Vitamin D and exercise improve VEGF-B production and IGF-1 levels in diabetic rats: insights the role of miR-1 suppression by Fatemeh Mazaheri, Rastegar Hoseini, Ahmad Gharzi

“…The study concludes that the combination of AT and Vit D has cardio-protective effects in T2DM rats, counteracting abnormal angiogenesis induced by diabetes. These effects are mediated, at least in part, by the upregulation of IGF-1 and VEGF-B, and the downregulation of miR-1.…”
Get full text

Interplay between BMI, neutrophil, triglyceride and uric acid: a case-control study and bidirectional multivariate mendelian randomization analysis by Haoyuan Lyu, Na Fan, Hao Wen, Xin Zhang, Herong Mao, Qinglai Bian, Jiaxu Chen

“…Conclusions Our study presents strong evidence of the complex interconnection between BMI, neutrophils, triglyceride, and UA, revealing complex causal links and highlighting potential inflammatory states as key mediators. The findings may contribute to a better understanding of these factors and potentially lead to improved clinical outcomes and patients’ health.…”
Get full text

Hyperglycemia Is a Potential Prognostic Factor for Exacerbation in Severe Psoriasis with Diabetes or Prediabetes by Yongpisarn T, Thadanipon K, Suchonwanit P, Rattanakaemakorn P

“…Tanat Yongpisarn,1 Kunlawat Thadanipon,1,2 Poonkiat Suchonwanit,1 Ploysyne Rattanakaemakorn1 1Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Ploysyne Rattanakaemakorn, Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand, Tel +662-201-1141, Fax +662-201-1211, Email ploysyne@gmail.comBackground: Psoriasis is an immune-mediated skin disease with a chronic relapsing-remitting course. …”
Get full text

Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy by Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao

“…Subsequent experiments confirmed that HVEM’s influence on T cell activation and metabolism is potentially mediated through its regulation of GPT2. In addition, GATA1 was validated to regulate HVEM expression in activated Jurkat T cells. …”
Get full text

EPIGENETICS TODAY AND TOMORROW by B. F. Vanyushin

“…The most known epigenetic mechanisms (signals) are enzymatic DNA methylation, the histone code (various enzymatic histone modifications including acetylation, methylation, phosphorylation, ubiquitination and others), and gene silencing mediated by small RNAs (miRNA, siRNA). Very often all these processes are interconnected or even partially interchangeable. …”
Get full text

The role of skill and expertise and organizational resources along with the relevant components in the competitive environment of the organization (case study: Tehran Province Muni... by Mehdi Aghighi, Rashid Zolfegari Zaferani, Behzad Mashali

“…Ghanbari & Ahmadi (2022) investigated the role of individual citizenship behavior in the organizational innovation of schools with the mediating role of knowledge sharing in primary school teachers. …”
Get full text

Designing the alignment model of petrochemical projects with the country's industrial strategies in the Ministry of Petroleum by Abdolrasoul Shojaeian, ghanbar abbaspour esfadan, Changiz Valmohammadi, Aboutorab Alirezaei

“…The result shows that project success has a positive direct relationship with strategy, risk, information technology, and stakeholders. Risk as a mediating variable with contract, information technology, and stakeholders, has a direct relationship with strategy; therefore, the contract has a significant indirect relationship with the success of the project. …”
Get full text

Providing a model of emotional and rational appeals in video marketing based on social networks by Moohan Mohammadi, payam paslari, saeed moradpour, sadegh masjoodi

“…Also, the effect of the attention-attracting variable was identified as a mediating variable in creating behavioral engagement.ConclusionThe present research was conducted with the aim of presenting the model of emotional and rational appeals in video marketing based on social networks with the approach of structural equations. …”
Get full text

Designing a Policy Making Model in Iran' Sport with the Approach of Sport for All Development by Behdad Sadeghi, Rahmatollah Gholipour, Mojtaba Amiri, Marjan Saffari

“…The primary categories of the sport policy-making model in Iran for the development of 'sport for all' include contextual factors, mediating factors, role players and influential institutions, executive requirements, environmental complexities, risks, legal problems, external organizational factors, costs and expenses, and interorganizational challenges. …”
Get full text

New Approach to Improving the Prognosis of Ischemic Stroke by Regulating SCFAs with Acupuncture-Rehabilitation Therapy Based on Gut-Brain Axis by TANG Qiang, LIU Chong, CHAI Fanglei, ZHANG Jinpeng, LI Hongyu, ZHU Luwen

“…The two communicate through various channels, such as inflammatory mediators, autonomic nervous system, endocrine system and metabolites of intestinal flora. …”
Get full text

Early Weaning Impairs the Growth Performance of Hu Lambs Through Damaging Intestinal Morphology and Disrupting Serum Metabolite Homeostasis by Haoyun Jiang, Haibo Wang, Haobin Jia, Yuhang Liu, Yue Pan, Xiaojun Zhong, Junhong Huo, Jinshun Zhan

