Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression by Jian Pang, Xiaoyan Huang, Ya Gao, Xinyu Guan, Lejia Xiong, Lun Li, Nana Yin, Mei Dai, Tong Han, Wenjun Yi

“…Furthermore, NET1 may mediate the malignant proliferation of tumour cells through the AKT signalling pathway. …”
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Angiogenesis Regulated by Electroacupuncture Combined with Rehabilitation Training in Cerebral Ischemia Involved in PI3K/Akt Signaling Pathway by Wenchao YAO, Mengxing LI, Qing LIU, Mingyue TONG, Peng HE, Wei TANG

“…The expression of protein in the combined acupuncture group was higher than that of the other two groups, and the difference was statistically significant respectively (<italic>P</italic>&lt; 0.01); the trend of each variable at different time points was significantly different respectively (<italic>F</italic>_Time=100.462, 53.714, 106.552, 75.381, <italic>P</italic>&lt; 0.001), the expression of VEGF and Akt protein in the model group increased on the 7th day, and the difference was statistically significant compared with 3 d and 14 d respectively (<italic>P</italic>&lt; 0.05); the expression of BDNF and PI3K increased on the 7th day in the model group, compared with that on the 3rd day, the difference was statistically significant (<italic>P</italic>&lt; 0.01); the expression of VEGF, BDNF, PI3K, Akt protein increased significantly on the 14th day of the combined acupuncture group, and the difference was statistically significant compared with 3 d and 7 d respectively (<italic>P</italic>&lt; 0.05); The expression group×time all had a significant interaction (<italic>P</italic>&lt; 0.001). (4) The analysis of variance of repeated measurements of VEGF, BDNF, PI3K, Akt mRNA in rat brain tissues in ischemic area showed that the variables were statistically significant in different groups respectively (<italic>F</italic>_Intergroup=445.845, 427.743, 918.388, 543.814, <italic>P</italic>&lt; 0.001), the combined acupuncture group expression was higher than the other two groups, the difference was statistically significant respectively (<italic>P</italic>&lt; 0.01); the change trend of each variable at different time points was significantly different (<italic>F</italic>_Time=100.343, 13.984, 9.162, 32.931, <italic>P</italic>&lt; 0.001), the expression of BDNF and PI3K mRNA in the model group increased on the 7th day, and the difference was statistically significant respectively (<italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.01); the expression of VEGF mRNA in the model group increased on the 7th day, compared with that on the 14th day, the difference was statistically significant (<italic>P</italic>&lt; 0.01); the expression of VEGF, BDNF, PI3K, Akt mRNA increased significantly on the 7th day in the combined acupuncture group, and the difference was statistically significant compared with 3 d and 14 d respectively (<italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.01); the mRNA expression group×time had significant interaction (<italic>P</italic>&lt; 0.001).Conclusion:Under the influence of intervention effect, time effect and the interaction of the two, the combination of electroacupuncture and rehabilitation training can play a protective role in cerebral ischemia, which may be related to the control of the expression of VEGF and BDNF and the downstream transduction pathway PI3K/Akt, which mediates the angiogenesis after cerebral ischemia.…”
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Jiedu Xiaozheng Decoction Augments 5-fluorouracil Induced Anti-hepatic Carcinoma Effect <italic>in Vitro</italic> and <italic>in Vivo</italic> by Zhiyun CAO, Liangpu ZHENG, Wei LIN, Xuzheng CHEN, Xiaoqin ZHU, Jiumao LIN, Wei LIN, Jian DU

“…The apoptosis rate of tumor was evaluated by terminal dexynucleotidyl transferase(TdT)-mediated dUTP nick end labeling(TUNEL).Results：EE-JXD, 5-FU and EE-JXD+5-FU inhibited proliferation of HepG2 cells in a concentration-dependent manner. …”
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Explanation and validation of the coordination model of the marketing and sales department in the insurance industry in Iran by Alireza Jahed, Ehsan Abedi, Hamidreza Saeednia

“…Arabshahi & Abbaszadehgaretekan (2023) studied the effect of electronic customer relationship management on marketing performance by analyzing the mediating role of product innovation and emphasizing customer knowledge. …”
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Providing effective innovative strategies in the development of cosmetics industry with emphasis on international entrepreneurship by Ali Khabaz, Jamshid Edalatian shahryari, Heydar Amiran

