianna Kan, Zhen Xiao, Zhiyan Jiang

“…Mediators of Inflammation…”
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TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma by Ziqing Yu, Lihua Zhong, Wangyang Tang, Wenfang Zhang, Ting Lin, Weifeng Zhu, Gang Chen, Jianchao Wang

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Hepatic Steatosis Aggravates Vascular Calcification via Extracellular Vesicle‐Mediated Osteochondrogenic Switch of Vascular Smooth Muscle Cells by Zhao‐Lin Zeng, Zhi‐Bo Zhao, Qing Yuan, Shi‐Qi Yang, Zhen‐Xing Wang, Zuo Wang, Shi‐Yu Zeng, An‐Qi Li, Qian Chen, Guo‐Qiang Zhu, Xin‐Hua Xiao, Guang‐Hua Luo, Hai‐Yan Luo, Jiao‐Yang Li, Xu‐Yu Zu, Hui Xie, Jiang‐Hua Liu

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Acinetobacter baumannii represses type VI secretion system through a manganese-dependent small RNA-mediated regulation by Somok Bhowmik, Avik Pathak, Shivam Pandey, Kuldip Devnath, Abhiroop Sett, Nishant Jyoti, Timsy Bhando, Jawed Akhter, Saurabh Chugh, Ramandeep Singh, Tarun Kumar Sharma, Ranjana Pathania

“…The sRNA-mediated regulation of type VI secretion system (T6SS) in Acinetobacter baumannii was unchartered. …”
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GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway by Wenjing Xue, Ying Li, Yanna Ma, Feng Zhang

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Structural Model of the Relationship between Professional Competence of Teachers and Self-Directed Learning of Students as Mediators of Students’ Achievement Motivation by mansoure hajhosseini, Halimeh Nafeie

“…Also Research results confirm the mediating role of the Achievement Motivation among them. …”
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Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasma by Tingting Shangguan, Jing Xu, Xiaochun Weng, Hao Lin

“…The ROC analysis indicated that the area under the curve (AUC) for RAR (AUC=0.593) was significantly greater than that for RDW and albumin individually. Mediation analysis indicated that AIP mediated 7.8% of the correlation of RAR with depression.ConclusionsThe findings of this study indicated a significant linear positive correlation between RAR and the prevalence of depression, with AIP serving as a mediator.…”
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Genistein Protects against Spinal Cord Injury in Mice by Inhibiting Neuroinflammation via TLR4-Mediated Microglial Polarization by Xin-Wu Li, Peng Wu, Jian Yao, Kai Zhang, Gen-Yang Jin

“…Our findings suggested that genistein exerted neuroprotective action by inhibiting neuroinflammation by promoting the activation of M2 macrophages, and its underlying mechanisms might be related to the inhibition of the TLR4-mediated MyD88-dependent signaling pathway.…”
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Trichinella spiralis excretory/secretory proteins mediated larval invasion via inducing gut epithelial apoptosis and barrier disruption. by Qi Qi Lu, Wen Wen Zheng, Zhao Yu Zhang, Pei Kun Cong, Xin Guo, Yao Zhang, Xin Zhuo Zhang, Shao Rong Long, Ruo Dan Liu, Zhong Quan Wang, Jing Cui

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Exploring the Mediating Role of Multiple Organ Dysfunction in Sepsis-Induced Disseminated Intravascular Coagulation and Its Impact on Worsening Prognosis by Guangjie Wang MD, Chenxiao Hao MD, Sun Yao MD, Yiqin Wang PHD, Zongtao Xu MD, Huiying Zhao MD, Youzhong An MD

“…Initial data comparison preceded logistic regression analysis of mortality factors post-propensity score matching (PSM). Employing mediation analysis estimated direct and indirect associations. …”
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Salinity Stress Resilience in Sorghum bicolor through Pseudomonas-Mediated Modulation of Growth, Antioxidant System, and Eco-Physiological Adaptations by Muhammad Azeem, Robina Sultana, Naeem Ahmed, Muhammad Waseem Abbasi, Khwaja Ali Hasan, Renjie Dong, Saud Alamri, Alanoud T. Alfagham

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mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4+ T Cell Apoptosis Mediated by ROS in Septic Immunosuppression by Hao Wang, Jianwei Chen, Guangxu Bai, Wen Han, Ran Guo, Na Cui

“…Mediators of Inflammation…”
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Slow Metabolism–Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone‐Induced Obesity‐Specific Liver Injury by Guanting Li, Yourong Hu, Han Zhao, Ziyu Peng, Xin Shang, Jia Zhang, Kunxin Xie, Meiwei Li, Xiaohang Zhou, Qinyao Zhou, Kai Li, Fang Zhou, Heyao Wang, Zhijian Xu, Jiali Liu, Peng Sun

“…This study demonstrates that a slow metabolism‐driven amplification of hepatic PPARγ agonism mediates BBR‐induced obesity‐specific hepatic steatosis and subsequent DILI, which also emphasizes the importance of the reduced hepatic drug metabolism capacity in patients with obesity or pre‐existing NAFLD in both clinical practice and drug discovery processes.…”
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