“…These differential metabolites were enriched in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, including inflammatory mediator regulation, protein digestion and absorption, and phenylalanine and tyrosine biosynthesis. …”
Get full text

Endothelial Dysfunction and Oxidative Stress in Patients with Severe Coronary Artery Disease: Does Diabetes Play a Contributing Role? by Alexandra Maria Boieriu, Cezar Dumitrel Luca, Carmen Daniela Neculoiu, Alina Bisoc, Diana Țînț

“…Blood samples were collected to measure plasma serotonin (5-HT; SER) levels, as well as levels of superoxide dismutase 1(SOD-1) and lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) to assess oxidative stress. Brachial flow-mediated dilation (FMD) was used as a surrogate for endothelial dysfunction (ED),along with serum concentrations of 5-HT. …”
Get full text

Selected cannabis cultivars modulate glial activation: in vitro and in vivo studies by Sigal Fleisher-Berkovich, Nitzan Sharon, Yvonne Ventura, Valeria Feinshtein, Jonathan Gorelick, Nirit Bernstein, Shimon Ben-Shabat

“…Conclusions While both cannabis cultivars, CN2 and CN4, significantly reduced the severity of the clinical signs throughout the course of the study, they modulated different inflammatory mediators and pathways, probably due to differences in their phytocannabinoid composition. …”
Get full text

Protective Mechanism of Electroacupuncture Combined with Enriched Rehabilitative Training on Hippocampal Neurons in Rats with Cerebral Ischemia-Reperfusion Injury by Li GONG, Wei TANG, Zhen QIU, Mengxing LI

“…Its effect may inhibit the release and activation of ERS-associated proteins PERK, CHOP and Bax, up-regulate the expression of anti-apoptotic protein Bcl-2 and p-Akt, interfere with ERS-mediated apoptosis pathway and reduce the apoptosis rate, so that the cerebral nerve can be protected.…”
Get full text

Acute effect of exercise with or without the integration of cooperative activities on inhibitory control in preadolescent school children by Melanie Berger, Markus Gerber, Sebastian Ludyga

“…Do different cognitive domains mediate the association between moderate‐to‐vigorous physical activity and adolescents’ off‐task behaviour in the classroom? …”
Get full text

Three-way relationships between gut microbiota, helminth assemblages and bacterial infections in wild rodent populations by Bouilloud, Marie, Galan, Maxime, Dubois, Adelaide, Diagne, Christophe, Marianneau, Philippe, Roche, Benjamin, Charbonnel, Nathalie

“…This variability is often mediated by environmental or host factors such as diet, genetics, and infections. …”
Get full text

Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity by Matthew C. Austin, Charanya Muralidharan, Saptarshi Roy, Justin J. Crowder, Jon D. Piganelli, Amelia K. Linnemann, Amelia K. Linnemann

“…BackgroundType 1 Diabetes (T1D) is caused by a combination of genetic and environmental factors that trigger autoimmune-mediated destruction of pancreatic β-cells. Defects in β-cell stress response pathways such as autophagy may play an important role in activating and/or exacerbating the immune response in disease development. …”
Get full text

Impact of the Mediterranean Diet on Patients With Psoriasis: Protocol for a Randomized Controlled Trial by Javier Perez-Bootello, Emilio Berna-Rico, Carlota Abbad-Jaime de Aragon, Ruth Cova-Martin, Leticia Goni, Asuncion Ballester-Martinez, Pedro Jaen-Olasolo, Nehal Mehta, Joel M Gelfand, Miguel Angel Martinez-Gonzalez, Alvaro Gonzalez-Cantero

“…This anti-inflammatory potential has prompted interest in exploring the MedDiet’s role in immune-mediated diseases, including psoriasis. Observational studies have indicated potential benefits, such as reductions in the Psoriasis Area and Severity Index. …”
Get full text

Oxidative Stress, Antioxidant Capacity, and Inflammatory Markers in Patients with Idiopathic Complete Heart Block by Shobhit Shah, Monika Bhandari, Pravesh Vishwakarma, Wahid Ali, Mohammad Kaleem Ahmad, Abhishek Singh, Ayush Shukla, Akhil Kumar Sharma, Gaurav Chaudhary, Akshyaya Pradhan, Sharad Chandra, Rishi Sethi, S. K. Dwivedi

“…High significant increases in MDA (P ≤ 0.001) were indicative of increased reactive oxygen species-mediated tissue damage. Serum IL-5 (pg/ml) has a mean value of 67.347 ± 20.445 (P < 0.001) in controls and 481.442 ± 28.8995 in patients. …”
Get full text

INTERNATIONAL AND NATIONAL LEGAL MECHANISMS OF JUDICIAL LIABILITY IN THE CONDITIONS OF ECONOMIC GLOBALISATION OF MODERN SOCIETY by Konul Akhundova

“…Within the framework of the national legal systems of the countries under consideration, the features of holding judges accountable in relation to their professional activities and for offences committed outside them are determined, which mediate the implementation of the content of the immunity and immunity of such officials. …”
Get full text