Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling by Kelly G. Jameson, Sabeen A. Kazmi, Takahiro E. Ohara, Celine Son, Kristie B. Yu, Donya Mazdeyasnan, Emma Leshan, Helen E. Vuong, Jorge Paramo, Arlene Lopez-Romero, Long Yang, Felix E. Schweizer, Elaine Y. Hsiao

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Enhancing Enzyme-Mediated Cellulose Hydrolysis by Incorporating Acid Groups Onto the Lignin During Biomass Pretreatment by Jie Wu, Richard P. Chandra, Masatsugu Takada, Masatsugu Takada, Li-Yang Liu, Scott Renneckar, Kwang Ho Kim, Chang Soo Kim, Jack N. Saddler

“…Lignin is known to limit the enzyme-mediated hydrolysis of biomass by both restricting substrate swelling and binding to the enzymes. …”
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Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation by Ayla Valinezhad Orang, Reza Safaralizadeh, Mina Kazemzadeh-Bavili

“…This paper provides an overview of the current understandings of the miRNA characteristics including their genes and biogenesis, as well as their mediated downregulation. We also review up-to-date knowledge of miRNA-mediated gene upregulation through highlighting some notable examples and discuss the emerging concepts of their associations with other posttranscriptional gene regulation processes.…”
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The impact of ESG and the institutional environment on investment efficiency in China through the mediators of agency costs and financial constraints by Zhao Donghui, Wan Sallha Yusoff, Mohd Fairuz Md Salleh, Ngan Sue Lin, Ainul Huda Jamil, Mohd Juraij Abd Rani, Mohd Shahidan Shaari

“…Using data from 3380 non-financial Chinese firms (2010–2021) and a fixed-effects panel regression model, we explore how ESG influences investment efficiency through the mediating roles of agency costs and financial constraints. …”
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HnRNPR-mediated UPF3B mRNA splicing drives hepatocellular carcinoma metastasis by Hong Wang, Dong Qian, Jiabei Wang, Yao Liu, Wenguang Luo, Hongyan Zhang, Jingjing Cheng, Heng Li, Yang Wu, Wuhan Li, Jing Wang, Xia Yang, Tianzhi Zhang, Dong Han, Qinyao Wang, Chris Zhiyi Zhang, Lianxin Liu

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AMPK Activation Mediated by Hinokitiol Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells through Autophagy Flux by Ju-Hee Lee, Jae-Kyo Jeong, Sang-Youel Park

“…The inhibition of AMPK phosphorylation also suppressed hinokitiol-mediated inhibition of autophagy and antiadipogenic effects. …”
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Inherited Thrombocytopenia Related Genes: GPS2 Mediates the Interplay Between ANKRD26 and ETV6 by Valeria Capaci, Melania Eva Zanchetta, Giorgia Fontana, Daniele Ammeti, Roberta Bottega, Michela Faleschini, Anna Savoia

“…We found that GPS2, a component of the NCoR complex, binds both ANKRD26 and ETV6, mediating this interaction. Furthermore, ANKRD26 overexpression deregulates ETV6 transcriptional repression, supporting a common pathogenic mechanism underlying ANKRD26-RT, FPD/AML, and ETV6-RT. …”
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Ambient air pollution and birth outcomes: a scoping review to investigate the mediating and moderating variables—protocol by Amy Mizen, Richard Fry, Lucy Perry, Kate Ellis-Davies, Amy Isham

“…This scoping review aims to understand the extent and type of evidence concerning the mediating and moderating factors between air pollution and birth outcomes. …”
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Moral distress, ethical climate, and compassion fatigue among oncology nurses: the mediating role of moral distress by Akbar Zare-Kaseb, Fariba Borhani, Abbas Abbaszadeh, Amir Mohamad Nazari

“…Moreover, the role of moral distress as a mediator in the link between ethical climate and compassion fatigue was examined. …”
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CDC20‐Mediated Selective Autophagy Degradation of PBRM1 Affects Immunotherapy for Renal Cell Carcinoma by Yizeng Fan, Weichao Dan, Taotao Que, Yi Wei, Bo Liu, Zixi Wang, Yulin Zhang, Yuzhao Wang, Tianjie Liu, Yanxin Zhuang, Mengxing Li, Chendong Guo, Jin Zeng, Bohan Ma, Lei Li

