Lunasin peptide promotes lysosome-mitochondrial mediated apoptosis and mitotic termination in MDA-MB-231 cells by Yuqiong Hao, Huimin Guo, Yechun Hong, Xin Fan, Yumei Su, Xiushi Yang, Guixing Ren

“…Overall, our study reveals that the anti-proliferation effect of lunasin peptide might be triggered via the inhibition of DNA replication and cell mitosis, as well as the promotion of lysosome-mitochondrial mediated cell apoptosis.…”
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Network of Mediators for Vascular Inflammation and Leakage Is Dysbalanced during Cytoreductive Surgery for Late-Stage Ovarian Cancer by Sven Klaschik, Jennifer Gehlen, Claudia Neumann, Mignon-Denise Keyver-Paik, Martin Soehle, Stilla Frede, Markus Velten, Andreas Hoeft, Tobias Hilbert

“…Mediators of Inflammation…”
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The Influence of Leadership and Teamwork on Employee Performance with Organizational Commitment as a Mediating Variable at PT. Primayudha Mandirijaya by Rizky Marsha Febriyanti, Jati Waskito

“…Primayudha Mandirijaya through Organizational Commitment as a mediating variable (H6). …”
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Nonlinear stability of a heterogeneous state in a PDE-ODE model for acid-mediated tumor invasion by Youshan Tao, J. Ignacio Tello

“…This work studies a general reaction-diffusion model foracid-mediated tumor invasion, where tumor cells produce excess acidthat primarily kills healthy cells, and thereby invade the microenvironment. …”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…Immunoprecipitation coupled with mass spectrometry (IP-MS), bioinformatics analysis and ubiquitination assays, were employed to identify the molecular targets responsible for SEL-induced degradation of XPO1. shRNA-mediated knockdown assays and small molecule inhibitors of USP7 were utilized to disrupt the function of USP7. …”
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The Role Of Cyberchondria In Mediating Health Anxiety, Fears And Obsessions Among Students Of Private Medical Colleges Sargodha by Muhammad Usman, Adnan Afzal, Muhammad Afzal, Sundas Ahmad, Bilal Habib, Amina Iqbal

“… Objective: This study was conducted to examine the role of cyberchondria in mediating health anxiety, fears and obsessions among Students of private medical college. …”
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Efficacy of the Bushen Jianpi Huoxue Formula on Beclin-1/Bcl-2-mediated autophagy and apoptosis in osteoblasts by Yanping Lin, Yanping Lin, Rui Zhao, Rui Zhao, Jiachun Huang, Tongying Chen, Tongying Chen, Haolin Yang, Haolin Yang, Haiwei Guo, Lei Wan, Zhihai Zhang, Ying Li, Genfu Zhu, Hongxing Huang, Hongxing Huang

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Neuroprotective Role of Transchalcone in Parkinson‘s Disease through AMP-activated Protein Kinase-mediated Signaling Pathway by Yao Cheng, Shaik Althaf Hussain, Turki Mayudh Alrubie, Xiaomin Zhang

“…Neuroprotective and mitoprotective impacts of trans-chalcone were mostly mediated through the activation of AMPK-SIRT1-PGC1α pathway. …”
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CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions by Lei Huang, Yalei Wen, Qin Guo, Caishi Zhang, Xiao Yang, Mei Li, YiXia Liu, Xinying Li, Jiaxin Tang, Xiaofeng Zhou, Qi Qi, Haoxing Zhang, Tongzheng Liu

“…Mechanistically, CK2α directly phosphorylates DUB3 at Thr495, thereby facilitating DUB3-mediated deubiquitination process of YAP1. On the contrary, the loss of Thr495 phosphorylation by the phosphorylation-defective mutant DUB3 T495A, the cancer-related mutant DUB3 D496H and CK2 inhibition failed to deubiquitinate and stabilize YAP1 effectively. …”
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Secretory mitophagy: an extracellular vesicle-mediated adaptive mechanism for cancer cell survival under oxidative stress by Purva V. Gade, Angela Victoria Rojas Rivera, Layla Hasanzadah, Sofie Strompf, Thomas Raymond Philipson, Matthew Gadziala, Atharva Tyagi, Arnav Bandam, Rithvik Gabbireddy, Fatah Kashanchi, Amanda Haymond, Lance A. Liotta, Marissa A. Howard

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2′-Hydroxycinnamaldehyde induces ROS-mediated apoptosis in cancer cells by targeting PRX1 and PRX2 by Yae Jin Yoon, Yu-Jin Lee, Jiyeon Choi, Seung-Wook Chi, Sangku Lee, Kyung Chan Park, Byoung-Mog Kwon, Dong Cho Han

