Repression of CADM1 transcription by HPV type 18 is mediated by three-dimensional rearrangement of promoter-enhancer interactions. by Karen Campos-León, Jack Ferguson, Thomas Günther, C David Wood, Steven W Wingett, Selin Pekel, Christy S Varghese, Leanne S Jones, Joanne D Stockton, Csilla Várnai, Michelle J West, Andrew Beggs, Adam Grundhoff, Boris Noyvert, Sally Roberts, Joanna L Parish

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The mediating role of Dark Triad of personality in the relationship between biological sex and problematic alcohol drinking in university students by Aleksandra M. Rogowska, Dawid Sobczak

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RevCAR-mediated T-cell response against PD-L1-expressing cells turns suppression into activation by Eugenia Crespo, Liliana R. Loureiro, Antonia Stammberger, Lydia Hoffmann, Nicole Berndt, Anja Hoffmann, Claudia Dagostino, Karla E. G. Soto, Luise Rupp, Claudia Arndt, Martin Schneider, Claudia R. Ball, Michael Bachmann, Marc Schmitz, Anja Feldmann

“…Our findings suggest that RevCAR-mediated targeting of PD-L1 could be a promising therapeutic approach for modulating the TME and improving solid tumor treatment.…”
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Small molecule APOL1 inhibitors as a precision medicine approach for APOL1-mediated kidney disease by Brandon Zimmerman, Leslie A. Dakin, Anne Fortier, Evanthia Nanou, Angelo Blasio, James Mann, Howard Miller, Marissa Fletcher, Tiansheng Wang, Suganthini Nanthakumar, Gizelle McCarthy, Caline Matar, Prachi Matsye, Guanyu Wang, Phillip Snyder, Kevin Daniel, Harsha Swamy, Kelly Sullivan, Franklin Bright, Audrey Powers, Kevin J. Gagnon, Fan Lu, Steven Paula, Suvarna Khare-Pandit, Larry Henry, Martine Hamel, Francois Denis, Olivier Nicolas, Niresh Hariparsad, Shyamesh Kumar, Jennifer Proctor, Timothy Senter, Brinley Furey, Mark E. Bunnage

“…We provide evidence that APOL1 channel activity drives podocyte injury and that inhibition of this activity stops APOL1-mediated cell death and kidney damage in a transgenic mouse model. …”
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High glucose promotes macrophage switching to the M1 phenotype via the downregulation of STAT-3 mediated autophagy. by Yu Zhao, Yuteng Jiang, Fengmei Wang, Li Sun, Mengyuan Ding, Liyuan Zhang, Beibei Wu, Xiaoliang Zhang

“…<h4>Conclusion</h4>High glucose promotes macrophage switching to the M1 phenotype via the downregulation of STAT-3-mediated autophagy.…”
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PDE12 mediated pruning of the poly-A tail of mitochondrial DNA-encoded tRNAs is essential for survival by Chenxiao Yu, Marco Tigano, Erin L Seifert

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Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia by Hang Zhang, Sheng Yang, Yi-Lin Lu, Luo-Qi Zhou, Ming-Hao Dong, Yun-Hui Chu, Xiao-Wei Pang, Lian Chen, Lu-Lu Xu, Lu-Yang Zhang, Li-Fang Zhu, Ting Xu, Wei Wang, Ke Shang, Dai-Shi Tian, Chuan Qin

“…Conclusion: Weakened Nrf2-mediated antioxidant responses in microglia induced metabolic disturbances and ferroptosis during chronic cerebral hypoperfusion. …”
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Conventional-Microwave Mediated Synthesis and In Vitro Antimicrobial Activity of Novel Carbazole-Efflux Pump Inhibitor Hybrid Antibacterials by Ghazala Yaqub, Zubi Sadiq, Almas Hamid, Amber Fatima, Zainab Ijaz

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LFA-1: A potential key player in microglia-mediated neuroprotection against oxygen-glucose deprivation in vitro. by Robin Jansen, Marc Pawlitzki, Michael Gliem, Sven G Meuth, Stefanie Schreiber, Michael-W Görtler, Jens Neumann

“…The enigma of neuroprotection after ischemic stroke remains to be solved, and our findings highlight the continuing importance and lack of understanding of integrin-mediated pathways after ischemic stroke and the need for further intensive research.…”
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Oxygen Vacancy-Mediated Interfacial Charge Transfer of Au/ZnO Schottky Heterojunctions for Enhanced UV Photodegradation by Zhufeng Shao, Hui Jia, Yufeng Zhang, Xiujuan Yang, Min Zhong, Chun Chang

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Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells by Naoki Suzuki

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<i>o</i>-Halogenation and -Alkoxylation of Phenylglycine Derivatives by Pd-Mediated C-H Functionalization: Scope and Limitations by Eduardo Laga, Sonia Nieto, Carlos Cativiela, Esteban P. Urriolabeitia

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Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice by Eleni Hackwell, Sharon R Ladyman, Jenny Clarkson, H James McQullian, Ulrich Boehm, Allan Edward Herbison, Rosemary Brown, David R Grattan

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The relationship of future anxiety with a multidimensional framework of well-being among undergraduate students: optimism and pessimism as mediators by Gülçin Güler Öztekin

“…Optimism and pessimism served as mediators in the link between future anxiety and well-being. …”
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Leptin Promotes the Expression of Pro-inflammatory Mediator Genes but Does Not Alter Osteoclastogenesis and Early Stage Differentiation of Osteoblasts by Chien-Ning Hsu, Chih-Hong Kao, Chin-Hua Yang, Ming-Te Cheng, Yu-Pao Hsu, Shinn-Gwo Hong, Chao-Ling Yao, Yu-Hsu Chen

“…The expression of inflammatory mediators was increased in differentiating RAW 264.7 cells. …”
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Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines by R. Sitarz, R. J. Leguit, W. W. J. de Leng, F. H. M. Morsink, W. P. Polkowski, R. Maciejewski, G. J. A. Offerhaus, A. N. Milne

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A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A by Ibrahim M. Sabbarini, Dvir Reif, Kibum Park, Alexander J. McQuown, Anjali R. Nelliat, Charlotte Trejtnar, Volker Dötsch, Eugene I. Shakhnovich, Andrew W. Murray, Vladimir Denic

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Pengaruh Workplace Incivility terhadap Kepuasan Kerja Karyawan Milenial dengan Kelelahan Emosional sebagai Variabel Mediator by Kania Agita Rachmanadya, Seger Handoyo

“…Penelitian ini bertujuan untuk mengetahui pengaruh perilaku ketidaksantunan di tempat kerja terhadap kepuasan kerja karyawan generasi Y dengan kelelahan emosional sebagai variabel mediator. Penelitian ini dilakukan kepada 120 karyawan generasi Y berusia 21- 41 tahun yang bekerja fulltime. …”
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Effects of macrolide antibiotics on blood inflammatory mediators and organ damage markers in lipopolysaccharide-induced pulmonary damage rats by Ayşe Er, Enver Yazar

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The mediating role of core self-evaluation in the association between perceived peer relationship quality and loneliness in university students. by Hongxiu Tan, Wen Xiao

“…This study investigated the mediating role of core self-evaluation (CSE) in the relationship between the perception of peer relationship quality and loneliness among university students during the COVID-19 pandemic. …”
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