“…Meanwhile, CDC20 catalyzes K27 ubiquitination of PBRM1 and promotes its degradation via p62‐mediated selective autophagy. A bicyclic peptide (PB1‐p62) is designed and constructed to target PBRM1 and p62, thereby promoting the degradation of PBRM1. …”
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Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-Labeled Reporter Nanoparticles by Govindarajan Srimathveeravalli PhD, Dalya Abdel-Atti BS, Carlos Pérez-Medina PhD, Haruyuki Takaki MD, PhD, Stephen B. Solomon MD, Willem J. M. Mulder PhD, Thomas Reiner PhD

“…We investigated a radiolabeled liposomal nanoparticle ( 89 Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DOX) delivery in mouse tumors. …”
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Activation of Hippocampal Microglia Mediates Chronic Stress-induced Depression-like Behavior in Rats with Ischemic Stroke by TAO Xi, YANG Chen, TANG Wenjing, WU Siyuan, DENG Jinggui

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Mediating role of fatigue driving in the influence of job demand and insecurity on safety incidents among bus drivers by Mustapha Amoadu, Isaac Tetteh Commey, Edward Wilson Ansah

“…Driving fatigue produced a partial mediation effect of job demands and job security on safety incidents of the drivers. …”
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A Study on the Effect of Abusive Supervision on Knowledge Hiding: Mediated by Emotional Exhaustion and Moderated by Coworkers Support by Bushra Khursheed, Um-e-Rubbab

“…This study was conducted to assess the effects of abusive supervision on knowledge hiding, taking into account the moderating influence of coworker support and the mediating function of emotional exhaustion. The current study's model suggests that when supervisors are abusive, people become emotionally exhausted and hide knowledge. …”
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The impact of physical exercise on adolescents’ mobile phone dependency: the serial mediating role of self-esteem and depression by Jingtao Wu, Yanhong Shao, Wanli Zang

“…Depression was negatively correlated with self-esteem (r = −0.396, p < 0.001). Mediation analysis revealed that self-esteem and depression significantly mediated the relationship between physical exercise and mobile phone dependency, with a total indirect effect of −0.116 (95% CI = [−0.239, −0.140]), accounting for 100% of the total effect. …”
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Complement-Mediated Hemolytic Uremic Syndrome Due to MCP/CD46 Mutation: A Case Report by Abdul Muhsen Abdeen MD, Jowan Al-Nusair MD, Malik Samardali MD, Mohamed Alshal MD, Amro Al-Astal MD, Zeid Khitan MD

“…Thrombotic microangiopathy (TMA) is a severe condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ damage, often involving the kidneys. Complement-mediated hemolytic uremic syndrome (cHUS), a rare form of TMA, arises from dysregulated alternative complement pathway activation, frequently due to genetic mutations. …”
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Siesta characteristics mediated the association between siesta duration and sleep quality in Chinese incoming college freshmen by Huiying Wang, Jiali Li, Yaohui Han, Shilei Zhai, Yumeng Liu, Peipu Shen, Guifang Shen, Lishun Xiao

“…Some siesta characteristics mediate the relationship between them.…”
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Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis by Chen Xi, Jie Zhou, Xin Zheng, Xiaoyi Fu, Minjuan Xie

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The Pathway Relationship Between Physical Activity Levels and Depressive Symptoms in University Students Mediated by Cognitive Flexibility by Fen Yu, Shuqi Jia, Qin Liu, Zhaohui Guo, Sen Li, Xing Wang, Pan Li

“…ABSTRACT Objective To explore the mediating pathway of cognitive flexibility in the relationship between physical activity and depressive symptoms among university students. …”
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How do social entrepreneurship factors influence sustainable business development? The mediating role of social network by Titik Kusmantini, Heru Tri Sutiono, Anis Siti Hartati, Anidah Robani, Aris Kusumo Diantoro, Ashila Metta Rahmadati

“…Firstly, it measured only two factors and one mediator of social entrepreneurship in addressing sustainable business development. …”
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