“…Our previous study showed that HCA induced reactive oxygen species (ROS) and apoptosis in cancer cells, and pretreatment of cancer cells with antioxidants abolished HCA-mediated ROS production and apoptosis. This indicates that ROS are critical effector for HCA activity. …”
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Moral disengagement as mediator and guilt as moderator between cyber moral literacy and cyberbullying among late adolescents by Ya-Xing Sun, Cui-Hong Cao, Zhi-Jun Tang, Fei-Mei Huang, Xiao-Bin Zhong, I-Hua Chen

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Fermion masses, neutrino mixing and Higgs-mediated flavor violation in 3HDM with S 3 permutation symmetry by K. S. Babu, Yongcheng Wu, Shiyuan Xu

“…The fit results in the Yukawa sector are further investigated, together with the scalar sector, imposing constraints from Higgs-mediated neutral meson mixing and neutron electric dipole moment (EDM). …”
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Trusting the trustless blockchain for its adoption in accounting: theorizing the mediating role of technology-organization-environment framework by Sujata Seshadrinathan, Shalini Chandra

“…The model proposes that TOE factors mediate trust's role in adopting blockchain for accounting applications. …”
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A Micro-RNA Connection in BRafV600E-Mediated Premature Senescence of Human Melanocytes by Gang Ren, Jingwei Feng, Ila Datar, Aaron H. Yeung, Srinivas Vinod Saladi, Yongqing Feng, Ivana de la Serna, Kam C. Yeung

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Adherence to a digital therapeutic mediates the relationship between momentary self-regulation and health risk behaviors by Enzo G. Plaitano, Enzo G. Plaitano, Daniel McNeish, Sophia M. Bartels, Sophia M. Bartels, Kathleen Bell, Jesse Dallery, Michael Grabinski, Michaela Kiernan, Hannah A. Lavoie, Hannah A. Lavoie, Shea M. Lemley, Michael R. Lowe, David P. MacKinnon, Stephen A. Metcalf, Stephen A. Metcalf, Lisa Onken, Judith J. Prochaska, Cady Lauren Sand, Cady Lauren Sand, Emily A. Scherer, Luke E. Stoeckel, Haiyi Xie, Lisa A. Marsch

“…Together, this work demonstrated the ability to digitally assess the transdiagnostic mediating effect of momentary self-regulation on medical regimen adherence and pro-health behavioral outcomes. …”
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HDAC6 inhibitor-loaded brain-targeted nanocarrier-mediated neuroprotection in methamphetamine-driven Parkinson's disease by Khang-Yen Pham, Shristi Khanal, Ganesh Bohara, Nikesh Rimal, Sang-Hoon Song, Thoa Thi Kim Nguyen, In-Sun Hong, Jinkyung Cho, Jong-Sun Kang, Sooyeun Lee, Dong-Young Choi, Simmyung Yook

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Navigating Innovation Highways: Unraveling the Entrepreneurial Culture's Role with Knowledge Management as the Mediator in Automotive Technology Innovations by K. Sumathi, Prabir Chandra Padhy

“…Moreover, it highlights the partial mediation effect of knowledge management in the relationship between entrepreneurial culture and technology innovation. …”
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Varicella-Zoster-Mediated Radiculitis Reactivation following Cervical Spine Surgery: Case Report and Review of the Literature by Doniel Drazin, George Hanna, Faris Shweikeh, Sunil Jeswani, Leah Lovely, Richard Sokolov, John C. Liu

“…We describe a 41-year-old male with a history of varicella-mediated skin eruptions, who presented with continuing right arm pain, burning, and numbness in a C6 dermatomal distribution following a C5-6 anterior cervical discectomy and fusion and epidural steroid injections. …”
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Voltammetric Determination of Homocysteine Using Multiwall Carbon Nanotube Paste Electrode in the Presence of Chlorpromazine as a Mediator by Fathali Gholami-Orimi, Farshad Taleshi, Pourya Biparva, Hassan Karimi-Maleh, Hadi Beitollahi, Hamid R. Ebrahimi, Mohamad Shamshiri, Hasan Bagheri, Masoud Fouladgar, Ali Taherkhani

“…We propose chlorpromazine (CHP) as a new mediator for the rapid, sensitive, and highly selective voltammetric determination of homocysteine (Hcy) using multiwall carbon nanotube paste electrode (MWCNTPE). …”
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