Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1 by Xiaowen Hu, Mengsiyu Li, Chunxue Zhang, Shuguang Pang

“…The present study indicated that the activation of AMPK-CAR pathway mediated the suppression of SULT2A1 by metformin. Metformin may affect the metabolism and clearance of drugs which are SULT2A1 substrates. …”
Get full text

Mesenchymal stem cell-mediated adipogenic transformation: a key driver of oral squamous cell carcinoma progression by Yiting Shao, Yu Du, Zheng Chen, Lei Xiang, Shaoqin Tu, Yi Feng, Yuluan Hou, Xiaoxing Kou, Hong Ai

Get full text

Neuroinflammation mediates the progression of neonate hypoxia-ischemia brain damage to Alzheimer’s disease: a bioinformatics and experimental study by Shengjie Zhang, Ruqiu Zhang, Zhaoqin Chen, Zihan Shao, An Li, Fan Li, Fang Huang

Get full text

The mediating effect of intrusive rumination on the relationship between illness uncertainty and fear of cancer recurrence in breast cancer survivors by Alper Türkel, Nur Nihal Türkel, Ahmet Kadıoğlu, Mutlu Doğan, İrem Ekmekçi Ertek

“…Aims: This study aimed to examine the mediating effect of intrusive rumination on the relationship between illness uncertainty and FCR in breast cancer survivors. …”
Get full text

In Vivo Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa Arising by AmpC- and Non-AmpC-Mediated Pathways by Erik Skoglund, Henrietta Abodakpi, Rafael Rios, Lorena Diaz, Elsa De La Cadena, An Q. Dinh, Javier Ardila, William R. Miller, Jose M. Munita, Cesar A. Arias, Vincent H. Tam, Truc T. Tran

Get full text

Sargachromenol from Sargassum micracanthum Inhibits the Lipopolysaccharide-Induced Production of Inflammatory Mediators in RAW 264.7 Macrophages by Eun-Jin Yang, Young Min Ham, Kyong-Wol Yang, Nam Ho Lee, Chang-Gu Hyun

Get full text

Insulin resistance as a mediator in the association between nickel exposure and metabolic dysfunction-associated steatotic liver disease by Zhou Liu, Liang Zhang, Yanrui Wu, Zongbiao Tan, Guang Li, Zhenwen Li, Liying Zhan, Weiguo Dong

“…To analyze the association between nickel exposure and MASLD, three multiple logistic regression models with weights were developed. Furthermore, a mediation analysis was performed to examine insulin resistance’s potential mediating role. …”
Get full text

SPI1 facilitates microfracture-mediated cartilage regeneration in the elderly by enhancing bone marrow stromal cells stemness by Changjiang Wang, Yishu Wang, Yueqiang Gu, Yi Zhu, Rui Yin, Yang Li, Jianchao Gui

Get full text

DNA-mediated self-assembly oxidative damage amplifier combined with copper and MTH1 inhibitor for cancer therapy by Cui Ren, Zhiyong Shi, Xiaowen Zhang, Xueer Yu, Yang Gao, Zhi Qi, Yu Chen, Yong Wang

“…Moreover, controllable-released TH588 prevented MTH1-mediated DNA repairing, thus aggravated oxidative damage to tumor cells. …”
Get full text

Tumor necrosis factor, interleukin-1 and interleukin-8 mediate the nociceptive activity of the supernatant of LPS-stimulated macrophages by S. M. Thomazzi, R. A. Ribeiro, D. I. Campos, F. Q. Cunha, S. H. Ferreira

“…Mediators of Inflammation…”
Get full text

Corrigendum to “Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease” by Celia Luchena, Jone Zuazo-Ibarra, Elena Alberdi, Carlos Matute, Estibaliz Capetillo-Zarate

“…Mediators of Inflammation…”
Get full text

The relationship between psychological capital and athlete burnout: the mediating relationship of coping strategies and the moderating relationship of perceived stress by Xiaomei Yu, Suxuan Xing, Yang Yang

“…Methods A cross-sectional survey was conducted among 344 athletes, and data were analyzed using SPSS Statistics 25.0 and PROCESS Macro v4.1 for hierarchical stepwise regression and moderated mediation analysis. Control variables included age, gender, sport type, and competitive experience. …”
Get full text

Intratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control by Helena Escuin-Ordinas, Ignacio Melero, Marisol Quintero, Jose Luis Perez-Gracia, Maite Alvarez, Maria E Rodriguez-Ruiz, Miguel F Sanmamed, Paloma Sanchez-Mateos, Inmaculada Rodríguez López, Irantzu Serrano-Mendioroz, Celia Barrio-Alonso, Eneko Garate-Soraluze, Victor Diaz Pascual, Leire Arbea Moreno

“…BO-112 is a viral mimetic based on nanoplexed double-stranded RNA (poly I:C) which exerts immune-mediated antitumor effects in mice and humans on intratumoral delivery. …”
Get full text

Apigenin suppresses osteoarthritis progression by inhibiting pyroptosis via SIRT1/mTOR pathway-mediated mitophagy by Jiahao Ying, Shijie Li, Anna Ying, Yindong Ding, Xiaoyin Zhu, Jiahao Lin, Kehe Yu

“…By promoting SIRT1/mTOR pathway-mediated mitophagy, Api shields chondrocytes from pyroptosis. …”
Get full text

Binge Eating Disorder Mediates Links between Symptoms of Depression, Anxiety, and Caloric Intake in Overweight and Obese Women by Roseann E. Peterson, Shawn J. Latendresse, Lindsay T. Bartholome, Cortney S. Warren, Nancy C. Raymond

“…Results from path analysis suggested that BED mediates the influence of internalizing symptoms on total kcal intake (empirical P<0.001 ). …”
Get full text

Increasing the neoantigen expression by nonsense mediated mRNA decay inhibitors: An effective therapeutic approach in oral cancer? by Saravanan Sekaran

Get full text

Association between Mediterranean diet and metabolic health status among adults was not mediated through serum adropin levels by Maryam Shafiei, Donya Poursalehi, Sobhan Mohammadi, Farnaz Shahdadian, Zahra Hajhashemy, Parisa Rouhani, Elahe Mokhtari, Parvane Saneei

Get full text

Superficial Dsg2 Expression Limits Epidermal Blister Formation Mediated by Pemphigus Foliaceus Antibodies and Exfoliative Toxins by Donna Brennan, Ying Hu, Walid Medhat, Alicia Dowling, Mỹ G. Mahoney

“…Cell-cell adhesion mediated by desmosomes is crucial for maintaining proper epidermal structure and function, as evidenced by several severe and potentially fatal skin disorders involving impairment of desmosomal proteins. …”
Get full text

Examining the Impacts of House Prices on Self-Rated Health of Older Adults: The Mediating Role of Subjective Well-Being by Min Wang, Zixuan Tan, Ruying Chen, Xuefang Zhuang

“…Evidence indicates that there is a complex association between house prices and older adults’ health, with their subjective well-being potentially acting as a mediator in this connection. A mediation model, utilizing data from China’s 2018 Labor Dynamics Survey, was employed to examine the impact pathway of house prices, subjective well-being, and self-rated health, while investigating the differences between young-old and old-old groups. …”
Get full text

Analysis of financial management decisions on company financial performance with economic value added (eva) as a mediating variable by Ainun Jariah

“…However, the direct impact of these decisions is often complex, involving mediating variables such as Economic Value Added (EVA). …”
Get full text