“…Also, the fit indices of the model indicate that the presented model has a suitable fit.Arabshahi & Abbaszadehgaretekan (2023) investigated the effect of electronic customer relationship management on marketing performance by analyzing the mediating role of product innovation and emphasizing customer knowledge. …”
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Identifying factors affecting the commercialization of products of knowledge-based companies based in science and technology parks and growth centers by yousef sofi, Vahid Reza Mirabi, Rahim Sarvar

“…From a study of 84 synthetic biology organizations, they found that disposal capacity mediates the relationship between management innovation and foreign technology commercialization. …”
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Presenting the internal evaluation model on the performance of the banking industry based on the data theory method of the foundation by Zahra Ramzanpour Osmavandani, mehdi Rouholamini, Shahrbanoo Gholipour

“…Zamaniyan & Yazdani Rad (2023) investigated the impact of internal marketing on competitive advantage by considering the mediating roles of strategic market tendencies, brand and value in the banking sector. …”
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Designing a defensive silence failure model of creative employees in organizations by Azam Khosravi, karam khalili, Esfandyar Mohammadi

“…Defensive silence is a type of organizational silence that occurs when the employee fears the consequences of speaking up, or perceives that speaking up will have a negative impact (Moalemian et al, 2021).Powell (2023) in a study investigated the drivers of organizational silence and strategies to deal with them and finally reached the conclusion that; the most important influencing factors in reducing organizational silence are the perception of organizational support and the rule of meritocracy in organizations.Fang-Shu & Ramayah (2022) in a study investigated the effect of participatory management on reducing employees' defensive silence by mediating the quality of communication and finally reached the conclusion that; participatory management and the quality of the organization's internal communication have a significant impact on the breaking of employees' defensive silence. …”
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Identification and analysis of drivers affecting the maturity of knowledge management in Tehran Municipal Sports Organization by ismail khandan, Ali Mohammad Safania, Mohsen Baghrian Farahabadi, Seyyed Salahuddin i Naqshband

“…Thus, creating an organizational knowledge base should be recognized as a valuable resource (Rossidis & Belias, 2020).Shafaei et al, (2024) investigated the impact of knowledge management on organizational performance with regard to the mediating variable of business process management. …”
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Designing an educational model based on identity development with an Iranian-Islamic approach for primary school students. by Ali Oladhamzehzadeh, masoumeh oladiyan, Mahmoud Safari

“…Imagined identity can play a powerful role in mediating external problems created in identity development. …”
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Presenting the agility model of the organization in order to improve the productivity of human resources by Asie Mohmedi, Rashid Zolfaghari, Mahsa Gholam hossein zadeh

“…Ali sofi & Salami (2023) investigated the effect of quantum management skills on susceptibility to change with the mediating role of organizational agility. The findings obtained from the structural equation model showed that the standard coefficient between quantum management was significant on readiness for change (0.19), quantum management on organizational agility (0.58), as well as susceptibility for change and organizational agility (0.64), and the indirect effect of quantum management on change readiness (0.47). …”
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Identifying and analyzing drivers of innovative behavior based on strategic management of human resources in knowledge-based organizations by Mitra Sadoughi

“…The result of research hypotheses indicates a positive and significant effect of cultural diversity on cultural intelligence as well as the impact of cultural diversity and cultural intelligence on innovative work behavior. The mediating role of cultural intelligence in relation to cultural diversity and innovative work behavior was also confirmed. …”
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Designing a Digital Branding Pattern in Healthy Agricultural Products by Abolghasem Mohammadnezhad Ali Zamini, Arezo Ahmadi danyali, Mahmoud Ahmadi Sharif

“…In addition, it highlighted the significant mediating effect of digital support and awareness on digital brand adoption intention. …”
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Addressing Shortcomings in Contingency Standards of Care by Alexander Quan

“…Between Usual and Crisis Phases of a Public Health Emergency: The Mediating Role of Contingency Measures. The American Journal of Bioethics, 21(8), 4–16. https://doi.org/10.1080/15265161.2021.1925778 [4] Rosenbaum, L. (2020). …”
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